Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HP80_LEIBR

TriTrypDb:

LbrM.35.2350 , LBRM2903_350030100

Length:

795

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HP80

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP80

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	326	330	PF00656	0.529
CLV_C14_Caspase3-7	749	753	PF00656	0.594
CLV_NRD_NRD_1	127	129	PF00675	0.568
CLV_NRD_NRD_1	173	175	PF00675	0.828
CLV_NRD_NRD_1	238	240	PF00675	0.829
CLV_NRD_NRD_1	408	410	PF00675	0.568
CLV_NRD_NRD_1	431	433	PF00675	0.663
CLV_NRD_NRD_1	448	450	PF00675	0.576
CLV_NRD_NRD_1	502	504	PF00675	0.728
CLV_NRD_NRD_1	590	592	PF00675	0.736
CLV_NRD_NRD_1	656	658	PF00675	0.712
CLV_NRD_NRD_1	698	700	PF00675	0.707
CLV_PCSK_KEX2_1	127	129	PF00082	0.568
CLV_PCSK_KEX2_1	173	175	PF00082	0.828
CLV_PCSK_KEX2_1	240	242	PF00082	0.675
CLV_PCSK_KEX2_1	408	410	PF00082	0.568
CLV_PCSK_KEX2_1	448	450	PF00082	0.596
CLV_PCSK_KEX2_1	502	504	PF00082	0.728
CLV_PCSK_KEX2_1	590	592	PF00082	0.730
CLV_PCSK_KEX2_1	655	657	PF00082	0.690
CLV_PCSK_KEX2_1	698	700	PF00082	0.707
CLV_PCSK_PC1ET2_1	240	242	PF00082	0.622
CLV_PCSK_SKI1_1	368	372	PF00082	0.559
CLV_PCSK_SKI1_1	432	436	PF00082	0.712
CLV_PCSK_SKI1_1	460	464	PF00082	0.619
CLV_PCSK_SKI1_1	502	506	PF00082	0.731
CLV_PCSK_SKI1_1	535	539	PF00082	0.560
CLV_PCSK_SKI1_1	698	702	PF00082	0.606
CLV_Separin_Metazoa	113	117	PF03568	0.810
DEG_APCC_DBOX_1	251	259	PF00400	0.556
DEG_APCC_DBOX_1	431	439	PF00400	0.711
DEG_APCC_DBOX_1	501	509	PF00400	0.730
DEG_SCF_FBW7_1	369	375	PF00400	0.564
DEG_SPOP_SBC_1	211	215	PF00917	0.679
DEG_SPOP_SBC_1	664	668	PF00917	0.557
DEG_SPOP_SBC_1	719	723	PF00917	0.606
DOC_CKS1_1	369	374	PF01111	0.571
DOC_CKS1_1	762	767	PF01111	0.721
DOC_CKS1_1	85	90	PF01111	0.807
DOC_CYCLIN_RxL_1	695	705	PF00134	0.699
DOC_CYCLIN_yCln2_LP_2	21	27	PF00134	0.534
DOC_CYCLIN_yCln2_LP_2	510	516	PF00134	0.499
DOC_CYCLIN_yCln2_LP_2	6	12	PF00134	0.784
DOC_MAPK_FxFP_2	771	774	PF00069	0.540
DOC_MAPK_gen_1	250	257	PF00069	0.650
DOC_MAPK_gen_1	388	397	PF00069	0.561
DOC_MAPK_gen_1	502	510	PF00069	0.731
DOC_MAPK_MEF2A_6	281	289	PF00069	0.549
DOC_MAPK_MEF2A_6	617	626	PF00069	0.529
DOC_PP2B_LxvP_1	519	522	PF13499	0.788
DOC_PP4_FxxP_1	169	172	PF00568	0.597
DOC_PP4_FxxP_1	424	427	PF00568	0.795
DOC_PP4_FxxP_1	672	675	PF00568	0.553
DOC_PP4_FxxP_1	771	774	PF00568	0.633
DOC_USP7_MATH_1	109	113	PF00917	0.541
DOC_USP7_MATH_1	161	165	PF00917	0.652
DOC_USP7_MATH_1	188	192	PF00917	0.692
DOC_USP7_MATH_1	195	199	PF00917	0.575
DOC_USP7_MATH_1	211	215	PF00917	0.663
DOC_USP7_MATH_1	229	233	PF00917	0.548
DOC_USP7_MATH_1	37	41	PF00917	0.687
DOC_USP7_MATH_1	372	376	PF00917	0.694
DOC_USP7_MATH_1	380	384	PF00917	0.575
DOC_USP7_MATH_1	549	553	PF00917	0.679
DOC_USP7_MATH_1	584	588	PF00917	0.540
DOC_USP7_MATH_1	665	669	PF00917	0.777
DOC_USP7_MATH_1	70	74	PF00917	0.581
DOC_USP7_MATH_1	707	711	PF00917	0.706
DOC_USP7_MATH_1	760	764	PF00917	0.673
DOC_USP7_MATH_1	772	776	PF00917	0.619
DOC_WW_Pin1_4	1	6	PF00397	0.775
DOC_WW_Pin1_4	181	186	PF00397	0.854
DOC_WW_Pin1_4	200	205	PF00397	0.518
DOC_WW_Pin1_4	281	286	PF00397	0.793
DOC_WW_Pin1_4	339	344	PF00397	0.628
DOC_WW_Pin1_4	368	373	PF00397	0.615
DOC_WW_Pin1_4	376	381	PF00397	0.548
DOC_WW_Pin1_4	39	44	PF00397	0.772
DOC_WW_Pin1_4	455	460	PF00397	0.609
DOC_WW_Pin1_4	477	482	PF00397	0.629
DOC_WW_Pin1_4	689	694	PF00397	0.692
DOC_WW_Pin1_4	720	725	PF00397	0.635
DOC_WW_Pin1_4	761	766	PF00397	0.723
DOC_WW_Pin1_4	778	783	PF00397	0.524
DOC_WW_Pin1_4	788	793	PF00397	0.627
DOC_WW_Pin1_4	8	13	PF00397	0.679
DOC_WW_Pin1_4	84	89	PF00397	0.558
LIG_14-3-3_CanoR_1	127	133	PF00244	0.593
LIG_14-3-3_CanoR_1	180	185	PF00244	0.641
LIG_14-3-3_CanoR_1	196	200	PF00244	0.678
LIG_14-3-3_CanoR_1	265	274	PF00244	0.780
LIG_14-3-3_CanoR_1	363	370	PF00244	0.561
LIG_14-3-3_CanoR_1	535	543	PF00244	0.554
LIG_14-3-3_CanoR_1	617	623	PF00244	0.771
LIG_14-3-3_CanoR_1	659	665	PF00244	0.777
LIG_Actin_WH2_2	103	118	PF00022	0.803
LIG_APCC_ABBA_1	673	678	PF00400	0.557
LIG_BRCT_BRCA1_1	561	565	PF00533	0.815
LIG_BRCT_BRCA1_1	614	618	PF00533	0.782
LIG_BRCT_BRCA1_1	668	672	PF00533	0.564
LIG_FHA_1	233	239	PF00498	0.564
LIG_FHA_1	49	55	PF00498	0.798
LIG_FHA_1	536	542	PF00498	0.553
LIG_FHA_1	570	576	PF00498	0.608
LIG_FHA_1	580	586	PF00498	0.518
LIG_FHA_1	727	733	PF00498	0.626
LIG_FHA_1	76	82	PF00498	0.708
LIG_FHA_1	762	768	PF00498	0.563
LIG_FHA_2	201	207	PF00498	0.796
LIG_FHA_2	295	301	PF00498	0.782
LIG_FHA_2	420	426	PF00498	0.655
LIG_FHA_2	58	64	PF00498	0.580
LIG_FHA_2	643	649	PF00498	0.589
LIG_Integrin_RGD_1	740	742	PF01839	0.591
LIG_LIR_Apic_2	421	427	PF02991	0.810
LIG_LIR_Apic_2	669	675	PF02991	0.557
LIG_LIR_Gen_1	101	110	PF02991	0.798
LIG_LIR_Gen_1	391	402	PF02991	0.551
LIG_LIR_Gen_1	667	677	PF02991	0.551
LIG_LIR_Nem_3	391	397	PF02991	0.651
LIG_LIR_Nem_3	562	568	PF02991	0.781
LIG_LIR_Nem_3	667	673	PF02991	0.555
LIG_LYPXL_S_1	494	498	PF13949	0.744
LIG_LYPXL_SIV_4	24	32	PF13949	0.740
LIG_LYPXL_SIV_4	427	435	PF13949	0.552
LIG_LYPXL_yS_3	495	498	PF13949	0.744
LIG_NRBOX	696	702	PF00104	0.706
LIG_PDZ_Class_2	790	795	PF00595	0.591
LIG_PTAP_UEV_1	58	63	PF05743	0.630
LIG_PTAP_UEV_1	71	76	PF05743	0.602
LIG_SH2_NCK_1	25	29	PF00017	0.737
LIG_SH2_PTP2	493	496	PF00017	0.757
LIG_SH2_SRC	493	496	PF00017	0.757
LIG_SH2_STAT3	119	122	PF00017	0.835
LIG_SH2_STAT5	189	192	PF00017	0.729
LIG_SH2_STAT5	400	403	PF00017	0.542
LIG_SH2_STAT5	489	492	PF00017	0.747
LIG_SH2_STAT5	493	496	PF00017	0.741
LIG_SH3_1	308	314	PF00018	0.567
LIG_SH3_3	16	22	PF00018	0.624
LIG_SH3_3	182	188	PF00018	0.850
LIG_SH3_3	279	285	PF00018	0.792
LIG_SH3_3	303	309	PF00018	0.790
LIG_SH3_3	337	343	PF00018	0.570
LIG_SH3_3	366	372	PF00018	0.666
LIG_SH3_3	392	398	PF00018	0.711
LIG_SH3_3	478	484	PF00018	0.590
LIG_SH3_3	485	491	PF00018	0.529
LIG_SH3_3	518	524	PF00018	0.805
LIG_SH3_3	53	59	PF00018	0.677
LIG_SH3_3	572	578	PF00018	0.592
LIG_SH3_3	6	12	PF00018	0.784
LIG_SH3_3	647	653	PF00018	0.751
LIG_SH3_3	66	72	PF00018	0.799
LIG_SH3_3	779	785	PF00018	0.569
LIG_SH3_3	85	91	PF00018	0.476
LIG_SUMO_SIM_anti_2	602	609	PF11976	0.544
LIG_SUMO_SIM_par_1	284	291	PF11976	0.550
LIG_SUMO_SIM_par_1	581	588	PF11976	0.551
LIG_TRAF2_1	497	500	PF00917	0.730
LIG_WW_3	520	524	PF00397	0.808
MOD_CDK_SPK_2	455	460	PF00069	0.609
MOD_CDK_SPxK_1	778	784	PF00069	0.725
MOD_CDK_SPxxK_3	1	8	PF00069	0.749
MOD_CDK_SPxxK_3	460	467	PF00069	0.608
MOD_CK1_1	101	107	PF00069	0.526
MOD_CK1_1	149	155	PF00069	0.589
MOD_CK1_1	179	185	PF00069	0.692
MOD_CK1_1	191	197	PF00069	0.763
MOD_CK1_1	220	226	PF00069	0.700
MOD_CK1_1	232	238	PF00069	0.612
MOD_CK1_1	267	273	PF00069	0.819
MOD_CK1_1	328	334	PF00069	0.748
MOD_CK1_1	348	354	PF00069	0.500
MOD_CK1_1	36	42	PF00069	0.551
MOD_CK1_1	376	382	PF00069	0.581
MOD_CK1_1	465	471	PF00069	0.655
MOD_CK1_1	480	486	PF00069	0.733
MOD_CK1_1	528	534	PF00069	0.695
MOD_CK1_1	544	550	PF00069	0.657
MOD_CK1_1	559	565	PF00069	0.556
MOD_CK1_1	569	575	PF00069	0.533
MOD_CK1_1	64	70	PF00069	0.834
MOD_CK1_1	663	669	PF00069	0.759
MOD_CK2_1	128	134	PF00069	0.846
MOD_CK2_1	245	251	PF00069	0.573
MOD_CK2_1	294	300	PF00069	0.780
MOD_CK2_1	57	63	PF00069	0.583
MOD_CK2_1	596	602	PF00069	0.783
MOD_CK2_1	643	649	PF00069	0.842
MOD_Cter_Amidation	406	409	PF01082	0.572
MOD_DYRK1A_RPxSP_1	368	372	PF00069	0.559
MOD_DYRK1A_RPxSP_1	460	464	PF00069	0.608
MOD_DYRK1A_RPxSP_1	8	12	PF00069	0.781
MOD_GlcNHglycan	190	193	PF01048	0.811
MOD_GlcNHglycan	219	222	PF01048	0.665
MOD_GlcNHglycan	35	38	PF01048	0.799
MOD_GlcNHglycan	350	353	PF01048	0.626
MOD_GlcNHglycan	356	359	PF01048	0.649
MOD_GlcNHglycan	39	42	PF01048	0.743
MOD_GlcNHglycan	468	471	PF01048	0.848
MOD_GlcNHglycan	473	476	PF01048	0.721
MOD_GlcNHglycan	528	531	PF01048	0.700
MOD_GlcNHglycan	558	561	PF01048	0.712
MOD_GlcNHglycan	568	571	PF01048	0.616
MOD_GlcNHglycan	598	601	PF01048	0.527
MOD_GlcNHglycan	662	665	PF01048	0.717
MOD_GlcNHglycan	693	696	PF01048	0.559
MOD_GlcNHglycan	72	75	PF01048	0.776
MOD_GlcNHglycan	748	751	PF01048	0.636
MOD_GSK3_1	128	135	PF00069	0.599
MOD_GSK3_1	146	153	PF00069	0.764
MOD_GSK3_1	172	179	PF00069	0.722
MOD_GSK3_1	190	197	PF00069	0.675
MOD_GSK3_1	213	220	PF00069	0.740
MOD_GSK3_1	263	270	PF00069	0.817
MOD_GSK3_1	281	288	PF00069	0.503
MOD_GSK3_1	323	330	PF00069	0.570
MOD_GSK3_1	33	40	PF00069	0.800
MOD_GSK3_1	335	342	PF00069	0.660
MOD_GSK3_1	368	375	PF00069	0.641
MOD_GSK3_1	376	383	PF00069	0.587
MOD_GSK3_1	458	465	PF00069	0.829
MOD_GSK3_1	471	478	PF00069	0.622
MOD_GSK3_1	524	531	PF00069	0.743
MOD_GSK3_1	566	573	PF00069	0.654
MOD_GSK3_1	57	64	PF00069	0.754
MOD_GSK3_1	579	586	PF00069	0.535
MOD_GSK3_1	612	619	PF00069	0.566
MOD_GSK3_1	637	644	PF00069	0.763
MOD_GSK3_1	659	666	PF00069	0.769
MOD_GSK3_1	727	734	PF00069	0.646
MOD_GSK3_1	772	779	PF00069	0.708
MOD_GSK3_1	8	15	PF00069	0.780
MOD_GSK3_1	94	101	PF00069	0.771
MOD_N-GLC_1	354	359	PF02516	0.575
MOD_N-GLC_1	595	600	PF02516	0.528
MOD_N-GLC_1	689	694	PF02516	0.575
MOD_NEK2_1	115	120	PF00069	0.824
MOD_NEK2_1	217	222	PF00069	0.824
MOD_NEK2_1	263	268	PF00069	0.562
MOD_NEK2_1	287	292	PF00069	0.550
MOD_NEK2_1	373	378	PF00069	0.576
MOD_NEK2_1	525	530	PF00069	0.764
MOD_NEK2_1	618	623	PF00069	0.651
MOD_NEK2_1	787	792	PF00069	0.729
MOD_NEK2_1	94	99	PF00069	0.558
MOD_NEK2_2	530	535	PF00069	0.569
MOD_PIKK_1	12	18	PF00454	0.783
MOD_PIKK_1	172	178	PF00454	0.606
MOD_PIKK_1	242	248	PF00454	0.607
MOD_PIKK_1	265	271	PF00454	0.820
MOD_PIKK_1	544	550	PF00454	0.565
MOD_PIKK_1	61	67	PF00454	0.584
MOD_PIKK_1	643	649	PF00454	0.842
MOD_PK_1	128	134	PF00069	0.574
MOD_PKA_2	115	121	PF00069	0.826
MOD_PKA_2	149	155	PF00069	0.677
MOD_PKA_2	172	178	PF00069	0.606
MOD_PKA_2	179	185	PF00069	0.611
MOD_PKA_2	195	201	PF00069	0.681
MOD_PKA_2	264	270	PF00069	0.778
MOD_PKA_2	362	368	PF00069	0.776
MOD_PKA_2	466	472	PF00069	0.765
MOD_PKA_2	57	63	PF00069	0.747
MOD_PKA_2	616	622	PF00069	0.562
MOD_PKA_2	701	707	PF00069	0.566
MOD_PKB_1	657	665	PF00069	0.581
MOD_Plk_1	323	329	PF00069	0.561
MOD_Plk_1	602	608	PF00069	0.756
MOD_Plk_2-3	23	29	PF00069	0.777
MOD_Plk_2-3	419	425	PF00069	0.609
MOD_Plk_4	101	107	PF00069	0.795
MOD_Plk_4	128	134	PF00069	0.632
MOD_Plk_4	213	219	PF00069	0.828
MOD_Plk_4	267	273	PF00069	0.761
MOD_Plk_4	419	425	PF00069	0.823
MOD_Plk_4	602	608	PF00069	0.756
MOD_Plk_4	707	713	PF00069	0.713
MOD_Plk_4	727	733	PF00069	0.516
MOD_ProDKin_1	1	7	PF00069	0.775
MOD_ProDKin_1	181	187	PF00069	0.853
MOD_ProDKin_1	200	206	PF00069	0.519
MOD_ProDKin_1	281	287	PF00069	0.796
MOD_ProDKin_1	339	345	PF00069	0.629
MOD_ProDKin_1	368	374	PF00069	0.616
MOD_ProDKin_1	376	382	PF00069	0.550
MOD_ProDKin_1	39	45	PF00069	0.773
MOD_ProDKin_1	455	461	PF00069	0.609
MOD_ProDKin_1	477	483	PF00069	0.627
MOD_ProDKin_1	689	695	PF00069	0.690
MOD_ProDKin_1	720	726	PF00069	0.634
MOD_ProDKin_1	761	767	PF00069	0.722
MOD_ProDKin_1	778	784	PF00069	0.526
MOD_ProDKin_1	788	794	PF00069	0.627
MOD_ProDKin_1	8	14	PF00069	0.677
MOD_ProDKin_1	84	90	PF00069	0.555
TRG_DiLeu_BaEn_1	500	505	PF01217	0.730
TRG_DiLeu_BaEn_1	602	607	PF01217	0.541
TRG_DiLeu_BaLyEn_6	16	21	PF01217	0.560
TRG_DiLeu_BaLyEn_6	2	7	PF01217	0.786
TRG_DiLeu_BaLyEn_6	282	287	PF01217	0.548
TRG_DiLeu_BaLyEn_6	510	515	PF01217	0.495
TRG_DiLeu_BaLyEn_6	696	701	PF01217	0.707
TRG_DiLeu_BaLyEn_6	88	93	PF01217	0.791
TRG_DiLeu_LyEn_5	500	505	PF01217	0.730
TRG_ENDOCYTIC_2	495	498	PF00928	0.744
TRG_ER_diArg_1	172	174	PF00400	0.611
TRG_ER_diArg_1	238	241	PF00400	0.618
TRG_ER_diArg_1	252	255	PF00400	0.537
TRG_ER_diArg_1	274	277	PF00400	0.657
TRG_ER_diArg_1	447	449	PF00400	0.618
TRG_ER_diArg_1	502	504	PF00400	0.728
TRG_ER_diArg_1	590	592	PF00400	0.736
TRG_ER_diArg_1	655	657	PF00400	0.709
TRG_ER_diArg_1	697	699	PF00400	0.700
TRG_NLS_MonoExtC_3	238	243	PF00514	0.615
TRG_Pf-PMV_PEXEL_1	502	507	PF00026	0.729
TRG_Pf-PMV_PEXEL_1	698	703	PF00026	0.695

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7XAU5	Leishmania donovani	58%	100%
A4IDI5	Leishmania infantum	58%	100%
E9ASY8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	59%	100%
Q4Q1L0	Leishmania major	59%	97%