Calmodulin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Calmodulin

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HPA6_LEIBR

TriTrypDb:

LbrM.35.2610 , LBRM2903_350033200

Length:

349

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HPA6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPA6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	5
GO:0005509	calcium ion binding	5	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	220	226	PF00089	0.321
CLV_NRD_NRD_1	304	306	PF00675	0.542
CLV_PCSK_KEX2_1	32	34	PF00082	0.574
CLV_PCSK_PC1ET2_1	32	34	PF00082	0.416
CLV_PCSK_SKI1_1	119	123	PF00082	0.475
CLV_PCSK_SKI1_1	183	187	PF00082	0.393
CLV_PCSK_SKI1_1	190	194	PF00082	0.338
DEG_APCC_DBOX_1	250	258	PF00400	0.392
DEG_Nend_Nbox_1	1	3	PF02207	0.407
DOC_MAPK_FxFP_2	206	209	PF00069	0.313
DOC_MAPK_gen_1	105	114	PF00069	0.400
DOC_PP2B_LxvP_1	112	115	PF13499	0.265
DOC_PP4_FxxP_1	206	209	PF00568	0.313
DOC_USP7_MATH_1	13	17	PF00917	0.348
DOC_USP7_MATH_1	164	168	PF00917	0.663
DOC_USP7_MATH_1	222	226	PF00917	0.331
DOC_USP7_UBL2_3	101	105	PF12436	0.389
DOC_USP7_UBL2_3	330	334	PF12436	0.525
DOC_USP7_UBL2_3	336	340	PF12436	0.553
DOC_WW_Pin1_4	147	152	PF00397	0.632
DOC_WW_Pin1_4	154	159	PF00397	0.629
DOC_WW_Pin1_4	162	167	PF00397	0.523
LIG_14-3-3_CanoR_1	274	279	PF00244	0.453
LIG_BIR_III_2	148	152	PF00653	0.519
LIG_BRCT_BRCA1_1	176	180	PF00533	0.309
LIG_BRCT_BRCA1_1	69	73	PF00533	0.368
LIG_Clathr_ClatBox_1	139	143	PF01394	0.432
LIG_CtBP_PxDLS_1	209	213	PF00389	0.394
LIG_FHA_1	163	169	PF00498	0.450
LIG_FHA_1	20	26	PF00498	0.475
LIG_FHA_1	274	280	PF00498	0.369
LIG_FHA_2	70	76	PF00498	0.469
LIG_Integrin_RGD_1	195	197	PF01839	0.345
LIG_LIR_Apic_2	138	144	PF02991	0.288
LIG_LIR_Apic_2	218	222	PF02991	0.482
LIG_LIR_Gen_1	4	14	PF02991	0.333
LIG_LIR_Gen_1	70	79	PF02991	0.473
LIG_LIR_Nem_3	170	174	PF02991	0.398
LIG_LIR_Nem_3	238	244	PF02991	0.352
LIG_LIR_Nem_3	4	10	PF02991	0.290
LIG_LIR_Nem_3	70	76	PF02991	0.468
LIG_NRBOX	108	114	PF00104	0.316
LIG_PTB_Apo_2	283	290	PF02174	0.467
LIG_PTB_Phospho_1	283	289	PF10480	0.461
LIG_SH2_CRK	171	175	PF00017	0.375
LIG_SH2_CRK	324	328	PF00017	0.470
LIG_SH2_CRK	7	11	PF00017	0.325
LIG_SH2_PTP2	219	222	PF00017	0.413
LIG_SH2_SRC	236	239	PF00017	0.305
LIG_SH2_SRC	88	91	PF00017	0.471
LIG_SH2_STAP1	230	234	PF00017	0.411
LIG_SH2_STAP1	88	92	PF00017	0.537
LIG_SH2_STAT3	320	323	PF00017	0.509
LIG_SH2_STAT5	205	208	PF00017	0.432
LIG_SH2_STAT5	219	222	PF00017	0.481
LIG_SH2_STAT5	241	244	PF00017	0.402
LIG_SH2_STAT5	331	334	PF00017	0.617
LIG_SH2_STAT5	34	37	PF00017	0.475
LIG_SH3_3	117	123	PF00018	0.424
LIG_UBA3_1	179	186	PF00899	0.442
LIG_WRC_WIRS_1	312	317	PF05994	0.544
MOD_CK1_1	150	156	PF00069	0.597
MOD_CK1_1	167	173	PF00069	0.409
MOD_CK1_1	273	279	PF00069	0.524
MOD_CK1_1	342	348	PF00069	0.533
MOD_CK2_1	69	75	PF00069	0.446
MOD_GlcNHglycan	152	155	PF01048	0.723
MOD_GlcNHglycan	293	296	PF01048	0.525
MOD_GlcNHglycan	49	52	PF01048	0.436
MOD_GSK3_1	131	138	PF00069	0.331
MOD_GSK3_1	150	157	PF00069	0.668
MOD_GSK3_1	160	167	PF00069	0.640
MOD_GSK3_1	270	277	PF00069	0.406
MOD_GSK3_1	43	50	PF00069	0.567
MOD_N-GLC_1	135	140	PF02516	0.342
MOD_N-GLC_1	19	24	PF02516	0.410
MOD_NEK2_1	131	136	PF00069	0.365
MOD_NEK2_1	339	344	PF00069	0.438
MOD_NEK2_2	246	251	PF00069	0.239
MOD_PKA_1	290	296	PF00069	0.507
MOD_PKA_2	222	228	PF00069	0.448
MOD_PKA_2	273	279	PF00069	0.430
MOD_PKA_2	52	58	PF00069	0.480
MOD_Plk_1	135	141	PF00069	0.249
MOD_Plk_1	230	236	PF00069	0.359
MOD_Plk_1	99	105	PF00069	0.423
MOD_Plk_4	135	141	PF00069	0.312
MOD_Plk_4	274	280	PF00069	0.484
MOD_Plk_4	99	105	PF00069	0.450
MOD_ProDKin_1	147	153	PF00069	0.636
MOD_ProDKin_1	154	160	PF00069	0.629
MOD_ProDKin_1	162	168	PF00069	0.520
TRG_DiLeu_BaEn_4	210	216	PF01217	0.289
TRG_ENDOCYTIC_2	171	174	PF00928	0.390
TRG_ENDOCYTIC_2	241	244	PF00928	0.320
TRG_ENDOCYTIC_2	324	327	PF00928	0.473
TRG_ENDOCYTIC_2	7	10	PF00928	0.327

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBZ0	Leptomonas seymouri	71%	100%
A0A1X0NFQ9	Trypanosomatidae	42%	100%
A0A3Q8IH99	Leishmania donovani	81%	100%
A0A3R7N4F8	Trypanosoma rangeli	41%	100%
A4IDL4	Leishmania infantum	82%	100%
D0A3B4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AT17	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q1I1	Leishmania major	82%	97%