Nitrogen permease regulator 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

base J-associated glucosyltransferase

Species:

Leishmania braziliensis

UniProt:

A4HPA4_LEIBR

TriTrypDb:

LbrM.35.2590 , LBRM2903_350033000

Length:

950

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HPA4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPA4

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006304	DNA modification	5	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1
GO:0016757	glycosyltransferase activity	3	1
GO:0016758	hexosyltransferase activity	4	1
GO:0046527	glucosyltransferase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	36	40	PF00656	0.767
CLV_C14_Caspase3-7	748	752	PF00656	0.712
CLV_NRD_NRD_1	362	364	PF00675	0.565
CLV_NRD_NRD_1	471	473	PF00675	0.439
CLV_NRD_NRD_1	603	605	PF00675	0.426
CLV_NRD_NRD_1	698	700	PF00675	0.547
CLV_NRD_NRD_1	766	768	PF00675	0.730
CLV_NRD_NRD_1	789	791	PF00675	0.643
CLV_PCSK_KEX2_1	362	364	PF00082	0.565
CLV_PCSK_KEX2_1	471	473	PF00082	0.439
CLV_PCSK_KEX2_1	603	605	PF00082	0.426
CLV_PCSK_KEX2_1	698	700	PF00082	0.471
CLV_PCSK_KEX2_1	768	770	PF00082	0.665
CLV_PCSK_KEX2_1	789	791	PF00082	0.643
CLV_PCSK_PC1ET2_1	768	770	PF00082	0.665
CLV_PCSK_SKI1_1	275	279	PF00082	0.416
CLV_PCSK_SKI1_1	337	341	PF00082	0.501
CLV_PCSK_SKI1_1	559	563	PF00082	0.522
CLV_PCSK_SKI1_1	678	682	PF00082	0.403
DEG_MDM2_SWIB_1	679	686	PF02201	0.308
DEG_Nend_Nbox_1	1	3	PF02207	0.619
DEG_SCF_FBW7_1	491	498	PF00400	0.525
DEG_SPOP_SBC_1	191	195	PF00917	0.522
DEG_SPOP_SBC_1	244	248	PF00917	0.548
DEG_SPOP_SBC_1	410	414	PF00917	0.627
DEG_SPOP_SBC_1	495	499	PF00917	0.512
DEG_SPOP_SBC_1	746	750	PF00917	0.713
DEG_SPOP_SBC_1	802	806	PF00917	0.674
DOC_ANK_TNKS_1	118	125	PF00023	0.381
DOC_CKS1_1	66	71	PF01111	0.665
DOC_CKS1_1	72	77	PF01111	0.628
DOC_CKS1_1	723	728	PF01111	0.427
DOC_CYCLIN_RxL_1	202	212	PF00134	0.581
DOC_CYCLIN_yCln2_LP_2	708	714	PF00134	0.406
DOC_MAPK_DCC_7	108	116	PF00069	0.367
DOC_MAPK_gen_1	698	704	PF00069	0.435
DOC_MAPK_MEF2A_6	100	107	PF00069	0.492
DOC_MAPK_MEF2A_6	108	116	PF00069	0.357
DOC_MAPK_MEF2A_6	294	302	PF00069	0.447
DOC_MAPK_MEF2A_6	912	919	PF00069	0.466
DOC_PP1_RVXF_1	643	650	PF00149	0.354
DOC_PP1_RVXF_1	701	707	PF00149	0.423
DOC_PP1_RVXF_1	899	905	PF00149	0.541
DOC_PP2B_LxvP_1	770	773	PF13499	0.704
DOC_PP4_FxxP_1	221	224	PF00568	0.388
DOC_PP4_FxxP_1	649	652	PF00568	0.375
DOC_PP4_FxxP_1	923	926	PF00568	0.480
DOC_SPAK_OSR1_1	621	625	PF12202	0.376
DOC_USP7_MATH_1	191	195	PF00917	0.595
DOC_USP7_MATH_1	23	27	PF00917	0.755
DOC_USP7_MATH_1	404	408	PF00917	0.682
DOC_USP7_MATH_1	493	497	PF00917	0.654
DOC_USP7_MATH_1	747	751	PF00917	0.610
DOC_USP7_MATH_1	784	788	PF00917	0.683
DOC_USP7_MATH_1	796	800	PF00917	0.488
DOC_USP7_MATH_1	873	877	PF00917	0.648
DOC_USP7_MATH_1	933	937	PF00917	0.483
DOC_WW_Pin1_4	181	186	PF00397	0.516
DOC_WW_Pin1_4	187	192	PF00397	0.662
DOC_WW_Pin1_4	193	198	PF00397	0.598
DOC_WW_Pin1_4	239	244	PF00397	0.827
DOC_WW_Pin1_4	245	250	PF00397	0.763
DOC_WW_Pin1_4	329	334	PF00397	0.555
DOC_WW_Pin1_4	366	371	PF00397	0.515
DOC_WW_Pin1_4	406	411	PF00397	0.726
DOC_WW_Pin1_4	41	46	PF00397	0.641
DOC_WW_Pin1_4	417	422	PF00397	0.571
DOC_WW_Pin1_4	475	480	PF00397	0.546
DOC_WW_Pin1_4	489	494	PF00397	0.627
DOC_WW_Pin1_4	501	506	PF00397	0.564
DOC_WW_Pin1_4	65	70	PF00397	0.834
DOC_WW_Pin1_4	707	712	PF00397	0.437
DOC_WW_Pin1_4	71	76	PF00397	0.579
DOC_WW_Pin1_4	722	727	PF00397	0.452
DOC_WW_Pin1_4	771	776	PF00397	0.652
DOC_WW_Pin1_4	780	785	PF00397	0.647
DOC_WW_Pin1_4	8	13	PF00397	0.592
LIG_14-3-3_CanoR_1	100	104	PF00244	0.389
LIG_14-3-3_CanoR_1	288	293	PF00244	0.407
LIG_14-3-3_CanoR_1	337	342	PF00244	0.496
LIG_14-3-3_CanoR_1	362	371	PF00244	0.591
LIG_14-3-3_CanoR_1	406	410	PF00244	0.585
LIG_14-3-3_CanoR_1	453	460	PF00244	0.416
LIG_14-3-3_CanoR_1	637	643	PF00244	0.359
LIG_14-3-3_CanoR_1	863	867	PF00244	0.530
LIG_14-3-3_CanoR_1	901	907	PF00244	0.513
LIG_APCC_ABBA_1	851	856	PF00400	0.477
LIG_BRCT_BRCA1_1	211	215	PF00533	0.487
LIG_BRCT_BRCA1_1	262	266	PF00533	0.491
LIG_BRCT_BRCA1_1	503	507	PF00533	0.532
LIG_BRCT_BRCA1_1	645	649	PF00533	0.426
LIG_Clathr_ClatBox_1	277	281	PF01394	0.405
LIG_deltaCOP1_diTrp_1	172	176	PF00928	0.579
LIG_eIF4E_1	296	302	PF01652	0.446
LIG_EVH1_2	485	489	PF00568	0.706
LIG_FHA_1	100	106	PF00498	0.565
LIG_FHA_1	194	200	PF00498	0.679
LIG_FHA_1	30	36	PF00498	0.684
LIG_FHA_1	366	372	PF00498	0.604
LIG_FHA_1	418	424	PF00498	0.571
LIG_FHA_1	629	635	PF00498	0.343
LIG_FHA_1	845	851	PF00498	0.497
LIG_FHA_2	154	160	PF00498	0.586
LIG_FHA_2	447	453	PF00498	0.571
LIG_FHA_2	518	524	PF00498	0.505
LIG_FHA_2	562	568	PF00498	0.517
LIG_FHA_2	755	761	PF00498	0.709
LIG_FHA_2	863	869	PF00498	0.461
LIG_FHA_2	919	925	PF00498	0.483
LIG_GBD_Chelix_1	609	617	PF00786	0.467
LIG_LIR_Apic_2	646	652	PF02991	0.370
LIG_LIR_Apic_2	920	926	PF02991	0.411
LIG_LIR_Gen_1	123	133	PF02991	0.342
LIG_LIR_Gen_1	344	350	PF02991	0.649
LIG_LIR_Gen_1	355	364	PF02991	0.512
LIG_LIR_Gen_1	554	565	PF02991	0.405
LIG_LIR_Gen_1	573	581	PF02991	0.356
LIG_LIR_Gen_1	938	948	PF02991	0.460
LIG_LIR_Nem_3	123	128	PF02991	0.330
LIG_LIR_Nem_3	344	349	PF02991	0.576
LIG_LIR_Nem_3	355	361	PF02991	0.574
LIG_LIR_Nem_3	436	442	PF02991	0.359
LIG_LIR_Nem_3	554	560	PF02991	0.375
LIG_LIR_Nem_3	573	577	PF02991	0.374
LIG_LIR_Nem_3	616	622	PF02991	0.394
LIG_LIR_Nem_3	641	647	PF02991	0.350
LIG_LIR_Nem_3	818	823	PF02991	0.527
LIG_MLH1_MIPbox_1	503	507	PF16413	0.532
LIG_MYND_1	728	732	PF01753	0.543
LIG_PDZ_Class_2	945	950	PF00595	0.439
LIG_Pex14_1	811	815	PF04695	0.598
LIG_Pex14_2	428	432	PF04695	0.376
LIG_Pex14_2	679	683	PF04695	0.389
LIG_PTAP_UEV_1	248	253	PF05743	0.626
LIG_REV1ctd_RIR_1	852	858	PF16727	0.492
LIG_REV1ctd_RIR_1	938	947	PF16727	0.530
LIG_SH2_CRK	125	129	PF00017	0.312
LIG_SH2_CRK	574	578	PF00017	0.365
LIG_SH2_CRK	583	587	PF00017	0.383
LIG_SH2_NCK_1	574	578	PF00017	0.365
LIG_SH2_SRC	358	361	PF00017	0.632
LIG_SH2_SRC	612	615	PF00017	0.588
LIG_SH2_STAP1	125	129	PF00017	0.333
LIG_SH2_STAP1	628	632	PF00017	0.436
LIG_SH2_STAP1	640	644	PF00017	0.351
LIG_SH2_STAT3	296	299	PF00017	0.371
LIG_SH2_STAT5	136	139	PF00017	0.518
LIG_SH2_STAT5	219	222	PF00017	0.436
LIG_SH2_STAT5	292	295	PF00017	0.419
LIG_SH2_STAT5	296	299	PF00017	0.406
LIG_SH2_STAT5	358	361	PF00017	0.556
LIG_SH2_STAT5	506	509	PF00017	0.685
LIG_SH2_STAT5	548	551	PF00017	0.398
LIG_SH2_STAT5	612	615	PF00017	0.609
LIG_SH2_STAT5	640	643	PF00017	0.267
LIG_SH2_STAT5	722	725	PF00017	0.438
LIG_SH2_STAT5	815	818	PF00017	0.593
LIG_SH3_1	769	775	PF00018	0.654
LIG_SH3_2	72	77	PF14604	0.642
LIG_SH3_2	896	901	PF14604	0.458
LIG_SH3_3	185	191	PF00018	0.643
LIG_SH3_3	217	223	PF00018	0.441
LIG_SH3_3	246	252	PF00018	0.710
LIG_SH3_3	297	303	PF00018	0.410
LIG_SH3_3	476	482	PF00018	0.559
LIG_SH3_3	599	605	PF00018	0.431
LIG_SH3_3	60	66	PF00018	0.642
LIG_SH3_3	69	75	PF00018	0.614
LIG_SH3_3	769	775	PF00018	0.654
LIG_SH3_3	81	87	PF00018	0.352
LIG_SH3_3	847	853	PF00018	0.497
LIG_SH3_3	891	897	PF00018	0.517
LIG_SH3_CIN85_PxpxPR_1	896	901	PF14604	0.458
LIG_SUMO_SIM_anti_2	847	852	PF11976	0.486
LIG_SUMO_SIM_par_1	113	118	PF11976	0.399
LIG_SUMO_SIM_par_1	31	37	PF11976	0.705
LIG_SUMO_SIM_par_1	567	573	PF11976	0.466
LIG_SUMO_SIM_par_1	833	838	PF11976	0.513
LIG_TRAF2_1	824	827	PF00917	0.538
LIG_UBA3_1	1	7	PF00899	0.685
LIG_WW_3	898	902	PF00397	0.447
MOD_CDC14_SPxK_1	710	713	PF00782	0.448
MOD_CDK_SPK_2	417	422	PF00069	0.595
MOD_CDK_SPxK_1	707	713	PF00069	0.434
MOD_CDK_SPxK_1	71	77	PF00069	0.651
MOD_CK1_1	11	17	PF00069	0.627
MOD_CK1_1	140	146	PF00069	0.476
MOD_CK1_1	190	196	PF00069	0.715
MOD_CK1_1	238	244	PF00069	0.686
MOD_CK1_1	329	335	PF00069	0.499
MOD_CK1_1	344	350	PF00069	0.489
MOD_CK1_1	365	371	PF00069	0.671
MOD_CK1_1	374	380	PF00069	0.599
MOD_CK1_1	40	46	PF00069	0.645
MOD_CK1_1	408	414	PF00069	0.580
MOD_CK1_1	444	450	PF00069	0.573
MOD_CK1_1	496	502	PF00069	0.649
MOD_CK1_1	570	576	PF00069	0.381
MOD_CK1_1	71	77	PF00069	0.577
MOD_CK1_1	745	751	PF00069	0.653
MOD_CK1_1	752	758	PF00069	0.574
MOD_CK1_1	801	807	PF00069	0.541
MOD_CK1_1	876	882	PF00069	0.615
MOD_CK2_1	153	159	PF00069	0.626
MOD_CK2_1	231	237	PF00069	0.546
MOD_CK2_1	344	350	PF00069	0.652
MOD_CK2_1	446	452	PF00069	0.579
MOD_CK2_1	517	523	PF00069	0.491
MOD_CK2_1	754	760	PF00069	0.709
MOD_CK2_1	821	827	PF00069	0.552
MOD_CK2_1	862	868	PF00069	0.451
MOD_CK2_1	884	890	PF00069	0.699
MOD_CK2_1	918	924	PF00069	0.494
MOD_Cter_Amidation	787	790	PF01082	0.721
MOD_DYRK1A_RPxSP_1	406	410	PF00069	0.585
MOD_DYRK1A_RPxSP_1	771	775	PF00069	0.649
MOD_GlcNHglycan	125	128	PF01048	0.345
MOD_GlcNHglycan	13	16	PF01048	0.663
MOD_GlcNHglycan	199	202	PF01048	0.621
MOD_GlcNHglycan	211	214	PF01048	0.667
MOD_GlcNHglycan	252	255	PF01048	0.641
MOD_GlcNHglycan	312	316	PF01048	0.499
MOD_GlcNHglycan	346	349	PF01048	0.590
MOD_GlcNHglycan	352	355	PF01048	0.584
MOD_GlcNHglycan	413	416	PF01048	0.629
MOD_GlcNHglycan	454	457	PF01048	0.357
MOD_GlcNHglycan	499	502	PF01048	0.690
MOD_GlcNHglycan	50	53	PF01048	0.685
MOD_GlcNHglycan	596	599	PF01048	0.430
MOD_GlcNHglycan	740	743	PF01048	0.592
MOD_GlcNHglycan	751	754	PF01048	0.674
MOD_GlcNHglycan	786	789	PF01048	0.593
MOD_GlcNHglycan	798	801	PF01048	0.677
MOD_GlcNHglycan	879	882	PF01048	0.650
MOD_GSK3_1	149	156	PF00069	0.604
MOD_GSK3_1	187	194	PF00069	0.705
MOD_GSK3_1	231	238	PF00069	0.692
MOD_GSK3_1	239	246	PF00069	0.805
MOD_GSK3_1	337	344	PF00069	0.538
MOD_GSK3_1	348	355	PF00069	0.668
MOD_GSK3_1	362	369	PF00069	0.523
MOD_GSK3_1	37	44	PF00069	0.704
MOD_GSK3_1	371	378	PF00069	0.621
MOD_GSK3_1	404	411	PF00069	0.708
MOD_GSK3_1	441	448	PF00069	0.521
MOD_GSK3_1	489	496	PF00069	0.599
MOD_GSK3_1	497	504	PF00069	0.559
MOD_GSK3_1	547	554	PF00069	0.355
MOD_GSK3_1	7	14	PF00069	0.619
MOD_GSK3_1	733	740	PF00069	0.649
MOD_GSK3_1	742	749	PF00069	0.617
MOD_GSK3_1	776	783	PF00069	0.750
MOD_GSK3_1	798	805	PF00069	0.574
MOD_GSK3_1	873	880	PF00069	0.661
MOD_GSK3_1	885	892	PF00069	0.567
MOD_GSK3_1	89	96	PF00069	0.411
MOD_N-GLC_1	239	244	PF02516	0.713
MOD_N-GLC_1	47	52	PF02516	0.712
MOD_N-GLC_1	742	747	PF02516	0.636
MOD_N-GLC_1	884	889	PF02516	0.697
MOD_NEK2_1	209	214	PF00069	0.504
MOD_NEK2_1	386	391	PF00069	0.546
MOD_NEK2_1	405	410	PF00069	0.679
MOD_NEK2_1	441	446	PF00069	0.495
MOD_NEK2_1	517	522	PF00069	0.562
MOD_NEK2_1	546	551	PF00069	0.382
MOD_NEK2_1	613	618	PF00069	0.473
MOD_NEK2_1	681	686	PF00069	0.311
MOD_NEK2_1	721	726	PF00069	0.516
MOD_NEK2_1	98	103	PF00069	0.491
MOD_NEK2_2	638	643	PF00069	0.359
MOD_PK_1	643	649	PF00069	0.402
MOD_PKA_1	362	368	PF00069	0.654
MOD_PKA_2	209	215	PF00069	0.529
MOD_PKA_2	260	266	PF00069	0.674
MOD_PKA_2	362	368	PF00069	0.587
MOD_PKA_2	405	411	PF00069	0.678
MOD_PKA_2	452	458	PF00069	0.430
MOD_PKA_2	733	739	PF00069	0.688
MOD_PKA_2	862	868	PF00069	0.475
MOD_PKA_2	99	105	PF00069	0.399
MOD_PKB_1	819	827	PF00069	0.570
MOD_Plk_1	140	146	PF00069	0.457
MOD_Plk_1	326	332	PF00069	0.506
MOD_Plk_1	613	619	PF00069	0.573
MOD_Plk_1	628	634	PF00069	0.260
MOD_Plk_1	884	890	PF00069	0.662
MOD_Plk_1	98	104	PF00069	0.408
MOD_Plk_2-3	37	43	PF00069	0.662
MOD_Plk_4	288	294	PF00069	0.433
MOD_Plk_4	341	347	PF00069	0.556
MOD_Plk_4	354	360	PF00069	0.583
MOD_Plk_4	386	392	PF00069	0.533
MOD_Plk_4	613	619	PF00069	0.457
MOD_Plk_4	798	804	PF00069	0.545
MOD_Plk_4	857	863	PF00069	0.449
MOD_ProDKin_1	181	187	PF00069	0.523
MOD_ProDKin_1	193	199	PF00069	0.595
MOD_ProDKin_1	239	245	PF00069	0.829
MOD_ProDKin_1	329	335	PF00069	0.552
MOD_ProDKin_1	366	372	PF00069	0.516
MOD_ProDKin_1	406	412	PF00069	0.725
MOD_ProDKin_1	41	47	PF00069	0.643
MOD_ProDKin_1	417	423	PF00069	0.566
MOD_ProDKin_1	475	481	PF00069	0.556
MOD_ProDKin_1	489	495	PF00069	0.624
MOD_ProDKin_1	501	507	PF00069	0.563
MOD_ProDKin_1	65	71	PF00069	0.832
MOD_ProDKin_1	707	713	PF00069	0.444
MOD_ProDKin_1	722	728	PF00069	0.458
MOD_ProDKin_1	771	777	PF00069	0.649
MOD_ProDKin_1	780	786	PF00069	0.646
MOD_ProDKin_1	8	14	PF00069	0.594
MOD_SUMO_for_1	6	9	PF00179	0.517
MOD_SUMO_rev_2	233	241	PF00179	0.574
MOD_SUMO_rev_2	344	353	PF00179	0.645
MOD_SUMO_rev_2	887	897	PF00179	0.526
TRG_ENDOCYTIC_2	125	128	PF00928	0.389
TRG_ENDOCYTIC_2	136	139	PF00928	0.476
TRG_ENDOCYTIC_2	346	349	PF00928	0.578
TRG_ENDOCYTIC_2	358	361	PF00928	0.556
TRG_ENDOCYTIC_2	431	434	PF00928	0.332
TRG_ENDOCYTIC_2	557	560	PF00928	0.491
TRG_ENDOCYTIC_2	574	577	PF00928	0.372
TRG_ENDOCYTIC_2	583	586	PF00928	0.382
TRG_ER_diArg_1	361	363	PF00400	0.529
TRG_ER_diArg_1	470	472	PF00400	0.520
TRG_ER_diArg_1	602	604	PF00400	0.428
TRG_ER_diArg_1	702	705	PF00400	0.416
TRG_ER_diArg_1	767	770	PF00400	0.674
TRG_ER_diArg_1	789	791	PF00400	0.719
TRG_NLS_MonoExtC_3	766	771	PF00514	0.665
TRG_NLS_MonoExtN_4	767	772	PF00514	0.738

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3R8	Leptomonas seymouri	54%	100%
A0A3Q8IKQ0	Leishmania donovani	81%	100%
A4IDL1	Leishmania infantum	81%	100%
E9AT14	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	99%
Q4Q1I4	Leishmania major	81%	100%