Vacuolar protein sorting-associated protein 45-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

vacuolar protein sorting-associated protein 45- like protein

Species:

Leishmania braziliensis

UniProt:

A4HP92_LEIBR

TriTrypDb:

LbrM.35.2470 , LBRM2903_350031300

Length:

560

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	2
GO:0016020	membrane	2	2
GO:0031090	organelle membrane	3	2
GO:0098588	bounding membrane of organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HP92

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP92

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	18
GO:0016192	vesicle-mediated transport	4	18
GO:0051179	localization	1	18
GO:0051234	establishment of localization	2	18
GO:0006886	intracellular protein transport	4	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0033036	macromolecule localization	2	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	149	151	PF00675	0.363
CLV_NRD_NRD_1	164	166	PF00675	0.279
CLV_NRD_NRD_1	408	410	PF00675	0.194
CLV_PCSK_KEX2_1	149	151	PF00082	0.340
CLV_PCSK_KEX2_1	163	165	PF00082	0.288
CLV_PCSK_KEX2_1	333	335	PF00082	0.314
CLV_PCSK_KEX2_1	453	455	PF00082	0.315
CLV_PCSK_PC1ET2_1	333	335	PF00082	0.314
CLV_PCSK_PC1ET2_1	453	455	PF00082	0.315
CLV_PCSK_SKI1_1	12	16	PF00082	0.319
CLV_PCSK_SKI1_1	285	289	PF00082	0.417
CLV_PCSK_SKI1_1	334	338	PF00082	0.352
CLV_PCSK_SKI1_1	433	437	PF00082	0.302
CLV_PCSK_SKI1_1	78	82	PF00082	0.352
DEG_APCC_DBOX_1	63	71	PF00400	0.372
DEG_Nend_UBRbox_3	1	3	PF02207	0.377
DEG_SCF_FBW7_1	213	219	PF00400	0.282
DOC_ANK_TNKS_1	148	155	PF00023	0.417
DOC_CKS1_1	130	135	PF01111	0.417
DOC_CKS1_1	213	218	PF01111	0.334
DOC_CKS1_1	392	397	PF01111	0.172
DOC_CYCLIN_RxL_1	331	340	PF00134	0.340
DOC_CYCLIN_yClb5_NLxxxL_5	49	57	PF00134	0.417
DOC_CYCLIN_yCln2_LP_2	217	223	PF00134	0.316
DOC_CYCLIN_yCln2_LP_2	238	244	PF00134	0.302
DOC_MAPK_gen_1	332	341	PF00069	0.315
DOC_MAPK_gen_1	433	441	PF00069	0.302
DOC_MAPK_gen_1	55	63	PF00069	0.329
DOC_MAPK_gen_1	81	89	PF00069	0.417
DOC_MAPK_MEF2A_6	200	207	PF00069	0.327
DOC_MAPK_MEF2A_6	332	341	PF00069	0.315
DOC_MAPK_MEF2A_6	7	15	PF00069	0.311
DOC_MAPK_RevD_3	395	410	PF00069	0.172
DOC_PP2B_LxvP_1	238	241	PF13499	0.372
DOC_USP7_MATH_1	366	370	PF00917	0.380
DOC_USP7_MATH_1	530	534	PF00917	0.429
DOC_WW_Pin1_4	129	134	PF00397	0.362
DOC_WW_Pin1_4	171	176	PF00397	0.417
DOC_WW_Pin1_4	212	217	PF00397	0.327
DOC_WW_Pin1_4	391	396	PF00397	0.172
DOC_WW_Pin1_4	555	560	PF00397	0.434
LIG_14-3-3_CanoR_1	179	187	PF00244	0.344
LIG_14-3-3_CanoR_1	234	239	PF00244	0.393
LIG_14-3-3_CanoR_1	292	298	PF00244	0.312
LIG_14-3-3_CanoR_1	419	425	PF00244	0.386
LIG_14-3-3_CanoR_1	66	71	PF00244	0.229
LIG_Actin_RPEL_3	44	63	PF02755	0.417
LIG_Actin_WH2_2	437	455	PF00022	0.321
LIG_Actin_WH2_2	63	80	PF00022	0.349
LIG_APCC_ABBA_1	393	398	PF00400	0.302
LIG_Clathr_ClatBox_1	204	208	PF01394	0.324
LIG_FHA_1	179	185	PF00498	0.218
LIG_FHA_1	200	206	PF00498	0.358
LIG_FHA_1	213	219	PF00498	0.219
LIG_FHA_1	235	241	PF00498	0.417
LIG_FHA_1	29	35	PF00498	0.337
LIG_FHA_1	292	298	PF00498	0.359
LIG_FHA_1	308	314	PF00498	0.336
LIG_FHA_1	322	328	PF00498	0.408
LIG_FHA_1	392	398	PF00498	0.333
LIG_FHA_1	419	425	PF00498	0.278
LIG_FHA_1	491	497	PF00498	0.314
LIG_FHA_2	294	300	PF00498	0.295
LIG_FHA_2	366	372	PF00498	0.403
LIG_FHA_2	435	441	PF00498	0.331
LIG_FHA_2	444	450	PF00498	0.258
LIG_FHA_2	502	508	PF00498	0.336
LIG_GBD_Chelix_1	151	159	PF00786	0.372
LIG_LIR_Apic_2	17	22	PF02991	0.172
LIG_LIR_Apic_2	192	198	PF02991	0.220
LIG_LIR_Gen_1	115	123	PF02991	0.309
LIG_LIR_Gen_1	222	231	PF02991	0.313
LIG_LIR_Gen_1	402	411	PF02991	0.417
LIG_LIR_Gen_1	437	445	PF02991	0.372
LIG_LIR_Gen_1	547	557	PF02991	0.315
LIG_LIR_Gen_1	84	93	PF02991	0.432
LIG_LIR_Nem_3	115	120	PF02991	0.309
LIG_LIR_Nem_3	268	273	PF02991	0.312
LIG_LIR_Nem_3	402	407	PF02991	0.417
LIG_LIR_Nem_3	437	441	PF02991	0.372
LIG_LIR_Nem_3	466	472	PF02991	0.319
LIG_LIR_Nem_3	547	553	PF02991	0.340
LIG_LIR_Nem_3	84	88	PF02991	0.365
LIG_LYPXL_yS_3	469	472	PF13949	0.315
LIG_MYND_1	216	220	PF01753	0.370
LIG_PCNA_yPIPBox_3	136	150	PF02747	0.302
LIG_PCNA_yPIPBox_3	49	57	PF02747	0.401
LIG_PTB_Apo_2	122	129	PF02174	0.172
LIG_PTB_Apo_2	261	268	PF02174	0.302
LIG_SH2_CRK	19	23	PF00017	0.172
LIG_SH2_CRK	195	199	PF00017	0.417
LIG_SH2_CRK	404	408	PF00017	0.417
LIG_SH2_NCK_1	384	388	PF00017	0.339
LIG_SH2_PTP2	60	63	PF00017	0.417
LIG_SH2_SRC	195	198	PF00017	0.417
LIG_SH2_STAP1	404	408	PF00017	0.417
LIG_SH2_STAT3	280	283	PF00017	0.417
LIG_SH2_STAT3	460	463	PF00017	0.377
LIG_SH2_STAT3	471	474	PF00017	0.347
LIG_SH2_STAT5	167	170	PF00017	0.222
LIG_SH2_STAT5	252	255	PF00017	0.295
LIG_SH2_STAT5	280	283	PF00017	0.315
LIG_SH2_STAT5	326	329	PF00017	0.417
LIG_SH2_STAT5	39	42	PF00017	0.302
LIG_SH2_STAT5	396	399	PF00017	0.370
LIG_SH2_STAT5	445	448	PF00017	0.315
LIG_SH2_STAT5	471	474	PF00017	0.315
LIG_SH2_STAT5	503	506	PF00017	0.405
LIG_SH2_STAT5	60	63	PF00017	0.417
LIG_SH3_3	210	216	PF00018	0.391
LIG_SUMO_SIM_anti_2	183	193	PF11976	0.326
LIG_SUMO_SIM_anti_2	201	208	PF11976	0.311
LIG_SUMO_SIM_anti_2	338	343	PF11976	0.337
LIG_SUMO_SIM_par_1	12	18	PF11976	0.295
LIG_SUMO_SIM_par_1	201	208	PF11976	0.310
LIG_SUMO_SIM_par_1	335	340	PF11976	0.315
LIG_TRAF2_1	296	299	PF00917	0.417
LIG_TRAF2_1	504	507	PF00917	0.315
LIG_WRC_WIRS_1	139	144	PF05994	0.302
LIG_WRC_WIRS_1	435	440	PF05994	0.340
MOD_CK1_1	137	143	PF00069	0.368
MOD_CK1_1	190	196	PF00069	0.277
MOD_CK1_1	361	367	PF00069	0.308
MOD_CK1_1	388	394	PF00069	0.288
MOD_CK1_1	43	49	PF00069	0.470
MOD_CK1_1	475	481	PF00069	0.236
MOD_CK2_1	105	111	PF00069	0.278
MOD_CK2_1	26	32	PF00069	0.407
MOD_CK2_1	293	299	PF00069	0.316
MOD_CK2_1	337	343	PF00069	0.307
MOD_CK2_1	443	449	PF00069	0.309
MOD_CK2_1	501	507	PF00069	0.336
MOD_GlcNHglycan	143	146	PF01048	0.291
MOD_GlcNHglycan	364	367	PF01048	0.229
MOD_GlcNHglycan	387	390	PF01048	0.253
MOD_GlcNHglycan	45	48	PF01048	0.417
MOD_GlcNHglycan	460	463	PF01048	0.315
MOD_GlcNHglycan	480	483	PF01048	0.132
MOD_GSK3_1	134	141	PF00069	0.387
MOD_GSK3_1	212	219	PF00069	0.266
MOD_GSK3_1	307	314	PF00069	0.307
MOD_GSK3_1	315	322	PF00069	0.317
MOD_GSK3_1	358	365	PF00069	0.315
MOD_GSK3_1	472	479	PF00069	0.212
MOD_GSK3_1	520	527	PF00069	0.338
MOD_GSK3_1	531	538	PF00069	0.356
MOD_N-GLC_1	105	110	PF02516	0.334
MOD_NEK2_1	138	143	PF00069	0.358
MOD_NEK2_1	23	28	PF00069	0.303
MOD_NEK2_1	273	278	PF00069	0.378
MOD_NEK2_1	313	318	PF00069	0.289
MOD_NEK2_1	337	342	PF00069	0.270
MOD_NEK2_1	40	45	PF00069	0.209
MOD_NEK2_1	425	430	PF00069	0.319
MOD_NEK2_1	452	457	PF00069	0.340
MOD_NEK2_1	472	477	PF00069	0.132
MOD_NEK2_1	510	515	PF00069	0.259
MOD_NEK2_1	89	94	PF00069	0.343
MOD_NEK2_2	531	536	PF00069	0.302
MOD_PIKK_1	143	149	PF00454	0.376
MOD_PIKK_1	26	32	PF00454	0.312
MOD_PIKK_1	307	313	PF00454	0.290
MOD_PIKK_1	366	372	PF00454	0.417
MOD_PIKK_1	388	394	PF00454	0.425
MOD_PIKK_1	443	449	PF00454	0.328
MOD_PK_1	358	364	PF00069	0.172
MOD_PK_1	66	72	PF00069	0.172
MOD_PKA_2	178	184	PF00069	0.172
MOD_PKA_2	199	205	PF00069	0.323
MOD_PKA_2	291	297	PF00069	0.324
MOD_PKA_2	418	424	PF00069	0.352
MOD_PKA_2	6	12	PF00069	0.520
MOD_PKB_1	64	72	PF00069	0.172
MOD_Plk_1	105	111	PF00069	0.413
MOD_Plk_1	190	196	PF00069	0.172
MOD_Plk_1	257	263	PF00069	0.377
MOD_Plk_1	337	343	PF00069	0.335
MOD_Plk_1	371	377	PF00069	0.417
MOD_Plk_1	541	547	PF00069	0.341
MOD_Plk_2-3	105	111	PF00069	0.417
MOD_Plk_4	105	111	PF00069	0.366
MOD_Plk_4	134	140	PF00069	0.385
MOD_Plk_4	154	160	PF00069	0.273
MOD_Plk_4	190	196	PF00069	0.348
MOD_Plk_4	199	205	PF00069	0.325
MOD_Plk_4	257	263	PF00069	0.373
MOD_Plk_4	322	328	PF00069	0.304
MOD_Plk_4	337	343	PF00069	0.365
MOD_Plk_4	434	440	PF00069	0.318
MOD_Plk_4	546	552	PF00069	0.347
MOD_ProDKin_1	129	135	PF00069	0.362
MOD_ProDKin_1	171	177	PF00069	0.417
MOD_ProDKin_1	212	218	PF00069	0.327
MOD_ProDKin_1	391	397	PF00069	0.172
MOD_SUMO_rev_2	298	303	PF00179	0.403
MOD_SUMO_rev_2	8	14	PF00179	0.225
TRG_DiLeu_BaEn_1	506	511	PF01217	0.315
TRG_DiLeu_BaEn_3	298	304	PF01217	0.417
TRG_DiLeu_BaLyEn_6	213	218	PF01217	0.337
TRG_ENDOCYTIC_2	223	226	PF00928	0.302
TRG_ENDOCYTIC_2	404	407	PF00928	0.372
TRG_ENDOCYTIC_2	469	472	PF00928	0.315
TRG_ENDOCYTIC_2	60	63	PF00928	0.395
TRG_ENDOCYTIC_2	85	88	PF00928	0.371
TRG_ER_diArg_1	148	150	PF00400	0.348
TRG_ER_diArg_1	163	165	PF00400	0.204
TRG_ER_diArg_1	63	66	PF00400	0.403
TRG_Pf-PMV_PEXEL_1	149	153	PF00026	0.417
TRG_Pf-PMV_PEXEL_1	334	338	PF00026	0.315
TRG_Pf-PMV_PEXEL_1	409	413	PF00026	0.212
TRG_Pf-PMV_PEXEL_1	454	458	PF00026	0.304

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7D5	Leptomonas seymouri	29%	91%
A0A0N0P7P1	Leptomonas seymouri	78%	93%
A0A0S4J1J9	Bodo saltans	23%	94%
A0A0S4JI94	Bodo saltans	32%	85%
A0A1X0P7K8	Trypanosomatidae	22%	86%
A0A1X0P7Y3	Trypanosomatidae	54%	93%
A0A1X0P895	Trypanosomatidae	32%	91%
A0A3Q8IG36	Leishmania donovani	89%	100%
A0A3R7MWF2	Trypanosoma rangeli	23%	85%
A0A3R7NER3	Trypanosoma rangeli	56%	100%
A0A3S7XAA1	Leishmania donovani	32%	91%
A0A422P2E3	Trypanosoma rangeli	30%	91%
A4HNQ4	Leishmania braziliensis	32%	100%
A4ICU1	Leishmania infantum	32%	91%
A4IDJ7	Leishmania infantum	89%	100%
C9ZX51	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	21%	87%
D0A395	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	95%
E9ASG3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	91%
E9AT00	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
O08599	Mus musculus	20%	94%
O08700	Rattus norvegicus	32%	98%
O18637	Drosophila virilis	22%	85%
O49048	Arabidopsis thaliana	29%	98%
O74534	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	21%	88%
O94590	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	81%
P38932	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	97%
P61763	Bos taurus	20%	94%
P61764	Homo sapiens	20%	94%
P61765	Rattus norvegicus	20%	94%
P97390	Mus musculus	32%	98%
Q07327	Drosophila melanogaster	21%	94%
Q09805	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
Q15833	Homo sapiens	22%	94%
Q24179	Drosophila melanogaster	21%	88%
Q28288	Canis lupus familiaris	22%	94%
Q4Q1J8	Leishmania major	88%	100%
Q4Q232	Leishmania major	32%	100%
Q54GE3	Dictyostelium discoideum	31%	99%
Q54QC8	Dictyostelium discoideum	23%	94%
Q5R6D2	Pongo abelii	20%	94%
Q5VNU3	Oryza sativa subsp. japonica	22%	85%
Q62753	Rattus norvegicus	23%	94%
Q64324	Mus musculus	23%	94%
Q851W1	Oryza sativa subsp. japonica	23%	90%
Q94KJ7	Arabidopsis thaliana	22%	95%
Q9C5P7	Arabidopsis thaliana	21%	83%
Q9NRW7	Homo sapiens	32%	98%
Q9Y1I2	Drosophila melanogaster	20%	91%
V5BV59	Trypanosoma cruzi	32%	90%
V5DCK0	Trypanosoma cruzi	54%	98%