Serine/threonine-protein phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine/threonine protein phosphatase, putative

Species:

Leishmania braziliensis

UniProt:

A4HP73_LEIBR

TriTrypDb:

LbrM.35.2280 , LBRM2903_350029400

Length:

884

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HP73

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP73

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004721	phosphoprotein phosphatase activity	3	7
GO:0004722	protein serine/threonine phosphatase activity	4	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016791	phosphatase activity	5	7
GO:0017018	myosin phosphatase activity	5	7
GO:0042578	phosphoric ester hydrolase activity	4	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	33	37	PF00656	0.654
CLV_C14_Caspase3-7	872	876	PF00656	0.532
CLV_NRD_NRD_1	47	49	PF00675	0.557
CLV_PCSK_KEX2_1	684	686	PF00082	0.532
CLV_PCSK_PC1ET2_1	684	686	PF00082	0.532
CLV_PCSK_SKI1_1	362	366	PF00082	0.312
CLV_PCSK_SKI1_1	42	46	PF00082	0.561
CLV_PCSK_SKI1_1	49	53	PF00082	0.539
CLV_PCSK_SKI1_1	622	626	PF00082	0.653
CLV_PCSK_SKI1_1	749	753	PF00082	0.672
CLV_PCSK_SKI1_1	827	831	PF00082	0.339
CLV_Separin_Metazoa	18	22	PF03568	0.548
CLV_Separin_Metazoa	336	340	PF03568	0.485
DEG_APCC_DBOX_1	125	133	PF00400	0.510
DEG_APCC_DBOX_1	361	369	PF00400	0.312
DEG_SPOP_SBC_1	27	31	PF00917	0.566
DEG_SPOP_SBC_1	615	619	PF00917	0.642
DOC_CYCLIN_yClb1_LxF_4	803	809	PF00134	0.357
DOC_CYCLIN_yCln2_LP_2	220	226	PF00134	0.424
DOC_MAPK_gen_1	227	234	PF00069	0.374
DOC_MAPK_gen_1	298	307	PF00069	0.493
DOC_MAPK_gen_1	692	702	PF00069	0.487
DOC_MAPK_gen_1	841	849	PF00069	0.367
DOC_MAPK_MEF2A_6	227	234	PF00069	0.374
DOC_MAPK_MEF2A_6	298	307	PF00069	0.493
DOC_MAPK_MEF2A_6	339	346	PF00069	0.386
DOC_MAPK_NFAT4_5	227	235	PF00069	0.452
DOC_PP2B_LxvP_1	101	104	PF13499	0.781
DOC_PP2B_LxvP_1	150	153	PF13499	0.382
DOC_PP4_FxxP_1	690	693	PF00568	0.601
DOC_PP4_FxxP_1	832	835	PF00568	0.341
DOC_USP7_MATH_1	115	119	PF00917	0.590
DOC_USP7_MATH_1	374	378	PF00917	0.369
DOC_USP7_MATH_1	386	390	PF00917	0.289
DOC_USP7_MATH_1	546	550	PF00917	0.578
DOC_USP7_MATH_1	570	574	PF00917	0.499
DOC_USP7_MATH_1	58	62	PF00917	0.689
DOC_USP7_MATH_1	629	633	PF00917	0.590
DOC_USP7_MATH_1	638	642	PF00917	0.684
DOC_USP7_MATH_1	653	657	PF00917	0.579
DOC_USP7_MATH_1	686	690	PF00917	0.624
DOC_USP7_MATH_1	742	746	PF00917	0.533
DOC_USP7_UBL2_3	42	46	PF12436	0.541
DOC_USP7_UBL2_3	9	13	PF12436	0.622
DOC_WW_Pin1_4	382	387	PF00397	0.419
DOC_WW_Pin1_4	395	400	PF00397	0.241
DOC_WW_Pin1_4	451	456	PF00397	0.312
DOC_WW_Pin1_4	498	503	PF00397	0.597
DOC_WW_Pin1_4	59	64	PF00397	0.619
DOC_WW_Pin1_4	608	613	PF00397	0.558
DOC_WW_Pin1_4	66	71	PF00397	0.631
DOC_WW_Pin1_4	707	712	PF00397	0.397
DOC_WW_Pin1_4	774	779	PF00397	0.372
DOC_WW_Pin1_4	865	870	PF00397	0.539
LIG_14-3-3_CanoR_1	126	130	PF00244	0.638
LIG_14-3-3_CanoR_1	168	174	PF00244	0.343
LIG_14-3-3_CanoR_1	175	180	PF00244	0.300
LIG_14-3-3_CanoR_1	436	442	PF00244	0.418
LIG_14-3-3_CanoR_1	542	551	PF00244	0.559
LIG_14-3-3_CanoR_1	685	691	PF00244	0.535
LIG_14-3-3_CanoR_1	749	755	PF00244	0.517
LIG_14-3-3_CanoR_1	827	832	PF00244	0.416
LIG_APCC_ABBA_1	313	318	PF00400	0.320
LIG_APCC_ABBA_1	709	714	PF00400	0.461
LIG_BRCT_BRCA1_1	287	291	PF00533	0.509
LIG_BRCT_BRCA1_1	686	690	PF00533	0.610
LIG_BRCT_BRCA1_2	686	692	PF00533	0.590
LIG_EVH1_1	101	105	PF00568	0.620
LIG_EVH1_2	879	883	PF00568	0.580
LIG_FHA_1	14	20	PF00498	0.586
LIG_FHA_1	196	202	PF00498	0.468
LIG_FHA_1	207	213	PF00498	0.559
LIG_FHA_1	447	453	PF00498	0.324
LIG_FHA_1	468	474	PF00498	0.409
LIG_FHA_1	523	529	PF00498	0.551
LIG_FHA_1	533	539	PF00498	0.497
LIG_FHA_1	638	644	PF00498	0.512
LIG_FHA_1	694	700	PF00498	0.434
LIG_FHA_1	786	792	PF00498	0.409
LIG_FHA_1	801	807	PF00498	0.366
LIG_FHA_1	96	102	PF00498	0.721
LIG_FHA_2	126	132	PF00498	0.603
LIG_FHA_2	162	168	PF00498	0.473
LIG_FHA_2	31	37	PF00498	0.613
LIG_FHA_2	736	742	PF00498	0.383
LIG_FHA_2	870	876	PF00498	0.570
LIG_LIR_Apic_2	687	693	PF02991	0.608
LIG_LIR_Apic_2	736	742	PF02991	0.364
LIG_LIR_Apic_2	830	835	PF02991	0.340
LIG_LIR_Gen_1	156	166	PF02991	0.447
LIG_LIR_Nem_3	156	162	PF02991	0.451
LIG_LIR_Nem_3	254	260	PF02991	0.598
LIG_LIR_Nem_3	714	720	PF02991	0.544
LIG_LYPXL_S_1	483	487	PF13949	0.231
LIG_LYPXL_yS_3	484	487	PF13949	0.312
LIG_MYND_1	265	269	PF01753	0.656
LIG_NRBOX	215	221	PF00104	0.413
LIG_PDZ_Class_2	879	884	PF00595	0.504
LIG_Pex14_2	206	210	PF04695	0.445
LIG_SH2_CRK	311	315	PF00017	0.441
LIG_SH2_PTP2	427	430	PF00017	0.231
LIG_SH2_SRC	320	323	PF00017	0.417
LIG_SH2_STAT5	320	323	PF00017	0.417
LIG_SH2_STAT5	427	430	PF00017	0.312
LIG_SH2_STAT5	433	436	PF00017	0.312
LIG_SH2_STAT5	807	810	PF00017	0.405
LIG_SH2_STAT5	837	840	PF00017	0.400
LIG_SH3_3	344	350	PF00018	0.450
LIG_SH3_3	418	424	PF00018	0.388
LIG_SH3_3	588	594	PF00018	0.594
LIG_SH3_3	606	612	PF00018	0.528
LIG_SH3_3	75	81	PF00018	0.667
LIG_SH3_3	874	880	PF00018	0.586
LIG_SH3_3	97	103	PF00018	0.604
LIG_SUMO_SIM_par_1	733	738	PF11976	0.272
LIG_SUMO_SIM_par_1	827	833	PF11976	0.337
LIG_SUMO_SIM_par_1	845	850	PF11976	0.338
LIG_TRAF2_1	323	326	PF00917	0.374
LIG_UBA3_1	846	851	PF00899	0.303
LIG_WRC_WIRS_1	162	167	PF05994	0.467
MOD_CDK_SPK_2	382	387	PF00069	0.364
MOD_CDK_SPK_2	395	400	PF00069	0.246
MOD_CK1_1	148	154	PF00069	0.621
MOD_CK1_1	251	257	PF00069	0.428
MOD_CK1_1	259	265	PF00069	0.421
MOD_CK1_1	26	32	PF00069	0.633
MOD_CK1_1	285	291	PF00069	0.506
MOD_CK1_1	37	43	PF00069	0.643
MOD_CK1_1	385	391	PF00069	0.342
MOD_CK1_1	393	399	PF00069	0.390
MOD_CK1_1	416	422	PF00069	0.281
MOD_CK1_1	454	460	PF00069	0.312
MOD_CK1_1	545	551	PF00069	0.541
MOD_CK1_1	59	65	PF00069	0.611
MOD_CK1_1	630	636	PF00069	0.536
MOD_CK1_1	637	643	PF00069	0.577
MOD_CK1_1	645	651	PF00069	0.561
MOD_CK1_1	675	681	PF00069	0.620
MOD_CK1_1	74	80	PF00069	0.580
MOD_CK1_1	744	750	PF00069	0.547
MOD_CK1_1	758	764	PF00069	0.381
MOD_CK1_1	770	776	PF00069	0.370
MOD_CK1_1	83	89	PF00069	0.539
MOD_CK2_1	320	326	PF00069	0.368
MOD_CK2_1	527	533	PF00069	0.613
MOD_CK2_1	617	623	PF00069	0.547
MOD_CK2_1	638	644	PF00069	0.669
MOD_Cter_Amidation	7	10	PF01082	0.699
MOD_GlcNHglycan	287	290	PF01048	0.538
MOD_GlcNHglycan	322	325	PF01048	0.418
MOD_GlcNHglycan	400	403	PF01048	0.319
MOD_GlcNHglycan	42	45	PF01048	0.702
MOD_GlcNHglycan	544	547	PF01048	0.562
MOD_GlcNHglycan	58	61	PF01048	0.542
MOD_GlcNHglycan	619	622	PF01048	0.571
MOD_GlcNHglycan	63	66	PF01048	0.591
MOD_GlcNHglycan	632	635	PF01048	0.597
MOD_GlcNHglycan	636	639	PF01048	0.553
MOD_GlcNHglycan	73	76	PF01048	0.786
MOD_GlcNHglycan	832	835	PF01048	0.379
MOD_GlcNHglycan	93	96	PF01048	0.742
MOD_GSK3_1	103	110	PF00069	0.643
MOD_GSK3_1	191	198	PF00069	0.490
MOD_GSK3_1	22	29	PF00069	0.688
MOD_GSK3_1	281	288	PF00069	0.540
MOD_GSK3_1	30	37	PF00069	0.774
MOD_GSK3_1	382	389	PF00069	0.315
MOD_GSK3_1	390	397	PF00069	0.326
MOD_GSK3_1	496	503	PF00069	0.651
MOD_GSK3_1	516	523	PF00069	0.632
MOD_GSK3_1	528	535	PF00069	0.643
MOD_GSK3_1	542	549	PF00069	0.682
MOD_GSK3_1	592	599	PF00069	0.656
MOD_GSK3_1	629	636	PF00069	0.628
MOD_GSK3_1	638	645	PF00069	0.723
MOD_GSK3_1	64	71	PF00069	0.681
MOD_GSK3_1	669	676	PF00069	0.744
MOD_GSK3_1	684	691	PF00069	0.552
MOD_GSK3_1	737	744	PF00069	0.404
MOD_GSK3_1	745	752	PF00069	0.575
MOD_GSK3_1	763	770	PF00069	0.473
MOD_GSK3_1	80	87	PF00069	0.745
MOD_GSK3_1	865	872	PF00069	0.564
MOD_GSK3_1	89	96	PF00069	0.538
MOD_LATS_1	47	53	PF00433	0.666
MOD_N-GLC_1	37	42	PF02516	0.788
MOD_N-GLC_1	416	421	PF02516	0.269
MOD_N-GLC_1	516	521	PF02516	0.669
MOD_N-GLC_1	526	531	PF02516	0.651
MOD_N-GLC_1	638	643	PF02516	0.704
MOD_N-GLC_1	672	677	PF02516	0.541
MOD_N-GLC_1	758	763	PF02516	0.550
MOD_N-GLC_1	774	779	PF02516	0.365
MOD_N-GLC_2	39	41	PF02516	0.547
MOD_N-GLC_2	836	838	PF02516	0.386
MOD_NEK2_1	124	129	PF00069	0.613
MOD_NEK2_1	133	138	PF00069	0.587
MOD_NEK2_1	256	261	PF00069	0.562
MOD_NEK2_1	281	286	PF00069	0.595
MOD_NEK2_1	291	296	PF00069	0.564
MOD_NEK2_1	446	451	PF00069	0.312
MOD_NEK2_1	496	501	PF00069	0.544
MOD_NEK2_1	526	531	PF00069	0.549
MOD_NEK2_1	624	629	PF00069	0.548
MOD_NEK2_1	642	647	PF00069	0.572
MOD_NEK2_1	768	773	PF00069	0.356
MOD_NEK2_1	800	805	PF00069	0.368
MOD_NEK2_1	820	825	PF00069	0.241
MOD_NEK2_1	84	89	PF00069	0.535
MOD_NEK2_2	2	7	PF00069	0.537
MOD_OFUCOSY	282	287	PF10250	0.502
MOD_PIKK_1	133	139	PF00454	0.623
MOD_PIKK_1	291	297	PF00454	0.463
MOD_PIKK_1	496	502	PF00454	0.604
MOD_PIKK_1	758	764	PF00454	0.535
MOD_PIKK_1	95	101	PF00454	0.550
MOD_PK_1	175	181	PF00069	0.468
MOD_PKA_1	684	690	PF00069	0.528
MOD_PKA_2	115	121	PF00069	0.668
MOD_PKA_2	125	131	PF00069	0.616
MOD_PKA_2	664	670	PF00069	0.669
MOD_PKA_2	684	690	PF00069	0.537
MOD_PKA_2	785	791	PF00069	0.426
MOD_Plk_1	148	154	PF00069	0.478
MOD_Plk_1	192	198	PF00069	0.459
MOD_Plk_1	599	605	PF00069	0.586
MOD_Plk_1	638	644	PF00069	0.648
MOD_Plk_1	713	719	PF00069	0.461
MOD_Plk_1	735	741	PF00069	0.361
MOD_Plk_1	758	764	PF00069	0.378
MOD_Plk_1	794	800	PF00069	0.361
MOD_Plk_4	161	167	PF00069	0.400
MOD_Plk_4	169	175	PF00069	0.323
MOD_Plk_4	454	460	PF00069	0.312
MOD_Plk_4	638	644	PF00069	0.512
MOD_Plk_4	827	833	PF00069	0.340
MOD_ProDKin_1	382	388	PF00069	0.419
MOD_ProDKin_1	395	401	PF00069	0.241
MOD_ProDKin_1	451	457	PF00069	0.312
MOD_ProDKin_1	498	504	PF00069	0.597
MOD_ProDKin_1	59	65	PF00069	0.621
MOD_ProDKin_1	608	614	PF00069	0.557
MOD_ProDKin_1	66	72	PF00069	0.632
MOD_ProDKin_1	707	713	PF00069	0.397
MOD_ProDKin_1	774	780	PF00069	0.366
MOD_ProDKin_1	865	871	PF00069	0.541
MOD_SUMO_for_1	297	300	PF00179	0.520
MOD_SUMO_rev_2	5	14	PF00179	0.537
TRG_DiLeu_BaEn_1	341	346	PF01217	0.287
TRG_DiLeu_BaEn_1	730	735	PF01217	0.310
TRG_DiLeu_BaLyEn_6	824	829	PF01217	0.360
TRG_ENDOCYTIC_2	311	314	PF00928	0.363
TRG_ENDOCYTIC_2	427	430	PF00928	0.312
TRG_ENDOCYTIC_2	474	477	PF00928	0.312
TRG_ENDOCYTIC_2	484	487	PF00928	0.312
TRG_ENDOCYTIC_2	807	810	PF00928	0.405
TRG_ENDOCYTIC_2	837	840	PF00928	0.400
TRG_ER_diArg_1	226	229	PF00400	0.423
TRG_NES_CRM1_1	306	318	PF08389	0.301
TRG_NLS_Bipartite_1	684	698	PF00514	0.482
TRG_NLS_MonoExtC_3	44	49	PF00514	0.533
TRG_NLS_MonoExtN_4	42	49	PF00514	0.537
TRG_NLS_MonoExtN_4	692	698	PF00514	0.592
TRG_Pf-PMV_PEXEL_1	239	243	PF00026	0.329
TRG_Pf-PMV_PEXEL_1	362	366	PF00026	0.312

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7N5	Leptomonas seymouri	50%	92%
A0A3S7XAZ4	Leishmania donovani	65%	97%
A4IDH8	Leishmania infantum	65%	97%
E9ASY1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	97%
Q4Q1L7	Leishmania major	65%	100%