Putative developmentally regulated GTP-binding protein 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

developmentally regulated GTP-binding protein 1, putative

Species:

Leishmania braziliensis

UniProt:

A4HP94_LEIBR

TriTrypDb:

LbrM.35.2490 , LBRM2903_350031800

Length:

368

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HP94

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP94

Function

Biological processes
Term	Name	Level	Count
GO:0002181	cytoplasmic translation	5	1
GO:0006412	translation	4	1
GO:0006518	peptide metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0019538	protein metabolic process	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	1
GO:0043043	peptide biosynthetic process	5	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043603	amide metabolic process	3	1
GO:0043604	amide biosynthetic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0003924	GTPase activity	7	12
GO:0005488	binding	1	12
GO:0005525	GTP binding	5	12
GO:0016462	pyrophosphatase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016817	hydrolase activity, acting on acid anhydrides	3	12
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	12
GO:0019001	guanyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032561	guanyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	228	232	PF00656	0.547
CLV_NRD_NRD_1	180	182	PF00675	0.482
CLV_PCSK_KEX2_1	38	40	PF00082	0.462
CLV_PCSK_PC1ET2_1	38	40	PF00082	0.466
CLV_PCSK_SKI1_1	108	112	PF00082	0.286
CLV_PCSK_SKI1_1	205	209	PF00082	0.286
DOC_MAPK_DCC_7	237	245	PF00069	0.486
DOC_MAPK_gen_1	108	117	PF00069	0.486
DOC_MAPK_gen_1	128	137	PF00069	0.355
DOC_MAPK_gen_1	170	180	PF00069	0.447
DOC_MAPK_gen_1	181	190	PF00069	0.309
DOC_MAPK_MEF2A_6	139	148	PF00069	0.486
DOC_MAPK_MEF2A_6	173	180	PF00069	0.476
DOC_MAPK_MEF2A_6	237	245	PF00069	0.486
DOC_MAPK_RevD_3	167	182	PF00069	0.431
DOC_PP1_RVXF_1	63	69	PF00149	0.338
DOC_PP2B_LxvP_1	115	118	PF13499	0.486
DOC_PP2B_PxIxI_1	175	181	PF00149	0.456
DOC_PP2B_PxIxI_1	240	246	PF00149	0.527
DOC_USP7_MATH_1	314	318	PF00917	0.568
DOC_USP7_MATH_1	43	47	PF00917	0.562
DOC_USP7_UBL2_3	48	52	PF12436	0.611
LIG_14-3-3_CanoR_1	139	144	PF00244	0.486
LIG_14-3-3_CanoR_1	170	176	PF00244	0.468
LIG_Actin_WH2_2	157	174	PF00022	0.564
LIG_BIR_II_1	1	5	PF00653	0.507
LIG_Clathr_ClatBox_1	145	149	PF01394	0.486
LIG_deltaCOP1_diTrp_1	282	290	PF00928	0.477
LIG_eIF4E_1	224	230	PF01652	0.406
LIG_FHA_1	138	144	PF00498	0.479
LIG_FHA_1	191	197	PF00498	0.486
LIG_FHA_2	195	201	PF00498	0.486
LIG_FHA_2	223	229	PF00498	0.572
LIG_FHA_2	84	90	PF00498	0.486
LIG_Integrin_RGD_1	221	223	PF01839	0.297
LIG_LIR_Apic_2	303	307	PF02991	0.486
LIG_LIR_Gen_1	282	293	PF02991	0.476
LIG_LIR_Gen_1	94	102	PF02991	0.491
LIG_LIR_Nem_3	282	288	PF02991	0.476
LIG_LIR_Nem_3	94	98	PF02991	0.491
LIG_LYPXL_SIV_4	238	246	PF13949	0.572
LIG_NRBOX	276	282	PF00104	0.497
LIG_PTB_Apo_2	329	336	PF02174	0.572
LIG_PTB_Phospho_1	329	335	PF10480	0.572
LIG_RPA_C_Fungi	134	146	PF08784	0.338
LIG_SH2_CRK	294	298	PF00017	0.338
LIG_SH2_CRK	304	308	PF00017	0.338
LIG_SH2_SRC	239	242	PF00017	0.424
LIG_SH2_STAP1	335	339	PF00017	0.380
LIG_SH2_STAT5	224	227	PF00017	0.409
LIG_SH2_STAT5	239	242	PF00017	0.228
LIG_SH2_STAT5	244	247	PF00017	0.155
LIG_SH2_STAT5	294	297	PF00017	0.338
LIG_SH3_3	147	153	PF00018	0.284
LIG_SH3_4	296	303	PF00018	0.338
LIG_SUMO_SIM_anti_2	142	149	PF11976	0.338
LIG_SUMO_SIM_anti_2	255	261	PF11976	0.338
LIG_SUMO_SIM_par_1	142	149	PF11976	0.338
LIG_TRAF2_1	253	256	PF00917	0.325
LIG_UBA3_1	144	152	PF00899	0.338
MOD_CK1_1	189	195	PF00069	0.354
MOD_CK1_1	81	87	PF00069	0.369
MOD_CK2_1	222	228	PF00069	0.396
MOD_CK2_1	250	256	PF00069	0.326
MOD_CK2_1	83	89	PF00069	0.338
MOD_GlcNHglycan	269	272	PF01048	0.338
MOD_GSK3_1	186	193	PF00069	0.341
MOD_GSK3_1	70	77	PF00069	0.338
MOD_GSK3_1	78	85	PF00069	0.338
MOD_N-GLC_1	171	176	PF02516	0.557
MOD_NEK2_1	14	19	PF00069	0.597
MOD_NEK2_1	171	176	PF00069	0.331
MOD_NEK2_1	83	88	PF00069	0.338
MOD_NEK2_2	216	221	PF00069	0.459
MOD_NEK2_2	339	344	PF00069	0.338
MOD_PIKK_1	14	20	PF00454	0.476
MOD_PIKK_1	171	177	PF00454	0.333
MOD_PIKK_1	194	200	PF00454	0.238
MOD_PKA_2	211	217	PF00069	0.238
MOD_Plk_1	216	222	PF00069	0.476
MOD_Plk_1	93	99	PF00069	0.338
MOD_Plk_2-3	250	256	PF00069	0.338
MOD_Plk_4	139	145	PF00069	0.338
MOD_Plk_4	203	209	PF00069	0.274
MOD_Plk_4	75	81	PF00069	0.338
MOD_SUMO_for_1	37	40	PF00179	0.508
TRG_ENDOCYTIC_2	335	338	PF00928	0.380

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7B2	Leptomonas seymouri	95%	100%
A0A0N1I7A1	Leptomonas seymouri	48%	98%
A0A0S4JLR9	Bodo saltans	50%	98%
A0A0S4JSR7	Bodo saltans	85%	100%
A0A1X0P4R4	Trypanosomatidae	50%	98%
A0A1X0P8M9	Trypanosomatidae	87%	100%
A0A3Q8IK74	Leishmania donovani	96%	100%
A0A3S7XAC8	Leishmania donovani	49%	98%
A0A422N5U7	Trypanosoma rangeli	49%	98%
A0A422NIT8	Trypanosoma rangeli	87%	100%
A4HNJ2	Leishmania braziliensis	49%	100%
A4IC49	Leishmania infantum	49%	98%
A4IDJ9	Leishmania infantum	96%	100%
C9ZYC5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	98%
D0A397	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	89%	100%
E9AG04	Leishmania major	49%	100%
E9AT02	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
E9B757	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	98%
P17103	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	40%	99%
P32233	Mus musculus	69%	100%
P32234	Drosophila melanogaster	65%	100%
P32235	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	52%	100%
P34280	Caenorhabditis elegans	55%	100%
P39729	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	60%	100%
P43690	Xenopus laevis	69%	100%
P53295	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	49%	100%
P55039	Homo sapiens	56%	100%
Q3MHP5	Bos taurus	69%	100%
Q4Q1J6	Leishmania major	96%	100%
Q54HP3	Dictyostelium discoideum	65%	99%
Q54WT4	Dictyostelium discoideum	52%	100%
Q58722	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	48%	94%
Q58D56	Bos taurus	55%	100%
Q9CAI1	Arabidopsis thaliana	52%	92%
Q9LQK0	Arabidopsis thaliana	52%	92%
Q9QXB9	Mus musculus	55%	100%
Q9SVA6	Arabidopsis thaliana	64%	100%
Q9UT21	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	61%	100%
Q9Y295	Homo sapiens	69%	100%
V5BKY5	Trypanosoma cruzi	88%	75%
V5DQF8	Trypanosoma cruzi	48%	98%