BRCT domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HP91_LEIBR

TriTrypDb:

LbrM.35.2460 , LBRM2903_350031200

Length:

370

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HP91

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP91

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	182	184	PF00675	0.514
CLV_NRD_NRD_1	363	365	PF00675	0.628
CLV_NRD_NRD_1	367	369	PF00675	0.643
CLV_NRD_NRD_1	90	92	PF00675	0.314
CLV_PCSK_FUR_1	364	368	PF00082	0.601
CLV_PCSK_KEX2_1	182	184	PF00082	0.514
CLV_PCSK_KEX2_1	365	367	PF00082	0.639
CLV_PCSK_PC1ET2_1	365	367	PF00082	0.639
CLV_PCSK_SKI1_1	254	258	PF00082	0.508
CLV_PCSK_SKI1_1	94	98	PF00082	0.422
DEG_Nend_Nbox_1	1	3	PF02207	0.380
DOC_CKS1_1	308	313	PF01111	0.471
DOC_CYCLIN_RxL_1	91	101	PF00134	0.356
DOC_MAPK_gen_1	72	80	PF00069	0.396
DOC_MAPK_gen_1	91	97	PF00069	0.335
DOC_PP2B_LxvP_1	266	269	PF13499	0.535
DOC_PP2B_LxvP_1	95	98	PF13499	0.435
DOC_USP7_MATH_1	175	179	PF00917	0.592
DOC_USP7_MATH_1	187	191	PF00917	0.541
DOC_USP7_MATH_1	218	222	PF00917	0.646
DOC_USP7_MATH_1	252	256	PF00917	0.571
DOC_USP7_MATH_1	279	283	PF00917	0.532
DOC_USP7_MATH_1	53	57	PF00917	0.610
DOC_WW_Pin1_4	11	16	PF00397	0.416
DOC_WW_Pin1_4	158	163	PF00397	0.623
DOC_WW_Pin1_4	234	239	PF00397	0.382
DOC_WW_Pin1_4	264	269	PF00397	0.683
DOC_WW_Pin1_4	307	312	PF00397	0.667
DOC_WW_Pin1_4	33	38	PF00397	0.420
LIG_14-3-3_CanoR_1	117	127	PF00244	0.300
LIG_14-3-3_CanoR_1	166	172	PF00244	0.661
LIG_14-3-3_CanoR_1	57	66	PF00244	0.555
LIG_14-3-3_CanoR_1	77	81	PF00244	0.286
LIG_Actin_WH2_2	151	168	PF00022	0.414
LIG_FHA_1	118	124	PF00498	0.364
LIG_FHA_1	147	153	PF00498	0.401
LIG_FHA_1	261	267	PF00498	0.594
LIG_FHA_1	344	350	PF00498	0.454
LIG_FHA_1	37	43	PF00498	0.376
LIG_FHA_1	4	10	PF00498	0.358
LIG_FHA_2	15	21	PF00498	0.469
LIG_FHA_2	65	71	PF00498	0.381
LIG_LIR_Gen_1	237	247	PF02991	0.437
LIG_LIR_Gen_1	329	334	PF02991	0.494
LIG_LIR_Nem_3	105	111	PF02991	0.456
LIG_LIR_Nem_3	237	243	PF02991	0.426
LIG_LIR_Nem_3	329	333	PF02991	0.493
LIG_SH2_GRB2like	142	145	PF00017	0.467
LIG_SH2_STAP1	82	86	PF00017	0.366
LIG_SH2_STAT5	111	114	PF00017	0.458
LIG_SH3_3	166	172	PF00018	0.606
LIG_SH3_5	98	102	PF00018	0.538
LIG_SUMO_SIM_anti_2	76	83	PF11976	0.444
LIG_SUMO_SIM_par_1	14	20	PF11976	0.524
MOD_CK1_1	14	20	PF00069	0.543
MOD_CK1_1	161	167	PF00069	0.580
MOD_CK1_1	267	273	PF00069	0.702
MOD_CK1_1	284	290	PF00069	0.516
MOD_CK1_1	329	335	PF00069	0.610
MOD_CK1_1	355	361	PF00069	0.700
MOD_CK1_1	76	82	PF00069	0.456
MOD_CK2_1	14	20	PF00069	0.490
MOD_CK2_1	187	193	PF00069	0.663
MOD_CK2_1	64	70	PF00069	0.385
MOD_GlcNHglycan	209	212	PF01048	0.702
MOD_GlcNHglycan	254	257	PF01048	0.711
MOD_GlcNHglycan	273	276	PF01048	0.509
MOD_GlcNHglycan	312	315	PF01048	0.724
MOD_GlcNHglycan	355	358	PF01048	0.567
MOD_GlcNHglycan	51	54	PF01048	0.595
MOD_GSK3_1	182	189	PF00069	0.577
MOD_GSK3_1	203	210	PF00069	0.651
MOD_GSK3_1	260	267	PF00069	0.727
MOD_GSK3_1	3	10	PF00069	0.392
MOD_GSK3_1	310	317	PF00069	0.595
MOD_GSK3_1	352	359	PF00069	0.480
MOD_GSK3_1	49	56	PF00069	0.510
MOD_N-GLC_1	271	276	PF02516	0.792
MOD_N-GLC_1	284	289	PF02516	0.463
MOD_N-GLC_2	198	200	PF02516	0.528
MOD_NEK2_1	116	121	PF00069	0.375
MOD_NEK2_1	146	151	PF00069	0.403
MOD_NEK2_1	153	158	PF00069	0.406
MOD_NEK2_1	262	267	PF00069	0.635
MOD_NEK2_1	353	358	PF00069	0.557
MOD_NEK2_1	49	54	PF00069	0.497
MOD_NEK2_1	7	12	PF00069	0.369
MOD_NEK2_1	90	95	PF00069	0.326
MOD_NEK2_2	187	192	PF00069	0.533
MOD_PIKK_1	118	124	PF00454	0.364
MOD_PKA_1	182	188	PF00069	0.523
MOD_PKA_2	116	122	PF00069	0.312
MOD_PKA_2	182	188	PF00069	0.523
MOD_PKA_2	203	209	PF00069	0.656
MOD_PKA_2	343	349	PF00069	0.455
MOD_PKA_2	53	59	PF00069	0.596
MOD_PKA_2	73	79	PF00069	0.502
MOD_PKA_2	90	96	PF00069	0.354
MOD_Plk_1	279	285	PF00069	0.524
MOD_Plk_4	3	9	PF00069	0.371
MOD_ProDKin_1	11	17	PF00069	0.406
MOD_ProDKin_1	158	164	PF00069	0.629
MOD_ProDKin_1	234	240	PF00069	0.379
MOD_ProDKin_1	264	270	PF00069	0.683
MOD_ProDKin_1	307	313	PF00069	0.672
MOD_ProDKin_1	33	39	PF00069	0.418
MOD_SUMO_rev_2	31	37	PF00179	0.476
TRG_DiLeu_BaLyEn_6	91	96	PF01217	0.408
TRG_ENDOCYTIC_2	155	158	PF00928	0.435
TRG_ER_diArg_1	364	367	PF00400	0.597
TRG_NLS_MonoCore_2	363	368	PF00514	0.599
TRG_NLS_MonoExtC_3	363	368	PF00514	0.599
TRG_NLS_MonoExtN_4	362	369	PF00514	0.595

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7A7	Leptomonas seymouri	44%	96%
A0A3Q8IW00	Leishmania donovani	71%	99%
A4IDJ6	Leishmania infantum	70%	99%
E9ASZ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	99%
Q4Q1J9	Leishmania major	69%	100%