RING-type E3 ubiquitin transferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ring finger domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HP59_LEIBR

TriTrypDb:

LbrM.35.2140 , LBRM2903_350028600

Length:

301

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	9
GO:0016020	membrane	2	8
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043231	intracellular membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A4HP59

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP59

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	9
GO:0006511	ubiquitin-dependent protein catabolic process	7	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0009056	catabolic process	2	9
GO:0009057	macromolecule catabolic process	4	9
GO:0009987	cellular process	1	9
GO:0019538	protein metabolic process	3	9
GO:0019941	modification-dependent protein catabolic process	6	9
GO:0043170	macromolecule metabolic process	3	9
GO:0043632	modification-dependent macromolecule catabolic process	5	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0044248	cellular catabolic process	3	9
GO:0044260	obsolete cellular macromolecule metabolic process	3	9
GO:0044265	obsolete cellular macromolecule catabolic process	4	9
GO:0051603	proteolysis involved in protein catabolic process	5	9
GO:0071704	organic substance metabolic process	2	9
GO:1901564	organonitrogen compound metabolic process	3	9
GO:1901575	organic substance catabolic process	3	9
GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	6	1
GO:0006950	response to stress	2	1
GO:0010033	response to organic substance	3	1
GO:0010243	response to organonitrogen compound	4	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0030163	protein catabolic process	4	1
GO:0033554	cellular response to stress	3	1
GO:0034976	response to endoplasmic reticulum stress	4	1
GO:0036503	ERAD pathway	5	1
GO:0042221	response to chemical	2	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0071712	ER-associated misfolded protein catabolic process	6	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901698	response to nitrogen compound	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0004842	ubiquitin-protein transferase activity	4	9
GO:0005488	binding	1	9
GO:0016740	transferase activity	2	9
GO:0019787	ubiquitin-like protein transferase activity	3	9
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9
GO:0061630	ubiquitin protein ligase activity	5	9
GO:0061659	ubiquitin-like protein ligase activity	4	9
GO:0140096	catalytic activity, acting on a protein	2	9
GO:0005515	protein binding	2	1
GO:0019899	enzyme binding	3	1
GO:0044390	ubiquitin-like protein conjugating enzyme binding	4	1
GO:0016746	acyltransferase activity	3	1
GO:0061631	ubiquitin conjugating enzyme activity	5	1
GO:0061650	ubiquitin-like protein conjugating enzyme activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	101	105	PF00082	0.425
CLV_PCSK_SKI1_1	112	116	PF00082	0.340
DEG_SPOP_SBC_1	93	97	PF00917	0.814
DOC_MAPK_MEF2A_6	176	183	PF00069	0.775
DOC_MAPK_MEF2A_6	282	290	PF00069	0.391
DOC_MAPK_NFAT4_5	176	184	PF00069	0.775
DOC_PP4_FxxP_1	115	118	PF00568	0.723
DOC_USP7_MATH_1	133	137	PF00917	0.799
DOC_USP7_MATH_1	150	154	PF00917	0.643
DOC_USP7_MATH_1	2	6	PF00917	0.569
DOC_USP7_MATH_1	218	222	PF00917	0.340
DOC_USP7_MATH_1	258	262	PF00917	0.587
DOC_USP7_MATH_1	93	97	PF00917	0.767
DOC_USP7_MATH_1	99	103	PF00917	0.809
DOC_WW_Pin1_4	273	278	PF00397	0.552
LIG_BIR_II_1	1	5	PF00653	0.582
LIG_BRCT_BRCA1_1	184	188	PF00533	0.506
LIG_deltaCOP1_diTrp_1	216	224	PF00928	0.460
LIG_FHA_1	19	25	PF00498	0.560
LIG_FHA_1	192	198	PF00498	0.412
LIG_GBD_Chelix_1	280	288	PF00786	0.492
LIG_IRF3_LxIS_1	280	287	PF10401	0.454
LIG_LIR_Gen_1	216	225	PF02991	0.422
LIG_LIR_Gen_1	287	297	PF02991	0.457
LIG_LIR_Nem_3	216	220	PF02991	0.419
LIG_LIR_Nem_3	287	292	PF02991	0.457
LIG_PALB2_WD40_1	220	228	PF16756	0.327
LIG_Rb_LxCxE_1	26	49	PF01857	0.598
LIG_REV1ctd_RIR_1	112	117	PF16727	0.716
LIG_SH3_3	103	109	PF00018	0.778
LIG_SH3_3	155	161	PF00018	0.738
LIG_SH3_3	45	51	PF00018	0.525
LIG_SUMO_SIM_anti_2	199	204	PF11976	0.363
LIG_SUMO_SIM_par_1	201	207	PF11976	0.492
LIG_UBA3_1	65	71	PF00899	0.634
MOD_CK1_1	102	108	PF00069	0.779
MOD_CK1_1	116	122	PF00069	0.655
MOD_CK1_1	191	197	PF00069	0.331
MOD_CK1_1	95	101	PF00069	0.780
MOD_CK2_1	235	241	PF00069	0.546
MOD_CMANNOS	214	217	PF00535	0.664
MOD_GlcNHglycan	101	104	PF01048	0.590
MOD_GlcNHglycan	118	121	PF01048	0.408
MOD_GlcNHglycan	152	155	PF01048	0.560
MOD_GlcNHglycan	184	187	PF01048	0.561
MOD_GlcNHglycan	190	193	PF01048	0.393
MOD_GlcNHglycan	220	223	PF01048	0.668
MOD_GlcNHglycan	260	263	PF01048	0.756
MOD_GlcNHglycan	42	45	PF01048	0.364
MOD_GlcNHglycan	61	64	PF01048	0.418
MOD_GlcNHglycan	86	89	PF01048	0.585
MOD_GlcNHglycan	97	100	PF01048	0.592
MOD_GSK3_1	175	182	PF00069	0.674
MOD_GSK3_1	256	263	PF00069	0.565
MOD_GSK3_1	78	85	PF00069	0.732
MOD_GSK3_1	88	95	PF00069	0.699
MOD_N-GLC_1	235	240	PF02516	0.757
MOD_N-GLC_1	273	278	PF02516	0.721
MOD_N-GLC_1	99	104	PF02516	0.432
MOD_NEK2_1	1	6	PF00069	0.718
MOD_NEK2_1	188	193	PF00069	0.240
MOD_NEK2_1	284	289	PF00069	0.438
MOD_NEK2_1	9	14	PF00069	0.497
MOD_NEK2_2	204	209	PF00069	0.492
MOD_PIKK_1	134	140	PF00454	0.824
MOD_PIKK_1	235	241	PF00454	0.557
MOD_PIKK_1	251	257	PF00454	0.427
MOD_PKA_2	116	122	PF00069	0.720
MOD_PKA_2	150	156	PF00069	0.707
MOD_PKA_2	175	181	PF00069	0.602
MOD_PKA_2	59	65	PF00069	0.596
MOD_ProDKin_1	273	279	PF00069	0.548

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6L3	Leptomonas seymouri	52%	100%
A0A3Q8IKK1	Leishmania donovani	82%	100%
A0A3R7KB29	Trypanosoma rangeli	43%	100%
A4IDG5	Leishmania infantum	80%	98%
E9ASW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4Q1N0	Leishmania major	78%	100%
V5BPK7	Trypanosoma cruzi	37%	100%