Suppressor of disruption of TFIIS

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HP83_LEIBR

TriTrypDb:

LbrM.35.2380 , LBRM2903_350030400

Length:

333

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HP83

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP83

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016787	hydrolase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	131	133	PF00675	0.339
CLV_NRD_NRD_1	194	196	PF00675	0.507
CLV_NRD_NRD_1	234	236	PF00675	0.665
CLV_NRD_NRD_1	50	52	PF00675	0.509
CLV_PCSK_KEX2_1	194	196	PF00082	0.507
CLV_PCSK_KEX2_1	50	52	PF00082	0.294
CLV_PCSK_SKI1_1	132	136	PF00082	0.434
CLV_PCSK_SKI1_1	141	145	PF00082	0.421
CLV_PCSK_SKI1_1	311	315	PF00082	0.487
DEG_SPOP_SBC_1	215	219	PF00917	0.655
DOC_CYCLIN_yCln2_LP_2	183	189	PF00134	0.323
DOC_MAPK_gen_1	146	154	PF00069	0.615
DOC_MAPK_JIP1_4	148	154	PF00069	0.585
DOC_MAPK_MEF2A_6	146	154	PF00069	0.615
DOC_MAPK_MEF2A_6	90	99	PF00069	0.506
DOC_PP4_FxxP_1	144	147	PF00568	0.525
DOC_USP7_MATH_1	126	130	PF00917	0.492
DOC_USP7_MATH_1	227	231	PF00917	0.735
DOC_USP7_MATH_1	301	305	PF00917	0.476
DOC_USP7_MATH_1	325	329	PF00917	0.475
DOC_WW_Pin1_4	228	233	PF00397	0.580
LIG_14-3-3_CanoR_1	235	243	PF00244	0.581
LIG_14-3-3_CterR_2	329	333	PF00244	0.683
LIG_Actin_WH2_2	303	319	PF00022	0.503
LIG_Clathr_ClatBox_1	262	266	PF01394	0.493
LIG_Clathr_ClatBox_1	7	11	PF01394	0.375
LIG_CtBP_PxDLS_1	268	272	PF00389	0.470
LIG_deltaCOP1_diTrp_1	171	175	PF00928	0.491
LIG_deltaCOP1_diTrp_1	270	277	PF00928	0.466
LIG_FHA_1	182	188	PF00498	0.393
LIG_FHA_2	11	17	PF00498	0.472
LIG_FHA_2	18	24	PF00498	0.523
LIG_FHA_2	316	322	PF00498	0.370
LIG_LIR_Apic_2	107	112	PF02991	0.635
LIG_LIR_Gen_1	156	164	PF02991	0.544
LIG_LIR_Gen_1	253	263	PF02991	0.469
LIG_LIR_Gen_1	3	10	PF02991	0.489
LIG_LIR_Gen_1	73	78	PF02991	0.442
LIG_LIR_Gen_1	82	91	PF02991	0.382
LIG_LIR_Nem_3	156	160	PF02991	0.602
LIG_LIR_Nem_3	171	175	PF02991	0.523
LIG_LIR_Nem_3	198	204	PF02991	0.449
LIG_LIR_Nem_3	253	258	PF02991	0.467
LIG_LIR_Nem_3	270	276	PF02991	0.467
LIG_LIR_Nem_3	3	8	PF02991	0.476
LIG_LIR_Nem_3	73	77	PF02991	0.369
LIG_LIR_Nem_3	82	86	PF02991	0.365
LIG_PCNA_yPIPBox_3	85	96	PF02747	0.506
LIG_PTB_Apo_2	25	32	PF02174	0.294
LIG_PTB_Apo_2	9	16	PF02174	0.344
LIG_PTB_Phospho_1	9	15	PF10480	0.337
LIG_SH2_CRK	109	113	PF00017	0.624
LIG_SH2_CRK	83	87	PF00017	0.480
LIG_SH2_CRK	88	92	PF00017	0.457
LIG_SH2_GRB2like	123	126	PF00017	0.314
LIG_SH2_NCK_1	123	127	PF00017	0.313
LIG_SH2_NCK_1	197	201	PF00017	0.467
LIG_SH2_SRC	15	18	PF00017	0.513
LIG_SH2_STAP1	177	181	PF00017	0.391
LIG_SH2_STAP1	197	201	PF00017	0.209
LIG_SH2_STAP1	298	302	PF00017	0.519
LIG_SH2_STAP1	74	78	PF00017	0.488
LIG_SH2_STAT3	177	180	PF00017	0.389
LIG_SH2_STAT5	101	104	PF00017	0.392
LIG_SH2_STAT5	123	126	PF00017	0.399
LIG_SH2_STAT5	63	66	PF00017	0.488
LIG_SH3_3	147	153	PF00018	0.629
LIG_SUMO_SIM_par_1	312	318	PF11976	0.392
LIG_SUMO_SIM_par_1	6	11	PF11976	0.383
LIG_UBA3_1	313	317	PF00899	0.348
MOD_CDK_SPxxK_3	228	235	PF00069	0.502
MOD_CK1_1	291	297	PF00069	0.587
MOD_CK2_1	10	16	PF00069	0.398
MOD_CK2_1	236	242	PF00069	0.533
MOD_CK2_1	309	315	PF00069	0.426
MOD_GlcNHglycan	225	228	PF01048	0.724
MOD_GlcNHglycan	238	241	PF01048	0.573
MOD_GlcNHglycan	293	296	PF01048	0.549
MOD_GlcNHglycan	303	306	PF01048	0.402
MOD_GSK3_1	210	217	PF00069	0.586
MOD_GSK3_1	223	230	PF00069	0.570
MOD_GSK3_1	284	291	PF00069	0.536
MOD_GSK3_1	325	332	PF00069	0.600
MOD_N-GLC_1	126	131	PF02516	0.455
MOD_N-GLC_1	291	296	PF02516	0.541
MOD_NEK2_1	214	219	PF00069	0.646
MOD_NEK2_1	234	239	PF00069	0.613
MOD_NEK2_1	95	100	PF00069	0.476
MOD_NEK2_2	56	61	PF00069	0.477
MOD_PKA_2	181	187	PF00069	0.505
MOD_PKA_2	234	240	PF00069	0.626
MOD_Plk_1	10	16	PF00069	0.346
MOD_Plk_1	210	216	PF00069	0.479
MOD_Plk_1	258	264	PF00069	0.498
MOD_Plk_4	10	16	PF00069	0.307
MOD_Plk_4	210	216	PF00069	0.484
MOD_Plk_4	258	264	PF00069	0.472
MOD_ProDKin_1	228	234	PF00069	0.576
MOD_SUMO_rev_2	239	248	PF00179	0.383
MOD_SUMO_rev_2	284	291	PF00179	0.530
MOD_SUMO_rev_2	312	319	PF00179	0.288
TRG_DiLeu_BaEn_1	210	215	PF01217	0.559
TRG_DiLeu_BaEn_2	72	78	PF01217	0.536
TRG_ENDOCYTIC_2	157	160	PF00928	0.568
TRG_ENDOCYTIC_2	197	200	PF00928	0.393
TRG_ENDOCYTIC_2	201	204	PF00928	0.398
TRG_ENDOCYTIC_2	74	77	PF00928	0.459
TRG_ENDOCYTIC_2	83	86	PF00928	0.473
TRG_ER_diArg_1	146	149	PF00400	0.569
TRG_ER_diArg_1	193	195	PF00400	0.519
TRG_ER_diArg_1	26	29	PF00400	0.303
TRG_ER_diArg_1	50	52	PF00400	0.294
TRG_Pf-PMV_PEXEL_1	311	315	PF00026	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I684	Leptomonas seymouri	67%	100%
A0A0S4JSE6	Bodo saltans	27%	100%
A0A1X0P7P0	Trypanosomatidae	29%	100%
A0A3S7XB03	Leishmania donovani	80%	94%
A0A422N520	Trypanosoma rangeli	27%	100%
A4IDI8	Leishmania infantum	79%	94%
E9ASZ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q1K7	Leishmania major	81%	100%
V5BKX8	Trypanosoma cruzi	28%	100%