Short chain dehydrogenase family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HPA2_LEIBR

TriTrypDb:

LbrM.35.2570 , LBRM2903_350032700

Length:

408

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HPA2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPA2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	318	322	PF00656	0.655
CLV_C14_Caspase3-7	82	86	PF00656	0.450
CLV_NRD_NRD_1	25	27	PF00675	0.271
CLV_NRD_NRD_1	44	46	PF00675	0.296
CLV_PCSK_KEX2_1	141	143	PF00082	0.302
CLV_PCSK_KEX2_1	343	345	PF00082	0.403
CLV_PCSK_KEX2_1	44	46	PF00082	0.296
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.302
CLV_PCSK_PC1ET2_1	343	345	PF00082	0.415
CLV_PCSK_SKI1_1	119	123	PF00082	0.247
CLV_PCSK_SKI1_1	167	171	PF00082	0.274
DEG_APCC_DBOX_1	166	174	PF00400	0.459
DEG_APCC_DBOX_1	272	280	PF00400	0.542
DEG_Nend_Nbox_1	1	3	PF02207	0.308
DEG_SCF_FBW7_1	304	311	PF00400	0.656
DEG_SCF_FBW7_1	396	403	PF00400	0.351
DOC_CKS1_1	305	310	PF01111	0.785
DOC_CKS1_1	397	402	PF01111	0.468
DOC_CYCLIN_yClb5_NLxxxL_5	154	163	PF00134	0.530
DOC_CYCLIN_yCln2_LP_2	124	130	PF00134	0.493
DOC_CYCLIN_yCln2_LP_2	159	165	PF00134	0.530
DOC_MAPK_gen_1	270	279	PF00069	0.581
DOC_MAPK_gen_1	44	50	PF00069	0.544
DOC_MAPK_MEF2A_6	167	174	PF00069	0.502
DOC_MAPK_NFAT4_5	167	175	PF00069	0.502
DOC_PP1_RVXF_1	389	396	PF00149	0.438
DOC_PP1_RVXF_1	54	61	PF00149	0.490
DOC_PP4_FxxP_1	384	387	PF00568	0.452
DOC_USP7_MATH_1	147	151	PF00917	0.483
DOC_USP7_MATH_1	204	208	PF00917	0.389
DOC_USP7_MATH_1	306	310	PF00917	0.728
DOC_WW_Pin1_4	158	163	PF00397	0.502
DOC_WW_Pin1_4	212	217	PF00397	0.450
DOC_WW_Pin1_4	304	309	PF00397	0.690
DOC_WW_Pin1_4	332	337	PF00397	0.677
DOC_WW_Pin1_4	367	372	PF00397	0.428
DOC_WW_Pin1_4	396	401	PF00397	0.478
LIG_14-3-3_CanoR_1	273	277	PF00244	0.509
LIG_14-3-3_CanoR_1	326	336	PF00244	0.720
LIG_14-3-3_CanoR_1	365	371	PF00244	0.477
LIG_Actin_WH2_2	63	78	PF00022	0.502
LIG_BRCT_BRCA1_1	100	104	PF00533	0.512
LIG_BRCT_BRCA1_1	290	294	PF00533	0.564
LIG_DCNL_PONY_1	1	4	PF03556	0.344
LIG_FHA_1	101	107	PF00498	0.490
LIG_FHA_1	155	161	PF00498	0.538
LIG_FHA_1	188	194	PF00498	0.389
LIG_FHA_1	272	278	PF00498	0.575
LIG_FHA_1	30	36	PF00498	0.466
LIG_FHA_1	300	306	PF00498	0.659
LIG_FHA_1	372	378	PF00498	0.409
LIG_FHA_1	388	394	PF00498	0.452
LIG_FHA_1	76	82	PF00498	0.508
LIG_FHA_1	8	14	PF00498	0.283
LIG_LIR_Apic_2	281	287	PF02991	0.621
LIG_LIR_Apic_2	330	336	PF02991	0.656
LIG_LIR_Gen_1	101	111	PF02991	0.588
LIG_LIR_Gen_1	195	204	PF02991	0.512
LIG_LIR_Gen_1	61	70	PF02991	0.530
LIG_LIR_Nem_3	19	23	PF02991	0.461
LIG_LIR_Nem_3	195	199	PF02991	0.512
LIG_LIR_Nem_3	221	226	PF02991	0.447
LIG_LIR_Nem_3	375	381	PF02991	0.323
LIG_LIR_Nem_3	61	65	PF02991	0.530
LIG_LYPXL_S_1	377	381	PF13949	0.360
LIG_LYPXL_yS_3	378	381	PF13949	0.360
LIG_MLH1_MIPbox_1	290	294	PF16413	0.564
LIG_Pex14_2	384	388	PF04695	0.447
LIG_REV1ctd_RIR_1	18	24	PF16727	0.437
LIG_SH2_CRK	196	200	PF00017	0.530
LIG_SH2_CRK	284	288	PF00017	0.684
LIG_SH2_CRK	333	337	PF00017	0.642
LIG_SH2_CRK	62	66	PF00017	0.530
LIG_SH2_STAP1	196	200	PF00017	0.530
LIG_SH2_STAT5	209	212	PF00017	0.516
LIG_SH2_STAT5	366	369	PF00017	0.598
LIG_SH3_3	373	379	PF00018	0.390
LIG_SUMO_SIM_anti_2	161	167	PF11976	0.502
LIG_SUMO_SIM_par_1	107	113	PF11976	0.485
LIG_SUMO_SIM_par_1	170	177	PF11976	0.579
LIG_SUMO_SIM_par_1	2	7	PF11976	0.203
LIG_SUMO_SIM_par_1	31	36	PF11976	0.465
LIG_TYR_ITIM	376	381	PF00017	0.434
LIG_WRC_WIRS_1	17	22	PF05994	0.361
MOD_CK1_1	16	22	PF00069	0.361
MOD_CK1_1	161	167	PF00069	0.389
MOD_CK1_1	177	183	PF00069	0.406
MOD_CK1_1	207	213	PF00069	0.266
MOD_CK1_1	29	35	PF00069	0.361
MOD_CK1_1	292	298	PF00069	0.617
MOD_CK1_1	311	317	PF00069	0.743
MOD_CK1_1	329	335	PF00069	0.662
MOD_CK1_1	98	104	PF00069	0.363
MOD_CK2_1	228	234	PF00069	0.360
MOD_CMANNOS	12	15	PF00535	0.284
MOD_Cter_Amidation	42	45	PF01082	0.400
MOD_GlcNHglycan	100	103	PF01048	0.438
MOD_GlcNHglycan	148	152	PF01048	0.448
MOD_GlcNHglycan	28	31	PF01048	0.538
MOD_GlcNHglycan	297	300	PF01048	0.682
MOD_GlcNHglycan	321	325	PF01048	0.707
MOD_GSK3_1	154	161	PF00069	0.491
MOD_GSK3_1	172	179	PF00069	0.221
MOD_GSK3_1	205	212	PF00069	0.437
MOD_GSK3_1	234	241	PF00069	0.565
MOD_GSK3_1	285	292	PF00069	0.549
MOD_GSK3_1	29	36	PF00069	0.308
MOD_GSK3_1	294	301	PF00069	0.602
MOD_GSK3_1	304	311	PF00069	0.562
MOD_GSK3_1	328	335	PF00069	0.659
MOD_GSK3_1	367	374	PF00069	0.400
MOD_GSK3_1	396	403	PF00069	0.519
MOD_N-GLC_1	181	186	PF02516	0.329
MOD_NEK2_1	172	177	PF00069	0.291
MOD_NEK2_1	187	192	PF00069	0.200
MOD_NEK2_1	228	233	PF00069	0.346
MOD_NEK2_1	293	298	PF00069	0.579
MOD_NEK2_1	4	9	PF00069	0.249
MOD_PIKK_1	110	116	PF00454	0.348
MOD_PIKK_1	187	193	PF00454	0.203
MOD_PIKK_1	218	224	PF00454	0.319
MOD_PIKK_1	234	240	PF00454	0.415
MOD_PKA_1	26	32	PF00069	0.309
MOD_PKA_2	272	278	PF00069	0.371
MOD_PKA_2	327	333	PF00069	0.606
MOD_PKB_1	24	32	PF00069	0.447
MOD_PKB_1	326	334	PF00069	0.483
MOD_Plk_1	181	187	PF00069	0.223
MOD_Plk_4	16	22	PF00069	0.304
MOD_Plk_4	161	167	PF00069	0.220
MOD_Plk_4	272	278	PF00069	0.347
MOD_Plk_4	289	295	PF00069	0.529
MOD_Plk_4	29	35	PF00069	0.323
MOD_Plk_4	372	378	PF00069	0.342
MOD_Plk_4	7	13	PF00069	0.321
MOD_ProDKin_1	158	164	PF00069	0.360
MOD_ProDKin_1	212	218	PF00069	0.288
MOD_ProDKin_1	304	310	PF00069	0.626
MOD_ProDKin_1	332	338	PF00069	0.597
MOD_ProDKin_1	367	373	PF00069	0.258
MOD_ProDKin_1	396	402	PF00069	0.615
MOD_SUMO_rev_2	250	258	PF00179	0.637
TRG_DiLeu_BaLyEn_6	376	381	PF01217	0.330
TRG_DiLeu_BaLyEn_6	388	393	PF01217	0.407
TRG_ENDOCYTIC_2	196	199	PF00928	0.400
TRG_ENDOCYTIC_2	378	381	PF00928	0.400
TRG_ENDOCYTIC_2	62	65	PF00928	0.417
TRG_ER_diArg_1	23	26	PF00400	0.392
TRG_ER_diArg_1	44	46	PF00400	0.350
TRG_Pf-PMV_PEXEL_1	44	49	PF00026	0.360

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7B0	Leptomonas seymouri	48%	100%
A0A1X0P7L9	Trypanosomatidae	30%	100%
A0A3Q8IQZ6	Leishmania donovani	75%	99%
A4IDK8	Leishmania infantum	75%	99%
D0A3A6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AT11	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	99%
Q4Q1I7	Leishmania major	75%	99%
V5DCK9	Trypanosoma cruzi	29%	100%