Putative T-lymphocyte triggering factor

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

T-lymphocyte triggering factor, putative

Species:

Leishmania braziliensis

UniProt:

A4HP56_LEIBR

TriTrypDb:

LbrM.35.2110 , LBRM2903_350027500

Length:

459

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0005856	cytoskeleton	5	11
GO:0005929	cilium	4	12
GO:0031514	motile cilium	5	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12
GO:0005794	Golgi apparatus	5	1
GO:0005874	microtubule	6	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0099080	supramolecular complex	2	1
GO:0099081	supramolecular polymer	3	1
GO:0099512	supramolecular fiber	4	1
GO:0099513	polymeric cytoskeletal fiber	5	1
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HP56

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP56

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	12
GO:0048870	cell motility	2	12
GO:0051179	localization	1	12
GO:0008104	protein localization	4	1
GO:0033036	macromolecule localization	2	1
GO:0051641	cellular localization	2	1
GO:0070727	cellular macromolecule localization	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0008017	microtubule binding	5	12
GO:0008092	cytoskeletal protein binding	3	12
GO:0015631	tubulin binding	4	12
GO:0019899	enzyme binding	3	12
GO:0031267	small GTPase binding	5	12
GO:0051020	GTPase binding	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.517
CLV_C14_Caspase3-7	162	166	PF00656	0.387
CLV_C14_Caspase3-7	208	212	PF00656	0.514
CLV_C14_Caspase3-7	380	384	PF00656	0.416
CLV_NRD_NRD_1	12	14	PF00675	0.502
CLV_NRD_NRD_1	176	178	PF00675	0.540
CLV_NRD_NRD_1	205	207	PF00675	0.375
CLV_NRD_NRD_1	426	428	PF00675	0.488
CLV_NRD_NRD_1	441	443	PF00675	0.288
CLV_PCSK_KEX2_1	12	14	PF00082	0.542
CLV_PCSK_KEX2_1	175	177	PF00082	0.524
CLV_PCSK_KEX2_1	204	206	PF00082	0.380
CLV_PCSK_KEX2_1	426	428	PF00082	0.496
CLV_PCSK_KEX2_1	441	443	PF00082	0.291
CLV_PCSK_PC1ET2_1	175	177	PF00082	0.524
CLV_PCSK_SKI1_1	103	107	PF00082	0.401
CLV_PCSK_SKI1_1	329	333	PF00082	0.319
DEG_APCC_DBOX_1	242	250	PF00400	0.350
DEG_APCC_KENBOX_2	274	278	PF00400	0.473
DOC_CYCLIN_RxL_1	100	108	PF00134	0.408
DOC_MAPK_gen_1	132	140	PF00069	0.314
DOC_MAPK_gen_1	441	448	PF00069	0.437
DOC_MAPK_RevD_3	282	298	PF00069	0.509
DOC_PP1_RVXF_1	417	424	PF00149	0.406
DOC_PP2B_LxvP_1	280	283	PF13499	0.416
DOC_USP7_UBL2_3	110	114	PF12436	0.420
DOC_USP7_UBL2_3	15	19	PF12436	0.654
LIG_14-3-3_CanoR_1	185	191	PF00244	0.428
LIG_14-3-3_CanoR_1	364	369	PF00244	0.452
LIG_14-3-3_CanoR_1	453	457	PF00244	0.531
LIG_Actin_WH2_2	109	127	PF00022	0.521
LIG_FHA_2	194	200	PF00498	0.513
LIG_FHA_2	346	352	PF00498	0.540
LIG_FHA_2	415	421	PF00498	0.446
LIG_FHA_2	64	70	PF00498	0.532
LIG_LIR_Gen_1	228	238	PF02991	0.410
LIG_LIR_Nem_3	236	241	PF02991	0.365
LIG_LIR_Nem_3	313	318	PF02991	0.499
LIG_LIR_Nem_3	333	339	PF02991	0.412
LIG_NBox_RRM_1	350	360	PF00076	0.406
LIG_PCNA_yPIPBox_3	96	106	PF02747	0.439
LIG_PDZ_Class_2	454	459	PF00595	0.464
LIG_PTB_Apo_2	69	76	PF02174	0.499
LIG_SH2_CRK	238	242	PF00017	0.358
LIG_SH2_CRK	315	319	PF00017	0.452
LIG_SH2_CRK	336	340	PF00017	0.430
LIG_SH2_GRB2like	237	240	PF00017	0.406
LIG_SH2_NCK_1	238	242	PF00017	0.406
LIG_SH2_STAP1	107	111	PF00017	0.379
LIG_SH2_STAP1	190	194	PF00017	0.433
LIG_SH2_STAT5	51	54	PF00017	0.473
LIG_SH3_3	443	449	PF00018	0.492
LIG_SUMO_SIM_par_1	169	174	PF11976	0.428
LIG_SUMO_SIM_par_1	269	274	PF11976	0.350
LIG_TRAF2_1	28	31	PF00917	0.538
LIG_TYR_ITSM	234	241	PF00017	0.245
LIG_UBA3_1	248	253	PF00899	0.240
LIG_UBA3_1	269	275	PF00899	0.334
MOD_CK1_1	310	316	PF00069	0.303
MOD_CK2_1	148	154	PF00069	0.506
MOD_CK2_1	193	199	PF00069	0.494
MOD_CK2_1	345	351	PF00069	0.211
MOD_CK2_1	63	69	PF00069	0.466
MOD_CK2_1	79	85	PF00069	0.521
MOD_Cter_Amidation	10	13	PF01082	0.699
MOD_GlcNHglycan	150	153	PF01048	0.575
MOD_GSK3_1	148	155	PF00069	0.505
MOD_N-GLC_1	239	244	PF02516	0.163
MOD_N-GLC_1	364	369	PF02516	0.305
MOD_N-GLC_1	414	419	PF02516	0.253
MOD_NEK2_1	171	176	PF00069	0.434
MOD_NEK2_1	308	313	PF00069	0.214
MOD_PIKK_1	152	158	PF00454	0.546
MOD_PKA_2	152	158	PF00069	0.517
MOD_PKA_2	308	314	PF00069	0.269
MOD_PKA_2	452	458	PF00069	0.566
MOD_Plk_1	364	370	PF00069	0.326
MOD_Plk_1	414	420	PF00069	0.179
MOD_Plk_2-3	401	407	PF00069	0.224
MOD_Plk_4	233	239	PF00069	0.308
MOD_Plk_4	335	341	PF00069	0.269
MOD_Plk_4	452	458	PF00069	0.580
MOD_Plk_4	58	64	PF00069	0.344
MOD_SUMO_for_1	252	255	PF00179	0.240
MOD_SUMO_rev_2	189	195	PF00179	0.452
MOD_SUMO_rev_2	228	236	PF00179	0.308
MOD_SUMO_rev_2	424	432	PF00179	0.553
MOD_SUMO_rev_2	69	75	PF00179	0.563
MOD_SUMO_rev_2	88	97	PF00179	0.403
TRG_DiLeu_BaEn_4	213	219	PF01217	0.445
TRG_ENDOCYTIC_2	238	241	PF00928	0.240
TRG_ENDOCYTIC_2	315	318	PF00928	0.305
TRG_ENDOCYTIC_2	336	339	PF00928	0.255
TRG_ER_diArg_1	132	135	PF00400	0.348
TRG_ER_diArg_1	203	206	PF00400	0.379
TRG_ER_diArg_1	312	315	PF00400	0.315
TRG_ER_diArg_1	425	427	PF00400	0.582
TRG_NES_CRM1_1	385	396	PF08389	0.240
TRG_NLS_MonoExtC_3	174	180	PF00514	0.487
TRG_Pf-PMV_PEXEL_1	103	108	PF00026	0.368

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWE1	Leptomonas seymouri	28%	95%
A0A0N1HYA1	Leptomonas seymouri	76%	100%
A0A0S4IRB6	Bodo saltans	31%	100%
A0A0S4J2F6	Bodo saltans	50%	100%
A0A1X0P612	Trypanosomatidae	29%	97%
A0A1X0P7Y2	Trypanosomatidae	54%	100%
A0A3S5H7Z1	Leishmania donovani	29%	100%
A0A3S7XAT7	Leishmania donovani	88%	100%
A0A422MVC9	Trypanosoma rangeli	55%	100%
A0A422NNP7	Trypanosoma rangeli	30%	100%
A4HMK2	Leishmania braziliensis	30%	100%
A4IB81	Leishmania infantum	29%	100%
A4IDG2	Leishmania infantum	89%	100%
A5D7M3	Bos taurus	37%	96%
C9ZZK6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
D0A342	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9AF02	Leishmania major	28%	99%
E9ASW4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9B658	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
F1QNW4	Danio rerio	33%	97%
O15697	Trypanosoma brucei rhodesiense	54%	100%
O95995	Homo sapiens	35%	96%
Q499U4	Rattus norvegicus	37%	96%
Q4Q1N3	Leishmania major	87%	100%
Q60779	Mus musculus	36%	96%
Q7XJ96	Chlamydomonas reinhardtii	34%	97%
Q8MT08	Drosophila melanogaster	26%	96%
V5ATF4	Trypanosoma cruzi	30%	100%
V5BTX8	Trypanosoma cruzi	57%	94%