Putative endochitinase

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

endochitinase, putative

Species:

Leishmania braziliensis

UniProt:

A4HP53_LEIBR

TriTrypDb:

LbrM.35.2080 , LBRM2903_350027200

Length:

179

Annotations

LeishMANIAdb annotations

Probably part of some larger protein. The previous identification as endochitinase is highly tenuous.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 10, no: 2
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4HP53

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP53

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	125	127	PF00082	0.617
CLV_PCSK_KEX2_1	96	98	PF00082	0.576
CLV_PCSK_PC1ET2_1	125	127	PF00082	0.582
CLV_PCSK_PC1ET2_1	96	98	PF00082	0.540
DEG_APCC_DBOX_1	5	13	PF00400	0.345
DEG_SPOP_SBC_1	35	39	PF00917	0.376
DOC_USP7_MATH_1	168	172	PF00917	0.634
DOC_USP7_MATH_1	35	39	PF00917	0.447
DOC_WW_Pin1_4	31	36	PF00397	0.581
LIG_FHA_1	100	106	PF00498	0.472
LIG_FHA_1	125	131	PF00498	0.395
LIG_FHA_1	84	90	PF00498	0.431
LIG_FHA_2	116	122	PF00498	0.430
LIG_LIR_Gen_1	148	157	PF02991	0.381
LIG_LIR_Nem_3	148	152	PF02991	0.336
LIG_LIR_Nem_3	153	158	PF02991	0.307
LIG_LIR_Nem_3	174	179	PF02991	0.600
LIG_Pex14_2	155	159	PF04695	0.276
LIG_SH2_CRK	144	148	PF00017	0.279
LIG_SH2_GRB2like	176	179	PF00017	0.590
LIG_SH2_NCK_1	144	148	PF00017	0.279
LIG_SH2_STAP1	135	139	PF00017	0.417
LIG_SH2_STAT5	176	179	PF00017	0.565
LIG_SH2_STAT5	76	79	PF00017	0.355
LIG_SUMO_SIM_par_1	101	107	PF11976	0.450
LIG_SUMO_SIM_par_1	109	115	PF11976	0.398
LIG_TYR_ITIM	142	147	PF00017	0.400
LIG_UBA3_1	154	163	PF00899	0.417
LIG_UBA3_1	89	96	PF00899	0.488
LIG_WRC_WIRS_1	146	151	PF05994	0.335
MOD_CK1_1	117	123	PF00069	0.373
MOD_CK1_1	145	151	PF00069	0.324
MOD_CK1_1	34	40	PF00069	0.413
MOD_CK1_1	53	59	PF00069	0.370
MOD_CK2_1	115	121	PF00069	0.372
MOD_CK2_1	168	174	PF00069	0.640
MOD_CK2_1	61	67	PF00069	0.426
MOD_Cter_Amidation	94	97	PF01082	0.539
MOD_GlcNHglycan	52	55	PF01048	0.580
MOD_GSK3_1	120	127	PF00069	0.444
MOD_GSK3_1	31	38	PF00069	0.546
MOD_GSK3_1	56	63	PF00069	0.387
MOD_LATS_1	81	87	PF00433	0.298
MOD_N-GLC_1	56	61	PF02516	0.510
MOD_N-GLC_1	99	104	PF02516	0.636
MOD_N-GLC_2	66	68	PF02516	0.508
MOD_NEK2_1	114	119	PF00069	0.395
MOD_NEK2_1	36	41	PF00069	0.302
MOD_NEK2_1	99	104	PF00069	0.510
MOD_OFUCOSY	119	124	PF10250	0.685
MOD_PKA_1	125	131	PF00069	0.356
MOD_PKA_2	125	131	PF00069	0.360
MOD_Plk_1	56	62	PF00069	0.304
MOD_Plk_4	142	148	PF00069	0.277
MOD_Plk_4	25	31	PF00069	0.398
MOD_Plk_4	36	42	PF00069	0.349
MOD_Plk_4	56	62	PF00069	0.217
MOD_Plk_4	99	105	PF00069	0.519
MOD_ProDKin_1	31	37	PF00069	0.582
MOD_SUMO_for_1	130	133	PF00179	0.321
TRG_DiLeu_BaLyEn_6	137	142	PF01217	0.399
TRG_ENDOCYTIC_2	144	147	PF00928	0.279
TRG_ER_diArg_1	5	8	PF00400	0.491

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILH5	Leptomonas seymouri	77%	100%
A0A0S4IW86	Bodo saltans	47%	100%
A0A0S4JL05	Bodo saltans	27%	75%
A0A0S4JS45	Bodo saltans	28%	67%
A0A1X0P825	Trypanosomatidae	67%	100%
A0A3Q8IJ94	Leishmania donovani	83%	100%
A0A422MXC2	Trypanosoma rangeli	62%	100%
A4IDG0	Leishmania infantum	83%	100%
E9ASW1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q1N5	Leishmania major	78%	100%
V5DL10	Trypanosoma cruzi	56%	96%