Putative dolichyl-P-Man:GDP-Man5GlcNAc2-PP-dolichyl alpha-1,3-mannosyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dolichyl-P-Man:GDP-Man5GlcNAc2-PP-dolichyl alpha-1,3-mannosyltransferase, putative

Species:

Leishmania braziliensis

UniProt:

A4HP72_LEIBR

TriTrypDb:

LbrM.35.2270 , LBRM2903_350029300

Length:

448

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005737	cytoplasm	2	1
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HP72

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP72

Function

Biological processes
Term	Name	Level	Count
GO:0006486	protein glycosylation	4	1
GO:0006490	oligosaccharide-lipid intermediate biosynthetic process	4	1
GO:0006629	lipid metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043413	macromolecule glycosylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0070085	glycosylation	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901137	carbohydrate derivative biosynthetic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000030	mannosyltransferase activity	5	12
GO:0003824	catalytic activity	1	12
GO:0016740	transferase activity	2	12
GO:0016757	glycosyltransferase activity	3	12
GO:0016758	hexosyltransferase activity	4	12
GO:0000033	alpha-1,3-mannosyltransferase activity	6	2
GO:0052925	dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity	7	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	194	196	PF00675	0.173
CLV_NRD_NRD_1	296	298	PF00675	0.349
CLV_NRD_NRD_1	426	428	PF00675	0.359
CLV_PCSK_FUR_1	423	427	PF00082	0.376
CLV_PCSK_KEX2_1	118	120	PF00082	0.249
CLV_PCSK_KEX2_1	154	156	PF00082	0.498
CLV_PCSK_KEX2_1	194	196	PF00082	0.173
CLV_PCSK_KEX2_1	296	298	PF00082	0.360
CLV_PCSK_KEX2_1	425	427	PF00082	0.361
CLV_PCSK_PC1ET2_1	118	120	PF00082	0.260
CLV_PCSK_PC1ET2_1	154	156	PF00082	0.554
CLV_PCSK_PC1ET2_1	425	427	PF00082	0.358
CLV_PCSK_SKI1_1	47	51	PF00082	0.499
DEG_MDM2_SWIB_1	129	136	PF02201	0.336
DEG_Nend_UBRbox_1	1	4	PF02207	0.617
DEG_SCF_FBW7_1	385	391	PF00400	0.335
DOC_CKS1_1	385	390	PF01111	0.335
DOC_MAPK_gen_1	118	128	PF00069	0.483
DOC_MAPK_gen_1	194	202	PF00069	0.373
DOC_MAPK_gen_1	74	81	PF00069	0.354
DOC_MAPK_MEF2A_6	109	116	PF00069	0.441
DOC_MAPK_NFAT4_5	109	117	PF00069	0.433
DOC_PP1_RVXF_1	192	199	PF00149	0.545
DOC_PP2B_LxvP_1	178	181	PF13499	0.301
DOC_PP2B_LxvP_1	20	23	PF13499	0.409
DOC_PP4_FxxP_1	249	252	PF00568	0.289
DOC_USP7_MATH_1	388	392	PF00917	0.257
DOC_WW_Pin1_4	384	389	PF00397	0.335
DOC_WW_Pin1_4	409	414	PF00397	0.510
LIG_14-3-3_CanoR_1	119	124	PF00244	0.360
LIG_14-3-3_CanoR_1	236	240	PF00244	0.263
LIG_14-3-3_CanoR_1	277	287	PF00244	0.544
LIG_14-3-3_CanoR_1	296	304	PF00244	0.439
LIG_14-3-3_CanoR_1	370	377	PF00244	0.448
LIG_14-3-3_CanoR_1	389	393	PF00244	0.129
LIG_14-3-3_CanoR_1	99	108	PF00244	0.398
LIG_Actin_WH2_2	179	196	PF00022	0.330
LIG_Actin_WH2_2	37	52	PF00022	0.354
LIG_APCC_ABBA_1	126	131	PF00400	0.301
LIG_APCC_ABBA_1	21	26	PF00400	0.419
LIG_BRCT_BRCA1_1	162	166	PF00533	0.195
LIG_BRCT_BRCA1_1	223	227	PF00533	0.286
LIG_BRCT_BRCA1_1	377	381	PF00533	0.173
LIG_deltaCOP1_diTrp_1	131	139	PF00928	0.358
LIG_DLG_GKlike_1	119	126	PF00625	0.473
LIG_eIF4E_1	86	92	PF01652	0.448
LIG_EVH1_1	384	388	PF00568	0.335
LIG_FHA_1	10	16	PF00498	0.388
LIG_FHA_1	105	111	PF00498	0.530
LIG_FHA_1	165	171	PF00498	0.195
LIG_FHA_1	188	194	PF00498	0.489
LIG_FHA_1	263	269	PF00498	0.447
LIG_FHA_1	298	304	PF00498	0.469
LIG_FHA_1	51	57	PF00498	0.249
LIG_FHA_2	23	29	PF00498	0.260
LIG_FHA_2	279	285	PF00498	0.530
LIG_FHA_2	327	333	PF00498	0.419
LIG_FHA_2	415	421	PF00498	0.689
LIG_IRF3_LxIS_1	110	117	PF10401	0.373
LIG_LIR_Apic_2	247	252	PF02991	0.291
LIG_LIR_Apic_2	363	368	PF02991	0.195
LIG_LIR_Gen_1	131	141	PF02991	0.336
LIG_LIR_Gen_1	238	249	PF02991	0.318
LIG_LIR_Gen_1	265	272	PF02991	0.271
LIG_LIR_Gen_1	378	388	PF02991	0.340
LIG_LIR_Gen_1	401	407	PF02991	0.358
LIG_LIR_Nem_3	107	111	PF02991	0.373
LIG_LIR_Nem_3	131	136	PF02991	0.325
LIG_LIR_Nem_3	238	244	PF02991	0.227
LIG_LIR_Nem_3	26	32	PF02991	0.248
LIG_LIR_Nem_3	265	269	PF02991	0.380
LIG_LIR_Nem_3	343	349	PF02991	0.452
LIG_LIR_Nem_3	350	356	PF02991	0.288
LIG_LIR_Nem_3	378	384	PF02991	0.311
LIG_LIR_Nem_3	401	406	PF02991	0.391
LIG_LIR_Nem_3	43	49	PF02991	0.235
LIG_PCNA_PIPBox_1	33	42	PF02747	0.249
LIG_PDZ_Class_3	443	448	PF00595	0.601
LIG_Pex14_1	133	137	PF04695	0.421
LIG_Pex14_1	237	241	PF04695	0.249
LIG_Pex14_2	129	133	PF04695	0.336
LIG_Pex14_2	233	237	PF04695	0.241
LIG_Pex14_2	348	352	PF04695	0.301
LIG_Pex14_2	403	407	PF04695	0.341
LIG_SH2_CRK	354	358	PF00017	0.392
LIG_SH2_CRK	46	50	PF00017	0.260
LIG_SH2_CRK	86	90	PF00017	0.330
LIG_SH2_NCK_1	24	28	PF00017	0.273
LIG_SH2_NCK_1	354	358	PF00017	0.351
LIG_SH2_NCK_1	86	90	PF00017	0.419
LIG_SH2_PTP2	185	188	PF00017	0.421
LIG_SH2_STAP1	323	327	PF00017	0.554
LIG_SH2_STAP1	349	353	PF00017	0.386
LIG_SH2_STAP1	86	90	PF00017	0.195
LIG_SH2_STAT5	124	127	PF00017	0.386
LIG_SH2_STAT5	185	188	PF00017	0.421
LIG_SH2_STAT5	199	202	PF00017	0.421
LIG_SH2_STAT5	222	225	PF00017	0.260
LIG_SH2_STAT5	24	27	PF00017	0.269
LIG_SH2_STAT5	279	282	PF00017	0.550
LIG_SH2_STAT5	349	352	PF00017	0.366
LIG_SH2_STAT5	354	357	PF00017	0.352
LIG_SH2_STAT5	362	365	PF00017	0.421
LIG_SH2_STAT5	71	74	PF00017	0.255
LIG_SH2_STAT5	90	93	PF00017	0.386
LIG_SH3_3	107	113	PF00018	0.470
LIG_SH3_3	284	290	PF00018	0.554
LIG_SH3_3	382	388	PF00018	0.323
LIG_SUMO_SIM_anti_2	11	18	PF11976	0.399
LIG_SUMO_SIM_par_1	166	171	PF11976	0.195
LIG_TRAF2_1	316	319	PF00917	0.476
LIG_TYR_ITIM	22	27	PF00017	0.358
LIG_TYR_ITIM	239	244	PF00017	0.309
LIG_TYR_ITIM	44	49	PF00017	0.260
LIG_TYR_ITIM	84	89	PF00017	0.195
LIG_UBA3_1	111	118	PF00899	0.462
LIG_WRC_WIRS_1	327	332	PF05994	0.554
MOD_CDK_SPK_2	384	389	PF00069	0.354
MOD_CDK_SPK_2	414	419	PF00069	0.592
MOD_CK1_1	104	110	PF00069	0.554
MOD_CK2_1	278	284	PF00069	0.530
MOD_CK2_1	326	332	PF00069	0.468
MOD_CK2_1	414	420	PF00069	0.676
MOD_Cter_Amidation	152	155	PF01082	0.412
MOD_GlcNHglycan	103	106	PF01048	0.335
MOD_GlcNHglycan	149	152	PF01048	0.548
MOD_GlcNHglycan	395	398	PF01048	0.223
MOD_GSK3_1	160	167	PF00069	0.306
MOD_GSK3_1	322	329	PF00069	0.441
MOD_GSK3_1	380	387	PF00069	0.258
MOD_N-GLC_1	298	303	PF02516	0.173
MOD_N-GLC_2	130	132	PF02516	0.317
MOD_NEK2_1	114	119	PF00069	0.452
MOD_NEK2_1	160	165	PF00069	0.306
MOD_NEK2_1	187	192	PF00069	0.473
MOD_NEK2_1	259	264	PF00069	0.301
MOD_NEK2_1	340	345	PF00069	0.499
MOD_NEK2_1	352	357	PF00069	0.281
MOD_NEK2_1	360	365	PF00069	0.308
MOD_NEK2_1	393	398	PF00069	0.360
MOD_PIKK_1	375	381	PF00454	0.173
MOD_PKA_2	147	153	PF00069	0.329
MOD_PKA_2	235	241	PF00069	0.260
MOD_PKA_2	388	394	PF00069	0.173
MOD_Plk_1	298	304	PF00069	0.418
MOD_Plk_4	140	146	PF00069	0.383
MOD_Plk_4	262	268	PF00069	0.335
MOD_Plk_4	299	305	PF00069	0.546
MOD_Plk_4	323	329	PF00069	0.459
MOD_Plk_4	347	353	PF00069	0.386
MOD_Plk_4	388	394	PF00069	0.301
MOD_Plk_4	398	404	PF00069	0.325
MOD_Plk_4	85	91	PF00069	0.360
MOD_Plk_4	9	15	PF00069	0.259
MOD_ProDKin_1	384	390	PF00069	0.335
MOD_ProDKin_1	409	415	PF00069	0.518
TRG_DiLeu_BaEn_1	80	85	PF01217	0.173
TRG_DiLeu_BaEn_3	34	40	PF01217	0.335
TRG_ENDOCYTIC_2	185	188	PF00928	0.401
TRG_ENDOCYTIC_2	199	202	PF00928	0.346
TRG_ENDOCYTIC_2	24	27	PF00928	0.266
TRG_ENDOCYTIC_2	241	244	PF00928	0.309
TRG_ENDOCYTIC_2	349	352	PF00928	0.310
TRG_ENDOCYTIC_2	46	49	PF00928	0.251
TRG_ENDOCYTIC_2	86	89	PF00928	0.330
TRG_ER_diArg_1	193	195	PF00400	0.373
TRG_ER_diArg_1	270	273	PF00400	0.318
TRG_NLS_MonoExtC_3	424	430	PF00514	0.522
TRG_NLS_MonoExtN_4	423	429	PF00514	0.642

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7A1	Leptomonas seymouri	57%	92%
A0A0S4J269	Bodo saltans	39%	100%
A0A1X0P7P8	Trypanosomatidae	45%	100%
A0A3R7K2K2	Trypanosoma rangeli	43%	100%
A0A3S7XAS6	Leishmania donovani	76%	100%
A1CBE6	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	33%	95%
A1DDZ3	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	32%	100%
A2RA94	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	30%	100%
A3LTB7	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	27%	94%
A4IDH7	Leishmania infantum	76%	100%
A5DJQ5	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	29%	94%
D0A365	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9ASY0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
O82244	Arabidopsis thaliana	35%	100%
P0CN92	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	31%	100%
P0CN93	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	31%	100%
P38179	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	98%
P82149	Drosophila melanogaster	36%	93%
Q24332	Drosophila virilis	33%	85%
Q2U6A4	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	31%	100%
Q4Q1L8	Leishmania major	77%	100%
Q4WVG2	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	31%	100%
Q55F69	Dictyostelium discoideum	31%	100%
Q6BYY8	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	29%	93%
Q6CMF1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	32%	97%
Q6DNA2	Komagataella phaffii (strain GS115 / ATCC 20864)	29%	96%
Q6FXS2	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	31%	100%
Q751K5	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	34%	100%
Q8K2A8	Mus musculus	38%	100%
Q92685	Homo sapiens	37%	100%
Q9C1K8	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	34%	100%
Q9Y7I4	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
V5BKW5	Trypanosoma cruzi	44%	100%