Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HP55_LEIBR

TriTrypDb:

LbrM.35.2100 , LBRM2903_350027400

Length:

439

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HP55

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP55

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	144	146	PF00675	0.692
CLV_NRD_NRD_1	161	163	PF00675	0.787
CLV_NRD_NRD_1	180	182	PF00675	0.593
CLV_NRD_NRD_1	284	286	PF00675	0.545
CLV_NRD_NRD_1	421	423	PF00675	0.576
CLV_NRD_NRD_1	434	436	PF00675	0.664
CLV_NRD_NRD_1	437	439	PF00675	0.675
CLV_PCSK_FUR_1	435	439	PF00082	0.831
CLV_PCSK_KEX2_1	144	146	PF00082	0.752
CLV_PCSK_KEX2_1	161	163	PF00082	0.699
CLV_PCSK_KEX2_1	180	182	PF00082	0.593
CLV_PCSK_KEX2_1	2	4	PF00082	0.700
CLV_PCSK_KEX2_1	266	268	PF00082	0.502
CLV_PCSK_KEX2_1	284	286	PF00082	0.475
CLV_PCSK_KEX2_1	373	375	PF00082	0.563
CLV_PCSK_KEX2_1	421	423	PF00082	0.778
CLV_PCSK_KEX2_1	434	436	PF00082	0.664
CLV_PCSK_KEX2_1	437	439	PF00082	0.675
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.700
CLV_PCSK_PC1ET2_1	266	268	PF00082	0.502
CLV_PCSK_PC1ET2_1	284	286	PF00082	0.475
CLV_PCSK_PC1ET2_1	373	375	PF00082	0.578
CLV_PCSK_PC1ET2_1	437	439	PF00082	0.841
CLV_PCSK_PC7_1	140	146	PF00082	0.589
CLV_PCSK_SKI1_1	263	267	PF00082	0.616
CLV_PCSK_SKI1_1	285	289	PF00082	0.799
CLV_PCSK_SKI1_1	341	345	PF00082	0.583
CLV_PCSK_SKI1_1	41	45	PF00082	0.763
CLV_Separin_Metazoa	42	46	PF03568	0.765
DEG_Nend_UBRbox_1	1	4	PF02207	0.800
DEG_SPOP_SBC_1	15	19	PF00917	0.698
DOC_CKS1_1	229	234	PF01111	0.810
DOC_CKS1_1	27	32	PF01111	0.558
DOC_CYCLIN_RxL_1	419	428	PF00134	0.787
DOC_MAPK_DCC_7	296	306	PF00069	0.651
DOC_PP1_RVXF_1	420	427	PF00149	0.784
DOC_PP2B_LxvP_1	188	191	PF13499	0.565
DOC_PP2B_LxvP_1	302	305	PF13499	0.523
DOC_PP4_FxxP_1	98	101	PF00568	0.799
DOC_USP7_MATH_1	14	18	PF00917	0.766
DOC_USP7_MATH_1	236	240	PF00917	0.689
DOC_USP7_MATH_1	291	295	PF00917	0.810
DOC_USP7_MATH_1	316	320	PF00917	0.693
DOC_USP7_MATH_1	321	325	PF00917	0.654
DOC_USP7_MATH_1	398	402	PF00917	0.821
DOC_USP7_MATH_1	49	53	PF00917	0.783
DOC_USP7_MATH_1	76	80	PF00917	0.659
DOC_USP7_MATH_1	82	86	PF00917	0.699
DOC_USP7_MATH_1	93	97	PF00917	0.537
DOC_WW_Pin1_4	116	121	PF00397	0.815
DOC_WW_Pin1_4	149	154	PF00397	0.811
DOC_WW_Pin1_4	161	166	PF00397	0.669
DOC_WW_Pin1_4	192	197	PF00397	0.807
DOC_WW_Pin1_4	20	25	PF00397	0.673
DOC_WW_Pin1_4	225	230	PF00397	0.772
DOC_WW_Pin1_4	26	31	PF00397	0.735
DOC_WW_Pin1_4	408	413	PF00397	0.651
DOC_WW_Pin1_4	78	83	PF00397	0.751
DOC_WW_Pin1_4	97	102	PF00397	0.580
LIG_14-3-3_CanoR_1	136	140	PF00244	0.731
LIG_14-3-3_CanoR_1	161	165	PF00244	0.715
LIG_14-3-3_CanoR_1	172	179	PF00244	0.543
LIG_14-3-3_CanoR_1	180	185	PF00244	0.598
LIG_14-3-3_CanoR_1	312	318	PF00244	0.587
LIG_14-3-3_CanoR_1	347	352	PF00244	0.651
LIG_14-3-3_CanoR_1	357	365	PF00244	0.573
LIG_14-3-3_CanoR_1	400	404	PF00244	0.825
LIG_Actin_WH2_2	29	47	PF00022	0.779
LIG_BIR_III_2	226	230	PF00653	0.571
LIG_BRCT_BRCA1_1	323	327	PF00533	0.574
LIG_CSL_BTD_1	98	101	PF09270	0.760
LIG_FHA_1	229	235	PF00498	0.629
LIG_FHA_1	33	39	PF00498	0.672
LIG_FHA_1	400	406	PF00498	0.742
LIG_FHA_1	69	75	PF00498	0.581
LIG_FHA_1	92	98	PF00498	0.578
LIG_FHA_2	202	208	PF00498	0.588
LIG_FHA_2	221	227	PF00498	0.544
LIG_LIR_Apic_2	10	14	PF02991	0.557
LIG_LIR_Apic_2	95	101	PF02991	0.804
LIG_LIR_Gen_1	217	227	PF02991	0.596
LIG_LIR_Gen_1	277	287	PF02991	0.524
LIG_LIR_Nem_3	100	106	PF02991	0.541
LIG_LIR_Nem_3	217	222	PF02991	0.599
LIG_LIR_Nem_3	277	282	PF02991	0.508
LIG_MYND_1	116	120	PF01753	0.814
LIG_PCNA_yPIPBox_3	373	383	PF02747	0.725
LIG_Pex14_1	99	103	PF04695	0.800
LIG_SH2_CRK	11	15	PF00017	0.562
LIG_SH2_CRK	391	395	PF00017	0.811
LIG_SH3_2	75	80	PF14604	0.811
LIG_SH3_3	114	120	PF00018	0.815
LIG_SH3_3	152	158	PF00018	0.769
LIG_SH3_3	226	232	PF00018	0.814
LIG_SH3_3	369	375	PF00018	0.574
LIG_SH3_3	379	385	PF00018	0.655
LIG_SH3_3	69	75	PF00018	0.766
LIG_SH3_3	87	93	PF00018	0.608
LIG_SH3_3	98	104	PF00018	0.688
LIG_SUMO_SIM_par_1	401	407	PF11976	0.576
LIG_TYR_ITIM	389	394	PF00017	0.555
LIG_WRC_WIRS_1	237	242	PF05994	0.545
MOD_CDC14_SPxK_1	411	414	PF00782	0.769
MOD_CDK_SPK_2	161	166	PF00069	0.615
MOD_CDK_SPxK_1	408	414	PF00069	0.774
MOD_CK1_1	134	140	PF00069	0.598
MOD_CK1_1	164	170	PF00069	0.657
MOD_CK1_1	174	180	PF00069	0.556
MOD_CK1_1	183	189	PF00069	0.849
MOD_CK1_1	218	224	PF00069	0.776
MOD_CK1_1	228	234	PF00069	0.671
MOD_CK1_1	26	32	PF00069	0.653
MOD_CK1_1	274	280	PF00069	0.751
MOD_CK1_1	320	326	PF00069	0.810
MOD_CK1_1	328	334	PF00069	0.684
MOD_CK1_1	361	367	PF00069	0.795
MOD_CK1_1	7	13	PF00069	0.639
MOD_CK2_1	218	224	PF00069	0.757
MOD_CK2_1	328	334	PF00069	0.576
MOD_GlcNHglycan	112	115	PF01048	0.717
MOD_GlcNHglycan	140	143	PF01048	0.655
MOD_GlcNHglycan	166	169	PF01048	0.605
MOD_GlcNHglycan	18	21	PF01048	0.732
MOD_GlcNHglycan	247	250	PF01048	0.697
MOD_GlcNHglycan	276	279	PF01048	0.748
MOD_GlcNHglycan	313	316	PF01048	0.799
MOD_GlcNHglycan	319	322	PF01048	0.722
MOD_GlcNHglycan	327	330	PF01048	0.603
MOD_GlcNHglycan	338	341	PF01048	0.545
MOD_GlcNHglycan	360	363	PF01048	0.554
MOD_GlcNHglycan	54	58	PF01048	0.720
MOD_GSK3_1	121	128	PF00069	0.808
MOD_GSK3_1	131	138	PF00069	0.632
MOD_GSK3_1	157	164	PF00069	0.861
MOD_GSK3_1	16	23	PF00069	0.653
MOD_GSK3_1	171	178	PF00069	0.607
MOD_GSK3_1	179	186	PF00069	0.612
MOD_GSK3_1	214	221	PF00069	0.816
MOD_GSK3_1	257	264	PF00069	0.685
MOD_GSK3_1	285	292	PF00069	0.799
MOD_GSK3_1	316	323	PF00069	0.561
MOD_GSK3_1	408	415	PF00069	0.809
MOD_GSK3_1	49	56	PF00069	0.738
MOD_GSK3_1	78	85	PF00069	0.773
MOD_GSK3_1	93	100	PF00069	0.651
MOD_N-GLC_1	20	25	PF02516	0.573
MOD_N-GLC_1	408	413	PF02516	0.667
MOD_NEK2_1	257	262	PF00069	0.613
MOD_NEK2_1	311	316	PF00069	0.798
MOD_NEK2_1	335	340	PF00069	0.582
MOD_NEK2_1	360	365	PF00069	0.811
MOD_NEK2_2	261	266	PF00069	0.754
MOD_NEK2_2	93	98	PF00069	0.561
MOD_PIKK_1	82	88	PF00454	0.686
MOD_PK_1	180	186	PF00069	0.599
MOD_PKA_1	180	186	PF00069	0.599
MOD_PKA_1	285	291	PF00069	0.546
MOD_PKA_2	135	141	PF00069	0.727
MOD_PKA_2	160	166	PF00069	0.716
MOD_PKA_2	171	177	PF00069	0.675
MOD_PKA_2	179	185	PF00069	0.594
MOD_PKA_2	311	317	PF00069	0.583
MOD_PKA_2	346	352	PF00069	0.790
MOD_PKA_2	399	405	PF00069	0.826
MOD_PKA_2	67	73	PF00069	0.701
MOD_Plk_1	255	261	PF00069	0.522
MOD_Plk_1	398	404	PF00069	0.784
MOD_Plk_1	4	10	PF00069	0.583
MOD_Plk_1	68	74	PF00069	0.588
MOD_Plk_4	121	127	PF00069	0.648
MOD_Plk_4	236	242	PF00069	0.660
MOD_Plk_4	93	99	PF00069	0.708
MOD_ProDKin_1	116	122	PF00069	0.812
MOD_ProDKin_1	149	155	PF00069	0.811
MOD_ProDKin_1	161	167	PF00069	0.668
MOD_ProDKin_1	192	198	PF00069	0.809
MOD_ProDKin_1	20	26	PF00069	0.673
MOD_ProDKin_1	225	231	PF00069	0.766
MOD_ProDKin_1	408	414	PF00069	0.651
MOD_ProDKin_1	78	84	PF00069	0.753
MOD_ProDKin_1	97	103	PF00069	0.580
MOD_SUMO_rev_2	328	338	PF00179	0.578
TRG_DiLeu_BaLyEn_6	229	234	PF01217	0.557
TRG_ENDOCYTIC_2	106	109	PF00928	0.551
TRG_ENDOCYTIC_2	391	394	PF00928	0.560
TRG_ER_diArg_1	143	145	PF00400	0.651
TRG_ER_diArg_1	179	181	PF00400	0.590
TRG_ER_diArg_1	354	357	PF00400	0.583
TRG_ER_diArg_1	420	422	PF00400	0.773
TRG_ER_diArg_1	434	436	PF00400	0.820
TRG_Pf-PMV_PEXEL_1	267	271	PF00026	0.493
TRG_Pf-PMV_PEXEL_1	387	392	PF00026	0.553

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IG15	Leishmania donovani	60%	100%
E9AG15	Leishmania major	57%	94%
E9AHX3	Leishmania infantum	60%	100%
E9ASW3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	59%	100%