FYVE-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HPB0_LEIBR

TriTrypDb:

LbrM.35.2650 , LBRM2903_350033600

Length:

233

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0016020	membrane	2	1
GO:0020018	ciliary pocket membrane	6	1
GO:0031090	organelle membrane	3	1
GO:0031253	cell projection membrane	4	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0060170	ciliary membrane	5	1
GO:0097014	ciliary plasm	5	1
GO:0098588	bounding membrane of organelle	4	1
GO:0098590	plasma membrane region	3	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HPB0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPB0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	57	61	PF00656	0.692
CLV_NRD_NRD_1	164	166	PF00675	0.495
CLV_PCSK_KEX2_1	164	166	PF00082	0.473
CLV_PCSK_KEX2_1	190	192	PF00082	0.550
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.311
CLV_PCSK_SKI1_1	190	194	PF00082	0.413
DEG_APCC_DBOX_1	219	227	PF00400	0.335
DOC_CYCLIN_RxL_1	188	198	PF00134	0.306
DOC_MAPK_gen_1	218	225	PF00069	0.303
DOC_PP1_RVXF_1	188	195	PF00149	0.306
DOC_USP7_MATH_1	104	108	PF00917	0.678
DOC_USP7_MATH_1	121	125	PF00917	0.763
DOC_USP7_MATH_1	176	180	PF00917	0.629
DOC_WW_Pin1_4	115	120	PF00397	0.676
DOC_WW_Pin1_4	122	127	PF00397	0.722
DOC_WW_Pin1_4	134	139	PF00397	0.617
DOC_WW_Pin1_4	140	145	PF00397	0.606
DOC_WW_Pin1_4	153	158	PF00397	0.504
DOC_WW_Pin1_4	183	188	PF00397	0.526
LIG_14-3-3_CanoR_1	108	112	PF00244	0.712
LIG_14-3-3_CanoR_1	132	138	PF00244	0.722
LIG_14-3-3_CanoR_1	212	219	PF00244	0.423
LIG_Clathr_ClatBox_1	193	197	PF01394	0.305
LIG_EH1_1	193	201	PF00400	0.307
LIG_FHA_1	5	11	PF00498	0.415
LIG_FHA_2	196	202	PF00498	0.309
LIG_FHA_2	74	80	PF00498	0.389
LIG_SH2_STAT5	222	225	PF00017	0.421
LIG_SH3_3	113	119	PF00018	0.683
LIG_SH3_3	120	126	PF00018	0.583
LIG_SH3_3	132	138	PF00018	0.597
LIG_SH3_3	148	154	PF00018	0.648
MOD_CDC14_SPxK_1	186	189	PF00782	0.520
MOD_CDK_SPxK_1	183	189	PF00069	0.554
MOD_CDK_SPxxK_3	183	190	PF00069	0.340
MOD_CK1_1	107	113	PF00069	0.767
MOD_CK1_1	131	137	PF00069	0.691
MOD_CK1_1	214	220	PF00069	0.313
MOD_CK1_1	23	29	PF00069	0.651
MOD_CK2_1	195	201	PF00069	0.372
MOD_CK2_1	71	77	PF00069	0.568
MOD_GlcNHglycan	102	105	PF01048	0.614
MOD_GlcNHglycan	25	28	PF01048	0.508
MOD_GlcNHglycan	55	59	PF01048	0.720
MOD_GSK3_1	100	107	PF00069	0.651
MOD_GSK3_1	130	137	PF00069	0.587
MOD_GSK3_1	225	232	PF00069	0.512
MOD_GSK3_1	38	45	PF00069	0.568
MOD_NEK2_1	100	105	PF00069	0.638
MOD_NEK2_1	130	135	PF00069	0.655
MOD_NEK2_1	225	230	PF00069	0.417
MOD_PIKK_1	59	65	PF00454	0.664
MOD_PKA_2	107	113	PF00069	0.676
MOD_PKA_2	131	137	PF00069	0.736
MOD_PKA_2	21	27	PF00069	0.568
MOD_PKA_2	211	217	PF00069	0.431
MOD_Plk_2-3	195	201	PF00069	0.306
MOD_Plk_2-3	71	77	PF00069	0.619
MOD_Plk_4	195	201	PF00069	0.306
MOD_ProDKin_1	115	121	PF00069	0.677
MOD_ProDKin_1	122	128	PF00069	0.720
MOD_ProDKin_1	134	140	PF00069	0.620
MOD_ProDKin_1	153	159	PF00069	0.552
MOD_ProDKin_1	183	189	PF00069	0.516
MOD_SUMO_for_1	29	32	PF00179	0.573
MOD_SUMO_rev_2	186	192	PF00179	0.423
MOD_SUMO_rev_2	214	219	PF00179	0.412
TRG_DiLeu_BaEn_1	188	193	PF01217	0.378
TRG_DiLeu_BaEn_1	195	200	PF01217	0.379
TRG_DiLeu_BaLyEn_6	80	85	PF01217	0.382
TRG_DiLeu_LyEn_5	188	193	PF01217	0.457
TRG_ENDOCYTIC_2	222	225	PF00928	0.565
TRG_ER_diArg_1	163	165	PF00400	0.491
TRG_ER_diArg_1	80	83	PF00400	0.616
TRG_Pf-PMV_PEXEL_1	165	169	PF00026	0.412
TRG_Pf-PMV_PEXEL_1	191	195	PF00026	0.523
TRG_Pf-PMV_PEXEL_1	83	87	PF00026	0.634

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I764	Leptomonas seymouri	49%	85%
A0A0S4JVE6	Bodo saltans	29%	100%
A0A1X0P7S3	Trypanosomatidae	33%	100%
A0A3Q8IR10	Leishmania donovani	69%	91%
A0A422NCC4	Trypanosoma rangeli	33%	100%
A4ICF0	Leishmania infantum	68%	91%
E9AT21	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	91%
Q4Q1H7	Leishmania major	67%	100%
V5D8K6	Trypanosoma cruzi	33%	100%