Phosphomannomutase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Phosphomannomutase

Gene product:

phosphomannomutase, putative

Species:

Leishmania braziliensis

UniProt:

A4HP63_LEIBR

TriTrypDb:

LbrM.35.2180 , LBRM2903_350028100

Length:

247

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	yes	yes: 1
Hassani et al.	no	yes: 1
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 1
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 3

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	12
GO:0005829	cytosol	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	12

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Expansion

Sequence features

A4HP63

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP63

Function

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Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	1
GO:0005996	monosaccharide metabolic process	3	1
GO:0006013	mannose metabolic process	5	1
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006486	protein glycosylation	4	1
GO:0006487	protein N-linked glycosylation	5	1
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004615	phosphomannomutase activity	5	12
GO:0016787	hydrolase activity	2	2
GO:0016853	isomerase activity	2	12
GO:0016866	intramolecular transferase activity	3	12
GO:0016868	intramolecular transferase activity, phosphotransferases	4	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	161	165	PF00082	0.412
CLV_PCSK_SKI1_1	27	31	PF00082	0.324
CLV_PCSK_SKI1_1	4	8	PF00082	0.631
DOC_CYCLIN_RxL_1	98	108	PF00134	0.578
DOC_PP1_RVXF_1	198	205	PF00149	0.524
DOC_PP2B_LxvP_1	109	112	PF13499	0.558
DOC_PP2B_LxvP_1	15	18	PF13499	0.683
DOC_USP7_UBL2_3	184	188	PF12436	0.620
DOC_WW_Pin1_4	126	131	PF00397	0.545
DOC_WW_Pin1_4	13	18	PF00397	0.696

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0K9RL25	Spinacia oleracea	59%	100%
A0A0N1I6J7	Leptomonas seymouri	81%	100%
A0A0S4ITP3	Bodo saltans	64%	100%
A0A0U1WZ18	Dendrobium officinale	60%	98%
A0A1S4A695	Nicotiana tabacum	59%	98%
A0A1X0P803	Trypanosomatidae	69%	100%
A0A3R7K9A3	Trypanosoma rangeli	67%	98%
A0A3S7XAQ9	Leishmania donovani	83%	100%
A4IDG8	Leishmania infantum	83%	100%
D0A356	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	100%

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