Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HPB1_LEIBR

TriTrypDb:

LbrM.35.2660 , LBRM2903_350033700

Length:

442

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A4HPB1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPB1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	200	204	PF00656	0.753
CLV_C14_Caspase3-7	308	312	PF00656	0.662
CLV_C14_Caspase3-7	317	321	PF00656	0.664
CLV_C14_Caspase3-7	59	63	PF00656	0.729
CLV_NRD_NRD_1	336	338	PF00675	0.395
CLV_NRD_NRD_1	34	36	PF00675	0.442
CLV_NRD_NRD_1	98	100	PF00675	0.345
CLV_PCSK_KEX2_1	336	338	PF00082	0.396
CLV_PCSK_KEX2_1	34	36	PF00082	0.459
CLV_PCSK_SKI1_1	160	164	PF00082	0.403
CLV_PCSK_SKI1_1	174	178	PF00082	0.415
CLV_PCSK_SKI1_1	421	425	PF00082	0.594
CLV_PCSK_SKI1_1	435	439	PF00082	0.577
DEG_Nend_UBRbox_3	1	3	PF02207	0.428
DEG_SPOP_SBC_1	253	257	PF00917	0.769
DOC_CYCLIN_RxL_1	170	179	PF00134	0.628
DOC_CYCLIN_RxL_1	29	42	PF00134	0.557
DOC_CYCLIN_yCln2_LP_2	19	25	PF00134	0.485
DOC_MAPK_gen_1	333	342	PF00069	0.647
DOC_MAPK_MEF2A_6	336	344	PF00069	0.591
DOC_PP1_RVXF_1	329	335	PF00149	0.678
DOC_PP1_RVXF_1	90	96	PF00149	0.465
DOC_PP2B_LxvP_1	19	22	PF13499	0.233
DOC_PP2B_LxvP_1	219	222	PF13499	0.703
DOC_PP2B_LxvP_1	340	343	PF13499	0.447
DOC_PP4_FxxP_1	366	369	PF00568	0.452
DOC_PP4_FxxP_1	405	408	PF00568	0.428
DOC_PP4_FxxP_1	409	412	PF00568	0.385
DOC_USP7_MATH_1	248	252	PF00917	0.819
DOC_USP7_MATH_1	253	257	PF00917	0.818
DOC_USP7_MATH_1	262	266	PF00917	0.598
DOC_USP7_MATH_1	343	347	PF00917	0.493
DOC_USP7_UBL2_3	431	435	PF12436	0.456
DOC_WW_Pin1_4	221	226	PF00397	0.787
DOC_WW_Pin1_4	254	259	PF00397	0.755
DOC_WW_Pin1_4	365	370	PF00397	0.399
LIG_14-3-3_CanoR_1	167	177	PF00244	0.576
LIG_14-3-3_CanoR_1	196	202	PF00244	0.717
LIG_14-3-3_CanoR_1	396	405	PF00244	0.433
LIG_Actin_WH2_2	23	39	PF00022	0.551
LIG_APCC_ABBAyCdc20_2	421	427	PF00400	0.509
LIG_BIR_III_4	185	189	PF00653	0.560
LIG_BIR_III_4	311	315	PF00653	0.547
LIG_CtBP_PxDLS_1	243	247	PF00389	0.622
LIG_FHA_1	135	141	PF00498	0.477
LIG_FHA_1	289	295	PF00498	0.681
LIG_FHA_1	322	328	PF00498	0.651
LIG_FHA_1	358	364	PF00498	0.348
LIG_FHA_1	398	404	PF00498	0.432
LIG_FHA_1	40	46	PF00498	0.743
LIG_FHA_1	436	442	PF00498	0.394
LIG_FHA_1	79	85	PF00498	0.637
LIG_FHA_2	121	127	PF00498	0.654
LIG_FHA_2	198	204	PF00498	0.755
LIG_FHA_2	306	312	PF00498	0.651
LIG_FHA_2	313	319	PF00498	0.682
LIG_FHA_2	54	60	PF00498	0.595
LIG_GBD_Chelix_1	150	158	PF00786	0.417
LIG_Integrin_RGD_1	72	74	PF01839	0.459
LIG_LIR_Apic_2	406	412	PF02991	0.446
LIG_LIR_Gen_1	145	154	PF02991	0.494
LIG_LIR_Gen_1	306	312	PF02991	0.644
LIG_LIR_Gen_1	65	75	PF02991	0.653
LIG_LIR_Nem_3	145	149	PF02991	0.542
LIG_LIR_Nem_3	213	219	PF02991	0.620
LIG_LIR_Nem_3	306	310	PF02991	0.626
LIG_LIR_Nem_3	388	394	PF02991	0.434
LIG_LIR_Nem_3	399	405	PF02991	0.329
LIG_LIR_Nem_3	65	70	PF02991	0.706
LIG_LYPXL_yS_3	216	219	PF13949	0.626
LIG_NRBOX	153	159	PF00104	0.618
LIG_PDZ_Class_1	437	442	PF00595	0.496
LIG_Pex14_2	405	409	PF04695	0.469
LIG_SH2_CRK	146	150	PF00017	0.512
LIG_SH2_GRB2like	142	145	PF00017	0.647
LIG_SH2_SRC	132	135	PF00017	0.496
LIG_SH2_SRC	49	52	PF00017	0.755
LIG_SH2_STAT5	115	118	PF00017	0.627
LIG_SH2_STAT5	132	135	PF00017	0.536
LIG_SH2_STAT5	142	145	PF00017	0.586
LIG_SH2_STAT5	199	202	PF00017	0.731
LIG_SH2_STAT5	273	276	PF00017	0.675
LIG_SH2_STAT5	307	310	PF00017	0.534
LIG_SH2_STAT5	392	395	PF00017	0.393
LIG_SH2_STAT5	49	52	PF00017	0.707
LIG_SH2_STAT5	85	88	PF00017	0.541
LIG_SH3_3	128	134	PF00018	0.706
LIG_SH3_3	219	225	PF00018	0.660
LIG_SH3_3	247	253	PF00018	0.768
LIG_SH3_3	255	261	PF00018	0.798
LIG_SH3_3	282	288	PF00018	0.633
LIG_SH3_3	352	358	PF00018	0.343
LIG_SUMO_SIM_par_1	136	141	PF11976	0.615
LIG_SUMO_SIM_par_1	173	179	PF11976	0.582
LIG_SUMO_SIM_par_1	297	303	PF11976	0.603
LIG_TRAF2_1	123	126	PF00917	0.577
LIG_UBA3_1	83	92	PF00899	0.457
LIG_WRC_WIRS_1	117	122	PF05994	0.527
MOD_CDK_SPK_2	221	226	PF00069	0.520
MOD_CK1_1	39	45	PF00069	0.740
MOD_CK1_1	426	432	PF00069	0.578
MOD_CK2_1	120	126	PF00069	0.555
MOD_CK2_1	312	318	PF00069	0.673
MOD_GlcNHglycan	250	253	PF01048	0.785
MOD_GlcNHglycan	270	273	PF01048	0.755
MOD_GlcNHglycan	276	280	PF01048	0.692
MOD_GlcNHglycan	345	348	PF01048	0.441
MOD_GlcNHglycan	38	41	PF01048	0.596
MOD_GSK3_1	101	108	PF00069	0.362
MOD_GSK3_1	116	123	PF00069	0.300
MOD_GSK3_1	134	141	PF00069	0.422
MOD_GSK3_1	248	255	PF00069	0.728
MOD_GSK3_1	264	271	PF00069	0.750
MOD_GSK3_1	288	295	PF00069	0.491
MOD_GSK3_1	419	426	PF00069	0.431
MOD_GSK3_1	49	56	PF00069	0.692
MOD_N-GLC_1	312	317	PF02516	0.678
MOD_N-GLC_1	397	402	PF02516	0.529
MOD_NEK2_1	138	143	PF00069	0.517
MOD_NEK2_1	176	181	PF00069	0.504
MOD_NEK2_1	275	280	PF00069	0.482
MOD_NEK2_1	319	324	PF00069	0.499
MOD_NEK2_1	36	41	PF00069	0.651
MOD_NEK2_1	437	442	PF00069	0.611
MOD_PIKK_1	207	213	PF00454	0.760
MOD_PIKK_1	371	377	PF00454	0.457
MOD_PIKK_1	397	403	PF00454	0.542
MOD_PIKK_1	53	59	PF00454	0.495
MOD_PKA_2	36	42	PF00069	0.648
MOD_Plk_1	160	166	PF00069	0.351
MOD_Plk_1	397	403	PF00069	0.529
MOD_Plk_4	138	144	PF00069	0.438
MOD_Plk_4	295	301	PF00069	0.583
MOD_Plk_4	305	311	PF00069	0.494
MOD_Plk_4	49	55	PF00069	0.644
MOD_ProDKin_1	221	227	PF00069	0.759
MOD_ProDKin_1	254	260	PF00069	0.711
MOD_ProDKin_1	365	371	PF00069	0.503
TRG_DiLeu_BaEn_1	173	178	PF01217	0.471
TRG_DiLeu_BaEn_3	125	131	PF01217	0.417
TRG_DiLeu_BaLyEn_6	153	158	PF01217	0.519
TRG_DiLeu_BaLyEn_6	172	177	PF01217	0.548
TRG_ENDOCYTIC_2	146	149	PF00928	0.388
TRG_ENDOCYTIC_2	216	219	PF00928	0.765
TRG_ENDOCYTIC_2	307	310	PF00928	0.536
TRG_ENDOCYTIC_2	391	394	PF00928	0.607
TRG_ER_diArg_1	331	334	PF00400	0.529
TRG_ER_diArg_1	336	339	PF00400	0.534
TRG_ER_diArg_1	34	37	PF00400	0.592
TRG_Pf-PMV_PEXEL_1	156	161	PF00026	0.529

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL22	Leptomonas seymouri	50%	97%
A0A3Q8IJ49	Leishmania donovani	69%	98%
A0A3R7KBE0	Trypanosoma rangeli	27%	100%
A4ICF1	Leishmania infantum	69%	98%
D0A3C0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AT22	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	98%
Q4Q1H6	Leishmania major	69%	100%
V5B844	Trypanosoma cruzi	27%	100%