N-acetyltransferase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HP78_LEIBR

TriTrypDb:

LbrM.35.2330 , LBRM2903_350029900

Length:

371

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HP78

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP78

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0016407	acetyltransferase activity	5	8
GO:0016740	transferase activity	2	8
GO:0016746	acyltransferase activity	3	8
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	126	128	PF00675	0.659
CLV_NRD_NRD_1	197	199	PF00675	0.547
CLV_PCSK_KEX2_1	126	128	PF00082	0.659
CLV_PCSK_KEX2_1	199	201	PF00082	0.503
CLV_PCSK_PC1ET2_1	199	201	PF00082	0.604
CLV_PCSK_SKI1_1	185	189	PF00082	0.481
CLV_PCSK_SKI1_1	288	292	PF00082	0.490
CLV_PCSK_SKI1_1	351	355	PF00082	0.504
CLV_PCSK_SKI1_1	359	363	PF00082	0.386
CLV_PCSK_SKI1_1	58	62	PF00082	0.570
DEG_Nend_Nbox_1	1	3	PF02207	0.551
DOC_CYCLIN_yCln2_LP_2	362	368	PF00134	0.364
DOC_MAPK_gen_1	162	170	PF00069	0.419
DOC_MAPK_gen_1	292	300	PF00069	0.494
DOC_PP1_RVXF_1	295	301	PF00149	0.426
DOC_PP1_RVXF_1	56	63	PF00149	0.575
DOC_PP4_FxxP_1	175	178	PF00568	0.443
DOC_PP4_FxxP_1	50	53	PF00568	0.611
DOC_USP7_MATH_1	108	112	PF00917	0.777
DOC_USP7_MATH_1	336	340	PF00917	0.682
DOC_WW_Pin1_4	65	70	PF00397	0.539
DOC_WW_Pin1_4	75	80	PF00397	0.699
DOC_WW_Pin1_4	99	104	PF00397	0.726
LIG_14-3-3_CanoR_1	126	134	PF00244	0.597
LIG_14-3-3_CanoR_1	185	190	PF00244	0.529
LIG_14-3-3_CanoR_1	210	218	PF00244	0.434
LIG_14-3-3_CanoR_1	7	11	PF00244	0.584
LIG_FHA_1	14	20	PF00498	0.511
LIG_FHA_1	212	218	PF00498	0.400
LIG_FHA_1	220	226	PF00498	0.397
LIG_FHA_1	356	362	PF00498	0.300
LIG_FHA_2	135	141	PF00498	0.587
LIG_FHA_2	161	167	PF00498	0.342
LIG_FHA_2	289	295	PF00498	0.532
LIG_FHA_2	33	39	PF00498	0.626
LIG_FHA_2	47	53	PF00498	0.552
LIG_LIR_Apic_2	173	178	PF02991	0.443
LIG_LIR_Apic_2	49	53	PF02991	0.604
LIG_LIR_Gen_1	230	240	PF02991	0.389
LIG_LIR_Gen_1	268	276	PF02991	0.428
LIG_LIR_Nem_3	140	145	PF02991	0.497
LIG_LIR_Nem_3	202	208	PF02991	0.423
LIG_LIR_Nem_3	268	272	PF02991	0.385
LIG_SH2_CRK	14	18	PF00017	0.532
LIG_SH2_STAP1	151	155	PF00017	0.503
LIG_SH2_STAP1	171	175	PF00017	0.432
LIG_SH2_STAP1	205	209	PF00017	0.352
LIG_SH2_STAP1	46	50	PF00017	0.501
LIG_SH2_STAT3	171	174	PF00017	0.431
LIG_SH2_STAT5	208	211	PF00017	0.360
LIG_SH2_STAT5	318	321	PF00017	0.432
LIG_SH3_3	102	108	PF00018	0.600
LIG_SH3_3	175	181	PF00018	0.435
LIG_SH3_3	184	190	PF00018	0.416
LIG_SH3_3	73	79	PF00018	0.608
LIG_SUMO_SIM_par_1	185	192	PF11976	0.622
LIG_TRAF2_1	137	140	PF00917	0.602
LIG_TRAF2_1	163	166	PF00917	0.309
LIG_TRAF2_1	213	216	PF00917	0.553
LIG_TRAF2_1	3	6	PF00917	0.622
LIG_TYR_ITIM	316	321	PF00017	0.509
MOD_CDK_SPK_2	104	109	PF00069	0.529
MOD_CK1_1	111	117	PF00069	0.642
MOD_CK1_1	160	166	PF00069	0.434
MOD_CK1_1	191	197	PF00069	0.553
MOD_CK1_1	339	345	PF00069	0.625
MOD_CK1_1	99	105	PF00069	0.729
MOD_CK2_1	134	140	PF00069	0.585
MOD_CK2_1	160	166	PF00069	0.439
MOD_CK2_1	288	294	PF00069	0.425
MOD_CK2_1	32	38	PF00069	0.565
MOD_GlcNHglycan	201	204	PF01048	0.520
MOD_GlcNHglycan	272	275	PF01048	0.370
MOD_GlcNHglycan	328	331	PF01048	0.724
MOD_GlcNHglycan	338	341	PF01048	0.682
MOD_GlcNHglycan	98	101	PF01048	0.740
MOD_GSK3_1	104	111	PF00069	0.668
MOD_GSK3_1	185	192	PF00069	0.572
MOD_GSK3_1	199	206	PF00069	0.555
MOD_GSK3_1	67	74	PF00069	0.554
MOD_NEK2_1	133	138	PF00069	0.490
MOD_NEK2_1	170	175	PF00069	0.482
MOD_NEK2_1	238	243	PF00069	0.371
MOD_NEK2_1	346	351	PF00069	0.495
MOD_NEK2_1	89	94	PF00069	0.687
MOD_NEK2_2	13	18	PF00069	0.637
MOD_PIKK_1	170	176	PF00454	0.488
MOD_PIKK_1	211	217	PF00454	0.472
MOD_PIKK_1	89	95	PF00454	0.519
MOD_PKA_1	199	205	PF00069	0.559
MOD_PKA_2	125	131	PF00069	0.622
MOD_PKA_2	134	140	PF00069	0.594
MOD_PKA_2	199	205	PF00069	0.559
MOD_PKA_2	6	12	PF00069	0.592
MOD_Plk_4	108	114	PF00069	0.779
MOD_Plk_4	203	209	PF00069	0.367
MOD_Plk_4	311	317	PF00069	0.470
MOD_Plk_4	46	52	PF00069	0.526
MOD_Plk_4	6	12	PF00069	0.587
MOD_ProDKin_1	65	71	PF00069	0.541
MOD_ProDKin_1	75	81	PF00069	0.700
MOD_ProDKin_1	99	105	PF00069	0.726
TRG_DiLeu_BaEn_1	6	11	PF01217	0.515
TRG_DiLeu_BaEn_4	165	171	PF01217	0.517
TRG_DiLeu_BaLyEn_6	129	134	PF01217	0.598
TRG_DiLeu_BaLyEn_6	249	254	PF01217	0.391
TRG_DiLeu_BaLyEn_6	55	60	PF01217	0.529
TRG_ENDOCYTIC_2	14	17	PF00928	0.509
TRG_ENDOCYTIC_2	287	290	PF00928	0.403
TRG_ENDOCYTIC_2	318	321	PF00928	0.533
TRG_ER_diArg_1	125	127	PF00400	0.727
TRG_ER_diArg_1	198	201	PF00400	0.525
TRG_NES_CRM1_1	352	363	PF08389	0.300
TRG_NLS_MonoExtN_4	196	202	PF00514	0.629
TRG_Pf-PMV_PEXEL_1	210	215	PF00026	0.502

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9D4	Leptomonas seymouri	70%	99%
A0A0S4IZI8	Bodo saltans	39%	86%
A0A1X0P7V3	Trypanosomatidae	50%	100%
A0A3R7K298	Trypanosoma rangeli	45%	100%
A0A3S7XAU7	Leishmania donovani	88%	100%
A4IDI3	Leishmania infantum	88%	100%
D0A374	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9ASY6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q1L2	Leishmania major	85%	100%
V5DCI4	Trypanosoma cruzi	45%	100%