Fe2OG dioxygenase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

2OG-Fe(II) oxygenase superfamily, putative

Species:

Leishmania braziliensis

UniProt:

A4HP64_LEIBR

TriTrypDb:

LbrM.35.2190

Length:

297

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HP64

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP64

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	11
GO:0070988	demethylation	2	11
GO:0070989	oxidative demethylation	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0005488	binding	1	4
GO:0016491	oxidoreductase activity	2	4
GO:0032451	demethylase activity	2	1
GO:0043167	ion binding	2	4
GO:0043169	cation binding	3	4
GO:0046872	metal ion binding	4	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	134	136	PF00675	0.253
CLV_NRD_NRD_1	240	242	PF00675	0.333
CLV_NRD_NRD_1	266	268	PF00675	0.258
CLV_PCSK_FUR_1	264	268	PF00082	0.356
CLV_PCSK_KEX2_1	134	136	PF00082	0.249
CLV_PCSK_KEX2_1	142	144	PF00082	0.253
CLV_PCSK_KEX2_1	240	242	PF00082	0.333
CLV_PCSK_KEX2_1	266	268	PF00082	0.258
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.260
CLV_PCSK_SKI1_1	143	147	PF00082	0.273
CLV_PCSK_SKI1_1	241	245	PF00082	0.267
DEG_Nend_UBRbox_2	1	3	PF02207	0.608
DEG_SPOP_SBC_1	89	93	PF00917	0.271
DOC_MAPK_gen_1	18	25	PF00069	0.242
DOC_MAPK_gen_1	264	272	PF00069	0.486
DOC_MAPK_MEF2A_6	264	272	PF00069	0.505
DOC_PP4_FxxP_1	226	229	PF00568	0.529
DOC_USP7_MATH_1	184	188	PF00917	0.474
DOC_USP7_MATH_1	239	243	PF00917	0.365
DOC_USP7_MATH_1	283	287	PF00917	0.274
DOC_USP7_MATH_1	79	83	PF00917	0.449
DOC_USP7_UBL2_3	142	146	PF12436	0.467
DOC_WW_Pin1_4	3	8	PF00397	0.330
LIG_14-3-3_CanoR_1	240	244	PF00244	0.394
LIG_14-3-3_CanoR_1	266	271	PF00244	0.447
LIG_14-3-3_CanoR_1	50	59	PF00244	0.393
LIG_APCC_ABBA_1	199	204	PF00400	0.453
LIG_APCC_ABBA_1	99	104	PF00400	0.379
LIG_BRCT_BRCA1_1	120	124	PF00533	0.556
LIG_BRCT_BRCA1_1	268	272	PF00533	0.467
LIG_BRCT_BRCA1_1	52	56	PF00533	0.358
LIG_deltaCOP1_diTrp_1	204	209	PF00928	0.453
LIG_FHA_1	110	116	PF00498	0.393
LIG_FHA_1	20	26	PF00498	0.360
LIG_FHA_1	283	289	PF00498	0.538
LIG_FHA_1	90	96	PF00498	0.386
LIG_FHA_2	105	111	PF00498	0.455
LIG_FHA_2	223	229	PF00498	0.449
LIG_FHA_2	269	275	PF00498	0.453
LIG_LIR_Apic_2	225	229	PF02991	0.529
LIG_LIR_Gen_1	53	64	PF02991	0.358
LIG_LIR_LC3C_4	97	101	PF02991	0.227
LIG_LIR_Nem_3	269	275	PF02991	0.483
LIG_LIR_Nem_3	53	59	PF02991	0.343
LIG_PDZ_Class_1	292	297	PF00595	0.310
LIG_SH2_SRC	191	194	PF00017	0.365
LIG_SH2_STAT5	117	120	PF00017	0.453
LIG_SH2_STAT5	191	194	PF00017	0.391
LIG_SH2_STAT5	237	240	PF00017	0.533
LIG_SH2_STAT5	66	69	PF00017	0.209
LIG_SH3_2	123	128	PF14604	0.533
LIG_SH3_3	120	126	PF00018	0.533
LIG_SH3_3	153	159	PF00018	0.484
LIG_SH3_3	233	239	PF00018	0.484
LIG_SUMO_SIM_par_1	158	163	PF11976	0.365
LIG_TRAF2_1	107	110	PF00917	0.293
LIG_WRC_WIRS_1	223	228	PF05994	0.449
MOD_CK1_1	170	176	PF00069	0.525
MOD_CK1_1	291	297	PF00069	0.488
MOD_CK1_1	36	42	PF00069	0.477
MOD_CK1_1	52	58	PF00069	0.265
MOD_CK1_1	62	68	PF00069	0.337
MOD_CK2_1	104	110	PF00069	0.346
MOD_CK2_1	168	174	PF00069	0.496
MOD_CK2_1	184	190	PF00069	0.502
MOD_CK2_1	222	228	PF00069	0.459
MOD_CK2_1	268	274	PF00069	0.453
MOD_CK2_1	37	43	PF00069	0.442
MOD_Cter_Amidation	132	135	PF01082	0.253
MOD_Cter_Amidation	264	267	PF01082	0.305
MOD_GlcNHglycan	10	13	PF01048	0.365
MOD_GlcNHglycan	131	134	PF01048	0.253
MOD_GlcNHglycan	185	189	PF01048	0.305
MOD_GlcNHglycan	246	249	PF01048	0.305
MOD_GlcNHglycan	29	32	PF01048	0.497
MOD_GlcNHglycan	290	293	PF01048	0.433
MOD_GlcNHglycan	36	39	PF01048	0.430
MOD_GlcNHglycan	96	99	PF01048	0.423
MOD_GSK3_1	165	172	PF00069	0.488
MOD_GSK3_1	288	295	PF00069	0.311
MOD_GSK3_1	29	36	PF00069	0.528
MOD_GSK3_1	69	76	PF00069	0.447
MOD_GSK3_1	90	97	PF00069	0.534
MOD_N-GLC_1	174	179	PF02516	0.165
MOD_NEK2_1	118	123	PF00069	0.497
MOD_NEK2_1	244	249	PF00069	0.525
MOD_NEK2_1	29	34	PF00069	0.545
MOD_NEK2_1	90	95	PF00069	0.498
MOD_NEK2_2	19	24	PF00069	0.247
MOD_NEK2_2	239	244	PF00069	0.480
MOD_PIKK_1	127	133	PF00454	0.453
MOD_PKA_1	266	272	PF00069	0.453
MOD_PKA_2	19	25	PF00069	0.431
MOD_PKA_2	239	245	PF00069	0.394
MOD_PKA_2	266	272	PF00069	0.451
MOD_PKA_2	49	55	PF00069	0.398
MOD_PKB_1	264	272	PF00069	0.556
MOD_Plk_1	109	115	PF00069	0.460
MOD_Plk_1	184	190	PF00069	0.469
MOD_Plk_1	203	209	PF00069	0.401
MOD_Plk_2-3	104	110	PF00069	0.447
MOD_Plk_4	203	209	PF00069	0.494
MOD_Plk_4	222	228	PF00069	0.386
MOD_Plk_4	29	35	PF00069	0.444
MOD_Plk_4	37	43	PF00069	0.473
MOD_Plk_4	69	75	PF00069	0.393
MOD_Plk_4	90	96	PF00069	0.345
MOD_ProDKin_1	3	9	PF00069	0.319
MOD_SUMO_for_1	74	77	PF00179	0.516
MOD_SUMO_rev_2	187	197	PF00179	0.541
TRG_DiLeu_BaEn_1	110	115	PF01217	0.297
TRG_ENDOCYTIC_2	252	255	PF00928	0.467
TRG_ER_diArg_1	239	241	PF00400	0.525
TRG_ER_diArg_1	263	266	PF00400	0.473
TRG_NLS_Bipartite_1	134	152	PF00514	0.453
TRG_NLS_MonoCore_2	145	150	PF00514	0.467
TRG_NLS_MonoExtC_3	146	151	PF00514	0.484
TRG_NLS_MonoExtN_4	143	150	PF00514	0.472
TRG_Pf-PMV_PEXEL_1	273	277	PF00026	0.401

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I860	Leptomonas seymouri	63%	97%
A0A0S4JT39	Bodo saltans	37%	87%
A0A1X0P7R1	Trypanosomatidae	46%	100%
A0A3Q8IH64	Leishmania donovani	81%	100%
A0A422N9C6	Trypanosoma rangeli	47%	100%
A4IDG9	Leishmania infantum	81%	100%
D0A357	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	98%
E9ASX2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q1M6	Leishmania major	79%	100%
Q8MNT9	Caenorhabditis elegans	33%	100%
Q8RWY1	Arabidopsis thaliana	29%	86%
Q9D8F1	Mus musculus	34%	99%
Q9NXW9	Homo sapiens	33%	98%