Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HP96_LEIBR

TriTrypDb:

LbrM.35.2510 , LBRM2903_350032000

Length:

466

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HP96

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP96

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	304	306	PF00675	0.558
CLV_NRD_NRD_1	33	35	PF00675	0.635
CLV_NRD_NRD_1	338	340	PF00675	0.754
CLV_NRD_NRD_1	412	414	PF00675	0.603
CLV_PCSK_KEX2_1	304	306	PF00082	0.587
CLV_PCSK_KEX2_1	33	35	PF00082	0.635
CLV_PCSK_KEX2_1	338	340	PF00082	0.726
CLV_PCSK_KEX2_1	412	414	PF00082	0.603
CLV_PCSK_PC7_1	300	306	PF00082	0.540
CLV_PCSK_SKI1_1	305	309	PF00082	0.556
CLV_PCSK_SKI1_1	333	337	PF00082	0.594
CLV_PCSK_SKI1_1	353	357	PF00082	0.618
CLV_PCSK_SKI1_1	5	9	PF00082	0.625
CLV_PCSK_SKI1_1	72	76	PF00082	0.522
CLV_Separin_Metazoa	69	73	PF03568	0.533
DEG_APCC_DBOX_1	130	138	PF00400	0.502
DEG_SPOP_SBC_1	208	212	PF00917	0.510
DOC_CYCLIN_yCln2_LP_2	130	136	PF00134	0.747
DOC_MAPK_gen_1	432	441	PF00069	0.473
DOC_MAPK_MEF2A_6	131	138	PF00069	0.507
DOC_MAPK_MEF2A_6	59	66	PF00069	0.549
DOC_PP1_RVXF_1	70	77	PF00149	0.403
DOC_USP7_MATH_1	101	105	PF00917	0.656
DOC_USP7_MATH_1	208	212	PF00917	0.724
DOC_USP7_MATH_1	228	232	PF00917	0.481
DOC_USP7_MATH_1	310	314	PF00917	0.786
DOC_USP7_MATH_1	93	97	PF00917	0.672
DOC_WW_Pin1_4	220	225	PF00397	0.632
DOC_WW_Pin1_4	226	231	PF00397	0.545
DOC_WW_Pin1_4	245	250	PF00397	0.600
DOC_WW_Pin1_4	261	266	PF00397	0.679
LIG_14-3-3_CanoR_1	126	131	PF00244	0.684
LIG_14-3-3_CanoR_1	181	188	PF00244	0.645
LIG_14-3-3_CanoR_1	206	216	PF00244	0.530
LIG_14-3-3_CanoR_1	353	359	PF00244	0.451
LIG_BIR_II_1	1	5	PF00653	0.653
LIG_BIR_III_3	1	5	PF00653	0.653
LIG_BIR_III_4	143	147	PF00653	0.539
LIG_FHA_1	125	131	PF00498	0.681
LIG_FHA_1	18	24	PF00498	0.477
LIG_FHA_1	221	227	PF00498	0.555
LIG_FHA_1	242	248	PF00498	0.516
LIG_FHA_1	251	257	PF00498	0.611
LIG_FHA_1	264	270	PF00498	0.681
LIG_FHA_1	394	400	PF00498	0.714
LIG_FHA_1	401	407	PF00498	0.605
LIG_FHA_1	446	452	PF00498	0.590
LIG_FHA_1	89	95	PF00498	0.746
LIG_FHA_2	335	341	PF00498	0.742
LIG_GBD_Chelix_1	54	62	PF00786	0.427
LIG_LIR_Gen_1	103	113	PF02991	0.390
LIG_LIR_Gen_1	198	207	PF02991	0.681
LIG_LIR_Gen_1	386	393	PF02991	0.620
LIG_LIR_Gen_1	443	452	PF02991	0.728
LIG_LIR_Gen_1	453	464	PF02991	0.562
LIG_LIR_Gen_1	60	67	PF02991	0.642
LIG_LIR_Gen_1	73	84	PF02991	0.402
LIG_LIR_Nem_3	103	108	PF02991	0.410
LIG_LIR_Nem_3	198	202	PF02991	0.668
LIG_LIR_Nem_3	386	392	PF02991	0.621
LIG_LIR_Nem_3	443	447	PF02991	0.721
LIG_LIR_Nem_3	453	459	PF02991	0.559
LIG_LIR_Nem_3	60	64	PF02991	0.654
LIG_LIR_Nem_3	73	79	PF02991	0.391
LIG_PCNA_yPIPBox_3	430	440	PF02747	0.476
LIG_PCNA_yPIPBox_3	63	75	PF02747	0.623
LIG_PDZ_Class_2	461	466	PF00595	0.631
LIG_RPA_C_Fungi	29	41	PF08784	0.634
LIG_SH2_CRK	444	448	PF00017	0.474
LIG_SH2_NCK_1	444	448	PF00017	0.727
LIG_SH2_PTP2	292	295	PF00017	0.535
LIG_SH2_SRC	294	297	PF00017	0.534
LIG_SH2_STAP1	158	162	PF00017	0.444
LIG_SH2_STAP1	199	203	PF00017	0.675
LIG_SH2_STAP1	389	393	PF00017	0.495
LIG_SH2_STAT5	128	131	PF00017	0.691
LIG_SH2_STAT5	292	295	PF00017	0.749
LIG_SH2_STAT5	35	38	PF00017	0.633
LIG_SH2_STAT5	463	466	PF00017	0.753
LIG_SH2_STAT5	61	64	PF00017	0.652
LIG_SH3_1	300	306	PF00018	0.540
LIG_SH3_3	227	233	PF00018	0.687
LIG_SH3_3	300	306	PF00018	0.540
LIG_SUMO_SIM_par_1	134	139	PF11976	0.784
LIG_TYR_ITIM	197	202	PF00017	0.670
MOD_CDK_SPxxK_3	245	252	PF00069	0.513
MOD_CK1_1	122	128	PF00069	0.659
MOD_CK1_1	211	217	PF00069	0.763
MOD_CK1_1	22	28	PF00069	0.611
MOD_CK1_1	245	251	PF00069	0.705
MOD_CK1_1	364	370	PF00069	0.775
MOD_CK1_1	372	378	PF00069	0.695
MOD_CK1_1	96	102	PF00069	0.499
MOD_CK2_1	13	19	PF00069	0.552
MOD_CK2_1	158	164	PF00069	0.583
MOD_CK2_1	334	340	PF00069	0.750
MOD_CK2_1	370	376	PF00069	0.794
MOD_GlcNHglycan	121	124	PF01048	0.646
MOD_GlcNHglycan	15	18	PF01048	0.568
MOD_GlcNHglycan	183	186	PF01048	0.656
MOD_GlcNHglycan	408	411	PF01048	0.761
MOD_GlcNHglycan	416	419	PF01048	0.636
MOD_GlcNHglycan	82	85	PF01048	0.599
MOD_GlcNHglycan	97	101	PF01048	0.499
MOD_GSK3_1	122	129	PF00069	0.664
MOD_GSK3_1	13	20	PF00069	0.625
MOD_GSK3_1	149	156	PF00069	0.518
MOD_GSK3_1	207	214	PF00069	0.726
MOD_GSK3_1	228	235	PF00069	0.543
MOD_GSK3_1	241	248	PF00069	0.547
MOD_GSK3_1	360	367	PF00069	0.751
MOD_GSK3_1	377	384	PF00069	0.554
MOD_GSK3_1	398	405	PF00069	0.682
MOD_GSK3_1	80	87	PF00069	0.397
MOD_GSK3_1	96	103	PF00069	0.431
MOD_N-GLC_1	377	382	PF02516	0.584
MOD_NEK2_1	121	126	PF00069	0.634
MOD_NEK2_1	207	212	PF00069	0.509
MOD_NEK2_1	241	246	PF00069	0.759
MOD_NEK2_1	360	365	PF00069	0.748
MOD_NEK2_1	398	403	PF00069	0.703
MOD_NEK2_1	406	411	PF00069	0.622
MOD_NEK2_1	440	445	PF00069	0.631
MOD_NEK2_1	50	55	PF00069	0.599
MOD_PIKK_1	176	182	PF00454	0.671
MOD_PIKK_1	209	215	PF00454	0.499
MOD_PKA_1	412	418	PF00069	0.542
MOD_PKA_2	208	214	PF00069	0.524
MOD_PKA_2	412	418	PF00069	0.565
MOD_Plk_1	149	155	PF00069	0.522
MOD_Plk_1	381	387	PF00069	0.541
MOD_Plk_2-3	381	387	PF00069	0.555
MOD_Plk_4	19	25	PF00069	0.474
MOD_Plk_4	212	218	PF00069	0.529
MOD_Plk_4	317	323	PF00069	0.534
MOD_Plk_4	50	56	PF00069	0.416
MOD_ProDKin_1	220	226	PF00069	0.633
MOD_ProDKin_1	245	251	PF00069	0.726
MOD_ProDKin_1	261	267	PF00069	0.673
TRG_ENDOCYTIC_2	199	202	PF00928	0.674
TRG_ENDOCYTIC_2	292	295	PF00928	0.619
TRG_ENDOCYTIC_2	389	392	PF00928	0.609
TRG_ENDOCYTIC_2	444	447	PF00928	0.735
TRG_ENDOCYTIC_2	61	64	PF00928	0.652
TRG_ER_diArg_1	303	305	PF00400	0.549
TRG_ER_diArg_1	33	35	PF00400	0.635
TRG_Pf-PMV_PEXEL_1	8	12	PF00026	0.637

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7XAU2	Leishmania donovani	71%	100%
A4IDK1	Leishmania infantum	71%	100%
E9AT04	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
Q4Q1J4	Leishmania major	69%	99%