Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HP98_LEIBR

TriTrypDb:

LbrM.35.2530 , LBRM2903_350032200

Length:

483

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4HP98

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP98

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	215	219	PF00656	0.443
CLV_NRD_NRD_1	258	260	PF00675	0.630
CLV_NRD_NRD_1	336	338	PF00675	0.329
CLV_PCSK_KEX2_1	258	260	PF00082	0.630
CLV_PCSK_KEX2_1	336	338	PF00082	0.329
CLV_PCSK_KEX2_1	365	367	PF00082	0.423
CLV_PCSK_PC1ET2_1	365	367	PF00082	0.423
CLV_PCSK_SKI1_1	258	262	PF00082	0.629
CLV_PCSK_SKI1_1	389	393	PF00082	0.435
CLV_PCSK_SKI1_1	46	50	PF00082	0.627
CLV_PCSK_SKI1_1	98	102	PF00082	0.369
DEG_APCC_DBOX_1	97	105	PF00400	0.227
DEG_Nend_UBRbox_1	1	4	PF02207	0.392
DEG_SPOP_SBC_1	113	117	PF00917	0.525
DOC_MAPK_gen_1	120	128	PF00069	0.681
DOC_PP4_FxxP_1	147	150	PF00568	0.664
DOC_USP7_MATH_1	16	20	PF00917	0.386
DOC_USP7_MATH_1	206	210	PF00917	0.370
DOC_USP7_MATH_1	399	403	PF00917	0.639
DOC_USP7_MATH_1	416	420	PF00917	0.622
DOC_USP7_MATH_1	425	429	PF00917	0.637
DOC_USP7_MATH_1	440	444	PF00917	0.625
DOC_USP7_MATH_1	470	474	PF00917	0.672
DOC_WW_Pin1_4	196	201	PF00397	0.354
DOC_WW_Pin1_4	347	352	PF00397	0.696
DOC_WW_Pin1_4	365	370	PF00397	0.635
DOC_WW_Pin1_4	477	482	PF00397	0.738
DOC_WW_Pin1_4	9	14	PF00397	0.411
LIG_14-3-3_CanoR_1	111	121	PF00244	0.619
LIG_14-3-3_CanoR_1	155	165	PF00244	0.526
LIG_14-3-3_CanoR_1	211	220	PF00244	0.361
LIG_14-3-3_CanoR_1	258	267	PF00244	0.431
LIG_14-3-3_CanoR_1	344	350	PF00244	0.659
LIG_14-3-3_CanoR_1	37	44	PF00244	0.464
LIG_14-3-3_CanoR_1	46	51	PF00244	0.358
LIG_Actin_RPEL_3	91	110	PF02755	0.369
LIG_Actin_WH2_2	17	34	PF00022	0.439
LIG_Actin_WH2_2	244	260	PF00022	0.395
LIG_Actin_WH2_2	95	113	PF00022	0.227
LIG_ActinCP_TwfCPI_2	147	155	PF01115	0.555
LIG_BRCT_BRCA1_1	236	240	PF00533	0.392
LIG_CaM_NSCaTE_8	220	227	PF13499	0.370
LIG_deltaCOP1_diTrp_1	195	202	PF00928	0.339
LIG_FHA_1	157	163	PF00498	0.611
LIG_FHA_1	179	185	PF00498	0.444
LIG_FHA_1	259	265	PF00498	0.428
LIG_FHA_1	344	350	PF00498	0.581
LIG_FHA_1	399	405	PF00498	0.709
LIG_FHA_1	90	96	PF00498	0.285
LIG_FHA_2	213	219	PF00498	0.429
LIG_FHA_2	24	30	PF00498	0.344
LIG_FHA_2	37	43	PF00498	0.438
LIG_FHA_2	379	385	PF00498	0.694
LIG_FHA_2	47	53	PF00498	0.353
LIG_FHA_2	473	479	PF00498	0.656
LIG_GBD_Chelix_1	171	179	PF00786	0.304
LIG_LIR_Apic_2	145	150	PF02991	0.663
LIG_LIR_Apic_2	195	200	PF02991	0.351
LIG_LIR_Gen_1	18	28	PF02991	0.398
LIG_LIR_Gen_1	252	260	PF02991	0.383
LIG_LIR_Nem_3	18	24	PF02991	0.402
LIG_LIR_Nem_3	195	201	PF02991	0.338
LIG_LIR_Nem_3	236	242	PF02991	0.482
LIG_LIR_Nem_3	252	257	PF02991	0.390
LIG_LIR_Nem_3	59	65	PF02991	0.495
LIG_LYPXL_SIV_4	16	24	PF13949	0.341
LIG_MLH1_MIPbox_1	236	240	PF16413	0.346
LIG_NRBOX	189	195	PF00104	0.478
LIG_NRBOX	327	333	PF00104	0.526
LIG_NRBOX	95	101	PF00104	0.304
LIG_PALB2_WD40_1	193	201	PF16756	0.335
LIG_PCNA_yPIPBox_3	323	332	PF02747	0.531
LIG_Pex14_1	283	287	PF04695	0.328
LIG_Pex14_2	198	202	PF04695	0.335
LIG_SH2_CRK	62	66	PF00017	0.357
LIG_SH2_NCK_1	17	21	PF00017	0.346
LIG_SH2_STAP1	17	21	PF00017	0.447
LIG_SH2_STAP1	235	239	PF00017	0.488
LIG_SH2_STAP1	287	291	PF00017	0.608
LIG_SH2_STAT5	235	238	PF00017	0.427
LIG_SH2_STAT5	268	271	PF00017	0.437
LIG_SH2_STAT5	301	304	PF00017	0.697
LIG_SUMO_SIM_anti_2	49	55	PF11976	0.382
LIG_SUMO_SIM_par_1	327	334	PF11976	0.524
LIG_SUMO_SIM_par_1	49	55	PF11976	0.369
LIG_TRAF2_1	313	316	PF00917	0.602
LIG_TRAF2_1	352	355	PF00917	0.574
LIG_TRAF2_1	434	437	PF00917	0.629
LIG_WRC_WIRS_1	251	256	PF05994	0.391
MOD_CDC14_SPxK_1	368	371	PF00782	0.529
MOD_CDK_SPxK_1	365	371	PF00069	0.525
MOD_CK1_1	216	222	PF00069	0.530
MOD_CK1_1	286	292	PF00069	0.511
MOD_CK1_1	347	353	PF00069	0.438
MOD_CK1_1	402	408	PF00069	0.536
MOD_CK1_1	454	460	PF00069	0.698
MOD_CK2_1	23	29	PF00069	0.390
MOD_CK2_1	46	52	PF00069	0.485
MOD_CK2_1	470	476	PF00069	0.567
MOD_GlcNHglycan	165	168	PF01048	0.353
MOD_GlcNHglycan	386	389	PF01048	0.616
MOD_GlcNHglycan	401	404	PF01048	0.588
MOD_GlcNHglycan	412	417	PF01048	0.646
MOD_GlcNHglycan	421	425	PF01048	0.714
MOD_GlcNHglycan	442	445	PF01048	0.488
MOD_GlcNHglycan	5	8	PF01048	0.586
MOD_GlcNHglycan	85	88	PF01048	0.548
MOD_GSK3_1	157	164	PF00069	0.511
MOD_GSK3_1	212	219	PF00069	0.665
MOD_GSK3_1	343	350	PF00069	0.425
MOD_GSK3_1	374	381	PF00069	0.657
MOD_GSK3_1	398	405	PF00069	0.535
MOD_GSK3_1	408	415	PF00069	0.610
MOD_GSK3_1	416	423	PF00069	0.541
MOD_GSK3_1	425	432	PF00069	0.462
MOD_GSK3_1	440	447	PF00069	0.525
MOD_GSK3_1	450	457	PF00069	0.667
MOD_GSK3_1	468	475	PF00069	0.547
MOD_GSK3_1	5	12	PF00069	0.613
MOD_GSK3_1	74	81	PF00069	0.534
MOD_N-GLC_1	157	162	PF02516	0.528
MOD_N-GLC_1	216	221	PF02516	0.515
MOD_N-GLC_1	295	300	PF02516	0.496
MOD_N-GLC_1	374	379	PF02516	0.542
MOD_N-GLC_1	382	387	PF02516	0.524
MOD_NEK2_1	112	117	PF00069	0.419
MOD_NEK2_1	161	166	PF00069	0.411
MOD_NEK2_1	23	28	PF00069	0.530
MOD_NEK2_1	250	255	PF00069	0.501
MOD_NEK2_1	331	336	PF00069	0.492
MOD_NEK2_1	345	350	PF00069	0.571
MOD_NEK2_2	16	21	PF00069	0.409
MOD_NEK2_2	178	183	PF00069	0.314
MOD_NEK2_2	220	225	PF00069	0.448
MOD_NEK2_2	235	240	PF00069	0.381
MOD_PIKK_1	258	264	PF00454	0.601
MOD_PIKK_1	317	323	PF00454	0.441
MOD_PIKK_1	331	337	PF00454	0.466
MOD_PIKK_1	470	476	PF00454	0.567
MOD_PKA_1	258	264	PF00069	0.532
MOD_PKA_2	113	119	PF00069	0.546
MOD_PKA_2	258	264	PF00069	0.532
MOD_PKA_2	343	349	PF00069	0.422
MOD_PKA_2	36	42	PF00069	0.546
MOD_Plk_1	157	163	PF00069	0.540
MOD_Plk_1	216	222	PF00069	0.439
MOD_Plk_1	295	301	PF00069	0.502
MOD_Plk_4	157	163	PF00069	0.559
MOD_Plk_4	16	22	PF00069	0.548
MOD_Plk_4	235	241	PF00069	0.699
MOD_Plk_4	273	279	PF00069	0.317
MOD_Plk_4	46	52	PF00069	0.456
MOD_Plk_4	79	85	PF00069	0.468
MOD_ProDKin_1	196	202	PF00069	0.423
MOD_ProDKin_1	347	353	PF00069	0.622
MOD_ProDKin_1	365	371	PF00069	0.539
MOD_ProDKin_1	477	483	PF00069	0.683
MOD_ProDKin_1	9	15	PF00069	0.497
TRG_DiLeu_BaLyEn_6	189	194	PF01217	0.527
TRG_DiLeu_BaLyEn_6	287	292	PF01217	0.448
TRG_DiLeu_BaLyEn_6	95	100	PF01217	0.369
TRG_DiLeu_LyEn_5	304	309	PF01217	0.566
TRG_ENDOCYTIC_2	17	20	PF00928	0.553
TRG_ENDOCYTIC_2	62	65	PF00928	0.571
TRG_ER_diArg_1	119	122	PF00400	0.546
TRG_ER_diArg_1	257	259	PF00400	0.538
TRG_Pf-PMV_PEXEL_1	389	393	PF00026	0.536

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I690	Leptomonas seymouri	27%	100%
A0A3S7XAV6	Leishmania donovani	64%	100%
A4IDK4	Leishmania infantum	63%	100%
E9AT07	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	100%
Q4Q1J1	Leishmania major	60%	99%