Phosphomannomutase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Phosphomannomutase

Gene product:

phosphomannomutase, putative

Species:

Leishmania braziliensis

UniProt:

A4HP63_LEIBR

TriTrypDb:

LbrM.35.2180 , LBRM2903_350028100

Length:

247

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	yes	yes: 1
Hassani et al.	no	yes: 1
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 1
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 3

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005654	nucleoplasm	2	1
GO:0005829	cytosol	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4HP63

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP63

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009225	nucleotide-sugar metabolic process	4	12
GO:0009226	nucleotide-sugar biosynthetic process	5	12
GO:0009298	GDP-mannose biosynthetic process	6	12
GO:0009987	cellular process	1	12
GO:0018130	heterocycle biosynthetic process	4	12
GO:0019438	aromatic compound biosynthetic process	4	12
GO:0019673	GDP-mannose metabolic process	5	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034654	nucleobase-containing compound biosynthetic process	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044271	cellular nitrogen compound biosynthetic process	4	12
GO:0044281	small molecule metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0055086	nucleobase-containing small molecule metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:1901135	carbohydrate derivative metabolic process	3	12
GO:1901137	carbohydrate derivative biosynthetic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901362	organic cyclic compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12
GO:0005975	carbohydrate metabolic process	3	1
GO:0005996	monosaccharide metabolic process	3	1
GO:0006013	mannose metabolic process	5	1
GO:0006486	protein glycosylation	4	1
GO:0006487	protein N-linked glycosylation	5	1
GO:0019318	hexose metabolic process	4	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043413	macromolecule glycosylation	3	1
GO:0070085	glycosylation	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004615	phosphomannomutase activity	5	12
GO:0016853	isomerase activity	2	12
GO:0016866	intramolecular transferase activity	3	12
GO:0016868	intramolecular transferase activity, phosphotransferases	4	12
GO:0016787	hydrolase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	161	165	PF00082	0.412
CLV_PCSK_SKI1_1	27	31	PF00082	0.324
CLV_PCSK_SKI1_1	4	8	PF00082	0.631
DOC_CYCLIN_RxL_1	98	108	PF00134	0.578
DOC_PP1_RVXF_1	198	205	PF00149	0.524
DOC_PP2B_LxvP_1	109	112	PF13499	0.558
DOC_PP2B_LxvP_1	15	18	PF13499	0.683
DOC_USP7_UBL2_3	184	188	PF12436	0.620
DOC_WW_Pin1_4	126	131	PF00397	0.545
DOC_WW_Pin1_4	13	18	PF00397	0.696
LIG_14-3-3_CanoR_1	83	87	PF00244	0.554
LIG_Actin_WH2_2	145	163	PF00022	0.458
LIG_BIR_II_1	1	5	PF00653	0.590
LIG_Clathr_ClatBox_1	8	12	PF01394	0.645
LIG_EH1_1	149	157	PF00400	0.458
LIG_FHA_1	168	174	PF00498	0.458
LIG_FHA_1	187	193	PF00498	0.558
LIG_FHA_1	233	239	PF00498	0.574
LIG_FHA_1	3	9	PF00498	0.582
LIG_FHA_2	115	121	PF00498	0.534
LIG_FHA_2	229	235	PF00498	0.555
LIG_FXI_DFP_1	60	64	PF00024	0.420
LIG_LIR_Gen_1	117	126	PF02991	0.574
LIG_LIR_Gen_1	144	152	PF02991	0.621
LIG_LIR_Gen_1	178	183	PF02991	0.534
LIG_LIR_Gen_1	61	67	PF02991	0.555
LIG_LIR_Nem_3	117	121	PF02991	0.534
LIG_LIR_Nem_3	141	146	PF02991	0.534
LIG_LIR_Nem_3	178	182	PF02991	0.534
LIG_LIR_Nem_3	196	202	PF02991	0.465
LIG_LIR_Nem_3	215	219	PF02991	0.532
LIG_LIR_Nem_3	61	66	PF02991	0.555
LIG_PCNA_yPIPBox_3	88	99	PF02747	0.540
LIG_Pex14_1	186	190	PF04695	0.534
LIG_Pex14_2	182	186	PF04695	0.534
LIG_Pex14_2	63	67	PF04695	0.545
LIG_PTB_Apo_2	198	205	PF02174	0.458
LIG_REV1ctd_RIR_1	202	212	PF16727	0.534
LIG_SH2_CRK	146	150	PF00017	0.458
LIG_SH2_STAT3	190	193	PF00017	0.574
LIG_SH2_STAT5	190	193	PF00017	0.545
LIG_SH2_STAT5	219	222	PF00017	0.568
LIG_SH2_STAT5	65	68	PF00017	0.534
LIG_SH3_3	15	21	PF00018	0.834
LIG_SUMO_SIM_anti_2	234	240	PF11976	0.594
LIG_SUMO_SIM_par_1	234	240	PF11976	0.621
LIG_SUMO_SIM_par_1	4	10	PF11976	0.600
LIG_TRAF2_1	136	139	PF00917	0.584
LIG_UBA3_1	156	162	PF00899	0.574
LIG_UBA3_1	238	244	PF00899	0.492
LIG_UBA3_1	86	94	PF00899	0.594
LIG_WW_3	16	20	PF00397	0.722
MOD_CDK_SPxK_1	13	19	PF00069	0.712
MOD_CDK_SPxxK_3	126	133	PF00069	0.545
MOD_CK1_1	228	234	PF00069	0.571
MOD_CK2_1	114	120	PF00069	0.534
MOD_CK2_1	133	139	PF00069	0.534
MOD_CK2_1	55	61	PF00069	0.620
MOD_GSK3_1	221	228	PF00069	0.543
MOD_N-GLC_1	126	131	PF02516	0.337
MOD_N-GLC_1	133	138	PF02516	0.328
MOD_NEK2_1	169	174	PF00069	0.560
MOD_NEK2_1	55	60	PF00069	0.620
MOD_PIKK_1	133	139	PF00454	0.534
MOD_PKA_2	114	120	PF00069	0.542
MOD_PKA_2	82	88	PF00069	0.554
MOD_Plk_1	107	113	PF00069	0.458
MOD_Plk_1	186	192	PF00069	0.541
MOD_Plk_4	114	120	PF00069	0.534
MOD_Plk_4	2	8	PF00069	0.584
MOD_Plk_4	55	61	PF00069	0.620
MOD_Plk_4	82	88	PF00069	0.558
MOD_ProDKin_1	126	132	PF00069	0.545
MOD_ProDKin_1	13	19	PF00069	0.699
MOD_SUMO_rev_2	154	163	PF00179	0.578
MOD_SUMO_rev_2	196	202	PF00179	0.458
MOD_SUMO_rev_2	22	29	PF00179	0.774
TRG_ENDOCYTIC_2	146	149	PF00928	0.458
TRG_NES_CRM1_1	147	159	PF08389	0.458

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0K9RL25	Spinacia oleracea	59%	100%
A0A0N1I6J7	Leptomonas seymouri	81%	100%
A0A0S4ITP3	Bodo saltans	64%	100%
A0A0U1WZ18	Dendrobium officinale	60%	98%
A0A1S4A695	Nicotiana tabacum	59%	98%
A0A1X0P803	Trypanosomatidae	69%	100%
A0A3R7K9A3	Trypanosoma rangeli	67%	98%
A0A3S7XAQ9	Leishmania donovani	83%	100%
A4IDG8	Leishmania infantum	83%	100%
D0A356	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	100%
E9ASX1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
M2VWL5	Galdieria sulphuraria	61%	98%
O15305	Homo sapiens	55%	100%
O35621	Mus musculus	50%	94%
O43976	Babesia bovis	42%	100%
O80840	Arabidopsis thaliana	60%	100%
P07283	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	56%	97%
P31353	Candida albicans (strain SC5314 / ATCC MYA-2876)	60%	98%
Q1W374	Triticum aestivum	60%	99%
Q1W375	Nicotiana benthamiana	59%	98%
Q1W376	Glycine max	57%	100%
Q1W377	Solanum lycopersicum	58%	98%
Q259G4	Oryza sativa subsp. indica	58%	100%
Q3SZJ9	Bos taurus	53%	100%
Q4Q1M7	Leishmania major	84%	100%
Q54X03	Dictyostelium discoideum	56%	99%
Q60HD6	Macaca fascicularis	55%	100%
Q7XPW5	Oryza sativa subsp. japonica	58%	100%
Q86B09	Dictyostelium discoideum	59%	99%
Q8SVM5	Encephalitozoon cuniculi (strain GB-M1)	46%	96%
Q92871	Homo sapiens	49%	94%
Q9UTJ2	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	57%	96%
Q9VTZ6	Drosophila melanogaster	52%	97%
Q9XUE6	Caenorhabditis elegans	50%	97%
Q9Z2M7	Mus musculus	55%	100%
V5AWD8	Trypanosoma cruzi	63%	100%