Tyrosine aminotransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tyrosine aminotransferase

Species:

Leishmania braziliensis

UniProt:

A4HPA3_LEIBR

TriTrypDb:

LbrM.35.2580 , LBRM2903_350032800

Length:

449

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

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Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A4HPA3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPA3

PDB structure(s): 4ix8_A , 4ix8_B

Function

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Biological processes
Term	Name	Level	Count
GO:0000096	sulfur amino acid metabolic process	4	1
GO:0000098	sulfur amino acid catabolic process	5	1
GO:0006082	organic acid metabolic process	3	15
GO:0006520	amino acid metabolic process	3	15
GO:0006555	methionine metabolic process	5	1
GO:0006570	tyrosine metabolic process	5	1
GO:0006572	tyrosine catabolic process	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006790	sulfur compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	15

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	15
GO:0004838	L-tyrosine:2-oxoglutarate aminotransferase activity	6	8
GO:0005488	binding	1	15
GO:0008483	transaminase activity	4	15
GO:0008793	aromatic-amino-acid:2-oxoglutarate aminotransferase activity	5	1
GO:0010326	methionine-oxo-acid transaminase activity	5	1
GO:0016740	transferase activity	2	15
GO:0016769	transferase activity, transferring nitrogenous groups	3	15
GO:0019842	vitamin binding	3	15
GO:0030170	pyridoxal phosphate binding	4	15

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	164	168	PF00656	0.224
CLV_NRD_NRD_1	128	130	PF00675	0.408
CLV_NRD_NRD_1	28	30	PF00675	0.730
CLV_NRD_NRD_1	43	45	PF00675	0.582
CLV_PCSK_KEX2_1	128	130	PF00082	0.409
CLV_PCSK_KEX2_1	28	30	PF00082	0.698
CLV_PCSK_KEX2_1	43	45	PF00082	0.470
CLV_PCSK_SKI1_1	279	283	PF00082	0.357
CLV_PCSK_SKI1_1	335	339	PF00082	0.428
CLV_PCSK_SKI1_1	43	47	PF00082	0.623

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7P4	Leptomonas seymouri	44%	100%
A0A0N1I393	Leptomonas seymouri	34%	100%
A0A0N1II57	Leptomonas seymouri	76%	100%
A0A0N1IIT9	Leptomonas seymouri	42%	100%
A0A0N1PA03	Leptomonas seymouri	60%	100%
A0A0P0VI36	Oryza sativa subsp. japonica	31%	91%
A0A0S4IKK8	Bodo saltans	22%	92%
A0A0S4J4K7	Bodo saltans	25%	100%
A0A0S4KND1	Bodo saltans	23%	100%
A0A0S4KNT6	Bodo saltans	23%	100%

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