Protein-tyrosine phosphatase 1-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein-tyrosine phosphatase 1-like protein

Species:

Leishmania braziliensis

UniProt:

A4HP87_LEIBR

TriTrypDb:

LbrM.35.2420 , LBRM2903_350030800

Length:

518

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HP87

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP87

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016311	dephosphorylation	5	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004721	phosphoprotein phosphatase activity	3	7
GO:0004725	protein tyrosine phosphatase activity	4	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016791	phosphatase activity	5	7
GO:0042578	phosphoric ester hydrolase activity	4	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	2	6	PF00656	0.466
CLV_C14_Caspase3-7	356	360	PF00656	0.202
CLV_NRD_NRD_1	224	226	PF00675	0.202
CLV_NRD_NRD_1	323	325	PF00675	0.344
CLV_NRD_NRD_1	449	451	PF00675	0.284
CLV_NRD_NRD_1	455	457	PF00675	0.286
CLV_NRD_NRD_1	484	486	PF00675	0.435
CLV_PCSK_KEX2_1	195	197	PF00082	0.412
CLV_PCSK_KEX2_1	223	225	PF00082	0.202
CLV_PCSK_KEX2_1	323	325	PF00082	0.344
CLV_PCSK_KEX2_1	449	451	PF00082	0.344
CLV_PCSK_PC1ET2_1	195	197	PF00082	0.338
CLV_PCSK_PC1ET2_1	223	225	PF00082	0.202
CLV_PCSK_PC7_1	220	226	PF00082	0.202
CLV_PCSK_SKI1_1	180	184	PF00082	0.491
CLV_PCSK_SKI1_1	195	199	PF00082	0.337
CLV_PCSK_SKI1_1	450	454	PF00082	0.284
CLV_PCSK_SKI1_1	508	512	PF00082	0.452
CLV_PCSK_SKI1_1	514	518	PF00082	0.439
CLV_Separin_Metazoa	320	324	PF03568	0.344
DEG_SPOP_SBC_1	392	396	PF00917	0.202
DOC_CYCLIN_RxL_1	191	200	PF00134	0.334
DOC_CYCLIN_RxL_1	505	512	PF00134	0.312
DOC_CYCLIN_yCln2_LP_2	410	416	PF00134	0.344
DOC_MAPK_gen_1	406	416	PF00069	0.201
DOC_MAPK_MEF2A_6	409	416	PF00069	0.284
DOC_MAPK_MEF2A_6	465	474	PF00069	0.280
DOC_MAPK_RevD_3	470	486	PF00069	0.391
DOC_PP2B_LxvP_1	410	413	PF13499	0.344
DOC_USP7_MATH_1	148	152	PF00917	0.407
DOC_USP7_MATH_1	170	174	PF00917	0.678
DOC_USP7_MATH_1	175	179	PF00917	0.536
DOC_USP7_MATH_1	18	22	PF00917	0.585
DOC_USP7_MATH_1	288	292	PF00917	0.284
DOC_USP7_MATH_1	378	382	PF00917	0.336
DOC_USP7_MATH_1	40	44	PF00917	0.525
DOC_USP7_MATH_1	444	448	PF00917	0.202
DOC_USP7_MATH_1	79	83	PF00917	0.653
DOC_USP7_UBL2_3	191	195	PF12436	0.320
DOC_WW_Pin1_4	14	19	PF00397	0.501
DOC_WW_Pin1_4	157	162	PF00397	0.620
DOC_WW_Pin1_4	165	170	PF00397	0.738
DOC_WW_Pin1_4	408	413	PF00397	0.344
DOC_WW_Pin1_4	69	74	PF00397	0.546
LIG_14-3-3_CanoR_1	196	202	PF00244	0.330
LIG_14-3-3_CanoR_1	485	493	PF00244	0.416
LIG_AP_GAE_1	105	111	PF02883	0.434
LIG_APCC_ABBA_1	303	308	PF00400	0.280
LIG_BIR_II_1	1	5	PF00653	0.619
LIG_BRCT_BRCA1_1	202	206	PF00533	0.361
LIG_BRCT_BRCA1_2	202	208	PF00533	0.381
LIG_CtBP_PxDLS_1	169	173	PF00389	0.621
LIG_FHA_1	265	271	PF00498	0.344
LIG_FHA_1	276	282	PF00498	0.242
LIG_FHA_1	316	322	PF00498	0.290
LIG_FHA_1	409	415	PF00498	0.382
LIG_FHA_1	423	429	PF00498	0.252
LIG_FHA_2	271	277	PF00498	0.297
LIG_FHA_2	399	405	PF00498	0.290
LIG_LIR_Gen_1	255	262	PF02991	0.344
LIG_LIR_Gen_1	358	368	PF02991	0.280
LIG_LIR_Gen_1	467	477	PF02991	0.320
LIG_LIR_Gen_1	98	109	PF02991	0.361
LIG_LIR_Nem_3	105	111	PF02991	0.306
LIG_LIR_Nem_3	255	260	PF02991	0.458
LIG_LIR_Nem_3	358	364	PF02991	0.280
LIG_LIR_Nem_3	467	472	PF02991	0.320
LIG_LIR_Nem_3	98	104	PF02991	0.326
LIG_NRP_CendR_1	517	518	PF00754	0.520
LIG_PCNA_PIPBox_1	251	260	PF02747	0.344
LIG_PTAP_UEV_1	374	379	PF05743	0.202
LIG_PTB_Apo_2	84	91	PF02174	0.458
LIG_SH2_CRK	344	348	PF00017	0.344
LIG_SH2_CRK	432	436	PF00017	0.280
LIG_SH2_CRK	469	473	PF00017	0.280
LIG_SH2_GRB2like	135	138	PF00017	0.405
LIG_SH2_GRB2like	229	232	PF00017	0.280
LIG_SH2_PTP2	135	138	PF00017	0.405
LIG_SH2_PTP2	327	330	PF00017	0.344
LIG_SH2_SRC	135	138	PF00017	0.405
LIG_SH2_SRC	229	232	PF00017	0.344
LIG_SH2_SRC	344	347	PF00017	0.344
LIG_SH2_STAP1	262	266	PF00017	0.344
LIG_SH2_STAP1	313	317	PF00017	0.280
LIG_SH2_STAT3	306	309	PF00017	0.202
LIG_SH2_STAT5	135	138	PF00017	0.405
LIG_SH2_STAT5	229	232	PF00017	0.280
LIG_SH2_STAT5	313	316	PF00017	0.280
LIG_SH2_STAT5	327	330	PF00017	0.280
LIG_SH2_STAT5	346	349	PF00017	0.167
LIG_SH2_STAT5	371	374	PF00017	0.279
LIG_SH2_STAT5	432	435	PF00017	0.280
LIG_SH3_3	158	164	PF00018	0.524
LIG_SH3_3	319	325	PF00018	0.340
LIG_SH3_3	344	350	PF00018	0.344
LIG_SH3_3	369	375	PF00018	0.295
LIG_SH3_3	386	392	PF00018	0.236
LIG_SUMO_SIM_anti_2	255	263	PF11976	0.344
LIG_SUMO_SIM_anti_2	265	270	PF11976	0.251
LIG_SUMO_SIM_par_1	10	17	PF11976	0.492
LIG_SUMO_SIM_par_1	267	274	PF11976	0.284
LIG_TRAF2_1	140	143	PF00917	0.354
LIG_TRAF2_1	249	252	PF00917	0.344
LIG_TRAF2_1	360	363	PF00917	0.280
LIG_TRAF2_1	96	99	PF00917	0.533
LIG_TYR_ITIM	342	347	PF00017	0.344
LIG_WRC_WIRS_1	297	302	PF05994	0.279
MOD_CDK_SPK_2	157	162	PF00069	0.544
MOD_CK1_1	168	174	PF00069	0.563
MOD_CK1_1	17	23	PF00069	0.594
MOD_CK1_1	178	184	PF00069	0.370
MOD_CK1_1	213	219	PF00069	0.563
MOD_CK1_1	29	35	PF00069	0.519
MOD_CK1_1	331	337	PF00069	0.344
MOD_CK1_1	357	363	PF00069	0.280
MOD_CK1_1	400	406	PF00069	0.244
MOD_CK1_1	68	74	PF00069	0.660
MOD_CK2_1	18	24	PF00069	0.601
MOD_CK2_1	270	276	PF00069	0.280
MOD_CK2_1	357	363	PF00069	0.280
MOD_CK2_1	68	74	PF00069	0.568
MOD_CK2_1	79	85	PF00069	0.609
MOD_CK2_1	93	99	PF00069	0.413
MOD_GlcNHglycan	165	168	PF01048	0.582
MOD_GlcNHglycan	20	23	PF01048	0.715
MOD_GlcNHglycan	202	205	PF01048	0.370
MOD_GlcNHglycan	290	293	PF01048	0.285
MOD_GlcNHglycan	330	333	PF01048	0.322
MOD_GlcNHglycan	375	378	PF01048	0.460
MOD_GlcNHglycan	418	421	PF01048	0.262
MOD_GlcNHglycan	48	51	PF01048	0.524
MOD_GlcNHglycan	487	490	PF01048	0.423
MOD_GlcNHglycan	52	56	PF01048	0.594
MOD_GSK3_1	12	19	PF00069	0.598
MOD_GSK3_1	150	157	PF00069	0.615
MOD_GSK3_1	170	177	PF00069	0.465
MOD_GSK3_1	178	185	PF00069	0.626
MOD_GSK3_1	196	203	PF00069	0.289
MOD_GSK3_1	210	217	PF00069	0.666
MOD_GSK3_1	256	263	PF00069	0.356
MOD_GSK3_1	311	318	PF00069	0.290
MOD_GSK3_1	328	335	PF00069	0.178
MOD_GSK3_1	393	400	PF00069	0.403
MOD_GSK3_1	53	60	PF00069	0.532
MOD_GSK3_1	65	72	PF00069	0.554
MOD_N-GLC_1	121	126	PF02516	0.358
MOD_N-GLC_1	26	31	PF02516	0.563
MOD_N-GLC_1	3	8	PF02516	0.529
MOD_N-GLC_1	398	403	PF02516	0.268
MOD_N-GLC_1	444	449	PF02516	0.344
MOD_N-GLC_1	57	62	PF02516	0.509
MOD_N-GLC_1	77	82	PF02516	0.519
MOD_N-GLC_2	302	304	PF02516	0.202
MOD_NEK2_1	123	128	PF00069	0.397
MOD_NEK2_1	174	179	PF00069	0.692
MOD_NEK2_1	182	187	PF00069	0.504
MOD_NEK2_1	197	202	PF00069	0.401
MOD_NEK2_1	243	248	PF00069	0.276
MOD_NEK2_1	443	448	PF00069	0.344
MOD_NEK2_1	46	51	PF00069	0.503
MOD_NEK2_1	66	71	PF00069	0.623
MOD_NEK2_2	175	180	PF00069	0.427
MOD_NEK2_2	444	449	PF00069	0.202
MOD_PIKK_1	243	249	PF00454	0.280
MOD_PKA_1	485	491	PF00069	0.427
MOD_PKA_2	219	225	PF00069	0.204
MOD_PKA_2	328	334	PF00069	0.306
MOD_PKA_2	378	384	PF00069	0.202
MOD_Plk_1	141	147	PF00069	0.386
MOD_Plk_1	235	241	PF00069	0.344
MOD_Plk_1	26	32	PF00069	0.579
MOD_Plk_1	264	270	PF00069	0.458
MOD_Plk_1	3	9	PF00069	0.618
MOD_Plk_1	444	450	PF00069	0.344
MOD_Plk_1	57	63	PF00069	0.508
MOD_Plk_2-3	311	317	PF00069	0.254
MOD_Plk_4	141	147	PF00069	0.354
MOD_Plk_4	256	262	PF00069	0.326
MOD_Plk_4	264	270	PF00069	0.343
MOD_Plk_4	424	430	PF00069	0.280
MOD_ProDKin_1	14	20	PF00069	0.502
MOD_ProDKin_1	157	163	PF00069	0.622
MOD_ProDKin_1	165	171	PF00069	0.737
MOD_ProDKin_1	408	414	PF00069	0.344
MOD_ProDKin_1	69	75	PF00069	0.546
MOD_SUMO_rev_2	106	116	PF00179	0.305
TRG_DiLeu_BaEn_1	265	270	PF01217	0.202
TRG_DiLeu_BaEn_1	99	104	PF01217	0.360
TRG_DiLeu_BaEn_2	275	281	PF01217	0.344
TRG_DiLeu_BaEn_2	466	472	PF01217	0.280
TRG_DiLeu_BaEn_3	362	368	PF01217	0.280
TRG_DiLeu_BaLyEn_6	193	198	PF01217	0.330
TRG_ENDOCYTIC_2	135	138	PF00928	0.405
TRG_ENDOCYTIC_2	344	347	PF00928	0.344
TRG_ENDOCYTIC_2	432	435	PF00928	0.280
TRG_ENDOCYTIC_2	469	472	PF00928	0.280
TRG_ENDOCYTIC_2	473	476	PF00928	0.280
TRG_ER_diArg_1	224	226	PF00400	0.202
TRG_ER_diArg_1	322	324	PF00400	0.344
TRG_ER_diArg_1	448	450	PF00400	0.344
TRG_NLS_MonoExtN_4	220	227	PF00514	0.202
TRG_Pf-PMV_PEXEL_1	508	512	PF00026	0.310

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILN6	Leptomonas seymouri	50%	100%
A0A3S7XAX7	Leishmania donovani	73%	99%
A4IDJ2	Leishmania infantum	73%	99%
E9ASZ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	99%
P34138	Dictyostelium discoideum	24%	100%
Q4Q1K3	Leishmania major	75%	100%