Dynein light chain

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Dynein light chain

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HP85_LEIBR

TriTrypDb:

LbrM.35.2400 , LBRM2903_350030600

Length:

129

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0005874	microtubule	6	10
GO:0005875	microtubule associated complex	2	10
GO:0030286	dynein complex	3	10
GO:0032991	protein-containing complex	1	10
GO:0099080	supramolecular complex	2	10
GO:0099081	supramolecular polymer	3	10
GO:0099512	supramolecular fiber	4	10
GO:0099513	polymeric cytoskeletal fiber	5	10
GO:0110165	cellular anatomical entity	1	10
GO:1902494	catalytic complex	2	10
GO:0005868	cytoplasmic dynein complex	4	1

Expansion

Sequence features

A4HP85

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP85

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	10
GO:0009987	cellular process	1	10

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0045505	dynein intermediate chain binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	67	69	PF00675	0.294
CLV_PCSK_KEX2_1	66	68	PF00082	0.276
CLV_PCSK_PC1ET2_1	66	68	PF00082	0.276
CLV_PCSK_SKI1_1	35	39	PF00082	0.311
DOC_MAPK_gen_1	18	28	PF00069	0.601
DOC_USP7_MATH_1	108	112	PF00917	0.561
LIG_BIR_II_1	1	5	PF00653	0.700
LIG_FHA_1	74	80	PF00498	0.490
LIG_FHA_2	55	61	PF00498	0.569
LIG_FHA_2	88	94	PF00498	0.561
LIG_GBD_Chelix_1	61	69	PF00786	0.290
LIG_HCF-1_HBM_1	55	58	PF13415	0.522
LIG_LIR_Gen_1	76	85	PF02991	0.490
LIG_LIR_Nem_3	55	61	PF02991	0.486
LIG_LIR_Nem_3	76	80	PF02991	0.490
LIG_PCNA_yPIPBox_3	98	110	PF02747	0.561
LIG_SH2_STAP1	7	11	PF00017	0.718
LIG_SH2_STAT5	105	108	PF00017	0.532
LIG_SH3_3	111	117	PF00018	0.552
LIG_Sin3_3	45	52	PF02671	0.480
LIG_TRAF2_1	2	5	PF00917	0.696
LIG_UBA3_1	96	100	PF00899	0.561
MOD_CK2_1	14	20	PF00069	0.615
MOD_GlcNHglycan	110	113	PF01048	0.393
MOD_GSK3_1	31	38	PF00069	0.472
MOD_GSK3_1	69	76	PF00069	0.461
MOD_N-GLC_1	87	92	PF02516	0.303
MOD_NEK2_1	69	74	PF00069	0.487
MOD_Plk_1	54	60	PF00069	0.600
MOD_Plk_1	69	75	PF00069	0.411
MOD_Plk_1	92	98	PF00069	0.561
MOD_Plk_4	92	98	PF00069	0.476
TRG_DiLeu_BaLyEn_6	21	26	PF01217	0.583
TRG_ENDOCYTIC_2	58	61	PF00928	0.490
TRG_ER_diArg_1	67	69	PF00400	0.494
TRG_Pf-PMV_PEXEL_1	35	40	PF00026	0.343
TRG_Pf-PMV_PEXEL_1	67	71	PF00026	0.244

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCT5	Leptomonas seymouri	72%	100%
A0A1X0P7U5	Trypanosomatidae	55%	100%
A0A3Q8IJ25	Leishmania donovani	83%	100%
A0A422NIV0	Trypanosoma rangeli	53%	100%
A4IDJ0	Leishmania infantum	83%	100%
D0A385	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9ASZ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4Q1K5	Leishmania major	82%	100%