TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR repeat/Tetratricopeptide repeat, putative

Species:

Leishmania braziliensis

UniProt:

A4HP75_LEIBR

TriTrypDb:

LbrM.35.2300 , LBRM2903_350029600

Length:

311

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HP75

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP75

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	13
GO:0009987	cellular process	1	13

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	13
GO:0005515	protein binding	2	13
GO:0030544	Hsp70 protein binding	4	13
GO:0031072	heat shock protein binding	3	13
GO:0051879	Hsp90 protein binding	4	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	260	262	PF00675	0.468
CLV_PCSK_FUR_1	258	262	PF00082	0.427
CLV_PCSK_KEX2_1	129	131	PF00082	0.473
CLV_PCSK_KEX2_1	260	262	PF00082	0.452
CLV_PCSK_PC1ET2_1	129	131	PF00082	0.472
CLV_PCSK_SKI1_1	115	119	PF00082	0.528
CLV_PCSK_SKI1_1	141	145	PF00082	0.448
CLV_PCSK_SKI1_1	236	240	PF00082	0.525
DOC_CYCLIN_RxL_1	67	78	PF00134	0.437
DOC_MAPK_gen_1	115	123	PF00069	0.462
DOC_MAPK_gen_1	258	266	PF00069	0.531
DOC_PP1_RVXF_1	43	49	PF00149	0.285
DOC_PP2B_LxvP_1	72	75	PF13499	0.550
DOC_USP7_MATH_1	2	6	PF00917	0.630
DOC_USP7_MATH_1	97	101	PF00917	0.325
DOC_USP7_UBL2_3	104	108	PF12436	0.503
LIG_14-3-3_CanoR_1	220	225	PF00244	0.724
LIG_14-3-3_CanoR_1	280	290	PF00244	0.653
LIG_14-3-3_CanoR_1	83	91	PF00244	0.441
LIG_Actin_WH2_2	88	106	PF00022	0.334
LIG_CtBP_PxDLS_1	98	104	PF00389	0.438
LIG_deltaCOP1_diTrp_1	125	133	PF00928	0.258
LIG_FHA_1	285	291	PF00498	0.520
LIG_FHA_1	301	307	PF00498	0.553
LIG_FHA_1	77	83	PF00498	0.472
LIG_FHA_2	23	29	PF00498	0.569
LIG_FHA_2	254	260	PF00498	0.548
LIG_IRF3_LxIS_1	290	295	PF10401	0.559
LIG_LIR_Gen_1	25	35	PF02991	0.499
LIG_LIR_Nem_3	25	30	PF02991	0.635
LIG_LIR_Nem_3	47	51	PF02991	0.392
LIG_Pex14_2	239	243	PF04695	0.370
LIG_PTB_Apo_2	50	57	PF02174	0.384
LIG_PTB_Phospho_1	50	56	PF10480	0.460
LIG_SH2_CRK	68	72	PF00017	0.496
LIG_SH2_NCK_1	283	287	PF00017	0.650
LIG_SH2_STAP1	68	72	PF00017	0.368
LIG_SH2_STAT5	90	93	PF00017	0.404
LIG_SH3_3	6	12	PF00018	0.535
LIG_TRAF2_1	188	191	PF00917	0.694
LIG_WW_2	9	12	PF00397	0.494
LIG_WW_3	174	178	PF00397	0.423
MOD_CK1_1	281	287	PF00069	0.633
MOD_CK1_1	84	90	PF00069	0.373
MOD_CK2_1	2	8	PF00069	0.711
MOD_CK2_1	206	212	PF00069	0.651
MOD_CK2_1	220	226	PF00069	0.562
MOD_CK2_1	246	252	PF00069	0.577
MOD_CK2_1	253	259	PF00069	0.549
MOD_CK2_1	28	34	PF00069	0.439
MOD_GlcNHglycan	151	154	PF01048	0.447
MOD_GlcNHglycan	251	256	PF01048	0.633
MOD_GlcNHglycan	28	33	PF01048	0.395
MOD_GlcNHglycan	4	7	PF01048	0.613
MOD_GlcNHglycan	86	89	PF01048	0.371
MOD_N-GLC_1	84	89	PF02516	0.400
MOD_N-GLC_2	53	55	PF02516	0.379
MOD_NEK2_1	22	27	PF00069	0.564
MOD_NEK2_1	253	258	PF00069	0.524
MOD_NEK2_1	279	284	PF00069	0.649
MOD_PIKK_1	193	199	PF00454	0.620
MOD_PIKK_1	39	45	PF00454	0.556
MOD_PKA_2	279	285	PF00069	0.627
MOD_PKB_1	218	226	PF00069	0.745
MOD_Plk_4	90	96	PF00069	0.359
MOD_SUMO_for_1	188	191	PF00179	0.752
MOD_SUMO_for_1	245	248	PF00179	0.532
MOD_SUMO_rev_2	107	117	PF00179	0.424
MOD_SUMO_rev_2	42	51	PF00179	0.469
TRG_DiLeu_BaEn_4	190	196	PF01217	0.712
TRG_DiLeu_BaLyEn_6	67	72	PF01217	0.511
TRG_ENDOCYTIC_2	68	71	PF00928	0.495
TRG_Pf-PMV_PEXEL_1	158	163	PF00026	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7A6	Leptomonas seymouri	56%	97%
A0A0S4IZ49	Bodo saltans	38%	95%
A0A1X0NJW2	Trypanosomatidae	28%	73%
A0A1X0P800	Trypanosomatidae	40%	93%
A0A3Q8IKL8	Leishmania donovani	76%	94%
A0A422N1V8	Trypanosoma rangeli	41%	100%
A4IDI0	Leishmania infantum	74%	94%
D0A371	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	97%
E9ASY3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	94%
Q4Q1L5	Leishmania major	74%	100%
V5BKW9	Trypanosoma cruzi	40%	100%