Guanylate kinase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

guanylate kinase-like protein

Species:

Leishmania braziliensis

UniProt:

A4HP95_LEIBR

TriTrypDb:

LbrM.35.2500 , LBRM2903_350031900

Length:

328

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	1
GO:0005829	cytosol	2	1
GO:0020015	glycosome	7	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HP95

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP95

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016310	phosphorylation	5	11
GO:0044237	cellular metabolic process	2	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0004385	guanylate kinase activity	6	3
GO:0016776	phosphotransferase activity, phosphate group as acceptor	4	3
GO:0019205	nucleobase-containing compound kinase activity	5	3
GO:0050145	nucleoside monophosphate kinase activity	5	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	164	166	PF00675	0.428
CLV_NRD_NRD_1	267	269	PF00675	0.386
CLV_NRD_NRD_1	82	84	PF00675	0.320
CLV_PCSK_FUR_1	181	185	PF00082	0.227
CLV_PCSK_KEX2_1	164	166	PF00082	0.378
CLV_PCSK_KEX2_1	183	185	PF00082	0.378
CLV_PCSK_KEX2_1	82	84	PF00082	0.424
CLV_PCSK_PC1ET2_1	183	185	PF00082	0.475
CLV_PCSK_SKI1_1	138	142	PF00082	0.428
CLV_PCSK_SKI1_1	149	153	PF00082	0.372
CLV_PCSK_SKI1_1	175	179	PF00082	0.377
CLV_PCSK_SKI1_1	285	289	PF00082	0.257
DEG_SCF_FBW7_1	1	8	PF00400	0.524
DEG_SPOP_SBC_1	117	121	PF00917	0.454
DEG_SPOP_SBC_1	5	9	PF00917	0.513
DOC_ANK_TNKS_1	82	89	PF00023	0.349
DOC_MAPK_DCC_7	169	179	PF00069	0.227
DOC_MAPK_gen_1	244	253	PF00069	0.357
DOC_MAPK_gen_1	61	70	PF00069	0.227
DOC_MAPK_MEF2A_6	244	253	PF00069	0.341
DOC_MAPK_MEF2A_6	40	48	PF00069	0.449
DOC_PP2B_LxvP_1	114	117	PF13499	0.441
DOC_PP4_FxxP_1	252	255	PF00568	0.447
DOC_PP4_FxxP_1	47	50	PF00568	0.335
DOC_USP7_MATH_1	117	121	PF00917	0.419
DOC_USP7_MATH_1	16	20	PF00917	0.719
DOC_USP7_MATH_1	5	9	PF00917	0.692
DOC_WW_Pin1_4	1	6	PF00397	0.527
DOC_WW_Pin1_4	120	125	PF00397	0.466
DOC_WW_Pin1_4	196	201	PF00397	0.649
DOC_WW_Pin1_4	231	236	PF00397	0.691
LIG_14-3-3_CanoR_1	175	180	PF00244	0.460
LIG_14-3-3_CanoR_1	181	187	PF00244	0.476
LIG_14-3-3_CanoR_1	268	276	PF00244	0.428
LIG_14-3-3_CanoR_1	279	289	PF00244	0.372
LIG_BIR_II_1	1	5	PF00653	0.748
LIG_deltaCOP1_diTrp_1	65	72	PF00928	0.447
LIG_FHA_1	153	159	PF00498	0.374
LIG_FHA_1	241	247	PF00498	0.491
LIG_FHA_1	33	39	PF00498	0.599
LIG_FHA_1	7	13	PF00498	0.515
LIG_FHA_2	141	147	PF00498	0.317
LIG_FHA_2	93	99	PF00498	0.480
LIG_HCF-1_HBM_1	307	310	PF13415	0.227
LIG_LIR_Apic_2	234	240	PF02991	0.599
LIG_LIR_Gen_1	110	117	PF02991	0.203
LIG_LIR_Gen_1	307	317	PF02991	0.422
LIG_LIR_Gen_1	97	107	PF02991	0.385
LIG_LIR_Nem_3	110	114	PF02991	0.226
LIG_LIR_Nem_3	295	300	PF02991	0.359
LIG_LIR_Nem_3	307	313	PF02991	0.349
LIG_LIR_Nem_3	65	69	PF02991	0.422
LIG_LIR_Nem_3	97	102	PF02991	0.368
LIG_PDZ_Class_1	323	328	PF00595	0.553
LIG_Pex14_1	66	70	PF04695	0.335
LIG_SH2_CRK	111	115	PF00017	0.355
LIG_SH2_CRK	237	241	PF00017	0.565
LIG_SH2_CRK	310	314	PF00017	0.466
LIG_SH2_CRK	91	95	PF00017	0.237
LIG_SH2_NCK_1	237	241	PF00017	0.410
LIG_SH2_STAT5	166	169	PF00017	0.335
LIG_SH2_STAT5	300	303	PF00017	0.434
LIG_SUMO_SIM_par_1	175	180	PF11976	0.420
LIG_SUMO_SIM_par_1	199	204	PF11976	0.736
LIG_SUMO_SIM_par_1	320	327	PF11976	0.592
LIG_SUMO_SIM_par_1	34	39	PF11976	0.382
LIG_TRAF2_1	95	98	PF00917	0.447
LIG_TYR_ITIM	109	114	PF00017	0.355
MOD_CDK_SPK_2	1	6	PF00069	0.527
MOD_CK1_1	120	126	PF00069	0.428
MOD_CK1_1	182	188	PF00069	0.439
MOD_CK1_1	199	205	PF00069	0.461
MOD_CK1_1	233	239	PF00069	0.676
MOD_CK1_1	75	81	PF00069	0.334
MOD_CK1_1	8	14	PF00069	0.512
MOD_CK2_1	140	146	PF00069	0.265
MOD_CK2_1	267	273	PF00069	0.428
MOD_CK2_1	92	98	PF00069	0.408
MOD_GlcNHglycan	1	4	PF01048	0.537
MOD_GlcNHglycan	104	107	PF01048	0.349
MOD_GlcNHglycan	19	22	PF01048	0.699
MOD_GlcNHglycan	50	53	PF01048	0.335
MOD_GSK3_1	1	8	PF00069	0.600
MOD_GSK3_1	116	123	PF00069	0.388
MOD_GSK3_1	17	24	PF00069	0.733
MOD_GSK3_1	175	182	PF00069	0.393
MOD_GSK3_1	199	206	PF00069	0.509
MOD_GSK3_1	221	228	PF00069	0.746
MOD_GSK3_1	288	295	PF00069	0.227
MOD_GSK3_1	32	39	PF00069	0.359
MOD_GSK3_1	70	77	PF00069	0.334
MOD_N-GLC_1	292	297	PF02516	0.417
MOD_NEK2_1	102	107	PF00069	0.341
MOD_NEK2_1	133	138	PF00069	0.426
MOD_NEK2_1	280	285	PF00069	0.350
MOD_NEK2_1	32	37	PF00069	0.671
MOD_NEK2_1	323	328	PF00069	0.661
MOD_NEK2_1	70	75	PF00069	0.341
MOD_NEK2_2	159	164	PF00069	0.385
MOD_PIKK_1	124	130	PF00454	0.227
MOD_PKA_2	267	273	PF00069	0.335
MOD_Plk_1	109	115	PF00069	0.447
MOD_Plk_1	228	234	PF00069	0.686
MOD_Plk_1	272	278	PF00069	0.373
MOD_Plk_1	292	298	PF00069	0.150
MOD_Plk_1	70	76	PF00069	0.451
MOD_Plk_2-3	267	273	PF00069	0.408
MOD_Plk_2-3	292	298	PF00069	0.480
MOD_Plk_4	140	146	PF00069	0.454
MOD_Plk_4	221	227	PF00069	0.642
MOD_Plk_4	292	298	PF00069	0.459
MOD_Plk_4	54	60	PF00069	0.335
MOD_ProDKin_1	1	7	PF00069	0.526
MOD_ProDKin_1	120	126	PF00069	0.466
MOD_ProDKin_1	196	202	PF00069	0.647
MOD_ProDKin_1	231	237	PF00069	0.693
MOD_SUMO_rev_2	262	270	PF00179	0.447
TRG_DiLeu_BaEn_1	98	103	PF01217	0.447
TRG_ENDOCYTIC_2	111	114	PF00928	0.355
TRG_ENDOCYTIC_2	299	302	PF00928	0.414
TRG_ENDOCYTIC_2	310	313	PF00928	0.438
TRG_ENDOCYTIC_2	91	94	PF00928	0.355
TRG_ER_diArg_1	147	150	PF00400	0.383
TRG_ER_diArg_1	163	165	PF00400	0.447
TRG_ER_diArg_1	81	83	PF00400	0.429

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I117	Leptomonas seymouri	54%	100%
A0A1X0P7T4	Trypanosomatidae	31%	100%
A0A3R7LXR6	Trypanosoma rangeli	31%	100%
A0A3S7XAW4	Leishmania donovani	74%	100%
A4IDK0	Leishmania infantum	73%	100%
D0A398	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AT03	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4Q1J5	Leishmania major	71%	100%
V5BBU2	Trypanosoma cruzi	31%	100%