Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function DUF72, putative

Species:

Leishmania braziliensis

UniProt:

A4HP74_LEIBR

TriTrypDb:

LbrM.35.2290 , LBRM2903_350029500

Length:

505

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HP74

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP74

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	408	412	PF00656	0.397
CLV_C14_Caspase3-7	463	467	PF00656	0.519
CLV_NRD_NRD_1	283	285	PF00675	0.453
CLV_NRD_NRD_1	286	288	PF00675	0.444
CLV_NRD_NRD_1	420	422	PF00675	0.498
CLV_NRD_NRD_1	98	100	PF00675	0.468
CLV_PCSK_FUR_1	284	288	PF00082	0.378
CLV_PCSK_KEX2_1	283	285	PF00082	0.453
CLV_PCSK_KEX2_1	286	288	PF00082	0.444
CLV_PCSK_KEX2_1	420	422	PF00082	0.318
CLV_PCSK_KEX2_1	486	488	PF00082	0.762
CLV_PCSK_KEX2_1	98	100	PF00082	0.382
CLV_PCSK_PC1ET2_1	486	488	PF00082	0.775
CLV_PCSK_SKI1_1	312	316	PF00082	0.378
CLV_PCSK_SKI1_1	389	393	PF00082	0.385
CLV_PCSK_SKI1_1	420	424	PF00082	0.485
CLV_PCSK_SKI1_1	91	95	PF00082	0.509
DEG_COP1_1	75	83	PF00400	0.596
DEG_Kelch_actinfilin_1	449	453	PF01344	0.489
DEG_SPOP_SBC_1	13	17	PF00917	0.684
DEG_SPOP_SBC_1	426	430	PF00917	0.601
DOC_CYCLIN_RxL_1	417	427	PF00134	0.552
DOC_MAPK_gen_1	283	294	PF00069	0.349
DOC_MAPK_gen_1	309	317	PF00069	0.385
DOC_MAPK_MEF2A_6	283	292	PF00069	0.335
DOC_MAPK_MEF2A_6	447	455	PF00069	0.587
DOC_PP2B_LxvP_1	18	21	PF13499	0.662
DOC_PP2B_LxvP_1	225	228	PF13499	0.264
DOC_PP2B_PxIxI_1	67	73	PF00149	0.480
DOC_PP4_FxxP_1	219	222	PF00568	0.423
DOC_PP4_FxxP_1	56	59	PF00568	0.550
DOC_USP7_MATH_1	167	171	PF00917	0.502
DOC_USP7_MATH_1	266	270	PF00917	0.463
DOC_USP7_MATH_1	275	279	PF00917	0.314
DOC_USP7_MATH_1	426	430	PF00917	0.551
DOC_USP7_MATH_1	457	461	PF00917	0.698
DOC_USP7_MATH_1	492	496	PF00917	0.745
DOC_USP7_MATH_1	81	85	PF00917	0.399
DOC_USP7_MATH_1	9	13	PF00917	0.649
DOC_WW_Pin1_4	271	276	PF00397	0.341
DOC_WW_Pin1_4	37	42	PF00397	0.501
DOC_WW_Pin1_4	380	385	PF00397	0.401
DOC_WW_Pin1_4	427	432	PF00397	0.622
DOC_WW_Pin1_4	480	485	PF00397	0.784
LIG_14-3-3_CanoR_1	136	145	PF00244	0.765
LIG_14-3-3_CanoR_1	148	153	PF00244	0.562
LIG_14-3-3_CanoR_1	177	181	PF00244	0.420
LIG_14-3-3_CanoR_1	295	300	PF00244	0.344
LIG_14-3-3_CanoR_1	46	51	PF00244	0.508
LIG_14-3-3_CanoR_1	469	473	PF00244	0.777
LIG_14-3-3_CanoR_1	487	492	PF00244	0.778
LIG_14-3-3_CanoR_1	88	94	PF00244	0.499
LIG_CSL_BTD_1	18	21	PF09270	0.475
LIG_deltaCOP1_diTrp_1	117	122	PF00928	0.434
LIG_eIF4E_1	50	56	PF01652	0.481
LIG_FHA_1	13	19	PF00498	0.737
LIG_FHA_1	155	161	PF00498	0.609
LIG_FHA_1	277	283	PF00498	0.335
LIG_FHA_1	302	308	PF00498	0.404
LIG_FHA_1	404	410	PF00498	0.417
LIG_FHA_1	428	434	PF00498	0.616
LIG_FHA_1	471	477	PF00498	0.560
LIG_FHA_1	59	65	PF00498	0.497
LIG_FHA_2	119	125	PF00498	0.526
LIG_FHA_2	148	154	PF00498	0.507
LIG_FHA_2	381	387	PF00498	0.417
LIG_FHA_2	61	67	PF00498	0.342
LIG_HCF-1_HBM_1	105	108	PF13415	0.380
LIG_LIR_Apic_2	217	222	PF02991	0.449
LIG_LIR_Gen_1	121	126	PF02991	0.454
LIG_LIR_Gen_1	302	311	PF02991	0.346
LIG_LIR_Gen_1	323	334	PF02991	0.449
LIG_LIR_Gen_1	390	399	PF02991	0.449
LIG_LIR_Nem_3	302	308	PF02991	0.347
LIG_LIR_Nem_3	310	316	PF02991	0.145
LIG_LIR_Nem_3	323	329	PF02991	0.449
LIG_LIR_Nem_3	351	355	PF02991	0.341
LIG_LIR_Nem_3	390	395	PF02991	0.344
LIG_LIR_Nem_3	49	55	PF02991	0.483
LIG_MYND_1	214	218	PF01753	0.449
LIG_NRBOX	243	249	PF00104	0.437
LIG_OCRL_FandH_1	240	252	PF00620	0.410
LIG_Pex14_1	52	56	PF04695	0.464
LIG_PTAP_UEV_1	20	25	PF05743	0.414
LIG_REV1ctd_RIR_1	206	213	PF16727	0.317
LIG_SH2_CRK	110	114	PF00017	0.591
LIG_SH2_CRK	352	356	PF00017	0.344
LIG_SH2_PTP2	338	341	PF00017	0.385
LIG_SH2_SRC	367	370	PF00017	0.428
LIG_SH2_STAP1	180	184	PF00017	0.412
LIG_SH2_STAP1	326	330	PF00017	0.475
LIG_SH2_STAT5	180	183	PF00017	0.345
LIG_SH2_STAT5	338	341	PF00017	0.316
LIG_SH2_STAT5	367	370	PF00017	0.382
LIG_SH3_1	38	44	PF00018	0.362
LIG_SH3_2	41	46	PF14604	0.573
LIG_SH3_3	18	24	PF00018	0.583
LIG_SH3_3	38	44	PF00018	0.512
LIG_SH3_3	433	439	PF00018	0.659
LIG_SH3_3	62	68	PF00018	0.560
LIG_TRAF2_1	249	252	PF00917	0.449
LIG_WRC_WIRS_1	168	173	PF05994	0.478
LIG_WRC_WIRS_1	308	313	PF05994	0.449
MOD_CDC14_SPxK_1	483	486	PF00782	0.546
MOD_CDK_SPxK_1	480	486	PF00069	0.546
MOD_CDK_SPxxK_3	427	434	PF00069	0.654
MOD_CDK_SPxxK_3	480	487	PF00069	0.787
MOD_CK1_1	12	18	PF00069	0.689
MOD_CK1_1	176	182	PF00069	0.403
MOD_CK1_1	268	274	PF00069	0.451
MOD_CK1_1	278	284	PF00069	0.453
MOD_CK1_1	427	433	PF00069	0.535
MOD_CK1_1	45	51	PF00069	0.586
MOD_CK1_1	86	92	PF00069	0.591
MOD_CK2_1	147	153	PF00069	0.509
MOD_CK2_1	246	252	PF00069	0.449
MOD_CK2_1	380	386	PF00069	0.413
MOD_CK2_1	457	463	PF00069	0.691
MOD_CMANNOS	119	122	PF00535	0.432
MOD_GlcNHglycan	11	14	PF01048	0.691
MOD_GlcNHglycan	133	136	PF01048	0.658
MOD_GlcNHglycan	380	383	PF01048	0.462
MOD_GlcNHglycan	494	497	PF01048	0.757
MOD_GlcNHglycan	5	8	PF01048	0.675
MOD_GSK3_1	227	234	PF00069	0.449
MOD_GSK3_1	256	263	PF00069	0.452
MOD_GSK3_1	264	271	PF00069	0.442
MOD_GSK3_1	376	383	PF00069	0.341
MOD_GSK3_1	42	49	PF00069	0.481
MOD_GSK3_1	457	464	PF00069	0.666
MOD_GSK3_1	475	482	PF00069	0.719
MOD_GSK3_1	487	494	PF00069	0.760
MOD_GSK3_1	79	86	PF00069	0.597
MOD_GSK3_1	8	15	PF00069	0.679
MOD_N-GLC_1	295	300	PF02516	0.223
MOD_N-GLC_1	395	400	PF02516	0.346
MOD_N-GLC_1	46	51	PF02516	0.585
MOD_NEK2_1	131	136	PF00069	0.580
MOD_NEK2_1	147	152	PF00069	0.539
MOD_NEK2_1	178	183	PF00069	0.328
MOD_NEK2_1	231	236	PF00069	0.350
MOD_NEK2_1	255	260	PF00069	0.442
MOD_NEK2_1	307	312	PF00069	0.409
MOD_NEK2_1	60	65	PF00069	0.563
MOD_NEK2_2	167	172	PF00069	0.633
MOD_PIKK_1	1	7	PF00454	0.522
MOD_PIKK_1	246	252	PF00454	0.482
MOD_PIKK_1	470	476	PF00454	0.814
MOD_PIKK_1	81	87	PF00454	0.519
MOD_PK_1	148	154	PF00069	0.532
MOD_PKA_2	147	153	PF00069	0.509
MOD_PKA_2	176	182	PF00069	0.223
MOD_PKA_2	239	245	PF00069	0.441
MOD_PKA_2	260	266	PF00069	0.223
MOD_PKA_2	45	51	PF00069	0.575
MOD_PKA_2	468	474	PF00069	0.778
MOD_PKA_2	492	498	PF00069	0.760
MOD_Plk_1	256	262	PF00069	0.442
MOD_Plk_1	295	301	PF00069	0.437
MOD_Plk_1	410	416	PF00069	0.405
MOD_Plk_1	46	52	PF00069	0.585
MOD_Plk_1	86	92	PF00069	0.623
MOD_Plk_2-3	475	481	PF00069	0.650
MOD_Plk_4	14	20	PF00069	0.544
MOD_Plk_4	32	38	PF00069	0.587
MOD_Plk_4	405	411	PF00069	0.432
MOD_ProDKin_1	271	277	PF00069	0.341
MOD_ProDKin_1	37	43	PF00069	0.497
MOD_ProDKin_1	380	386	PF00069	0.401
MOD_ProDKin_1	427	433	PF00069	0.628
MOD_ProDKin_1	480	486	PF00069	0.786
TRG_AP2beta_CARGO_1	302	312	PF09066	0.451
TRG_DiLeu_BaEn_1	303	308	PF01217	0.385
TRG_DiLeu_BaEn_2	389	395	PF01217	0.449
TRG_DiLeu_BaLyEn_6	418	423	PF01217	0.301
TRG_DiLeu_LyEn_5	211	216	PF01217	0.475
TRG_ENDOCYTIC_2	110	113	PF00928	0.560
TRG_ENDOCYTIC_2	326	329	PF00928	0.449
TRG_ENDOCYTIC_2	338	341	PF00928	0.316
TRG_ENDOCYTIC_2	352	355	PF00928	0.319
TRG_ER_diArg_1	282	284	PF00400	0.423
TRG_ER_diArg_1	286	289	PF00400	0.397
TRG_ER_diArg_1	294	297	PF00400	0.333
TRG_ER_diArg_1	419	421	PF00400	0.440
TRG_ER_diArg_1	97	99	PF00400	0.377
TRG_NLS_MonoExtC_3	485	491	PF00514	0.546
TRG_NLS_MonoExtN_4	484	490	PF00514	0.767
TRG_Pf-PMV_PEXEL_1	420	424	PF00026	0.549
TRG_Pf-PMV_PEXEL_1	91	96	PF00026	0.561

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILN3	Leptomonas seymouri	55%	100%
A0A0S4J806	Bodo saltans	34%	100%
A0A1X0P7Q2	Trypanosomatidae	42%	100%
A0A3Q8IG26	Leishmania donovani	72%	100%
A0A422N1S4	Trypanosoma rangeli	40%	100%
A4IDH9	Leishmania infantum	73%	100%
D0A370	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9ASY2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4Q1L6	Leishmania major	72%	100%
V5BGE6	Trypanosoma cruzi	42%	100%