LeishMANIAdb
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Choline transporter-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Choline transporter-like protein
Gene product:
Plasma-membrane choline transporter, putative
Species:
Leishmania braziliensis
UniProt:
A4HP90_LEIBR
TriTrypDb:
LbrM.35.2450 , LBRM2903_350031100 *
Length:
508

Annotations

LeishMANIAdb annotations

Highly homologous to other eukaryotic choline transporters. The protein family expanded in parazitic kinetoplastids.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 6
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 23
NetGPI no yes: 0, no: 23
Cellular components
Term Name Level Count
GO:0005886 plasma membrane 3 24
GO:0016020 membrane 2 24
GO:0110165 cellular anatomical entity 1 24
GO:0005737 cytoplasm 2 1
GO:0020016 ciliary pocket 2 1

Expansion

Sequence features

A4HP90
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP90

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 2
GO:0009987 cellular process 1 2
GO:0051179 localization 1 2
GO:0051234 establishment of localization 2 2
GO:0055085 transmembrane transport 2 2
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 24
GO:0022857 transmembrane transporter activity 2 24

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 19 23 PF00656 0.551
CLV_C14_Caspase3-7 476 480 PF00656 0.528
CLV_PCSK_KEX2_1 319 321 PF00082 0.410
CLV_PCSK_KEX2_1 396 398 PF00082 0.239
CLV_PCSK_PC1ET2_1 319 321 PF00082 0.415
CLV_PCSK_PC1ET2_1 396 398 PF00082 0.259
CLV_PCSK_SKI1_1 16 20 PF00082 0.357
CLV_PCSK_SKI1_1 320 324 PF00082 0.425
CLV_PCSK_SKI1_1 359 363 PF00082 0.178
CLV_PCSK_SKI1_1 378 382 PF00082 0.321
CLV_PCSK_SKI1_1 80 84 PF00082 0.422
DEG_APCC_DBOX_1 358 366 PF00400 0.485
DEG_MDM2_SWIB_1 198 206 PF02201 0.388
DEG_MDM2_SWIB_1 277 285 PF02201 0.339
DEG_MDM2_SWIB_1 82 89 PF02201 0.562
DEG_MDM2_SWIB_1 97 104 PF02201 0.351
DEG_ODPH_VHL_1 416 429 PF01847 0.159
DEG_SPOP_SBC_1 144 148 PF00917 0.426
DEG_SPOP_SBC_1 321 325 PF00917 0.328
DOC_ANK_TNKS_1 439 446 PF00023 0.189
DOC_CYCLIN_RxL_1 356 363 PF00134 0.548
DOC_MAPK_MEF2A_6 183 192 PF00069 0.312
DOC_MAPK_MEF2A_6 228 237 PF00069 0.491
DOC_MAPK_MEF2A_6 378 386 PF00069 0.537
DOC_MAPK_MEF2A_6 440 448 PF00069 0.314
DOC_PP1_RVXF_1 126 132 PF00149 0.296
DOC_PP2B_LxvP_1 415 418 PF13499 0.159
DOC_PP4_FxxP_1 459 462 PF00568 0.445
DOC_SPAK_OSR1_1 76 80 PF12202 0.494
DOC_USP7_MATH_1 113 117 PF00917 0.394
DOC_USP7_MATH_1 120 124 PF00917 0.450
DOC_USP7_MATH_1 140 144 PF00917 0.326
DOC_USP7_MATH_1 462 466 PF00917 0.345
DOC_WW_Pin1_4 116 121 PF00397 0.476
DOC_WW_Pin1_4 50 55 PF00397 0.635
LIG_14-3-3_CanoR_1 118 127 PF00244 0.388
LIG_14-3-3_CanoR_1 218 224 PF00244 0.491
LIG_14-3-3_CanoR_1 320 329 PF00244 0.251
LIG_Actin_WH2_2 203 220 PF00022 0.303
LIG_BIR_II_1 1 5 PF00653 0.680
LIG_BIR_III_4 496 500 PF00653 0.652
LIG_BRCT_BRCA1_1 327 331 PF00533 0.251
LIG_BRCT_BRCA1_1 33 37 PF00533 0.538
LIG_BRCT_BRCA1_1 456 460 PF00533 0.442
LIG_BRCT_BRCA1_1 87 91 PF00533 0.421
LIG_deltaCOP1_diTrp_1 84 91 PF00928 0.452
LIG_EH1_1 269 277 PF00400 0.424
LIG_EH1_1 448 456 PF00400 0.341
LIG_eIF4E_1 410 416 PF01652 0.462
LIG_FAT_LD_1 362 370 PF03623 0.348
LIG_FHA_1 228 234 PF00498 0.468
LIG_FHA_1 292 298 PF00498 0.263
LIG_FHA_1 396 402 PF00498 0.453
LIG_FHA_1 467 473 PF00498 0.467
LIG_FHA_2 17 23 PF00498 0.574
LIG_FHA_2 51 57 PF00498 0.500
LIG_LIR_Apic_2 457 462 PF02991 0.467
LIG_LIR_Gen_1 196 206 PF02991 0.419
LIG_LIR_Gen_1 241 252 PF02991 0.340
LIG_LIR_Gen_1 428 438 PF02991 0.443
LIG_LIR_Gen_1 44 55 PF02991 0.638
LIG_LIR_Gen_1 468 478 PF02991 0.494
LIG_LIR_Gen_1 487 497 PF02991 0.424
LIG_LIR_Gen_1 84 94 PF02991 0.451
LIG_LIR_Gen_1 98 109 PF02991 0.303
LIG_LIR_LC3C_4 333 336 PF02991 0.285
LIG_LIR_Nem_3 196 201 PF02991 0.419
LIG_LIR_Nem_3 241 247 PF02991 0.343
LIG_LIR_Nem_3 323 329 PF02991 0.306
LIG_LIR_Nem_3 34 40 PF02991 0.647
LIG_LIR_Nem_3 428 434 PF02991 0.381
LIG_LIR_Nem_3 44 50 PF02991 0.670
LIG_LIR_Nem_3 457 463 PF02991 0.353
LIG_LIR_Nem_3 468 474 PF02991 0.408
LIG_LIR_Nem_3 487 492 PF02991 0.469
LIG_LIR_Nem_3 58 64 PF02991 0.458
LIG_LIR_Nem_3 84 89 PF02991 0.449
LIG_LIR_Nem_3 98 104 PF02991 0.310
LIG_LYPXL_S_1 60 64 PF13949 0.255
LIG_LYPXL_yS_3 61 64 PF13949 0.463
LIG_MLH1_MIPbox_1 456 460 PF16413 0.285
LIG_NRBOX 357 363 PF00104 0.559
LIG_Pex14_2 198 202 PF04695 0.351
LIG_Pex14_2 277 281 PF04695 0.319
LIG_Pex14_2 407 411 PF04695 0.468
LIG_Pex14_2 82 86 PF04695 0.606
LIG_Pex14_2 97 101 PF04695 0.311
LIG_REV1ctd_RIR_1 201 210 PF16727 0.337
LIG_SH2_CRK 268 272 PF00017 0.392
LIG_SH2_CRK 379 383 PF00017 0.462
LIG_SH2_CRK 431 435 PF00017 0.372
LIG_SH2_CRK 489 493 PF00017 0.532
LIG_SH2_GRB2like 353 356 PF00017 0.438
LIG_SH2_GRB2like 375 378 PF00017 0.456
LIG_SH2_GRB2like 410 413 PF00017 0.462
LIG_SH2_NCK_1 431 435 PF00017 0.159
LIG_SH2_NCK_1 489 493 PF00017 0.475
LIG_SH2_PTP2 244 247 PF00017 0.424
LIG_SH2_SRC 353 356 PF00017 0.438
LIG_SH2_SRC 391 394 PF00017 0.477
LIG_SH2_STAP1 33 37 PF00017 0.679
LIG_SH2_STAP1 431 435 PF00017 0.159
LIG_SH2_STAP1 489 493 PF00017 0.566
LIG_SH2_STAT5 163 166 PF00017 0.387
LIG_SH2_STAT5 244 247 PF00017 0.344
LIG_SH2_STAT5 302 305 PF00017 0.303
LIG_SH2_STAT5 375 378 PF00017 0.446
LIG_SH2_STAT5 391 394 PF00017 0.446
LIG_SH2_STAT5 410 413 PF00017 0.462
LIG_SH2_STAT5 5 8 PF00017 0.735
LIG_SH3_3 249 255 PF00018 0.390
LIG_SH3_3 307 313 PF00018 0.241
LIG_SUMO_SIM_anti_2 146 154 PF11976 0.208
LIG_TYR_ITIM 242 247 PF00017 0.439
LIG_TYR_ITIM 429 434 PF00017 0.159
LIG_TYR_ITIM 59 64 PF00017 0.454
LIG_WRC_WIRS_1 315 320 PF05994 0.233
MOD_CK1_1 116 122 PF00069 0.401
MOD_CK1_1 143 149 PF00069 0.372
MOD_CK1_1 325 331 PF00069 0.308
MOD_CK1_1 348 354 PF00069 0.522
MOD_CK1_1 465 471 PF00069 0.461
MOD_CK2_1 348 354 PF00069 0.437
MOD_CK2_1 368 374 PF00069 0.384
MOD_CK2_1 481 487 PF00069 0.528
MOD_GlcNHglycan 114 118 PF01048 0.567
MOD_GlcNHglycan 122 125 PF01048 0.632
MOD_GlcNHglycan 138 141 PF01048 0.190
MOD_GlcNHglycan 147 150 PF01048 0.380
MOD_GlcNHglycan 175 178 PF01048 0.324
MOD_GlcNHglycan 219 222 PF01048 0.244
MOD_GlcNHglycan 294 297 PF01048 0.336
MOD_GlcNHglycan 347 351 PF01048 0.275
MOD_GlcNHglycan 464 467 PF01048 0.234
MOD_GlcNHglycan 50 53 PF01048 0.470
MOD_GSK3_1 112 119 PF00069 0.311
MOD_GSK3_1 136 143 PF00069 0.423
MOD_GSK3_1 222 229 PF00069 0.486
MOD_GSK3_1 321 328 PF00069 0.296
MOD_GSK3_1 462 469 PF00069 0.295
MOD_GSK3_1 95 102 PF00069 0.324
MOD_N-GLC_1 16 21 PF02516 0.348
MOD_N-GLC_1 497 502 PF02516 0.373
MOD_N-GLC_2 412 414 PF02516 0.337
MOD_NEK2_1 173 178 PF00069 0.350
MOD_NEK2_1 216 221 PF00069 0.473
MOD_NEK2_1 223 228 PF00069 0.458
MOD_NEK2_1 275 280 PF00069 0.268
MOD_NEK2_1 290 295 PF00069 0.225
MOD_NEK2_1 297 302 PF00069 0.375
MOD_NEK2_1 303 308 PF00069 0.281
MOD_NEK2_1 345 350 PF00069 0.494
MOD_NEK2_1 425 430 PF00069 0.292
MOD_NEK2_1 454 459 PF00069 0.335
MOD_NEK2_2 466 471 PF00069 0.464
MOD_PIKK_1 280 286 PF00454 0.278
MOD_PKA_2 217 223 PF00069 0.526
MOD_PKA_2 481 487 PF00069 0.605
MOD_PKA_2 72 78 PF00069 0.590
MOD_Plk_4 140 146 PF00069 0.354
MOD_Plk_4 166 172 PF00069 0.418
MOD_Plk_4 193 199 PF00069 0.338
MOD_Plk_4 227 233 PF00069 0.446
MOD_Plk_4 297 303 PF00069 0.311
MOD_Plk_4 330 336 PF00069 0.298
MOD_Plk_4 368 374 PF00069 0.411
MOD_Plk_4 454 460 PF00069 0.335
MOD_Plk_4 466 472 PF00069 0.410
MOD_Plk_4 55 61 PF00069 0.532
MOD_ProDKin_1 116 122 PF00069 0.474
MOD_ProDKin_1 50 56 PF00069 0.636
TRG_DiLeu_BaLyEn_6 219 224 PF01217 0.519
TRG_ENDOCYTIC_2 244 247 PF00928 0.404
TRG_ENDOCYTIC_2 268 271 PF00928 0.407
TRG_ENDOCYTIC_2 379 382 PF00928 0.447
TRG_ENDOCYTIC_2 431 434 PF00928 0.372
TRG_ENDOCYTIC_2 47 50 PF00928 0.666
TRG_ENDOCYTIC_2 489 492 PF00928 0.523
TRG_ENDOCYTIC_2 61 64 PF00928 0.463
TRG_ER_diArg_1 77 80 PF00400 0.609
TRG_Pf-PMV_PEXEL_1 343 347 PF00026 0.312
TRG_Pf-PMV_PEXEL_1 359 363 PF00026 0.312

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I9D8 Leptomonas seymouri 64% 100%
A0A0N1PA24 Leptomonas seymouri 34% 86%
A0A0S4IW21 Bodo saltans 35% 94%
A0A0S4KHP0 Bodo saltans 41% 100%
A0A1X0P8J3 Trypanosomatidae 48% 100%
A0A3Q8I9V7 Leishmania donovani 36% 84%
A0A3R7MAJ2 Trypanosoma rangeli 30% 100%
A0A3S5IRA1 Trypanosoma rangeli 45% 100%
A0A3S7XAV8 Leishmania donovani 75% 99%
A4H7J7 Leishmania braziliensis 36% 84%
A4HVY0 Leishmania infantum 36% 84%
A4IDJ5 Leishmania infantum 75% 99%
A5PMW0 Danio rerio 27% 72%
D0A390 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 100%
D0A391 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 100%
D0A392 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 100%
D0A393 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 98%
E9APN1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 38% 84%
E9ASZ8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 74% 100%
Q12412 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 25% 94%
Q4I8E9 Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) 28% 94%
Q4PIP8 Ustilago maydis (strain 521 / FGSC 9021) 29% 96%
Q4Q1K0 Leishmania major 76% 100%
Q4QFU7 Leishmania major 37% 84%
Q4WYG7 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 27% 95%
Q54IJ2 Dictyostelium discoideum 25% 93%
Q5AB93 Candida albicans (strain SC5314 / ATCC MYA-2876) 27% 98%
Q6BIV4 Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) 27% 99%
Q6C938 Yarrowia lipolytica (strain CLIB 122 / E 150) 28% 89%
Q6CY85 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 25% 92%
Q6FLC9 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 27% 91%
Q75EG5 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 27% 92%
Q870V7 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 30% 92%
Q921V7 Mus musculus 23% 77%
V5AWF7 Trypanosoma cruzi 47% 100%
V5BMB4 Trypanosoma cruzi 33% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS