Glucokinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Glucokinase

Gene product:

glucokinase

Species:

Leishmania braziliensis

UniProt:

A4HPA0_LEIBR

TriTrypDb:

LbrM.35.2550 , LBRM2903_350032400 , LBRM2903_350032500

Length:

411

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0043226	organelle	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005777	peroxisome	6	1
GO:0020015	glycosome	7	1
GO:0042579	microbody	5	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HPA0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPA0

PDB structure(s): 6edi_A , 6edi_B

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	10
GO:0006082	organic acid metabolic process	3	10
GO:0006090	pyruvate metabolic process	7	10
GO:0006091	generation of precursor metabolites and energy	3	10
GO:0006096	glycolytic process	5	10
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006163	purine nucleotide metabolic process	5	10
GO:0006165	obsolete nucleoside diphosphate phosphorylation	6	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006753	nucleoside phosphate metabolic process	4	10
GO:0006757	obsolete ATP generation from ADP	4	10
GO:0006793	phosphorus metabolic process	3	10
GO:0006796	phosphate-containing compound metabolic process	4	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009056	catabolic process	2	10
GO:0009117	nucleotide metabolic process	5	10
GO:0009132	nucleoside diphosphate metabolic process	5	10
GO:0009135	purine nucleoside diphosphate metabolic process	6	10
GO:0009141	nucleoside triphosphate metabolic process	5	10
GO:0009144	purine nucleoside triphosphate metabolic process	6	10
GO:0009150	purine ribonucleotide metabolic process	6	10
GO:0009179	purine ribonucleoside diphosphate metabolic process	7	10
GO:0009185	ribonucleoside diphosphate metabolic process	6	10
GO:0009199	ribonucleoside triphosphate metabolic process	6	10
GO:0009205	purine ribonucleoside triphosphate metabolic process	7	10
GO:0009259	ribonucleotide metabolic process	5	10
GO:0009987	cellular process	1	10
GO:0016052	carbohydrate catabolic process	4	10
GO:0016310	phosphorylation	5	10
GO:0019637	organophosphate metabolic process	3	10
GO:0019693	ribose phosphate metabolic process	4	10
GO:0019752	carboxylic acid metabolic process	5	10
GO:0032787	monocarboxylic acid metabolic process	6	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0043436	oxoacid metabolic process	4	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044281	small molecule metabolic process	2	10
GO:0046031	ADP metabolic process	7	10
GO:0046034	ATP metabolic process	7	10
GO:0046483	heterocycle metabolic process	3	10
GO:0046939	obsolete nucleotide phosphorylation	6	10
GO:0055086	nucleobase-containing small molecule metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:0072521	purine-containing compound metabolic process	4	10
GO:1901135	carbohydrate derivative metabolic process	3	10
GO:1901360	organic cyclic compound metabolic process	3	10
GO:1901564	organonitrogen compound metabolic process	3	10
GO:1901575	organic substance catabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003824	catalytic activity	1	10
GO:0004340	glucokinase activity	6	10
GO:0004396	hexokinase activity	5	10
GO:0005488	binding	1	10
GO:0005524	ATP binding	5	10
GO:0005536	glucose binding	4	10
GO:0016301	kinase activity	4	10
GO:0016740	transferase activity	2	10
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	10
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	10
GO:0017076	purine nucleotide binding	4	10
GO:0019200	carbohydrate kinase activity	5	10
GO:0030246	carbohydrate binding	2	10
GO:0030554	adenyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032559	adenyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0048029	monosaccharide binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	94	96	PF00675	0.307
CLV_PCSK_KEX2_1	353	355	PF00082	0.395
CLV_PCSK_KEX2_1	94	96	PF00082	0.304
CLV_PCSK_PC1ET2_1	353	355	PF00082	0.395
CLV_PCSK_SKI1_1	137	141	PF00082	0.321
CLV_PCSK_SKI1_1	295	299	PF00082	0.363
CLV_PCSK_SKI1_1	366	370	PF00082	0.523
CLV_PCSK_SKI1_1	68	72	PF00082	0.299
DEG_APCC_DBOX_1	49	57	PF00400	0.466
DOC_MAPK_gen_1	311	319	PF00069	0.546
DOC_MAPK_MEF2A_6	378	387	PF00069	0.358
DOC_PP1_RVXF_1	163	169	PF00149	0.546
DOC_PP1_RVXF_1	37	43	PF00149	0.504
DOC_PP4_FxxP_1	346	349	PF00568	0.502
DOC_SPAK_OSR1_1	59	63	PF12202	0.507
DOC_USP7_MATH_1	181	185	PF00917	0.504
DOC_USP7_MATH_1	286	290	PF00917	0.593
DOC_USP7_MATH_1	406	410	PF00917	0.627
DOC_USP7_UBL2_3	165	169	PF12436	0.516
DOC_USP7_UBL2_3	247	251	PF12436	0.526
DOC_USP7_UBL2_3	278	282	PF12436	0.600
LIG_14-3-3_CanoR_1	373	377	PF00244	0.328
LIG_14-3-3_CanoR_1	378	384	PF00244	0.334
LIG_Actin_WH2_2	364	380	PF00022	0.412
LIG_Actin_WH2_2	78	96	PF00022	0.507
LIG_BRCT_BRCA1_1	160	164	PF00533	0.526
LIG_BRCT_BRCA1_1	342	346	PF00533	0.453
LIG_BRCT_BRCA1_2	342	348	PF00533	0.271
LIG_FHA_1	2	8	PF00498	0.495
LIG_FHA_1	301	307	PF00498	0.402
LIG_FHA_1	329	335	PF00498	0.498
LIG_FHA_1	372	378	PF00498	0.442
LIG_FHA_2	169	175	PF00498	0.507
LIG_FHA_2	61	67	PF00498	0.554
LIG_LIR_Apic_2	343	349	PF02991	0.482
LIG_LIR_Gen_1	171	181	PF02991	0.522
LIG_LIR_Gen_1	211	219	PF02991	0.479
LIG_LIR_Gen_1	72	81	PF02991	0.557
LIG_LIR_Nem_3	161	166	PF02991	0.446
LIG_LIR_Nem_3	171	176	PF02991	0.493
LIG_LIR_Nem_3	211	217	PF02991	0.479
LIG_LIR_Nem_3	310	316	PF02991	0.504
LIG_LIR_Nem_3	324	330	PF02991	0.504
LIG_LIR_Nem_3	365	371	PF02991	0.344
LIG_LIR_Nem_3	72	77	PF02991	0.557
LIG_MLH1_MIPbox_1	160	164	PF16413	0.504
LIG_MLH1_MIPbox_1	342	346	PF16413	0.456
LIG_PDZ_Class_1	406	411	PF00595	0.656
LIG_Pex14_2	164	168	PF04695	0.507
LIG_PTB_Apo_2	339	346	PF02174	0.366
LIG_PTB_Phospho_1	339	345	PF10480	0.404
LIG_SH2_CRK	149	153	PF00017	0.504
LIG_SH2_CRK	313	317	PF00017	0.546
LIG_SH2_PTP2	207	210	PF00017	0.531
LIG_SH2_PTP2	214	217	PF00017	0.478
LIG_SH2_SRC	274	277	PF00017	0.518
LIG_SH2_STAT5	163	166	PF00017	0.463
LIG_SH2_STAT5	207	210	PF00017	0.506
LIG_SH2_STAT5	214	217	PF00017	0.455
LIG_SH2_STAT5	236	239	PF00017	0.540
LIG_SH2_STAT5	28	31	PF00017	0.439
LIG_SH2_STAT5	345	348	PF00017	0.425
LIG_SH2_STAT5	57	60	PF00017	0.504
LIG_SH3_3	123	129	PF00018	0.438
LIG_SH3_3	190	196	PF00018	0.479
LIG_SH3_3	98	104	PF00018	0.474
LIG_SUMO_SIM_par_1	150	155	PF11976	0.473
LIG_SUMO_SIM_par_1	215	220	PF11976	0.511
LIG_TYR_ITIM	205	210	PF00017	0.413
MOD_CK1_1	21	27	PF00069	0.508
MOD_CK1_1	372	378	PF00069	0.326
MOD_CK1_1	395	401	PF00069	0.479
MOD_CK1_1	43	49	PF00069	0.211
MOD_CK2_1	286	292	PF00069	0.364
MOD_GlcNHglycan	137	140	PF01048	0.316
MOD_GlcNHglycan	23	26	PF01048	0.340
MOD_GlcNHglycan	283	286	PF01048	0.442
MOD_GlcNHglycan	288	291	PF01048	0.386
MOD_GlcNHglycan	298	301	PF01048	0.343
MOD_GlcNHglycan	36	39	PF01048	0.258
MOD_GlcNHglycan	399	402	PF01048	0.402
MOD_GlcNHglycan	49	53	PF01048	0.378
MOD_GlcNHglycan	97	100	PF01048	0.386
MOD_GSK3_1	14	21	PF00069	0.452
MOD_GSK3_1	195	202	PF00069	0.335
MOD_GSK3_1	220	227	PF00069	0.281
MOD_GSK3_1	296	303	PF00069	0.430
MOD_GSK3_1	317	324	PF00069	0.460
MOD_GSK3_1	95	102	PF00069	0.430
MOD_NEK2_1	12	17	PF00069	0.291
MOD_NEK2_1	152	157	PF00069	0.413
MOD_NEK2_1	224	229	PF00069	0.425
MOD_NEK2_1	253	258	PF00069	0.476
MOD_NEK2_1	296	301	PF00069	0.435
MOD_NEK2_1	371	376	PF00069	0.471
MOD_NEK2_1	60	65	PF00069	0.451
MOD_PIKK_1	168	174	PF00454	0.405
MOD_PIKK_1	392	398	PF00454	0.473
MOD_PIKK_1	40	46	PF00454	0.211
MOD_PKA_2	372	378	PF00069	0.331
MOD_Plk_1	18	24	PF00069	0.563
MOD_Plk_1	253	259	PF00069	0.335
MOD_Plk_1	321	327	PF00069	0.320
MOD_Plk_4	200	206	PF00069	0.380
MOD_Plk_4	210	216	PF00069	0.283
MOD_Plk_4	340	346	PF00069	0.404
MOD_Plk_4	372	378	PF00069	0.326
MOD_Plk_4	88	94	PF00069	0.228
MOD_SUMO_rev_2	174	182	PF00179	0.358
MOD_SUMO_rev_2	227	237	PF00179	0.421
TRG_ENDOCYTIC_2	149	152	PF00928	0.360
TRG_ENDOCYTIC_2	163	166	PF00928	0.332
TRG_ENDOCYTIC_2	207	210	PF00928	0.300
TRG_ENDOCYTIC_2	214	217	PF00928	0.330
TRG_ENDOCYTIC_2	313	316	PF00928	0.357
TRG_ENDOCYTIC_2	57	60	PF00928	0.405
TRG_ER_diArg_1	93	95	PF00400	0.358
TRG_Pf-PMV_PEXEL_1	68	72	PF00026	0.405
TRG_PTS1	408	411	PF00515	0.621

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZF4	Leptomonas seymouri	64%	100%
A0A0S4JSI6	Bodo saltans	32%	100%
A0A3R7L110	Trypanosoma rangeli	44%	100%
A0A3S7XAU3	Leishmania donovani	87%	100%
A4IDK6	Leishmania infantum	87%	100%
E9AT09	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q1I9	Leishmania major	86%	100%
Q9GTW8	Trichomonas vaginalis	28%	100%
Q9GTW9	Trichomonas vaginalis	28%	100%
V5BBU8	Trypanosoma cruzi	45%	100%