Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HP88_LEIBR

TriTrypDb:

LbrM.35.2430 , LBRM2903_350030900

Length:

591

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HP88

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP88

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.567
CLV_C14_Caspase3-7	98	102	PF00656	0.632
CLV_NRD_NRD_1	133	135	PF00675	0.533
CLV_NRD_NRD_1	213	215	PF00675	0.754
CLV_NRD_NRD_1	312	314	PF00675	0.729
CLV_NRD_NRD_1	359	361	PF00675	0.616
CLV_NRD_NRD_1	485	487	PF00675	0.710
CLV_NRD_NRD_1	506	508	PF00675	0.550
CLV_NRD_NRD_1	520	522	PF00675	0.491
CLV_NRD_NRD_1	566	568	PF00675	0.557
CLV_NRD_NRD_1	570	572	PF00675	0.567
CLV_PCSK_FUR_1	518	522	PF00082	0.469
CLV_PCSK_KEX2_1	205	207	PF00082	0.669
CLV_PCSK_KEX2_1	213	215	PF00082	0.685
CLV_PCSK_KEX2_1	442	444	PF00082	0.658
CLV_PCSK_KEX2_1	485	487	PF00082	0.710
CLV_PCSK_KEX2_1	520	522	PF00082	0.583
CLV_PCSK_PC1ET2_1	205	207	PF00082	0.631
CLV_PCSK_PC1ET2_1	442	444	PF00082	0.661
CLV_PCSK_PC7_1	438	444	PF00082	0.543
CLV_PCSK_PC7_1	516	522	PF00082	0.461
CLV_PCSK_SKI1_1	269	273	PF00082	0.469
CLV_PCSK_SKI1_1	431	435	PF00082	0.502
CLV_PCSK_SKI1_1	464	468	PF00082	0.637
CLV_PCSK_SKI1_1	576	580	PF00082	0.694
CLV_PCSK_SKI1_1	87	91	PF00082	0.579
DEG_APCC_DBOX_1	570	578	PF00400	0.568
DEG_SCF_FBW7_2	222	227	PF00400	0.496
DOC_CYCLIN_RxL_1	406	418	PF00134	0.477
DOC_PP4_FxxP_1	585	588	PF00568	0.616
DOC_USP7_MATH_1	147	151	PF00917	0.560
DOC_USP7_MATH_1	307	311	PF00917	0.579
DOC_USP7_MATH_1	481	485	PF00917	0.572
DOC_USP7_UBL2_3	265	269	PF12436	0.458
DOC_USP7_UBL2_3	564	568	PF12436	0.606
DOC_USP7_UBL2_3	572	576	PF12436	0.514
DOC_WW_Pin1_4	218	223	PF00397	0.668
DOC_WW_Pin1_4	301	306	PF00397	0.627
DOC_WW_Pin1_4	456	461	PF00397	0.666
LIG_14-3-3_CanoR_1	125	129	PF00244	0.543
LIG_14-3-3_CanoR_1	134	140	PF00244	0.479
LIG_14-3-3_CanoR_1	141	147	PF00244	0.497
LIG_14-3-3_CanoR_1	366	370	PF00244	0.580
LIG_14-3-3_CanoR_1	507	511	PF00244	0.550
LIG_14-3-3_CanoR_1	76	81	PF00244	0.592
LIG_BIR_II_1	1	5	PF00653	0.798
LIG_EVH1_1	585	589	PF00568	0.639
LIG_EVH1_1	69	73	PF00568	0.542
LIG_FHA_1	182	188	PF00498	0.497
LIG_FHA_1	270	276	PF00498	0.733
LIG_FHA_1	30	36	PF00498	0.660
LIG_FHA_1	323	329	PF00498	0.518
LIG_FHA_1	37	43	PF00498	0.606
LIG_FHA_1	421	427	PF00498	0.515
LIG_FHA_2	416	422	PF00498	0.535
LIG_FHA_2	457	463	PF00498	0.582
LIG_FHA_2	77	83	PF00498	0.757
LIG_FHA_2	92	98	PF00498	0.589
LIG_LIR_Gen_1	472	482	PF02991	0.517
LIG_LIR_Gen_1	509	514	PF02991	0.598
LIG_LIR_Nem_3	472	477	PF02991	0.517
LIG_LIR_Nem_3	509	513	PF02991	0.600
LIG_NRBOX	228	234	PF00104	0.626
LIG_Pex14_1	506	510	PF04695	0.551
LIG_Pex14_2	259	263	PF04695	0.620
LIG_PTAP_UEV_1	236	241	PF05743	0.512
LIG_RPA_C_Fungi	136	148	PF08784	0.495
LIG_SH2_CRK	510	514	PF00017	0.605
LIG_SH2_STAP1	346	350	PF00017	0.594
LIG_SH2_STAP1	49	53	PF00017	0.558
LIG_SH2_STAP1	510	514	PF00017	0.549
LIG_SH2_STAT3	117	120	PF00017	0.530
LIG_SH2_STAT5	117	120	PF00017	0.530
LIG_SH3_2	10	15	PF14604	0.668
LIG_SH3_2	237	242	PF14604	0.633
LIG_SH3_2	586	591	PF14604	0.513
LIG_SH3_3	219	225	PF00018	0.658
LIG_SH3_3	234	240	PF00018	0.622
LIG_SH3_3	285	291	PF00018	0.558
LIG_SH3_3	457	463	PF00018	0.523
LIG_SH3_3	583	589	PF00018	0.629
LIG_SH3_3	64	70	PF00018	0.604
LIG_SH3_3	7	13	PF00018	0.793
LIG_SUMO_SIM_par_1	32	39	PF11976	0.550
LIG_SUMO_SIM_par_1	59	65	PF11976	0.575
LIG_TRAF2_1	459	462	PF00917	0.517
LIG_TRFH_1	585	589	PF08558	0.555
MOD_CDK_SPxxK_3	301	308	PF00069	0.625
MOD_CK1_1	509	515	PF00069	0.410
MOD_CK1_1	51	57	PF00069	0.640
MOD_CK2_1	415	421	PF00069	0.554
MOD_CK2_1	456	462	PF00069	0.531
MOD_CK2_1	481	487	PF00069	0.580
MOD_CK2_1	528	534	PF00069	0.624
MOD_CK2_1	76	82	PF00069	0.690
MOD_GlcNHglycan	169	173	PF01048	0.636
MOD_GlcNHglycan	237	240	PF01048	0.521
MOD_GlcNHglycan	256	259	PF01048	0.610
MOD_GlcNHglycan	27	32	PF01048	0.691
MOD_GlcNHglycan	479	482	PF01048	0.607
MOD_GlcNHglycan	87	90	PF01048	0.662
MOD_GSK3_1	135	142	PF00069	0.481
MOD_GSK3_1	179	186	PF00069	0.540
MOD_GSK3_1	250	257	PF00069	0.680
MOD_GSK3_1	360	367	PF00069	0.652
MOD_GSK3_1	411	418	PF00069	0.530
MOD_GSK3_1	44	51	PF00069	0.662
MOD_GSK3_1	477	484	PF00069	0.575
MOD_GSK3_1	502	509	PF00069	0.481
MOD_N-GLC_1	301	306	PF02516	0.571
MOD_N-GLC_2	183	185	PF02516	0.526
MOD_NEK2_1	139	144	PF00069	0.558
MOD_NEK2_1	179	184	PF00069	0.595
MOD_NEK2_1	369	374	PF00069	0.524
MOD_NEK2_1	415	420	PF00069	0.488
MOD_PIKK_1	308	314	PF00454	0.586
MOD_PIKK_1	433	439	PF00454	0.538
MOD_PIKK_1	489	495	PF00454	0.456
MOD_PKA_1	360	366	PF00069	0.623
MOD_PKA_1	411	417	PF00069	0.620
MOD_PKA_2	124	130	PF00069	0.554
MOD_PKA_2	307	313	PF00069	0.606
MOD_PKA_2	365	371	PF00069	0.605
MOD_PKA_2	506	512	PF00069	0.550
MOD_PKA_2	75	81	PF00069	0.706
MOD_PKA_2	91	97	PF00069	0.570
MOD_Plk_2-3	97	103	PF00069	0.590
MOD_Plk_4	365	371	PF00069	0.525
MOD_Plk_4	411	417	PF00069	0.620
MOD_Plk_4	509	515	PF00069	0.410
MOD_ProDKin_1	218	224	PF00069	0.662
MOD_ProDKin_1	301	307	PF00069	0.621
MOD_ProDKin_1	456	462	PF00069	0.661
MOD_SUMO_rev_2	457	466	PF00179	0.656
TRG_DiLeu_BaEn_3	158	164	PF01217	0.650
TRG_ENDOCYTIC_2	346	349	PF00928	0.594
TRG_ENDOCYTIC_2	510	513	PF00928	0.608
TRG_ER_diArg_1	200	203	PF00400	0.487
TRG_ER_diArg_1	518	521	PF00400	0.467
TRG_NLS_MonoExtC_3	440	446	PF00514	0.549
TRG_NLS_MonoExtN_4	438	445	PF00514	0.568
TRG_Pf-PMV_PEXEL_1	242	246	PF00026	0.672

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7XAV9	Leishmania donovani	64%	100%
A4IDJ3	Leishmania infantum	64%	100%
E9ASZ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	100%
Q4Q1K2	Leishmania major	64%	99%