Putative Bardet-Biedl syndrome 4 protein homolog (BBS4-like protein 4)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

bardet-biedl syndrome 4 protein

Species:

Leishmania braziliensis

UniProt:

A4HP97_LEIBR

TriTrypDb:

LbrM.35.2520 , LBRM2903_350032100

Length:

492

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	11
GO:0016020	membrane	2	11
GO:0031090	organelle membrane	3	11
GO:0031253	cell projection membrane	4	11
GO:0060170	ciliary membrane	5	11
GO:0098588	bounding membrane of organelle	4	11
GO:0098590	plasma membrane region	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0012506	vesicle membrane	4	1
GO:0020018	ciliary pocket membrane	6	1
GO:0030659	cytoplasmic vesicle membrane	5	1
GO:0030662	coated vesicle membrane	5	1
GO:0030665	clathrin-coated vesicle membrane	6	1
GO:0032991	protein-containing complex	1	1
GO:0034464	BBSome	2	1
GO:0035869	ciliary transition zone	2	1
GO:0036064	ciliary basal body	3	1

Expansion

Sequence features

A4HP97

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP97

Function

Biological processes
Term	Name	Level	Count
GO:0000041	transition metal ion transport	7	1
GO:0006810	transport	3	1
GO:0006811	monoatomic ion transport	4	1
GO:0006812	monoatomic cation transport	5	1
GO:0006826	iron ion transport	8	1
GO:0006996	organelle organization	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0030001	metal ion transport	6	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0033572	transferrin transport	5	1
GO:0044782	cilium organization	5	1
GO:0045184	establishment of protein localization	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0060271	cilium assembly	6	1
GO:0061512	protein localization to cilium	6	1
GO:0070727	cellular macromolecule localization	3	1
GO:0070925	organelle assembly	5	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0030276	clathrin binding	3	1
GO:0032050	clathrin heavy chain binding	4	1
GO:0032182	ubiquitin-like protein binding	3	1
GO:0043130	ubiquitin binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	254	258	PF00656	0.441
CLV_NRD_NRD_1	168	170	PF00675	0.534
CLV_NRD_NRD_1	313	315	PF00675	0.327
CLV_NRD_NRD_1	429	431	PF00675	0.522
CLV_NRD_NRD_1	49	51	PF00675	0.373
CLV_NRD_NRD_1	6	8	PF00675	0.703
CLV_PCSK_FUR_1	47	51	PF00082	0.372
CLV_PCSK_KEX2_1	168	170	PF00082	0.406
CLV_PCSK_KEX2_1	429	431	PF00082	0.522
CLV_PCSK_KEX2_1	49	51	PF00082	0.373
CLV_PCSK_KEX2_1	6	8	PF00082	0.643
CLV_PCSK_KEX2_1	92	94	PF00082	0.319
CLV_PCSK_PC1ET2_1	92	94	PF00082	0.361
CLV_PCSK_SKI1_1	146	150	PF00082	0.433
CLV_PCSK_SKI1_1	196	200	PF00082	0.365
CLV_PCSK_SKI1_1	247	251	PF00082	0.370
CLV_PCSK_SKI1_1	303	307	PF00082	0.513
CLV_PCSK_SKI1_1	315	319	PF00082	0.363
CLV_PCSK_SKI1_1	88	92	PF00082	0.310
DEG_APCC_DBOX_1	49	57	PF00400	0.465
DEG_MDM2_SWIB_1	417	424	PF02201	0.492
DEG_Nend_UBRbox_3	1	3	PF02207	0.683
DEG_SPOP_SBC_1	454	458	PF00917	0.704
DOC_ANK_TNKS_1	5	12	PF00023	0.477
DOC_CKS1_1	423	428	PF01111	0.486
DOC_CYCLIN_RxL_1	85	95	PF00134	0.321
DOC_MAPK_gen_1	47	56	PF00069	0.483
DOC_PP2B_LxvP_1	447	450	PF13499	0.577
DOC_PP4_FxxP_1	318	321	PF00568	0.459
DOC_USP7_MATH_1	261	265	PF00917	0.327
DOC_USP7_MATH_1	287	291	PF00917	0.387
DOC_USP7_MATH_1	473	477	PF00917	0.389
DOC_USP7_UBL2_3	88	92	PF12436	0.333
DOC_WW_Pin1_4	109	114	PF00397	0.444
DOC_WW_Pin1_4	215	220	PF00397	0.256
DOC_WW_Pin1_4	422	427	PF00397	0.483
DOC_WW_Pin1_4	449	454	PF00397	0.508
LIG_14-3-3_CanoR_1	314	318	PF00244	0.372
LIG_14-3-3_CanoR_1	339	347	PF00244	0.435
LIG_14-3-3_CanoR_1	415	421	PF00244	0.456
LIG_Actin_WH2_2	298	316	PF00022	0.380
LIG_APCC_ABBA_1	208	213	PF00400	0.296
LIG_FHA_1	105	111	PF00498	0.430
LIG_FHA_1	358	364	PF00498	0.367
LIG_FHA_1	465	471	PF00498	0.512
LIG_FHA_1	486	492	PF00498	0.560
LIG_FHA_2	218	224	PF00498	0.377
LIG_FHA_2	252	258	PF00498	0.467
LIG_LIR_Apic_2	316	321	PF02991	0.441
LIG_LIR_Gen_1	188	199	PF02991	0.425
LIG_LIR_Gen_1	290	301	PF02991	0.369
LIG_LIR_Gen_1	306	313	PF02991	0.466
LIG_LIR_Gen_1	360	368	PF02991	0.284
LIG_LIR_Gen_1	419	426	PF02991	0.429
LIG_LIR_Nem_3	188	194	PF02991	0.428
LIG_LIR_Nem_3	277	282	PF02991	0.384
LIG_LIR_Nem_3	290	296	PF02991	0.384
LIG_LIR_Nem_3	306	310	PF02991	0.470
LIG_LIR_Nem_3	360	364	PF02991	0.285
LIG_LIR_Nem_3	389	394	PF02991	0.442
LIG_LIR_Nem_3	419	424	PF02991	0.492
LIG_LIR_Nem_3	80	86	PF02991	0.361
LIG_NRBOX	52	58	PF00104	0.398
LIG_Pex14_1	155	159	PF04695	0.290
LIG_Pex14_1	324	328	PF04695	0.315
LIG_Pex14_2	318	322	PF04695	0.431
LIG_Pex14_2	417	421	PF04695	0.361
LIG_SH2_CRK	279	283	PF00017	0.384
LIG_SH2_CRK	307	311	PF00017	0.440
LIG_SH2_GRB2like	394	397	PF00017	0.419
LIG_SH2_GRB2like	63	66	PF00017	0.401
LIG_SH2_NCK_1	307	311	PF00017	0.440
LIG_SH2_PTP2	160	163	PF00017	0.432
LIG_SH2_SRC	211	214	PF00017	0.384
LIG_SH2_SRC	381	384	PF00017	0.446
LIG_SH2_STAP1	204	208	PF00017	0.296
LIG_SH2_STAP1	211	215	PF00017	0.296
LIG_SH2_STAP1	272	276	PF00017	0.384
LIG_SH2_STAP1	307	311	PF00017	0.440
LIG_SH2_STAP1	381	385	PF00017	0.349
LIG_SH2_STAP1	397	401	PF00017	0.249
LIG_SH2_STAP1	63	67	PF00017	0.338
LIG_SH2_STAP1	83	87	PF00017	0.171
LIG_SH2_STAT3	232	235	PF00017	0.328
LIG_SH2_STAT3	58	61	PF00017	0.341
LIG_SH2_STAT5	160	163	PF00017	0.366
LIG_SH2_STAT5	191	194	PF00017	0.399
LIG_SH2_STAT5	232	235	PF00017	0.283
LIG_SH2_STAT5	244	247	PF00017	0.270
LIG_SH2_STAT5	394	397	PF00017	0.345
LIG_SH2_STAT5	58	61	PF00017	0.372
LIG_SH2_STAT5	86	89	PF00017	0.343
LIG_SH3_3	216	222	PF00018	0.324
LIG_SH3_3	443	449	PF00018	0.598
LIG_SUMO_SIM_anti_2	99	107	PF11976	0.455
LIG_TYR_ITSM	275	282	PF00017	0.301
LIG_WRC_WIRS_1	136	141	PF05994	0.230
MOD_CDK_SPxxK_3	422	429	PF00069	0.485
MOD_CK2_1	457	463	PF00069	0.619
MOD_CK2_1	94	100	PF00069	0.415
MOD_Cter_Amidation	301	304	PF01082	0.453
MOD_Cter_Amidation	4	7	PF01082	0.741
MOD_GlcNHglycan	19	22	PF01048	0.645
MOD_GlcNHglycan	341	344	PF01048	0.333
MOD_GlcNHglycan	457	460	PF01048	0.726
MOD_GlcNHglycan	463	467	PF01048	0.680
MOD_GlcNHglycan	475	478	PF01048	0.538
MOD_GSK3_1	213	220	PF00069	0.401
MOD_GSK3_1	24	31	PF00069	0.489
MOD_GSK3_1	247	254	PF00069	0.375
MOD_GSK3_1	449	456	PF00069	0.605
MOD_GSK3_1	469	476	PF00069	0.523
MOD_GSK3_1	485	492	PF00069	0.548
MOD_GSK3_1	94	101	PF00069	0.385
MOD_N-GLC_2	376	378	PF02516	0.352
MOD_NEK2_1	104	109	PF00069	0.285
MOD_NEK2_1	178	183	PF00069	0.317
MOD_NEK2_1	24	29	PF00069	0.598
MOD_NEK2_1	313	318	PF00069	0.439
MOD_NEK2_1	462	467	PF00069	0.729
MOD_NEK2_1	74	79	PF00069	0.510
MOD_NEK2_1	94	99	PF00069	0.263
MOD_NEK2_2	397	402	PF00069	0.367
MOD_PIKK_1	117	123	PF00454	0.393
MOD_PIKK_1	287	293	PF00454	0.404
MOD_PIKK_1	69	75	PF00454	0.317
MOD_PKA_1	303	309	PF00069	0.398
MOD_PKA_2	313	319	PF00069	0.425
MOD_PKA_2	74	80	PF00069	0.476
MOD_Plk_1	287	293	PF00069	0.344
MOD_Plk_1	430	436	PF00069	0.520
MOD_Plk_4	261	267	PF00069	0.305
MOD_Plk_4	313	319	PF00069	0.438
MOD_Plk_4	357	363	PF00069	0.299
MOD_Plk_4	397	403	PF00069	0.431
MOD_Plk_4	431	437	PF00069	0.557
MOD_Plk_4	457	463	PF00069	0.574
MOD_ProDKin_1	109	115	PF00069	0.443
MOD_ProDKin_1	215	221	PF00069	0.256
MOD_ProDKin_1	422	428	PF00069	0.484
MOD_ProDKin_1	449	455	PF00069	0.508
TRG_DiLeu_BaEn_1	100	105	PF01217	0.442
TRG_DiLeu_BaEn_1	431	436	PF01217	0.517
TRG_ENDOCYTIC_2	160	163	PF00928	0.310
TRG_ENDOCYTIC_2	191	194	PF00928	0.420
TRG_ENDOCYTIC_2	279	282	PF00928	0.384
TRG_ENDOCYTIC_2	307	310	PF00928	0.433
TRG_ER_diArg_1	6	8	PF00400	0.479
TRG_NES_CRM1_1	100	114	PF08389	0.465
TRG_NES_CRM1_1	223	235	PF08389	0.270
TRG_Pf-PMV_PEXEL_1	149	153	PF00026	0.284
TRG_Pf-PMV_PEXEL_1	441	445	PF00026	0.546

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PED7	Leptomonas seymouri	70%	100%
A0A1X0P7L4	Trypanosomatidae	49%	87%
A0A3Q8IH89	Leishmania donovani	85%	99%
A0A3R7MGH4	Trypanosoma rangeli	45%	100%
A1Z8E9	Drosophila melanogaster	30%	100%
A4IDK2	Leishmania infantum	85%	99%
D0A3A0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AT05	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	99%
Q1JQ97	Bos taurus	43%	95%
Q28G25	Xenopus tropicalis	41%	95%
Q4Q1J3	Leishmania major	84%	100%
Q5CZ52	Caenorhabditis elegans	27%	100%
Q8C1Z7	Mus musculus	44%	95%
Q96RK4	Homo sapiens	44%	95%
V5DCK5	Trypanosoma cruzi	47%	100%