LeishMANIAdb
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TLDc domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
TLDc domain-containing protein
Gene product:
TLD, putative
Species:
Leishmania braziliensis
UniProt:
A4HP62_LEIBR
TriTrypDb:
LbrM.35.2170 , LBRM2903_350028000 *
Length:
371

Annotations

LeishMANIAdb annotations

Distantly related to a domain found in MEAK7, a regulatory subunit of animal mTOR complex. The hydrophobic segment is likely a perimembrane anchor, not a TM region (used instead of a mirystoylation site found in mammals)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 10
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 4
GO:0110165 cellular anatomical entity 1 4

Expansion

Sequence features

A4HP62
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP62

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 3
GO:0004386 helicase activity 2 3
GO:0140640 catalytic activity, acting on a nucleic acid 2 3
GO:0140657 ATP-dependent activity 1 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 232 236 PF00656 0.287
CLV_PCSK_KEX2_1 189 191 PF00082 0.293
CLV_PCSK_PC1ET2_1 189 191 PF00082 0.367
CLV_PCSK_SKI1_1 12 16 PF00082 0.672
CLV_PCSK_SKI1_1 121 125 PF00082 0.541
CLV_PCSK_SKI1_1 186 190 PF00082 0.375
CLV_PCSK_SKI1_1 206 210 PF00082 0.344
CLV_PCSK_SKI1_1 216 220 PF00082 0.237
CLV_PCSK_SKI1_1 99 103 PF00082 0.532
DOC_ANK_TNKS_1 227 234 PF00023 0.433
DOC_MAPK_HePTP_8 151 163 PF00069 0.446
DOC_MAPK_MEF2A_6 154 163 PF00069 0.446
DOC_MAPK_MEF2A_6 349 357 PF00069 0.630
DOC_MAPK_MEF2A_6 78 86 PF00069 0.453
DOC_PP2B_LxvP_1 84 87 PF13499 0.587
DOC_PP2B_PxIxI_1 155 161 PF00149 0.449
DOC_PP4_FxxP_1 299 302 PF00568 0.344
DOC_USP7_MATH_1 115 119 PF00917 0.394
DOC_USP7_MATH_1 192 196 PF00917 0.445
DOC_WW_Pin1_4 163 168 PF00397 0.449
DOC_WW_Pin1_4 298 303 PF00397 0.413
DOC_WW_Pin1_4 31 36 PF00397 0.465
DOC_WW_Pin1_4 85 90 PF00397 0.533
LIG_14-3-3_CanoR_1 150 158 PF00244 0.415
LIG_14-3-3_CanoR_1 206 211 PF00244 0.371
LIG_14-3-3_CanoR_1 295 300 PF00244 0.361
LIG_14-3-3_CanoR_1 303 312 PF00244 0.363
LIG_Actin_WH2_2 317 332 PF00022 0.503
LIG_APCC_ABBA_1 43 48 PF00400 0.468
LIG_BIR_III_2 114 118 PF00653 0.546
LIG_FHA_1 13 19 PF00498 0.459
LIG_FHA_1 155 161 PF00498 0.363
LIG_FHA_1 194 200 PF00498 0.407
LIG_FHA_1 23 29 PF00498 0.456
LIG_FHA_1 36 42 PF00498 0.409
LIG_FHA_2 122 128 PF00498 0.536
LIG_FHA_2 180 186 PF00498 0.371
LIG_FHA_2 237 243 PF00498 0.469
LIG_FHA_2 329 335 PF00498 0.547
LIG_GBD_Chelix_1 108 116 PF00786 0.526
LIG_LIR_Apic_2 297 302 PF02991 0.346
LIG_LIR_Apic_2 30 36 PF02991 0.467
LIG_LIR_Gen_1 124 133 PF02991 0.322
LIG_LIR_Gen_1 143 151 PF02991 0.344
LIG_LIR_Gen_1 175 185 PF02991 0.346
LIG_LIR_Gen_1 20 29 PF02991 0.693
LIG_LIR_Gen_1 252 262 PF02991 0.413
LIG_LIR_Nem_3 124 128 PF02991 0.378
LIG_LIR_Nem_3 143 147 PF02991 0.344
LIG_LIR_Nem_3 175 181 PF02991 0.353
LIG_LIR_Nem_3 20 26 PF02991 0.587
LIG_LIR_Nem_3 252 257 PF02991 0.413
LIG_PDZ_Class_1 366 371 PF00595 0.713
LIG_Pex14_1 131 135 PF04695 0.328
LIG_Pex14_2 23 27 PF04695 0.451
LIG_Pex14_2 254 258 PF04695 0.344
LIG_Pex14_2 281 285 PF04695 0.344
LIG_Pex14_2 56 60 PF04695 0.515
LIG_SH2_CRK 33 37 PF00017 0.488
LIG_SH2_CRK 80 84 PF00017 0.707
LIG_SH2_GRB2like 138 141 PF00017 0.227
LIG_SH2_NCK_1 33 37 PF00017 0.438
LIG_SH2_SRC 138 141 PF00017 0.330
LIG_SH2_STAP1 135 139 PF00017 0.413
LIG_SH2_STAT5 132 135 PF00017 0.366
LIG_SH2_STAT5 138 141 PF00017 0.358
LIG_SH2_STAT5 256 259 PF00017 0.314
LIG_SH2_STAT5 277 280 PF00017 0.227
LIG_SUMO_SIM_anti_2 157 162 PF11976 0.344
LIG_SUMO_SIM_par_1 82 88 PF11976 0.531
LIG_TRAF2_1 262 265 PF00917 0.449
LIG_UBA3_1 101 107 PF00899 0.461
LIG_UBA3_1 158 164 PF00899 0.449
MOD_CDK_SPK_2 163 168 PF00069 0.474
MOD_CDK_SPK_2 298 303 PF00069 0.227
MOD_CK1_1 246 252 PF00069 0.366
MOD_CK1_1 291 297 PF00069 0.291
MOD_CK1_1 306 312 PF00069 0.466
MOD_CK1_1 337 343 PF00069 0.538
MOD_CK1_1 55 61 PF00069 0.773
MOD_CK2_1 121 127 PF00069 0.536
MOD_CK2_1 179 185 PF00069 0.363
MOD_CK2_1 236 242 PF00069 0.433
MOD_CK2_1 302 308 PF00069 0.369
MOD_CK2_1 328 334 PF00069 0.329
MOD_DYRK1A_RPxSP_1 31 35 PF00069 0.449
MOD_GlcNHglycan 336 339 PF01048 0.683
MOD_GlcNHglycan 5 8 PF01048 0.450
MOD_GSK3_1 150 157 PF00069 0.449
MOD_GSK3_1 173 180 PF00069 0.437
MOD_GSK3_1 243 250 PF00069 0.357
MOD_GSK3_1 27 34 PF00069 0.459
MOD_GSK3_1 287 294 PF00069 0.295
MOD_GSK3_1 298 305 PF00069 0.324
MOD_N-GLC_1 235 240 PF02516 0.227
MOD_N-GLC_1 287 292 PF02516 0.449
MOD_N-GLC_1 71 76 PF02516 0.655
MOD_N-GLC_2 333 335 PF02516 0.365
MOD_N-GLC_2 66 68 PF02516 0.760
MOD_NEK2_1 1 6 PF00069 0.513
MOD_NEK2_1 133 138 PF00069 0.324
MOD_NEK2_1 14 19 PF00069 0.705
MOD_NEK2_1 179 184 PF00069 0.351
MOD_NEK2_1 257 262 PF00069 0.426
MOD_NEK2_1 27 32 PF00069 0.629
MOD_NEK2_1 328 333 PF00069 0.564
MOD_NEK2_1 52 57 PF00069 0.686
MOD_NEK2_2 22 27 PF00069 0.447
MOD_OFUCOSY 335 341 PF10250 0.453
MOD_PIKK_1 12 18 PF00454 0.450
MOD_PIKK_1 179 185 PF00454 0.466
MOD_PIKK_1 55 61 PF00454 0.658
MOD_PKA_2 149 155 PF00069 0.423
MOD_PKA_2 294 300 PF00069 0.393
MOD_PKA_2 302 308 PF00069 0.280
MOD_Plk_4 134 140 PF00069 0.449
MOD_Plk_4 154 160 PF00069 0.145
MOD_Plk_4 22 28 PF00069 0.453
MOD_Plk_4 306 312 PF00069 0.457
MOD_ProDKin_1 163 169 PF00069 0.449
MOD_ProDKin_1 298 304 PF00069 0.413
MOD_ProDKin_1 31 37 PF00069 0.464
MOD_ProDKin_1 85 91 PF00069 0.525
MOD_SUMO_for_1 320 323 PF00179 0.303
MOD_SUMO_rev_2 259 267 PF00179 0.410
MOD_SUMO_rev_2 343 350 PF00179 0.560
MOD_SUMO_rev_2 70 79 PF00179 0.721
TRG_DiLeu_BaEn_1 98 103 PF01217 0.446

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HZW5 Leptomonas seymouri 60% 100%
A0A0S4JCM6 Bodo saltans 28% 100%
A0A0S4JIE3 Bodo saltans 40% 100%
A0A1X0P7Q9 Trypanosomatidae 50% 100%
A0A3R7M9V1 Trypanosoma rangeli 46% 100%
A0A3S7XAT0 Leishmania donovani 79% 99%
E9AG16 Leishmania major 78% 100%
E9AHX4 Leishmania infantum 79% 100%
E9ASX0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 77% 100%
V5BGD9 Trypanosoma cruzi 46% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS