LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Putative nucleoside transporter 1

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative nucleoside transporter 1
Gene product:
inosine-guanosine transporter
Species:
Leishmania braziliensis
UniProt:
A4HP60_LEIBR
TriTrypDb:
LbrM.35.2150 , LBRM2903_350027800
Length:
499

Annotations

LeishMANIAdb annotations

An expanded family of eukaryotic equlibrative nuceloside transporters.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 4
Forrest at al. (procyclic) no yes: 4
Silverman et al. no yes: 0
Pissara et al. yes yes: 45
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 10
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 53
NetGPI no yes: 0, no: 53
Cellular components
Term Name Level Count
GO:0016020 membrane 2 54
GO:0110165 cellular anatomical entity 1 54
GO:0005886 plasma membrane 3 5

Expansion

Sequence features

A4HP60
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP60

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 2
GO:0015851 nucleobase transport 5 2
GO:0051179 localization 1 2
GO:0051234 establishment of localization 2 2
GO:0071702 organic substance transport 4 2
GO:0071705 nitrogen compound transport 4 2
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 54
GO:0005337 nucleoside transmembrane transporter activity 4 54
GO:0015932 nucleobase-containing compound transmembrane transporter activity 3 54
GO:0022857 transmembrane transporter activity 2 54
GO:1901505 carbohydrate derivative transmembrane transporter activity 3 54
GO:0015205 nucleobase transmembrane transporter activity 3 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 258 262 PF00656 0.526
CLV_NRD_NRD_1 251 253 PF00675 0.293
CLV_PCSK_KEX2_1 251 253 PF00082 0.326
CLV_PCSK_KEX2_1 342 344 PF00082 0.330
CLV_PCSK_PC1ET2_1 342 344 PF00082 0.291
CLV_PCSK_SKI1_1 111 115 PF00082 0.300
CLV_PCSK_SKI1_1 324 328 PF00082 0.404
CLV_PCSK_SKI1_1 392 396 PF00082 0.342
DOC_CDC14_PxL_1 415 423 PF14671 0.427
DOC_CKS1_1 458 463 PF01111 0.515
DOC_MAPK_DCC_7 398 408 PF00069 0.455
DOC_MAPK_DCC_7 414 423 PF00069 0.345
DOC_MAPK_DCC_7 426 434 PF00069 0.295
DOC_MAPK_FxFP_2 360 363 PF00069 0.392
DOC_MAPK_gen_1 342 349 PF00069 0.512
DOC_MAPK_gen_1 398 408 PF00069 0.556
DOC_MAPK_HePTP_8 108 120 PF00069 0.525
DOC_MAPK_MEF2A_6 104 112 PF00069 0.550
DOC_MAPK_MEF2A_6 211 220 PF00069 0.408
DOC_MAPK_MEF2A_6 401 408 PF00069 0.516
DOC_MAPK_MEF2A_6 414 423 PF00069 0.370
DOC_MAPK_MEF2A_6 426 434 PF00069 0.309
DOC_MAPK_NFAT4_5 111 119 PF00069 0.449
DOC_PP1_RVXF_1 209 215 PF00149 0.282
DOC_PP2B_LxvP_1 116 119 PF13499 0.327
DOC_PP2B_LxvP_1 400 403 PF13499 0.448
DOC_PP2B_PxIxI_1 434 440 PF00149 0.369
DOC_PP4_FxxP_1 360 363 PF00568 0.406
DOC_PP4_FxxP_1 367 370 PF00568 0.346
DOC_USP7_MATH_1 271 275 PF00917 0.603
DOC_USP7_MATH_1 301 305 PF00917 0.583
DOC_USP7_MATH_1 370 374 PF00917 0.387
DOC_USP7_MATH_1 47 51 PF00917 0.411
DOC_USP7_UBL2_3 276 280 PF12436 0.418
DOC_WW_Pin1_4 457 462 PF00397 0.483
DOC_WW_Pin1_4 69 74 PF00397 0.476
DOC_WW_Pin1_4 97 102 PF00397 0.417
LIG_14-3-3_CanoR_1 334 338 PF00244 0.564
LIG_Actin_WH2_2 181 198 PF00022 0.488
LIG_BRCT_BRCA1_1 475 479 PF00533 0.369
LIG_EH_1 233 237 PF12763 0.503
LIG_eIF4E_1 31 37 PF01652 0.361
LIG_eIF4E_1 436 442 PF01652 0.366
LIG_FHA_1 160 166 PF00498 0.522
LIG_FHA_1 265 271 PF00498 0.605
LIG_FHA_1 31 37 PF00498 0.354
LIG_FHA_1 321 327 PF00498 0.486
LIG_FHA_1 376 382 PF00498 0.375
LIG_FHA_1 43 49 PF00498 0.307
LIG_FHA_1 458 464 PF00498 0.464
LIG_FHA_1 98 104 PF00498 0.412
LIG_FHA_2 200 206 PF00498 0.220
LIG_FHA_2 22 28 PF00498 0.533
LIG_FHA_2 316 322 PF00498 0.523
LIG_FHA_2 325 331 PF00498 0.522
LIG_IRF3_LxIS_1 203 210 PF10401 0.221
LIG_LIR_Apic_2 357 363 PF02991 0.372
LIG_LIR_Gen_1 201 209 PF02991 0.315
LIG_LIR_Gen_1 24 32 PF02991 0.475
LIG_LIR_Gen_1 33 42 PF02991 0.321
LIG_LIR_Gen_1 335 346 PF02991 0.575
LIG_LIR_Gen_1 373 384 PF02991 0.359
LIG_LIR_Gen_1 476 486 PF02991 0.311
LIG_LIR_Nem_3 201 206 PF02991 0.322
LIG_LIR_Nem_3 210 216 PF02991 0.248
LIG_LIR_Nem_3 24 28 PF02991 0.529
LIG_LIR_Nem_3 30 34 PF02991 0.339
LIG_LIR_Nem_3 335 341 PF02991 0.546
LIG_LIR_Nem_3 373 379 PF02991 0.319
LIG_LIR_Nem_3 476 482 PF02991 0.322
LIG_LIR_Nem_3 56 61 PF02991 0.352
LIG_LYPXL_S_1 344 348 PF13949 0.375
LIG_LYPXL_yS_3 345 348 PF13949 0.575
LIG_NRBOX 437 443 PF00104 0.208
LIG_PCNA_PIPBox_1 377 386 PF02747 0.334
LIG_Pex14_2 169 173 PF04695 0.464
LIG_Pex14_2 352 356 PF04695 0.299
LIG_Pex14_2 362 366 PF04695 0.280
LIG_PTB_Apo_2 443 450 PF02174 0.349
LIG_SH2_CRK 376 380 PF00017 0.282
LIG_SH2_PTP2 436 439 PF00017 0.428
LIG_SH2_SRC 59 62 PF00017 0.259
LIG_SH2_STAT5 213 216 PF00017 0.316
LIG_SH2_STAT5 240 243 PF00017 0.525
LIG_SH2_STAT5 31 34 PF00017 0.348
LIG_SH2_STAT5 436 439 PF00017 0.360
LIG_SH2_STAT5 448 451 PF00017 0.326
LIG_SH2_STAT5 456 459 PF00017 0.439
LIG_SH2_STAT5 59 62 PF00017 0.333
LIG_SH3_3 429 435 PF00018 0.308
LIG_SH3_3 455 461 PF00018 0.431
LIG_SUMO_SIM_anti_2 122 128 PF11976 0.340
LIG_SUMO_SIM_anti_2 391 397 PF11976 0.350
LIG_SUMO_SIM_par_1 205 210 PF11976 0.341
LIG_SUMO_SIM_par_1 221 227 PF11976 0.295
LIG_TRFH_1 366 370 PF08558 0.342
LIG_TYR_ITIM 434 439 PF00017 0.344
LIG_WRC_WIRS_1 22 27 PF05994 0.498
LIG_WRC_WIRS_1 31 36 PF05994 0.285
MOD_CDK_SPxxK_3 97 104 PF00069 0.413
MOD_CK1_1 198 204 PF00069 0.263
MOD_CK1_1 259 265 PF00069 0.511
MOD_CK1_1 336 342 PF00069 0.528
MOD_CK1_1 46 52 PF00069 0.415
MOD_CK1_1 488 494 PF00069 0.357
MOD_CK2_1 21 27 PF00069 0.548
MOD_CK2_1 324 330 PF00069 0.539
MOD_GlcNHglycan 245 248 PF01048 0.269
MOD_GlcNHglycan 299 302 PF01048 0.407
MOD_GlcNHglycan 303 306 PF01048 0.391
MOD_GlcNHglycan 4 7 PF01048 0.378
MOD_GlcNHglycan 45 48 PF01048 0.376
MOD_GlcNHglycan 475 478 PF01048 0.345
MOD_GlcNHglycan 49 52 PF01048 0.582
MOD_GlcNHglycan 8 11 PF01048 0.528
MOD_GSK3_1 195 202 PF00069 0.304
MOD_GSK3_1 2 9 PF00069 0.538
MOD_GSK3_1 297 304 PF00069 0.580
MOD_GSK3_1 320 327 PF00069 0.538
MOD_GSK3_1 332 339 PF00069 0.566
MOD_GSK3_1 42 49 PF00069 0.353
MOD_GSK3_1 488 495 PF00069 0.448
MOD_N-GLC_1 297 302 PF02516 0.306
MOD_N-GLC_1 324 329 PF02516 0.305
MOD_N-GLC_1 488 493 PF02516 0.441
MOD_N-GLC_2 159 161 PF02516 0.306
MOD_NEK2_1 102 107 PF00069 0.538
MOD_NEK2_1 157 162 PF00069 0.351
MOD_NEK2_1 186 191 PF00069 0.354
MOD_NEK2_1 195 200 PF00069 0.282
MOD_NEK2_1 207 212 PF00069 0.254
MOD_NEK2_1 320 325 PF00069 0.545
MOD_NEK2_1 332 337 PF00069 0.514
MOD_NEK2_1 355 360 PF00069 0.379
MOD_NEK2_1 37 42 PF00069 0.334
MOD_NEK2_1 43 48 PF00069 0.348
MOD_NEK2_1 442 447 PF00069 0.418
MOD_NEK2_1 492 497 PF00069 0.469
MOD_NEK2_1 8 13 PF00069 0.663
MOD_PIKK_1 133 139 PF00454 0.393
MOD_PKA_2 333 339 PF00069 0.534
MOD_Plk_1 271 277 PF00069 0.569
MOD_Plk_1 467 473 PF00069 0.496
MOD_Plk_1 488 494 PF00069 0.451
MOD_Plk_2-3 315 321 PF00069 0.488
MOD_Plk_4 179 185 PF00069 0.371
MOD_Plk_4 186 192 PF00069 0.340
MOD_Plk_4 27 33 PF00069 0.494
MOD_Plk_4 333 339 PF00069 0.485
MOD_Plk_4 355 361 PF00069 0.328
MOD_Plk_4 37 43 PF00069 0.362
MOD_Plk_4 375 381 PF00069 0.347
MOD_Plk_4 78 84 PF00069 0.316
MOD_ProDKin_1 457 463 PF00069 0.483
MOD_ProDKin_1 69 75 PF00069 0.471
MOD_ProDKin_1 97 103 PF00069 0.413
MOD_SUMO_rev_2 257 265 PF00179 0.509
TRG_DiLeu_BaLyEn_6 411 416 PF01217 0.378
TRG_ENDOCYTIC_2 213 216 PF00928 0.292
TRG_ENDOCYTIC_2 233 236 PF00928 0.508
TRG_ENDOCYTIC_2 31 34 PF00928 0.348
TRG_ENDOCYTIC_2 345 348 PF00928 0.556
TRG_ENDOCYTIC_2 376 379 PF00928 0.254
TRG_ENDOCYTIC_2 436 439 PF00928 0.391

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P486 Leptomonas seymouri 33% 100%
A0A0N0P6Z5 Leptomonas seymouri 69% 100%
A0A0N1I1J0 Leptomonas seymouri 31% 100%
A0A0N1I8E8 Leptomonas seymouri 27% 100%
A0A0N1PBQ1 Leptomonas seymouri 33% 99%
A0A0S4JBS4 Bodo saltans 32% 100%
A0A1X0NN91 Trypanosomatidae 32% 100%
A0A1X0NPL0 Trypanosomatidae 35% 100%
A0A1X0NV38 Trypanosomatidae 36% 100%
A0A1X0NWJ5 Trypanosomatidae 34% 100%
A0A3Q8ICX7 Leishmania donovani 34% 100%
A0A3R7NQR3 Trypanosoma rangeli 33% 100%
A0A3S7WTL0 Leishmania donovani 31% 100%
A0A3S7XAS5 Leishmania donovani 80% 100%
A0A422MQ08 Trypanosoma rangeli 33% 100%
A0A422N8M2 Trypanosoma rangeli 45% 100%
A0A422NHH9 Trypanosoma rangeli 45% 100%
A0A422NR81 Trypanosoma rangeli 29% 100%
A1L272 Danio rerio 23% 96%
A4H6I0 Leishmania braziliensis 32% 100%
A4H7A5 Leishmania braziliensis 33% 100%
A4HG96 Leishmania braziliensis 25% 100%
A4HUW2 Leishmania infantum 34% 91%
A4HVP9 Leishmania infantum 34% 100%
A4HWK9 Leishmania infantum 32% 100%
A4IDG6 Leishmania infantum 80% 100%
C9ZJU3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 100%
C9ZJU5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 100%
C9ZJU7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 100%
C9ZKT6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 100%
C9ZN88 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 100%
C9ZY31 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 48% 100%
C9ZZR9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 100%
D0A6J2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 100%
D0A6J4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 100%
D0A6J6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 100%
E9AGM5 Leishmania infantum 31% 100%
E9AGM6 Leishmania infantum 31% 100%
E9AGM7 Leishmania infantum 31% 100%
E9ANK1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 91%
E9APE5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
E9AQB5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9AQB6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9ASW8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 80% 100%
O76343 Leishmania donovani 32% 100%
Q4Q1M9 Leishmania major 79% 100%
Q4QF58 Leishmania major 31% 100%
Q4QF59 Leishmania major 31% 100%
Q4QG33 Leishmania major 33% 98%
Q4QH25 Leishmania major 32% 100%
V5BGB1 Trypanosoma cruzi 33% 100%
V5BRM5 Trypanosoma cruzi 31% 100%
V5DSF4 Trypanosoma cruzi 46% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS