SAM_MT_RSMB_NOP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NOL1/NOP2/sun family, putative

Species:

Leishmania braziliensis

UniProt:

A4HP86_LEIBR

TriTrypDb:

LbrM.35.2410 , LBRM2903_350030700

Length:

761

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4HP86

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP86

Function

Biological processes
Term	Name	Level	Count
GO:0001510	RNA methylation	4	8
GO:0006139	nucleobase-containing compound metabolic process	3	8
GO:0006725	cellular aromatic compound metabolic process	3	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0009451	RNA modification	5	8
GO:0009987	cellular process	1	8
GO:0016070	RNA metabolic process	5	8
GO:0032259	methylation	2	8
GO:0034641	cellular nitrogen compound metabolic process	3	8
GO:0043170	macromolecule metabolic process	3	8
GO:0043412	macromolecule modification	4	8
GO:0043414	macromolecule methylation	3	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0044260	obsolete cellular macromolecule metabolic process	3	8
GO:0046483	heterocycle metabolic process	3	8
GO:0071704	organic substance metabolic process	2	8
GO:0090304	nucleic acid metabolic process	4	8
GO:1901360	organic cyclic compound metabolic process	3	8

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0008168	methyltransferase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016741	transferase activity, transferring one-carbon groups	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0000049	tRNA binding	5	3
GO:0008173	RNA methyltransferase activity	4	3
GO:0008175	tRNA methyltransferase activity	5	3
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	3
GO:0016427	tRNA (cytosine) methyltransferase activity	6	3
GO:0016428	tRNA (cytosine-5-)-methyltransferase activity	7	3
GO:0140098	catalytic activity, acting on RNA	3	3
GO:0140101	catalytic activity, acting on a tRNA	4	3
GO:0140640	catalytic activity, acting on a nucleic acid	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	409	413	PF00656	0.506
CLV_C14_Caspase3-7	441	445	PF00656	0.422
CLV_C14_Caspase3-7	69	73	PF00656	0.592
CLV_NRD_NRD_1	15	17	PF00675	0.566
CLV_NRD_NRD_1	157	159	PF00675	0.372
CLV_NRD_NRD_1	321	323	PF00675	0.212
CLV_NRD_NRD_1	41	43	PF00675	0.315
CLV_NRD_NRD_1	5	7	PF00675	0.625
CLV_NRD_NRD_1	653	655	PF00675	0.484
CLV_NRD_NRD_1	691	693	PF00675	0.249
CLV_PCSK_KEX2_1	15	17	PF00082	0.530
CLV_PCSK_KEX2_1	159	161	PF00082	0.385
CLV_PCSK_KEX2_1	252	254	PF00082	0.212
CLV_PCSK_KEX2_1	262	264	PF00082	0.212
CLV_PCSK_KEX2_1	41	43	PF00082	0.315
CLV_PCSK_KEX2_1	5	7	PF00082	0.587
CLV_PCSK_KEX2_1	513	515	PF00082	0.626
CLV_PCSK_KEX2_1	653	655	PF00082	0.482
CLV_PCSK_KEX2_1	690	692	PF00082	0.266
CLV_PCSK_PC1ET2_1	159	161	PF00082	0.403
CLV_PCSK_PC1ET2_1	252	254	PF00082	0.212
CLV_PCSK_PC1ET2_1	262	264	PF00082	0.212
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.468
CLV_PCSK_PC1ET2_1	513	515	PF00082	0.626
CLV_PCSK_SKI1_1	16	20	PF00082	0.556
CLV_PCSK_SKI1_1	265	269	PF00082	0.214
CLV_PCSK_SKI1_1	384	388	PF00082	0.259
CLV_PCSK_SKI1_1	393	397	PF00082	0.221
CLV_PCSK_SKI1_1	478	482	PF00082	0.417
CLV_PCSK_SKI1_1	488	492	PF00082	0.417
CLV_PCSK_SKI1_1	6	10	PF00082	0.522
CLV_Separin_Metazoa	302	306	PF03568	0.415
DEG_APCC_DBOX_1	383	391	PF00400	0.459
DEG_APCC_DBOX_1	392	400	PF00400	0.421
DEG_APCC_DBOX_1	689	697	PF00400	0.327
DEG_SCF_FBW7_1	102	109	PF00400	0.388
DEG_SCF_FBW7_1	541	548	PF00400	0.483
DEG_SPOP_SBC_1	73	77	PF00917	0.536
DOC_CKS1_1	103	108	PF01111	0.394
DOC_CKS1_1	32	37	PF01111	0.537
DOC_CKS1_1	432	437	PF01111	0.412
DOC_CYCLIN_yCln2_LP_2	266	272	PF00134	0.430
DOC_MAPK_gen_1	13	21	PF00069	0.478
DOC_MAPK_gen_1	252	258	PF00069	0.423
DOC_MAPK_gen_1	262	268	PF00069	0.455
DOC_MAPK_gen_1	382	389	PF00069	0.425
DOC_MAPK_gen_1	476	485	PF00069	0.366
DOC_MAPK_gen_1	613	622	PF00069	0.500
DOC_MAPK_gen_1	653	663	PF00069	0.331
DOC_MAPK_gen_1	690	698	PF00069	0.402
DOC_MAPK_HePTP_8	651	663	PF00069	0.383
DOC_MAPK_HePTP_8	718	730	PF00069	0.275
DOC_MAPK_MEF2A_6	211	219	PF00069	0.292
DOC_MAPK_MEF2A_6	279	286	PF00069	0.384
DOC_MAPK_MEF2A_6	341	348	PF00069	0.422
DOC_MAPK_MEF2A_6	654	663	PF00069	0.323
DOC_MAPK_MEF2A_6	721	730	PF00069	0.335
DOC_MIT_MIM_1	686	696	PF04212	0.413
DOC_PP1_RVXF_1	263	269	PF00149	0.412
DOC_PP1_RVXF_1	625	632	PF00149	0.425
DOC_PP2B_LxvP_1	429	432	PF13499	0.412
DOC_PP4_FxxP_1	103	106	PF00568	0.317
DOC_PP4_FxxP_1	418	421	PF00568	0.466
DOC_PP4_MxPP_1	187	190	PF00568	0.282
DOC_USP7_MATH_1	118	122	PF00917	0.270
DOC_USP7_MATH_1	226	230	PF00917	0.389
DOC_USP7_MATH_1	630	634	PF00917	0.268
DOC_USP7_MATH_1	73	77	PF00917	0.693
DOC_USP7_MATH_1	78	82	PF00917	0.701
DOC_USP7_MATH_1	91	95	PF00917	0.238
DOC_USP7_UBL2_3	484	488	PF12436	0.554
DOC_USP7_UBL2_3	5	9	PF12436	0.598
DOC_USP7_UBL2_3	675	679	PF12436	0.485
DOC_WW_Pin1_4	102	107	PF00397	0.408
DOC_WW_Pin1_4	204	209	PF00397	0.313
DOC_WW_Pin1_4	229	234	PF00397	0.376
DOC_WW_Pin1_4	31	36	PF00397	0.659
DOC_WW_Pin1_4	329	334	PF00397	0.412
DOC_WW_Pin1_4	431	436	PF00397	0.412
DOC_WW_Pin1_4	541	546	PF00397	0.591
DOC_WW_Pin1_4	593	598	PF00397	0.547
DOC_WW_Pin1_4	749	754	PF00397	0.578
LIG_14-3-3_CanoR_1	172	179	PF00244	0.430
LIG_14-3-3_CanoR_1	359	369	PF00244	0.412
LIG_14-3-3_CanoR_1	50	56	PF00244	0.419
LIG_14-3-3_CanoR_1	566	575	PF00244	0.376
LIG_14-3-3_CanoR_1	613	622	PF00244	0.432
LIG_14-3-3_CanoR_1	639	648	PF00244	0.319
LIG_14-3-3_CanoR_1	653	661	PF00244	0.348
LIG_Actin_WH2_2	306	324	PF00022	0.443
LIG_Actin_WH2_2	339	357	PF00022	0.445
LIG_Actin_WH2_2	372	390	PF00022	0.354
LIG_BIR_III_2	230	234	PF00653	0.458
LIG_BIR_III_2	391	395	PF00653	0.354
LIG_BIR_III_4	412	416	PF00653	0.506
LIG_BIR_III_4	531	535	PF00653	0.481
LIG_CaM_IQ_9	374	390	PF13499	0.354
LIG_Clathr_ClatBox_1	702	706	PF01394	0.288
LIG_CSL_BTD_1	330	333	PF09270	0.412
LIG_eIF4E_1	238	244	PF01652	0.249
LIG_FHA_1	103	109	PF00498	0.334
LIG_FHA_1	114	120	PF00498	0.294
LIG_FHA_1	362	368	PF00498	0.506
LIG_FHA_1	375	381	PF00498	0.506
LIG_FHA_1	405	411	PF00498	0.400
LIG_FHA_1	614	620	PF00498	0.389
LIG_FHA_2	21	27	PF00498	0.557
LIG_FHA_2	272	278	PF00498	0.412
LIG_FHA_2	407	413	PF00498	0.506
LIG_FHA_2	439	445	PF00498	0.428
LIG_FHA_2	519	525	PF00498	0.696
LIG_FHA_2	67	73	PF00498	0.614
LIG_LIR_Apic_2	569	575	PF02991	0.422
LIG_LIR_Gen_1	49	58	PF02991	0.365
LIG_LIR_Nem_3	139	143	PF02991	0.348
LIG_LIR_Nem_3	46	51	PF02991	0.349
LIG_LIR_Nem_3	569	574	PF02991	0.371
LIG_PCNA_PIPBox_1	163	172	PF02747	0.385
LIG_PCNA_PIPBox_1	565	574	PF02747	0.453
LIG_PCNA_yPIPBox_3	37	50	PF02747	0.305
LIG_PTB_Apo_2	42	49	PF02174	0.508
LIG_SH2_CRK	52	56	PF00017	0.490
LIG_SH2_CRK	572	576	PF00017	0.245
LIG_SH2_NCK_1	572	576	PF00017	0.342
LIG_SH2_STAP1	438	442	PF00017	0.443
LIG_SH2_STAP1	716	720	PF00017	0.283
LIG_SH2_STAT5	169	172	PF00017	0.469
LIG_SH2_STAT5	280	283	PF00017	0.425
LIG_SH2_STAT5	557	560	PF00017	0.287
LIG_SH3_1	279	285	PF00018	0.422
LIG_SH3_1	572	578	PF00018	0.331
LIG_SH3_3	279	285	PF00018	0.376
LIG_SH3_3	29	35	PF00018	0.616
LIG_SH3_3	391	397	PF00018	0.499
LIG_SH3_3	429	435	PF00018	0.435
LIG_SH3_3	544	550	PF00018	0.650
LIG_SH3_3	555	561	PF00018	0.350
LIG_SH3_3	572	578	PF00018	0.331
LIG_SH3_3	656	662	PF00018	0.434
LIG_SUMO_SIM_anti_2	131	136	PF11976	0.237
LIG_SUMO_SIM_anti_2	616	623	PF11976	0.359
LIG_SUMO_SIM_par_1	17	24	PF11976	0.425
LIG_SUMO_SIM_par_1	616	623	PF11976	0.329
LIG_SUMO_SIM_par_1	701	706	PF11976	0.313
LIG_TRAF2_1	748	751	PF00917	0.446
LIG_TRAF2_1	83	86	PF00917	0.469
LIG_UBA3_1	215	223	PF00899	0.316
LIG_UBA3_1	702	709	PF00899	0.448
LIG_WRC_WIRS_1	108	113	PF05994	0.408
LIG_WW_1	554	557	PF00397	0.323
MOD_CDK_SPK_2	329	334	PF00069	0.412
MOD_CDK_SPK_2	541	546	PF00069	0.487
MOD_CDK_SPxxK_3	204	211	PF00069	0.310
MOD_CK1_1	20	26	PF00069	0.563
MOD_CK1_1	207	213	PF00069	0.327
MOD_CK1_1	229	235	PF00069	0.369
MOD_CK1_1	363	369	PF00069	0.412
MOD_CK1_1	596	602	PF00069	0.368
MOD_CK1_1	749	755	PF00069	0.466
MOD_CK1_1	76	82	PF00069	0.754
MOD_CK2_1	130	136	PF00069	0.354
MOD_CK2_1	21	27	PF00069	0.603
MOD_CK2_1	329	335	PF00069	0.430
MOD_GlcNHglycan	315	318	PF01048	0.223
MOD_GlcNHglycan	412	416	PF01048	0.310
MOD_GlcNHglycan	521	524	PF01048	0.591
MOD_GlcNHglycan	622	625	PF01048	0.411
MOD_GlcNHglycan	643	646	PF01048	0.367
MOD_GlcNHglycan	671	674	PF01048	0.432
MOD_GlcNHglycan	76	79	PF01048	0.601
MOD_GlcNHglycan	80	83	PF01048	0.605
MOD_GlcNHglycan	86	90	PF01048	0.499
MOD_GSK3_1	102	109	PF00069	0.430
MOD_GSK3_1	126	133	PF00069	0.356
MOD_GSK3_1	17	24	PF00069	0.649
MOD_GSK3_1	171	178	PF00069	0.334
MOD_GSK3_1	313	320	PF00069	0.424
MOD_GSK3_1	404	411	PF00069	0.493
MOD_GSK3_1	502	509	PF00069	0.629
MOD_GSK3_1	515	522	PF00069	0.758
MOD_GSK3_1	541	548	PF00069	0.530
MOD_GSK3_1	68	75	PF00069	0.637
MOD_GSK3_1	680	687	PF00069	0.453
MOD_N-GLC_1	113	118	PF02516	0.322
MOD_N-GLC_1	44	49	PF02516	0.392
MOD_NEK2_1	107	112	PF00069	0.397
MOD_NEK2_1	130	135	PF00069	0.272
MOD_NEK2_1	19	24	PF00069	0.521
MOD_NEK2_1	360	365	PF00069	0.443
MOD_NEK2_1	446	451	PF00069	0.514
MOD_NEK2_1	583	588	PF00069	0.464
MOD_NEK2_1	652	657	PF00069	0.449
MOD_NEK2_1	669	674	PF00069	0.477
MOD_NEK2_2	317	322	PF00069	0.423
MOD_PIKK_1	118	124	PF00454	0.260
MOD_PIKK_1	374	380	PF00454	0.354
MOD_PIKK_1	684	690	PF00454	0.369
MOD_PKA_1	653	659	PF00069	0.388
MOD_PKA_2	171	177	PF00069	0.462
MOD_PKA_2	638	644	PF00069	0.450
MOD_PKA_2	652	658	PF00069	0.432
MOD_Plk_1	130	136	PF00069	0.266
MOD_Plk_1	183	189	PF00069	0.310
MOD_Plk_1	44	50	PF00069	0.285
MOD_Plk_1	446	452	PF00069	0.466
MOD_Plk_1	684	690	PF00069	0.480
MOD_Plk_4	107	113	PF00069	0.211
MOD_Plk_4	130	136	PF00069	0.344
MOD_Plk_4	183	189	PF00069	0.288
MOD_Plk_4	599	605	PF00069	0.302
MOD_Plk_4	661	667	PF00069	0.354
MOD_Plk_4	91	97	PF00069	0.396
MOD_ProDKin_1	102	108	PF00069	0.504
MOD_ProDKin_1	204	210	PF00069	0.313
MOD_ProDKin_1	229	235	PF00069	0.369
MOD_ProDKin_1	31	37	PF00069	0.654
MOD_ProDKin_1	329	335	PF00069	0.412
MOD_ProDKin_1	431	437	PF00069	0.412
MOD_ProDKin_1	541	547	PF00069	0.589
MOD_ProDKin_1	593	599	PF00069	0.535
MOD_ProDKin_1	749	755	PF00069	0.580
MOD_SUMO_for_1	483	486	PF00179	0.566
MOD_SUMO_for_1	512	515	PF00179	0.710
MOD_SUMO_rev_2	248	254	PF00179	0.412
MOD_SUMO_rev_2	482	490	PF00179	0.606
TRG_DiLeu_BaLyEn_6	103	108	PF01217	0.460
TRG_DiLeu_BaLyEn_6	262	267	PF01217	0.412
TRG_DiLeu_BaLyEn_6	391	396	PF01217	0.354
TRG_ENDOCYTIC_2	52	55	PF00928	0.346
TRG_ER_diArg_1	157	160	PF00400	0.366
TRG_ER_diArg_1	263	266	PF00400	0.439
TRG_ER_diArg_1	40	42	PF00400	0.312
TRG_ER_diArg_1	652	654	PF00400	0.480
TRG_ER_diArg_1	689	692	PF00400	0.379
TRG_NLS_Bipartite_1	252	266	PF00514	0.412
TRG_NLS_MonoExtC_3	4	9	PF00514	0.521
TRG_NLS_MonoExtN_4	2	9	PF00514	0.522
TRG_Pf-PMV_PEXEL_1	149	153	PF00026	0.397
TRG_Pf-PMV_PEXEL_1	478	482	PF00026	0.566
TRG_Pf-PMV_PEXEL_1	566	570	PF00026	0.526

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZE7	Leptomonas seymouri	73%	98%
A0A1X0P7M3	Trypanosomatidae	58%	100%
A0A3Q8INR5	Leishmania donovani	85%	99%
A0A3R7NNX1	Trypanosoma rangeli	58%	100%
A4IDJ1	Leishmania infantum	85%	99%
D0A386	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9ASZ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
O13935	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
P38205	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
Q08J23	Homo sapiens	31%	99%
Q1HFZ0	Mus musculus	31%	100%
Q28E61	Xenopus tropicalis	31%	95%
Q4Q1K4	Leishmania major	84%	100%
Q4V7N2	Xenopus laevis	31%	100%
Q5ZLV4	Gallus gallus	31%	96%
Q9HGQ2	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	100%
V5DCJ5	Trypanosoma cruzi	63%	100%