Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HP68_LEIBR

TriTrypDb:

LbrM.35.2230 , LBRM2903_350028800

Length:

285

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HP68

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP68

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	35	37	PF00675	0.670
CLV_NRD_NRD_1	53	55	PF00675	0.377
CLV_PCSK_KEX2_1	35	37	PF00082	0.538
CLV_PCSK_KEX2_1	53	55	PF00082	0.575
CLV_PCSK_SKI1_1	100	104	PF00082	0.378
CLV_PCSK_SKI1_1	131	135	PF00082	0.370
CLV_PCSK_SKI1_1	142	146	PF00082	0.644
CLV_PCSK_SKI1_1	46	50	PF00082	0.439
DEG_APCC_DBOX_1	34	42	PF00400	0.500
DOC_CYCLIN_RxL_1	97	105	PF00134	0.370
DOC_USP7_MATH_1	22	26	PF00917	0.524
DOC_WW_Pin1_4	18	23	PF00397	0.607
LIG_14-3-3_CanoR_1	13	22	PF00244	0.757
LIG_14-3-3_CanoR_1	172	176	PF00244	0.392
LIG_14-3-3_CanoR_1	280	285	PF00244	0.431
LIG_Actin_WH2_2	2	17	PF00022	0.545
LIG_APCC_ABBA_1	67	72	PF00400	0.356
LIG_deltaCOP1_diTrp_1	65	70	PF00928	0.503
LIG_FHA_1	127	133	PF00498	0.373
LIG_FHA_1	190	196	PF00498	0.484
LIG_FHA_1	246	252	PF00498	0.566
LIG_FHA_1	40	46	PF00498	0.614
LIG_FHA_2	194	200	PF00498	0.385
LIG_HP1_1	254	258	PF01393	0.354
LIG_LIR_Gen_1	248	258	PF02991	0.468
LIG_LIR_Gen_1	65	70	PF02991	0.611
LIG_LIR_Nem_3	248	253	PF02991	0.485
LIG_LIR_Nem_3	65	69	PF02991	0.614
LIG_MYND_1	235	239	PF01753	0.585
LIG_PCNA_PIPBox_1	197	206	PF02747	0.640
LIG_Pex14_1	66	70	PF04695	0.364
LIG_PTB_Apo_2	76	83	PF02174	0.373
LIG_Rb_LxCxE_1	86	105	PF01857	0.569
LIG_SH2_CRK	262	266	PF00017	0.466
LIG_SH2_STAT3	59	62	PF00017	0.383
LIG_SH2_STAT5	212	215	PF00017	0.432
LIG_SH3_3	221	227	PF00018	0.529
LIG_SH3_3	229	235	PF00018	0.525
LIG_SH3_3	248	254	PF00018	0.537
LIG_SH3_3	4	10	PF00018	0.733
LIG_TRAF2_1	181	184	PF00917	0.638
LIG_TRFH_1	250	254	PF08558	0.527
LIG_TRFH_1	262	266	PF08558	0.494
MOD_CK1_1	150	156	PF00069	0.622
MOD_CK1_1	17	23	PF00069	0.699
MOD_CK1_1	174	180	PF00069	0.381
MOD_CK1_1	83	89	PF00069	0.408
MOD_CK2_1	107	113	PF00069	0.423
MOD_CK2_1	178	184	PF00069	0.597
MOD_CK2_1	193	199	PF00069	0.390
MOD_GlcNHglycan	109	112	PF01048	0.344
MOD_GlcNHglycan	149	152	PF01048	0.628
MOD_GlcNHglycan	94	98	PF01048	0.475
MOD_GSK3_1	14	21	PF00069	0.658
MOD_GSK3_1	167	174	PF00069	0.384
MOD_GSK3_1	189	196	PF00069	0.437
MOD_N-GLC_1	15	20	PF02516	0.593
MOD_N-GLC_1	22	27	PF02516	0.568
MOD_NEK2_1	14	19	PF00069	0.633
MOD_NEK2_1	171	176	PF00069	0.553
MOD_NEK2_1	186	191	PF00069	0.490
MOD_NEK2_1	193	198	PF00069	0.456
MOD_PIKK_1	126	132	PF00454	0.406
MOD_PIKK_1	144	150	PF00454	0.580
MOD_PIKK_1	174	180	PF00454	0.556
MOD_PIKK_1	186	192	PF00454	0.534
MOD_PIKK_1	193	199	PF00454	0.524
MOD_PIKK_1	80	86	PF00454	0.447
MOD_PKA_2	14	20	PF00069	0.701
MOD_PKA_2	171	177	PF00069	0.630
MOD_PKB_1	13	21	PF00069	0.712
MOD_ProDKin_1	18	24	PF00069	0.604
MOD_SUMO_rev_2	177	186	PF00179	0.640
TRG_DiLeu_BaEn_1	159	164	PF01217	0.422
TRG_DiLeu_BaEn_2	245	251	PF01217	0.580
TRG_DiLeu_BaEn_4	159	165	PF01217	0.621
TRG_DiLeu_BaLyEn_6	86	91	PF01217	0.405
TRG_ENDOCYTIC_2	262	265	PF00928	0.459
TRG_ER_diArg_1	12	15	PF00400	0.719
TRG_ER_diArg_1	34	36	PF00400	0.659
TRG_Pf-PMV_PEXEL_1	180	184	PF00026	0.591
TRG_Pf-PMV_PEXEL_1	202	206	PF00026	0.632
TRG_Pf-PMV_PEXEL_1	89	94	PF00026	0.409

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6L0	Leptomonas seymouri	50%	86%
A0A3Q8INP8	Leishmania donovani	74%	78%
A4IDH3	Leishmania infantum	74%	78%
E9ASX6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	77%
Q4Q1M2	Leishmania major	73%	100%