Methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Methyltransferase

Gene product:

sterol 24-c-methyltransferase, putative

Species:

Leishmania braziliensis

UniProt:

A4HPA5_LEIBR

TriTrypDb:

LbrM.35.2600 , LBRM2903_350033100

Length:

353

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005783	endoplasmic reticulum	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HPA5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPA5

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	15
GO:0006694	steroid biosynthetic process	5	15
GO:0008152	metabolic process	1	15
GO:0008202	steroid metabolic process	4	15
GO:0008610	lipid biosynthetic process	4	15
GO:0009058	biosynthetic process	2	15
GO:0032259	methylation	2	15
GO:0044238	primary metabolic process	2	15
GO:0071704	organic substance metabolic process	2	15
GO:1901360	organic cyclic compound metabolic process	3	15
GO:1901362	organic cyclic compound biosynthetic process	4	15
GO:1901576	organic substance biosynthetic process	3	15
GO:0016125	sterol metabolic process	4	2
GO:0016126	sterol biosynthetic process	5	2
GO:1901615	organic hydroxy compound metabolic process	3	2
GO:1901617	organic hydroxy compound biosynthetic process	4	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	15
GO:0008168	methyltransferase activity	4	15
GO:0016740	transferase activity	2	15
GO:0016741	transferase activity, transferring one-carbon groups	3	15
GO:0003838	sterol 24-C-methyltransferase activity	6	2
GO:0008169	C-methyltransferase activity	5	2
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	165	169	PF00656	0.404
CLV_C14_Caspase3-7	229	233	PF00656	0.422
CLV_NRD_NRD_1	142	144	PF00675	0.340
CLV_NRD_NRD_1	16	18	PF00675	0.561
CLV_NRD_NRD_1	221	223	PF00675	0.337
CLV_NRD_NRD_1	346	348	PF00675	0.318
CLV_NRD_NRD_1	44	46	PF00675	0.464
CLV_PCSK_FUR_1	140	144	PF00082	0.340
CLV_PCSK_KEX2_1	142	144	PF00082	0.340
CLV_PCSK_KEX2_1	15	17	PF00082	0.579
CLV_PCSK_KEX2_1	248	250	PF00082	0.290
CLV_PCSK_PC1ET2_1	248	250	PF00082	0.290
CLV_PCSK_SKI1_1	195	199	PF00082	0.321
CLV_PCSK_SKI1_1	222	226	PF00082	0.546
CLV_PCSK_SKI1_1	295	299	PF00082	0.318
CLV_PCSK_SKI1_1	348	352	PF00082	0.329
CLV_PCSK_SKI1_1	46	50	PF00082	0.586
DEG_SPOP_SBC_1	47	51	PF00917	0.602
DOC_CKS1_1	337	342	PF01111	0.318
DOC_MAPK_gen_1	222	230	PF00069	0.411
DOC_MAPK_MEF2A_6	6	13	PF00069	0.557
DOC_PP1_RVXF_1	301	308	PF00149	0.437
DOC_USP7_MATH_1	148	152	PF00917	0.451
DOC_USP7_MATH_1	268	272	PF00917	0.471
DOC_USP7_MATH_1	325	329	PF00917	0.428
DOC_USP7_UBL2_3	184	188	PF12436	0.451
DOC_USP7_UBL2_3	313	317	PF12436	0.362
DOC_WW_Pin1_4	264	269	PF00397	0.446
DOC_WW_Pin1_4	288	293	PF00397	0.318
DOC_WW_Pin1_4	336	341	PF00397	0.318
LIG_14-3-3_CanoR_1	45	53	PF00244	0.550
LIG_14-3-3_CanoR_1	97	107	PF00244	0.329
LIG_Actin_WH2_2	293	311	PF00022	0.304
LIG_BIR_II_1	1	5	PF00653	0.591
LIG_BRCT_BRCA1_1	162	166	PF00533	0.220
LIG_BRCT_BRCA1_1	190	194	PF00533	0.365
LIG_deltaCOP1_diTrp_1	65	74	PF00928	0.385
LIG_FHA_1	317	323	PF00498	0.334
LIG_FHA_1	337	343	PF00498	0.268
LIG_FHA_1	48	54	PF00498	0.482
LIG_FHA_2	80	86	PF00498	0.457
LIG_FHA_2	99	105	PF00498	0.323
LIG_LIR_Apic_2	271	277	PF02991	0.415
LIG_LIR_Gen_1	159	167	PF02991	0.340
LIG_LIR_Gen_1	279	288	PF02991	0.465
LIG_LIR_Gen_1	306	312	PF02991	0.362
LIG_LIR_Gen_1	55	64	PF02991	0.406
LIG_LIR_Gen_1	81	92	PF02991	0.376
LIG_LIR_Nem_3	191	197	PF02991	0.344
LIG_LIR_Nem_3	201	206	PF02991	0.361
LIG_LIR_Nem_3	279	285	PF02991	0.511
LIG_LIR_Nem_3	306	310	PF02991	0.421
LIG_LIR_Nem_3	55	60	PF02991	0.418
LIG_LIR_Nem_3	61	66	PF02991	0.427
LIG_LIR_Nem_3	81	87	PF02991	0.402
LIG_PCNA_PIPBox_1	301	310	PF02747	0.300
LIG_Pex14_1	68	72	PF04695	0.381
LIG_Pex14_2	33	37	PF04695	0.485
LIG_PTB_Apo_2	130	137	PF02174	0.321
LIG_PTB_Apo_2	51	58	PF02174	0.427
LIG_PTB_Phospho_1	130	136	PF10480	0.321
LIG_PTB_Phospho_1	51	57	PF10480	0.428
LIG_SH2_CRK	275	279	PF00017	0.407
LIG_SH2_CRK	282	286	PF00017	0.489
LIG_SH2_CRK	57	61	PF00017	0.403
LIG_SH2_NCK_1	190	194	PF00017	0.366
LIG_SH2_NCK_1	57	61	PF00017	0.403
LIG_SH2_NCK_1	84	88	PF00017	0.276
LIG_SH2_SRC	64	67	PF00017	0.422
LIG_SH2_STAP1	175	179	PF00017	0.325
LIG_SH2_STAP1	190	194	PF00017	0.340
LIG_SH2_STAP1	206	210	PF00017	0.376
LIG_SH2_STAP1	84	88	PF00017	0.290
LIG_SH2_STAT5	156	159	PF00017	0.365
LIG_SH2_STAT5	343	346	PF00017	0.449
LIG_SH2_STAT5	92	95	PF00017	0.469
LIG_SH3_3	110	116	PF00018	0.369
LIG_SH3_3	193	199	PF00018	0.369
LIG_SUMO_SIM_anti_2	255	262	PF11976	0.462
LIG_TRAF2_1	41	44	PF00917	0.613
LIG_TYR_ITSM	80	87	PF00017	0.295
MOD_CDC14_SPxK_1	267	270	PF00782	0.489
MOD_CDK_SPxK_1	264	270	PF00069	0.479
MOD_CDK_SPxxK_3	288	295	PF00069	0.318
MOD_CK1_1	281	287	PF00069	0.404
MOD_CK2_1	38	44	PF00069	0.531
MOD_CK2_1	79	85	PF00069	0.443
MOD_GlcNHglycan	1	4	PF01048	0.613
MOD_GlcNHglycan	145	149	PF01048	0.288
MOD_GlcNHglycan	24	29	PF01048	0.533
MOD_GSK3_1	144	151	PF00069	0.367
MOD_GSK3_1	156	163	PF00069	0.273
MOD_GSK3_1	264	271	PF00069	0.589
MOD_GSK3_1	276	283	PF00069	0.395
MOD_GSK3_1	312	319	PF00069	0.318
MOD_GSK3_1	79	86	PF00069	0.436
MOD_N-GLC_1	126	131	PF02516	0.412
MOD_NEK2_1	278	283	PF00069	0.363
MOD_NEK2_1	83	88	PF00069	0.412
MOD_NEK2_2	79	84	PF00069	0.496
MOD_PKA_2	121	127	PF00069	0.340
MOD_Plk_1	167	173	PF00069	0.444
MOD_Plk_2-3	38	44	PF00069	0.612
MOD_Plk_4	338	344	PF00069	0.320
MOD_Plk_4	48	54	PF00069	0.456
MOD_Plk_4	79	85	PF00069	0.413
MOD_ProDKin_1	264	270	PF00069	0.451
MOD_ProDKin_1	288	294	PF00069	0.318
MOD_ProDKin_1	336	342	PF00069	0.318
MOD_SUMO_rev_2	38	48	PF00179	0.526
TRG_DiLeu_BaEn_1	55	60	PF01217	0.429
TRG_ENDOCYTIC_2	190	193	PF00928	0.366
TRG_ENDOCYTIC_2	275	278	PF00928	0.388
TRG_ENDOCYTIC_2	282	285	PF00928	0.508
TRG_ENDOCYTIC_2	56	59	PF00928	0.429
TRG_ENDOCYTIC_2	84	87	PF00928	0.300
TRG_ER_diArg_1	14	17	PF00400	0.555
TRG_ER_diArg_1	140	143	PF00400	0.340
TRG_ER_diArg_1	33	36	PF00400	0.465
TRG_ER_diArg_1	344	347	PF00400	0.449
TRG_Pf-PMV_PEXEL_1	348	352	PF00026	0.329

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0E0SMA3	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	39%	93%
A0A0N0P458	Leptomonas seymouri	82%	100%
A0A0S4JSP5	Bodo saltans	63%	100%
A0A1X0NFC9	Trypanosomatidae	64%	98%
A0A3Q8IK91	Leishmania donovani	86%	100%
A0A3S7XAX3	Leishmania donovani	86%	100%
A0A422N3F9	Trypanosoma rangeli	67%	98%
A4IDL2	Leishmania infantum	86%	100%
A4IDL3	Leishmania infantum	86%	100%
D0A3B2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	98%
E9AT15	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
E9AT16	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
H2E7T5	Botryococcus braunii	32%	93%
H2E7T6	Botryococcus braunii	33%	93%
H2E7T7	Botryococcus braunii	35%	93%
H2E7T8	Botryococcus braunii	32%	91%
H2E7T9	Botryococcus braunii	34%	91%
H2E7U0	Botryococcus braunii	34%	90%
I1RGC4	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	44%	93%
L0E172	Penicillium fellutanum	38%	100%
L7IP31	Magnaporthe oryzae (strain Y34)	42%	91%
O14321	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	40%	93%
O74198	Candida albicans (strain SC5314 / ATCC MYA-2876)	43%	94%
O82427	Oryza sativa subsp. japonica	38%	97%
P0CT10	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	42%	91%
P25087	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	43%	92%
Q39227	Arabidopsis thaliana	37%	98%
Q4Q1I2	Leishmania major	86%	100%
Q4Q1I3	Leishmania major	86%	100%
Q4W9V1	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	44%	94%
Q54I98	Dictyostelium discoideum	44%	100%
Q6BRB7	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	43%	94%
Q6C2D9	Yarrowia lipolytica (strain CLIB 122 / E 150)	41%	93%
Q6CYB3	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	43%	95%
Q6FRZ7	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	42%	95%
Q6ZIX2	Oryza sativa subsp. japonica	50%	100%
Q759S7	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	41%	95%
Q875K1	Clavispora lusitaniae (strain ATCC 42720)	44%	94%
Q94JS4	Arabidopsis thaliana	36%	98%
Q96WX4	Pneumocystis carinii (strain B80)	41%	94%
Q9LM02	Arabidopsis thaliana	48%	100%
Q9P3R1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	42%	93%
Q9TYP1	Caenorhabditis elegans	27%	100%