UDENN domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HP77_LEIBR

TriTrypDb:

LbrM.35.2320 , LBRM2903_350029800

Length:

962

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005768	endosome	7	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0055037	recycling endosome	8	1
GO:0097708	intracellular vesicle	5	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HP77

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP77

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005085	guanyl-nucleotide exchange factor activity	3	7
GO:0030234	enzyme regulator activity	2	7
GO:0030695	GTPase regulator activity	4	7
GO:0060589	nucleoside-triphosphatase regulator activity	3	7
GO:0098772	molecular function regulator activity	1	7
GO:0140677	molecular function activator activity	2	7
GO:0140678	molecular function inhibitor activity	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	552	556	PF00656	0.726
CLV_C14_Caspase3-7	612	616	PF00656	0.688
CLV_C14_Caspase3-7	707	711	PF00656	0.536
CLV_NRD_NRD_1	257	259	PF00675	0.544
CLV_NRD_NRD_1	661	663	PF00675	0.463
CLV_NRD_NRD_1	787	789	PF00675	0.315
CLV_NRD_NRD_1	839	841	PF00675	0.475
CLV_PCSK_FUR_1	255	259	PF00082	0.543
CLV_PCSK_KEX2_1	257	259	PF00082	0.538
CLV_PCSK_KEX2_1	661	663	PF00082	0.455
CLV_PCSK_KEX2_1	701	703	PF00082	0.343
CLV_PCSK_KEX2_1	839	841	PF00082	0.475
CLV_PCSK_PC1ET2_1	701	703	PF00082	0.340
CLV_PCSK_SKI1_1	46	50	PF00082	0.556
CLV_PCSK_SKI1_1	788	792	PF00082	0.275
DEG_COP1_1	85	93	PF00400	0.402
DEG_SCF_FBW7_1	212	219	PF00400	0.340
DEG_SCF_FBW7_1	624	631	PF00400	0.634
DEG_SPOP_SBC_1	4	8	PF00917	0.326
DOC_CKS1_1	213	218	PF01111	0.337
DOC_CKS1_1	629	634	PF01111	0.626
DOC_CKS1_1	798	803	PF01111	0.312
DOC_CKS1_1	827	832	PF01111	0.367
DOC_CYCLIN_RxL_1	335	349	PF00134	0.535
DOC_CYCLIN_yCln2_LP_2	312	318	PF00134	0.312
DOC_CYCLIN_yCln2_LP_2	490	496	PF00134	0.731
DOC_MAPK_gen_1	335	345	PF00069	0.534
DOC_MAPK_gen_1	701	708	PF00069	0.542
DOC_MAPK_MEF2A_6	715	722	PF00069	0.597
DOC_MAPK_MEF2A_6	905	912	PF00069	0.309
DOC_PP1_RVXF_1	24	30	PF00149	0.373
DOC_PP1_RVXF_1	241	247	PF00149	0.357
DOC_PP1_RVXF_1	339	346	PF00149	0.591
DOC_PP2B_LxvP_1	157	160	PF13499	0.366
DOC_PP2B_LxvP_1	312	315	PF13499	0.312
DOC_PP2B_LxvP_1	464	467	PF13499	0.625
DOC_PP2B_LxvP_1	490	493	PF13499	0.726
DOC_PP2B_LxvP_1	747	750	PF13499	0.715
DOC_PP4_FxxP_1	213	216	PF00568	0.330
DOC_PP4_FxxP_1	29	32	PF00568	0.373
DOC_PP4_FxxP_1	64	67	PF00568	0.349
DOC_PP4_FxxP_1	798	801	PF00568	0.312
DOC_USP7_MATH_1	153	157	PF00917	0.342
DOC_USP7_MATH_1	216	220	PF00917	0.360
DOC_USP7_MATH_1	226	230	PF00917	0.450
DOC_USP7_MATH_1	250	254	PF00917	0.434
DOC_USP7_MATH_1	4	8	PF00917	0.333
DOC_USP7_MATH_1	539	543	PF00917	0.664
DOC_USP7_MATH_1	566	570	PF00917	0.708
DOC_USP7_MATH_1	634	638	PF00917	0.604
DOC_USP7_MATH_1	716	720	PF00917	0.578
DOC_USP7_MATH_1	73	77	PF00917	0.377
DOC_USP7_MATH_1	750	754	PF00917	0.638
DOC_WW_Pin1_4	143	148	PF00397	0.335
DOC_WW_Pin1_4	158	163	PF00397	0.353
DOC_WW_Pin1_4	192	197	PF00397	0.330
DOC_WW_Pin1_4	212	217	PF00397	0.241
DOC_WW_Pin1_4	28	33	PF00397	0.381
DOC_WW_Pin1_4	295	300	PF00397	0.314
DOC_WW_Pin1_4	441	446	PF00397	0.715
DOC_WW_Pin1_4	509	514	PF00397	0.802
DOC_WW_Pin1_4	543	548	PF00397	0.689
DOC_WW_Pin1_4	624	629	PF00397	0.693
DOC_WW_Pin1_4	630	635	PF00397	0.719
DOC_WW_Pin1_4	742	747	PF00397	0.771
DOC_WW_Pin1_4	797	802	PF00397	0.312
DOC_WW_Pin1_4	826	831	PF00397	0.339
LIG_14-3-3_CanoR_1	201	207	PF00244	0.371
LIG_14-3-3_CanoR_1	235	241	PF00244	0.392
LIG_14-3-3_CanoR_1	255	265	PF00244	0.353
LIG_14-3-3_CanoR_1	323	329	PF00244	0.509
LIG_14-3-3_CanoR_1	540	544	PF00244	0.695
LIG_14-3-3_CanoR_1	715	721	PF00244	0.590
LIG_14-3-3_CanoR_1	792	802	PF00244	0.317
LIG_14-3-3_CanoR_1	808	812	PF00244	0.393
LIG_14-3-3_CanoR_1	852	856	PF00244	0.440
LIG_AP2alpha_1	833	837	PF02296	0.363
LIG_BRCT_BRCA1_1	15	19	PF00533	0.323
LIG_BRCT_BRCA1_1	684	688	PF00533	0.545
LIG_Clathr_ClatBox_1	641	645	PF01394	0.501
LIG_CtBP_PxDLS_1	437	441	PF00389	0.634
LIG_CtBP_PxDLS_1	498	502	PF00389	0.625
LIG_EH_1	356	360	PF12763	0.515
LIG_EH1_1	124	132	PF00400	0.298
LIG_EH1_1	306	314	PF00400	0.312
LIG_eIF4E_1	111	117	PF01652	0.368
LIG_eIF4E_1	281	287	PF01652	0.247
LIG_FHA_1	147	153	PF00498	0.349
LIG_FHA_1	201	207	PF00498	0.371
LIG_FHA_1	345	351	PF00498	0.481
LIG_FHA_1	409	415	PF00498	0.653
LIG_FHA_1	442	448	PF00498	0.638
LIG_FHA_1	472	478	PF00498	0.789
LIG_FHA_1	694	700	PF00498	0.574
LIG_FHA_1	729	735	PF00498	0.673
LIG_FHA_1	769	775	PF00498	0.698
LIG_FHA_1	933	939	PF00498	0.366
LIG_FHA_2	176	182	PF00498	0.306
LIG_FHA_2	607	613	PF00498	0.621
LIG_FHA_2	63	69	PF00498	0.312
LIG_FHA_2	647	653	PF00498	0.566
LIG_FHA_2	87	93	PF00498	0.384
LIG_LIR_Apic_2	28	32	PF02991	0.375
LIG_LIR_Apic_2	795	801	PF02991	0.312
LIG_LIR_Gen_1	245	254	PF02991	0.412
LIG_LIR_Gen_1	280	291	PF02991	0.286
LIG_LIR_Gen_1	331	339	PF02991	0.476
LIG_LIR_Gen_1	55	66	PF02991	0.312
LIG_LIR_Gen_1	581	591	PF02991	0.629
LIG_LIR_Gen_1	803	813	PF02991	0.371
LIG_LIR_Nem_3	163	168	PF02991	0.376
LIG_LIR_Nem_3	245	249	PF02991	0.383
LIG_LIR_Nem_3	263	268	PF02991	0.377
LIG_LIR_Nem_3	280	286	PF02991	0.213
LIG_LIR_Nem_3	324	328	PF02991	0.517
LIG_LIR_Nem_3	331	336	PF02991	0.544
LIG_LIR_Nem_3	365	370	PF02991	0.498
LIG_LIR_Nem_3	55	61	PF02991	0.346
LIG_LIR_Nem_3	581	587	PF02991	0.637
LIG_LIR_Nem_3	803	809	PF02991	0.362
LIG_LIR_Nem_3	810	816	PF02991	0.314
LIG_LIR_Nem_3	854	858	PF02991	0.350
LIG_NRBOX	908	914	PF00104	0.249
LIG_PDZ_Class_2	957	962	PF00595	0.353
LIG_Pex14_2	265	269	PF04695	0.372
LIG_Pex14_2	60	64	PF04695	0.287
LIG_Pex14_2	833	837	PF04695	0.309
LIG_PTB_Apo_2	327	334	PF02174	0.528
LIG_REV1ctd_RIR_1	788	796	PF16727	0.417
LIG_SH2_CRK	58	62	PF00017	0.297
LIG_SH2_CRK	858	862	PF00017	0.302
LIG_SH2_GRB2like	124	127	PF00017	0.306
LIG_SH2_STAP1	172	176	PF00017	0.285
LIG_SH2_STAP1	202	206	PF00017	0.315
LIG_SH2_STAP1	862	866	PF00017	0.296
LIG_SH2_STAT3	111	114	PF00017	0.305
LIG_SH2_STAT3	176	179	PF00017	0.268
LIG_SH2_STAT3	874	877	PF00017	0.305
LIG_SH2_STAT5	111	114	PF00017	0.305
LIG_SH2_STAT5	165	168	PF00017	0.366
LIG_SH2_STAT5	177	180	PF00017	0.340
LIG_SH2_STAT5	202	205	PF00017	0.376
LIG_SH2_STAT5	281	284	PF00017	0.249
LIG_SH2_STAT5	325	328	PF00017	0.504
LIG_SH2_STAT5	529	532	PF00017	0.639
LIG_SH2_STAT5	63	66	PF00017	0.288
LIG_SH2_STAT5	681	684	PF00017	0.532
LIG_SH2_STAT5	813	816	PF00017	0.303
LIG_SH2_STAT5	874	877	PF00017	0.303
LIG_SH3_1	102	108	PF00018	0.369
LIG_SH3_3	102	108	PF00018	0.369
LIG_SH3_3	131	137	PF00018	0.290
LIG_SH3_3	141	147	PF00018	0.343
LIG_SH3_3	403	409	PF00018	0.740
LIG_SH3_3	492	498	PF00018	0.643
LIG_SH3_3	585	591	PF00018	0.684
LIG_SH3_3	78	84	PF00018	0.448
LIG_SH3_3	806	812	PF00018	0.341
LIG_SUMO_SIM_anti_2	203	208	PF11976	0.374
LIG_SUMO_SIM_anti_2	349	354	PF11976	0.439
LIG_SUMO_SIM_anti_2	369	375	PF11976	0.479
LIG_SUMO_SIM_anti_2	904	910	PF11976	0.315
LIG_SUMO_SIM_par_1	114	120	PF11976	0.283
LIG_SUMO_SIM_par_1	704	710	PF11976	0.554
LIG_TYR_ITIM	122	127	PF00017	0.305
LIG_UBA3_1	641	648	PF00899	0.501
LIG_UBA3_1	954	961	PF00899	0.400
LIG_WRC_WIRS_1	361	366	PF05994	0.518
MOD_CK1_1	146	152	PF00069	0.350
MOD_CK1_1	224	230	PF00069	0.491
MOD_CK1_1	233	239	PF00069	0.323
MOD_CK1_1	3	9	PF00069	0.370
MOD_CK1_1	308	314	PF00069	0.286
MOD_CK1_1	324	330	PF00069	0.590
MOD_CK1_1	334	340	PF00069	0.503
MOD_CK1_1	344	350	PF00069	0.534
MOD_CK1_1	379	385	PF00069	0.693
MOD_CK1_1	399	405	PF00069	0.681
MOD_CK1_1	450	456	PF00069	0.678
MOD_CK1_1	470	476	PF00069	0.751
MOD_CK1_1	502	508	PF00069	0.764
MOD_CK1_1	518	524	PF00069	0.745
MOD_CK1_1	525	531	PF00069	0.724
MOD_CK1_1	538	544	PF00069	0.660
MOD_CK1_1	545	551	PF00069	0.691
MOD_CK1_1	553	559	PF00069	0.749
MOD_CK1_1	637	643	PF00069	0.640
MOD_CK1_1	752	758	PF00069	0.773
MOD_CK1_1	778	784	PF00069	0.542
MOD_CK1_1	793	799	PF00069	0.312
MOD_CK1_1	847	853	PF00069	0.422
MOD_CK1_1	933	939	PF00069	0.308
MOD_CK2_1	239	245	PF00069	0.364
MOD_CK2_1	456	462	PF00069	0.746
MOD_CK2_1	566	572	PF00069	0.668
MOD_CK2_1	646	652	PF00069	0.565
MOD_CK2_1	667	673	PF00069	0.600
MOD_CK2_1	86	92	PF00069	0.408
MOD_DYRK1A_RPxSP_1	441	445	PF00069	0.643
MOD_GlcNHglycan	172	175	PF01048	0.600
MOD_GlcNHglycan	232	235	PF01048	0.680
MOD_GlcNHglycan	252	255	PF01048	0.657
MOD_GlcNHglycan	302	305	PF01048	0.312
MOD_GlcNHglycan	364	367	PF01048	0.309
MOD_GlcNHglycan	391	394	PF01048	0.572
MOD_GlcNHglycan	396	399	PF01048	0.530
MOD_GlcNHglycan	458	461	PF01048	0.468
MOD_GlcNHglycan	478	481	PF01048	0.632
MOD_GlcNHglycan	504	507	PF01048	0.438
MOD_GlcNHglycan	537	540	PF01048	0.483
MOD_GlcNHglycan	555	558	PF01048	0.509
MOD_GlcNHglycan	663	666	PF01048	0.462
MOD_GlcNHglycan	752	755	PF01048	0.482
MOD_GlcNHglycan	932	935	PF01048	0.518
MOD_GSK3_1	212	219	PF00069	0.340
MOD_GSK3_1	226	233	PF00069	0.421
MOD_GSK3_1	256	263	PF00069	0.506
MOD_GSK3_1	362	369	PF00069	0.520
MOD_GSK3_1	441	448	PF00069	0.670
MOD_GSK3_1	450	457	PF00069	0.668
MOD_GSK3_1	467	474	PF00069	0.744
MOD_GSK3_1	476	483	PF00069	0.695
MOD_GSK3_1	514	521	PF00069	0.692
MOD_GSK3_1	523	530	PF00069	0.718
MOD_GSK3_1	535	542	PF00069	0.801
MOD_GSK3_1	545	552	PF00069	0.705
MOD_GSK3_1	574	581	PF00069	0.689
MOD_GSK3_1	606	613	PF00069	0.702
MOD_GSK3_1	623	630	PF00069	0.658
MOD_GSK3_1	646	653	PF00069	0.544
MOD_GSK3_1	714	721	PF00069	0.602
MOD_GSK3_1	73	80	PF00069	0.389
MOD_GSK3_1	745	752	PF00069	0.775
MOD_GSK3_1	753	760	PF00069	0.785
MOD_GSK3_1	764	771	PF00069	0.603
MOD_GSK3_1	793	800	PF00069	0.317
MOD_GSK3_1	807	814	PF00069	0.349
MOD_GSK3_1	82	89	PF00069	0.445
MOD_GSK3_1	847	854	PF00069	0.367
MOD_GSK3_1	929	936	PF00069	0.350
MOD_LATS_1	659	665	PF00433	0.643
MOD_N-GLC_1	318	323	PF02516	0.252
MOD_N-GLC_1	376	381	PF02516	0.427
MOD_N-GLC_1	382	387	PF02516	0.452
MOD_N-GLC_1	450	455	PF02516	0.433
MOD_N-GLC_1	499	504	PF02516	0.431
MOD_N-GLC_1	543	548	PF02516	0.426
MOD_N-GLC_1	757	762	PF02516	0.451
MOD_N-GLC_1	920	925	PF02516	0.603
MOD_NEK2_1	168	173	PF00069	0.379
MOD_NEK2_1	293	298	PF00069	0.295
MOD_NEK2_1	318	323	PF00069	0.514
MOD_NEK2_1	360	365	PF00069	0.513
MOD_NEK2_1	447	452	PF00069	0.647
MOD_NEK2_1	471	476	PF00069	0.733
MOD_NEK2_1	5	10	PF00069	0.328
MOD_NEK2_1	523	528	PF00069	0.785
MOD_NEK2_1	62	67	PF00069	0.298
MOD_NEK2_1	682	687	PF00069	0.625
MOD_NEK2_1	720	725	PF00069	0.728
MOD_NEK2_1	77	82	PF00069	0.432
MOD_NEK2_1	790	795	PF00069	0.312
MOD_NEK2_1	912	917	PF00069	0.311
MOD_NEK2_1	929	934	PF00069	0.322
MOD_NEK2_2	13	18	PF00069	0.243
MOD_PIKK_1	175	181	PF00454	0.336
MOD_PIKK_1	216	222	PF00454	0.432
MOD_PIKK_1	586	592	PF00454	0.620
MOD_PIKK_1	693	699	PF00454	0.601
MOD_PIKK_1	720	726	PF00454	0.593
MOD_PIKK_1	75	81	PF00454	0.414
MOD_PIKK_1	775	781	PF00454	0.620
MOD_PIKK_1	847	853	PF00454	0.355
MOD_PK_1	376	382	PF00069	0.555
MOD_PKA_1	257	263	PF00069	0.315
MOD_PKA_1	661	667	PF00069	0.657
MOD_PKA_2	200	206	PF00069	0.375
MOD_PKA_2	224	230	PF00069	0.464
MOD_PKA_2	256	262	PF00069	0.382
MOD_PKA_2	334	340	PF00069	0.531
MOD_PKA_2	518	524	PF00069	0.625
MOD_PKA_2	539	545	PF00069	0.682
MOD_PKA_2	553	559	PF00069	0.661
MOD_PKA_2	660	666	PF00069	0.648
MOD_PKA_2	714	720	PF00069	0.580
MOD_PKA_2	807	813	PF00069	0.389
MOD_PKA_2	851	857	PF00069	0.384
MOD_PKB_1	255	263	PF00069	0.324
MOD_PKB_1	604	612	PF00069	0.622
MOD_Plk_1	168	174	PF00069	0.336
MOD_Plk_1	331	337	PF00069	0.470
MOD_Plk_1	376	382	PF00069	0.667
MOD_Plk_1	499	505	PF00069	0.629
MOD_Plk_1	682	688	PF00069	0.542
MOD_Plk_1	693	699	PF00069	0.560
MOD_Plk_1	920	926	PF00069	0.401
MOD_Plk_4	153	159	PF00069	0.350
MOD_Plk_4	202	208	PF00069	0.394
MOD_Plk_4	277	283	PF00069	0.276
MOD_Plk_4	308	314	PF00069	0.335
MOD_Plk_4	366	372	PF00069	0.498
MOD_Plk_4	376	382	PF00069	0.613
MOD_Plk_4	396	402	PF00069	0.604
MOD_Plk_4	409	415	PF00069	0.632
MOD_Plk_4	423	429	PF00069	0.678
MOD_Plk_4	518	524	PF00069	0.625
MOD_Plk_4	6	12	PF00069	0.277
MOD_Plk_4	704	710	PF00069	0.554
MOD_Plk_4	844	850	PF00069	0.347
MOD_Plk_4	933	939	PF00069	0.308
MOD_ProDKin_1	143	149	PF00069	0.341
MOD_ProDKin_1	158	164	PF00069	0.354
MOD_ProDKin_1	192	198	PF00069	0.329
MOD_ProDKin_1	212	218	PF00069	0.243
MOD_ProDKin_1	28	34	PF00069	0.388
MOD_ProDKin_1	295	301	PF00069	0.314
MOD_ProDKin_1	441	447	PF00069	0.715
MOD_ProDKin_1	509	515	PF00069	0.801
MOD_ProDKin_1	543	549	PF00069	0.689
MOD_ProDKin_1	624	630	PF00069	0.692
MOD_ProDKin_1	742	748	PF00069	0.771
MOD_ProDKin_1	797	803	PF00069	0.312
MOD_ProDKin_1	826	832	PF00069	0.341
MOD_SUMO_for_1	25	28	PF00179	0.324
MOD_SUMO_rev_2	34	42	PF00179	0.343
TRG_DiLeu_BaLyEn_6	267	272	PF01217	0.364
TRG_ENDOCYTIC_2	124	127	PF00928	0.306
TRG_ENDOCYTIC_2	165	168	PF00928	0.366
TRG_ENDOCYTIC_2	325	328	PF00928	0.504
TRG_ENDOCYTIC_2	58	61	PF00928	0.301
TRG_ENDOCYTIC_2	584	587	PF00928	0.639
TRG_ENDOCYTIC_2	63	66	PF00928	0.288
TRG_ENDOCYTIC_2	813	816	PF00928	0.303
TRG_ENDOCYTIC_2	858	861	PF00928	0.307
TRG_ENDOCYTIC_2	862	865	PF00928	0.298
TRG_ER_diArg_1	256	258	PF00400	0.438
TRG_NES_CRM1_1	697	712	PF08389	0.606
TRG_NES_CRM1_1	881	894	PF08389	0.269
TRG_NLS_Bipartite_1	839	860	PF00514	0.279
TRG_Pf-PMV_PEXEL_1	270	274	PF00026	0.570
TRG_Pf-PMV_PEXEL_1	792	797	PF00026	0.231
TRG_Pf-PMV_PEXEL_1	821	825	PF00026	0.510
TRG_Pf-PMV_PEXEL_1	918	922	PF00026	0.540

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILZ2	Leptomonas seymouri	58%	96%
A0A3Q8IK61	Leishmania donovani	76%	100%
A4IDI2	Leishmania infantum	76%	100%
E9ASY5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4Q1L3	Leishmania major	76%	99%