Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HP57_LEIBR

TriTrypDb:

LbrM.35.2120 , LBRM2903_350027600

Length:

494

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HP57

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP57

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	194	198	PF00656	0.301
CLV_C14_Caspase3-7	225	229	PF00656	0.314
CLV_C14_Caspase3-7	267	271	PF00656	0.491
CLV_NRD_NRD_1	159	161	PF00675	0.400
CLV_NRD_NRD_1	21	23	PF00675	0.645
CLV_NRD_NRD_1	218	220	PF00675	0.633
CLV_NRD_NRD_1	336	338	PF00675	0.445
CLV_NRD_NRD_1	435	437	PF00675	0.478
CLV_PCSK_KEX2_1	159	161	PF00082	0.567
CLV_PCSK_KEX2_1	175	177	PF00082	0.503
CLV_PCSK_KEX2_1	218	220	PF00082	0.488
CLV_PCSK_KEX2_1	434	436	PF00082	0.552
CLV_PCSK_KEX2_1	484	486	PF00082	0.554
CLV_PCSK_PC1ET2_1	175	177	PF00082	0.442
CLV_PCSK_PC1ET2_1	434	436	PF00082	0.571
CLV_PCSK_PC1ET2_1	484	486	PF00082	0.548
CLV_PCSK_SKI1_1	135	139	PF00082	0.429
CLV_PCSK_SKI1_1	171	175	PF00082	0.424
CLV_PCSK_SKI1_1	227	231	PF00082	0.340
CLV_PCSK_SKI1_1	299	303	PF00082	0.459
CLV_PCSK_SKI1_1	321	325	PF00082	0.505
CLV_PCSK_SKI1_1	445	449	PF00082	0.486
CLV_PCSK_SKI1_1	487	491	PF00082	0.613
CLV_Separin_Metazoa	390	394	PF03568	0.331
DEG_APCC_DBOX_1	245	253	PF00400	0.471
DEG_APCC_DBOX_1	290	298	PF00400	0.303
DEG_Nend_UBRbox_3	1	3	PF02207	0.631
DEG_SPOP_SBC_1	488	492	PF00917	0.433
DOC_CYCLIN_RxL_1	296	306	PF00134	0.462
DOC_CYCLIN_RxL_1	318	325	PF00134	0.479
DOC_MAPK_gen_1	182	190	PF00069	0.487
DOC_MAPK_gen_1	224	233	PF00069	0.549
DOC_MAPK_gen_1	76	84	PF00069	0.377
DOC_MAPK_MEF2A_6	329	336	PF00069	0.474
DOC_MAPK_RevD_3	324	338	PF00069	0.367
DOC_PP1_RVXF_1	133	139	PF00149	0.338
DOC_PP4_FxxP_1	161	164	PF00568	0.513
DOC_USP7_MATH_1	107	111	PF00917	0.615
DOC_USP7_MATH_1	177	181	PF00917	0.331
DOC_USP7_MATH_1	273	277	PF00917	0.511
DOC_USP7_MATH_1	358	362	PF00917	0.564
DOC_USP7_MATH_1	452	456	PF00917	0.555
DOC_USP7_MATH_1	488	492	PF00917	0.651
DOC_USP7_UBL2_3	171	175	PF12436	0.302
DOC_USP7_UBL2_3	471	475	PF12436	0.535
DOC_WW_Pin1_4	327	332	PF00397	0.555
DOC_WW_Pin1_4	34	39	PF00397	0.531
DOC_WW_Pin1_4	421	426	PF00397	0.607
DOC_WW_Pin1_4	59	64	PF00397	0.637
LIG_14-3-3_CanoR_1	176	182	PF00244	0.560
LIG_14-3-3_CanoR_1	3	11	PF00244	0.579
LIG_14-3-3_CanoR_1	318	324	PF00244	0.429
LIG_14-3-3_CanoR_1	337	343	PF00244	0.455
LIG_14-3-3_CanoR_1	419	423	PF00244	0.485
LIG_AP2alpha_2	51	53	PF02296	0.455
LIG_BRCT_BRCA1_1	275	279	PF00533	0.501
LIG_BRCT_BRCA1_1	49	53	PF00533	0.627
LIG_Clathr_ClatBox_1	67	71	PF01394	0.432
LIG_eIF4E_1	289	295	PF01652	0.459
LIG_FHA_1	183	189	PF00498	0.490
LIG_FHA_2	192	198	PF00498	0.429
LIG_FHA_2	248	254	PF00498	0.482
LIG_FHA_2	265	271	PF00498	0.509
LIG_FHA_2	320	326	PF00498	0.458
LIG_FHA_2	427	433	PF00498	0.575
LIG_FHA_2	78	84	PF00498	0.563
LIG_Integrin_RGD_1	219	221	PF01839	0.487
LIG_KLC1_Yacidic_2	193	197	PF13176	0.309
LIG_LIR_Apic_2	158	164	PF02991	0.527
LIG_LIR_Apic_2	421	425	PF02991	0.575
LIG_LIR_Gen_1	200	210	PF02991	0.444
LIG_LIR_Gen_1	276	286	PF02991	0.418
LIG_LIR_Gen_1	305	316	PF02991	0.369
LIG_LIR_Gen_1	387	395	PF02991	0.570
LIG_LIR_Gen_1	462	470	PF02991	0.520
LIG_LIR_Gen_1	9	17	PF02991	0.465
LIG_LIR_Nem_3	115	120	PF02991	0.409
LIG_LIR_Nem_3	200	206	PF02991	0.447
LIG_LIR_Nem_3	276	282	PF02991	0.389
LIG_LIR_Nem_3	305	311	PF02991	0.361
LIG_LIR_Nem_3	387	391	PF02991	0.573
LIG_LIR_Nem_3	458	463	PF02991	0.472
LIG_LIR_Nem_3	9	14	PF02991	0.553
LIG_LYPXL_yS_3	272	275	PF13949	0.473
LIG_Pex14_1	460	464	PF04695	0.567
LIG_Pex14_2	349	353	PF04695	0.360
LIG_SH2_CRK	464	468	PF00017	0.538
LIG_SH2_PTP2	422	425	PF00017	0.574
LIG_SH2_SRC	195	198	PF00017	0.292
LIG_SH2_SRC	25	28	PF00017	0.493
LIG_SH2_STAP1	120	124	PF00017	0.470
LIG_SH2_STAP1	235	239	PF00017	0.431
LIG_SH2_STAP1	464	468	PF00017	0.520
LIG_SH2_STAT5	195	198	PF00017	0.505
LIG_SH2_STAT5	264	267	PF00017	0.518
LIG_SH2_STAT5	289	292	PF00017	0.572
LIG_SH2_STAT5	310	313	PF00017	0.447
LIG_SH2_STAT5	422	425	PF00017	0.511
LIG_SH2_STAT6	408	412	PF00017	0.517
LIG_SH3_3	325	331	PF00018	0.563
LIG_SUMO_SIM_par_1	330	335	PF11976	0.531
LIG_SUMO_SIM_par_1	66	71	PF11976	0.510
LIG_TRAF2_1	254	257	PF00917	0.507
LIG_TRAF2_2	24	29	PF00917	0.494
LIG_UBA3_1	323	329	PF00899	0.528
MOD_CDK_SPxxK_3	34	41	PF00069	0.531
MOD_CK1_1	100	106	PF00069	0.581
MOD_CK1_1	180	186	PF00069	0.486
MOD_CK1_1	191	197	PF00069	0.368
MOD_CK1_1	37	43	PF00069	0.527
MOD_CK1_1	476	482	PF00069	0.490
MOD_CK1_1	9	15	PF00069	0.472
MOD_CK2_1	107	113	PF00069	0.558
MOD_CK2_1	247	253	PF00069	0.521
MOD_CK2_1	282	288	PF00069	0.422
MOD_CK2_1	311	317	PF00069	0.384
MOD_CK2_1	319	325	PF00069	0.393
MOD_CK2_1	338	344	PF00069	0.334
MOD_CK2_1	426	432	PF00069	0.658
MOD_CK2_1	452	458	PF00069	0.493
MOD_CK2_1	476	482	PF00069	0.370
MOD_CK2_1	58	64	PF00069	0.606
MOD_CK2_1	77	83	PF00069	0.435
MOD_GlcNHglycan	109	112	PF01048	0.588
MOD_GlcNHglycan	190	193	PF01048	0.480
MOD_GlcNHglycan	7	11	PF01048	0.542
MOD_GSK3_1	2	9	PF00069	0.513
MOD_GSK3_1	30	37	PF00069	0.749
MOD_GSK3_1	426	433	PF00069	0.593
MOD_GSK3_1	452	459	PF00069	0.470
MOD_GSK3_1	473	480	PF00069	0.573
MOD_N-GLC_1	3	8	PF02516	0.645
MOD_NEK2_1	131	136	PF00069	0.396
MOD_NEK2_1	282	287	PF00069	0.464
MOD_NEK2_1	311	316	PF00069	0.357
MOD_NEK2_1	319	324	PF00069	0.384
MOD_NEK2_1	489	494	PF00069	0.513
MOD_NEK2_2	177	182	PF00069	0.290
MOD_PIKK_1	12	18	PF00454	0.451
MOD_PIKK_1	359	365	PF00454	0.545
MOD_PIKK_1	396	402	PF00454	0.457
MOD_PKA_2	2	8	PF00069	0.590
MOD_PKA_2	317	323	PF00069	0.483
MOD_PKA_2	418	424	PF00069	0.524
MOD_PKB_1	485	493	PF00069	0.488
MOD_Plk_1	476	482	PF00069	0.472
MOD_Plk_1	6	12	PF00069	0.516
MOD_Plk_2-3	163	169	PF00069	0.492
MOD_Plk_2-3	477	483	PF00069	0.533
MOD_Plk_4	191	197	PF00069	0.478
MOD_Plk_4	319	325	PF00069	0.484
MOD_Plk_4	418	424	PF00069	0.466
MOD_Plk_4	426	432	PF00069	0.500
MOD_ProDKin_1	327	333	PF00069	0.547
MOD_ProDKin_1	34	40	PF00069	0.531
MOD_ProDKin_1	421	427	PF00069	0.610
MOD_ProDKin_1	59	65	PF00069	0.633
MOD_SUMO_for_1	474	477	PF00179	0.534
MOD_SUMO_rev_2	225	231	PF00179	0.447
MOD_SUMO_rev_2	441	449	PF00179	0.460
MOD_SUMO_rev_2	465	473	PF00179	0.526
TRG_DiLeu_BaEn_2	112	118	PF01217	0.438
TRG_ENDOCYTIC_2	272	275	PF00928	0.430
TRG_ENDOCYTIC_2	310	313	PF00928	0.447
TRG_ENDOCYTIC_2	409	412	PF00928	0.456
TRG_ENDOCYTIC_2	464	467	PF00928	0.541
TRG_ER_diArg_1	159	161	PF00400	0.405
TRG_ER_diArg_1	217	219	PF00400	0.500
TRG_Pf-PMV_PEXEL_1	122	126	PF00026	0.478
TRG_Pf-PMV_PEXEL_1	299	303	PF00026	0.459
TRG_Pf-PMV_PEXEL_1	321	325	PF00026	0.516

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCT1	Leptomonas seymouri	60%	97%
A0A0S4ITY0	Bodo saltans	34%	100%
A0A1X0P7R8	Trypanosomatidae	31%	97%
A0A3S7XAS3	Leishmania donovani	76%	100%
A4IDG3	Leishmania infantum	76%	100%
E9ASW5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4Q1N2	Leishmania major	74%	100%