Putative endonuclease V

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

endonuclease V, putative

Species:

Leishmania braziliensis

UniProt:

A4HPA1_LEIBR

TriTrypDb:

LbrM.35.2560 , LBRM2903_350032600

Length:

395

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HPA1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPA1

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006259	DNA metabolic process	4	7
GO:0006281	DNA repair	5	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0006950	response to stress	2	7
GO:0006974	DNA damage response	4	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0033554	cellular response to stress	3	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044260	obsolete cellular macromolecule metabolic process	3	7
GO:0046483	heterocycle metabolic process	3	7
GO:0050896	response to stimulus	1	7
GO:0051716	cellular response to stimulus	2	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004518	nuclease activity	4	7
GO:0004519	endonuclease activity	5	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0003727	single-stranded RNA binding	5	1
GO:0004521	RNA endonuclease activity	5	1
GO:0004540	RNA nuclease activity	4	1
GO:0005488	binding	1	1
GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	6	1
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	1
GO:0097159	organic cyclic compound binding	2	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	113	117	PF00656	0.374
CLV_C14_Caspase3-7	231	235	PF00656	0.415
CLV_NRD_NRD_1	261	263	PF00675	0.271
CLV_NRD_NRD_1	98	100	PF00675	0.520
CLV_PCSK_KEX2_1	13	15	PF00082	0.661
CLV_PCSK_KEX2_1	261	263	PF00082	0.271
CLV_PCSK_KEX2_1	98	100	PF00082	0.497
CLV_PCSK_PC1ET2_1	13	15	PF00082	0.661
CLV_PCSK_PC7_1	9	15	PF00082	0.657
CLV_PCSK_SKI1_1	282	286	PF00082	0.294
CLV_PCSK_SKI1_1	53	57	PF00082	0.494
CLV_PCSK_SKI1_1	93	97	PF00082	0.642
CLV_PCSK_SKI1_1	99	103	PF00082	0.588
DEG_Nend_UBRbox_2	1	3	PF02207	0.469
DEG_SPOP_SBC_1	305	309	PF00917	0.520
DEG_SPOP_SBC_1	391	395	PF00917	0.574
DOC_MAPK_MEF2A_6	166	173	PF00069	0.320
DOC_MAPK_RevD_3	247	262	PF00069	0.415
DOC_PP2B_LxvP_1	273	276	PF13499	0.471
DOC_PP4_FxxP_1	100	103	PF00568	0.361
DOC_USP7_MATH_1	110	114	PF00917	0.338
DOC_USP7_MATH_1	152	156	PF00917	0.476
DOC_USP7_MATH_1	215	219	PF00917	0.471
DOC_USP7_MATH_1	30	34	PF00917	0.481
DOC_USP7_MATH_1	305	309	PF00917	0.520
DOC_USP7_MATH_1	386	390	PF00917	0.669
DOC_USP7_MATH_1	391	395	PF00917	0.698
DOC_WW_Pin1_4	132	137	PF00397	0.436
DOC_WW_Pin1_4	28	33	PF00397	0.460
DOC_WW_Pin1_4	343	348	PF00397	0.471
DOC_WW_Pin1_4	87	92	PF00397	0.360
LIG_14-3-3_CanoR_1	209	213	PF00244	0.471
LIG_14-3-3_CanoR_1	380	388	PF00244	0.479
LIG_deltaCOP1_diTrp_1	141	149	PF00928	0.368
LIG_deltaCOP1_diTrp_1	41	47	PF00928	0.310
LIG_eIF4E_1	197	203	PF01652	0.415
LIG_eIF4E_1	382	388	PF01652	0.479
LIG_FHA_1	127	133	PF00498	0.488
LIG_FHA_1	154	160	PF00498	0.228
LIG_FHA_1	241	247	PF00498	0.415
LIG_FHA_1	307	313	PF00498	0.450
LIG_FHA_1	355	361	PF00498	0.464
LIG_FHA_2	209	215	PF00498	0.471
LIG_FHA_2	299	305	PF00498	0.510
LIG_GBD_Chelix_1	265	273	PF00786	0.271
LIG_GBD_Chelix_1	355	363	PF00786	0.271
LIG_LIR_Gen_1	138	147	PF02991	0.416
LIG_LIR_Gen_1	218	228	PF02991	0.471
LIG_LIR_Nem_3	138	143	PF02991	0.406
LIG_LIR_Nem_3	218	223	PF02991	0.471
LIG_LYPXL_yS_3	197	200	PF13949	0.471
LIG_PCNA_PIPBox_1	200	209	PF02747	0.415
LIG_SH2_PTP2	344	347	PF00017	0.520
LIG_SH2_STAT5	206	209	PF00017	0.451
LIG_SH2_STAT5	216	219	PF00017	0.460
LIG_SH2_STAT5	344	347	PF00017	0.520
LIG_SH2_STAT5	382	385	PF00017	0.573
LIG_SH2_STAT5	67	70	PF00017	0.538
LIG_SH3_3	130	136	PF00018	0.366
LIG_SH3_3	254	260	PF00018	0.471
LIG_Sin3_3	356	363	PF02671	0.471
LIG_SUMO_SIM_par_1	248	253	PF11976	0.471
LIG_SUMO_SIM_par_1	271	277	PF11976	0.415
LIG_TRAF2_1	39	42	PF00917	0.430
LIG_TRAF2_1	46	49	PF00917	0.346
LIG_WRC_WIRS_1	220	225	PF05994	0.455
MOD_CDK_SPxK_1	87	93	PF00069	0.359
MOD_CK1_1	135	141	PF00069	0.395
MOD_CK1_1	160	166	PF00069	0.223
MOD_CK1_1	307	313	PF00069	0.482
MOD_CK1_1	322	328	PF00069	0.541
MOD_CK1_1	33	39	PF00069	0.431
MOD_CK2_1	116	122	PF00069	0.470
MOD_CK2_1	135	141	PF00069	0.399
MOD_CK2_1	208	214	PF00069	0.471
MOD_CK2_1	219	225	PF00069	0.471
MOD_CK2_1	298	304	PF00069	0.526
MOD_CMANNOS	44	47	PF00535	0.497
MOD_GlcNHglycan	217	220	PF01048	0.271
MOD_GlcNHglycan	32	35	PF01048	0.641
MOD_GlcNHglycan	384	387	PF01048	0.385
MOD_GlcNHglycan	388	391	PF01048	0.416
MOD_GlcNHglycan	76	79	PF01048	0.697
MOD_GSK3_1	112	119	PF00069	0.470
MOD_GSK3_1	131	138	PF00069	0.451
MOD_GSK3_1	153	160	PF00069	0.228
MOD_GSK3_1	215	222	PF00069	0.459
MOD_GSK3_1	274	281	PF00069	0.472
MOD_GSK3_1	294	301	PF00069	0.465
MOD_GSK3_1	304	311	PF00069	0.503
MOD_GSK3_1	318	325	PF00069	0.407
MOD_GSK3_1	33	40	PF00069	0.415
MOD_GSK3_1	382	389	PF00069	0.529
MOD_GSK3_1	70	77	PF00069	0.437
MOD_N-GLC_1	126	131	PF02516	0.609
MOD_NEK2_1	105	110	PF00069	0.361
MOD_NEK2_1	159	164	PF00069	0.228
MOD_NEK2_1	202	207	PF00069	0.497
MOD_NEK2_1	240	245	PF00069	0.480
MOD_NEK2_1	318	323	PF00069	0.596
MOD_NEK2_1	359	364	PF00069	0.471
MOD_NEK2_2	219	224	PF00069	0.455
MOD_PIKK_1	240	246	PF00454	0.520
MOD_PIKK_1	322	328	PF00454	0.520
MOD_PKA_2	208	214	PF00069	0.471
MOD_Plk_1	105	111	PF00069	0.398
MOD_Plk_1	177	183	PF00069	0.471
MOD_Plk_4	169	175	PF00069	0.530
MOD_Plk_4	202	208	PF00069	0.473
MOD_ProDKin_1	132	138	PF00069	0.426
MOD_ProDKin_1	28	34	PF00069	0.456
MOD_ProDKin_1	343	349	PF00069	0.471
MOD_ProDKin_1	87	93	PF00069	0.359
MOD_SUMO_rev_2	72	78	PF00179	0.399
TRG_DiLeu_BaLyEn_6	314	319	PF01217	0.504
TRG_ENDOCYTIC_2	197	200	PF00928	0.500
TRG_ER_diArg_1	260	262	PF00400	0.471
TRG_ER_diArg_1	98	100	PF00400	0.325
TRG_NES_CRM1_1	50	64	PF08389	0.271

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILN9	Leptomonas seymouri	52%	100%
A0A3S7XAV3	Leishmania donovani	71%	100%
A4IDK7	Leishmania infantum	71%	100%
E9AT10	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	99%
Q4Q1I8	Leishmania major	71%	100%