CBF domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CBF/Mak21 family, putative

Species:

Leishmania braziliensis

UniProt:

A4HP52_LEIBR

TriTrypDb:

LbrM.35.2070 , LBRM2903_350027100

Length:

633

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	11
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	12
GO:0005634	nucleus	5	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HP52

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP52

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006270	DNA replication initiation	5	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003682	chromatin binding	2	1
GO:0005488	binding	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	152	156	PF00656	0.344
CLV_C14_Caspase3-7	400	404	PF00656	0.184
CLV_NRD_NRD_1	174	176	PF00675	0.367
CLV_NRD_NRD_1	231	233	PF00675	0.450
CLV_NRD_NRD_1	477	479	PF00675	0.245
CLV_NRD_NRD_1	619	621	PF00675	0.439
CLV_NRD_NRD_1	64	66	PF00675	0.492
CLV_NRD_NRD_1	91	93	PF00675	0.348
CLV_NRD_NRD_1	95	97	PF00675	0.377
CLV_PCSK_KEX2_1	176	178	PF00082	0.512
CLV_PCSK_KEX2_1	212	214	PF00082	0.547
CLV_PCSK_KEX2_1	231	233	PF00082	0.450
CLV_PCSK_KEX2_1	477	479	PF00082	0.245
CLV_PCSK_KEX2_1	621	623	PF00082	0.427
CLV_PCSK_PC1ET2_1	176	178	PF00082	0.562
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.495
CLV_PCSK_PC1ET2_1	621	623	PF00082	0.425
CLV_PCSK_PC7_1	172	178	PF00082	0.516
CLV_PCSK_SKI1_1	212	216	PF00082	0.571
CLV_PCSK_SKI1_1	24	28	PF00082	0.434
CLV_PCSK_SKI1_1	352	356	PF00082	0.260
CLV_PCSK_SKI1_1	500	504	PF00082	0.307
DEG_Nend_UBRbox_3	1	3	PF02207	0.520
DEG_SPOP_SBC_1	385	389	PF00917	0.390
DOC_MAPK_gen_1	240	250	PF00069	0.352
DOC_MAPK_MEF2A_6	184	192	PF00069	0.328
DOC_MAPK_MEF2A_6	247	255	PF00069	0.294
DOC_MAPK_MEF2A_6	280	289	PF00069	0.367
DOC_PP2B_LxvP_1	380	383	PF13499	0.245
DOC_USP7_MATH_1	104	108	PF00917	0.333
DOC_USP7_MATH_1	258	262	PF00917	0.285
DOC_USP7_MATH_1	356	360	PF00917	0.287
DOC_USP7_MATH_1	385	389	PF00917	0.390
DOC_USP7_MATH_1	482	486	PF00917	0.243
DOC_USP7_MATH_1	538	542	PF00917	0.245
DOC_USP7_MATH_1	614	618	PF00917	0.347
DOC_USP7_UBL2_3	208	212	PF12436	0.517
DOC_USP7_UBL2_3	215	219	PF12436	0.449
DOC_USP7_UBL2_3	298	302	PF12436	0.490
DOC_USP7_UBL2_3	566	570	PF12436	0.496
DOC_USP7_UBL2_3	93	97	PF12436	0.402
DOC_WW_Pin1_4	606	611	PF00397	0.347
LIG_14-3-3_CanoR_1	175	180	PF00244	0.432
LIG_14-3-3_CanoR_1	471	479	PF00244	0.260
LIG_14-3-3_CanoR_1	51	57	PF00244	0.567
LIG_14-3-3_CanoR_1	96	100	PF00244	0.424
LIG_Actin_WH2_2	241	256	PF00022	0.364
LIG_Actin_WH2_2	542	560	PF00022	0.362
LIG_APCC_ABBA_1	197	202	PF00400	0.620
LIG_BIR_III_4	587	591	PF00653	0.290
LIG_BRCT_BRCA1_1	422	426	PF00533	0.245
LIG_Clathr_ClatBox_1	284	288	PF01394	0.359
LIG_deltaCOP1_diTrp_1	360	368	PF00928	0.260
LIG_deltaCOP1_diTrp_1	445	448	PF00928	0.260
LIG_EH1_1	164	172	PF00400	0.404
LIG_eIF4E_1	367	373	PF01652	0.260
LIG_FHA_1	161	167	PF00498	0.317
LIG_FHA_1	240	246	PF00498	0.417
LIG_FHA_1	266	272	PF00498	0.370
LIG_FHA_1	335	341	PF00498	0.352
LIG_FHA_1	445	451	PF00498	0.238
LIG_FHA_1	471	477	PF00498	0.276
LIG_FHA_1	541	547	PF00498	0.285
LIG_FHA_1	581	587	PF00498	0.389
LIG_FHA_1	6	12	PF00498	0.381
LIG_FHA_1	83	89	PF00498	0.455
LIG_FHA_2	23	29	PF00498	0.402
LIG_FHA_2	355	361	PF00498	0.279
LIG_FHA_2	392	398	PF00498	0.278
LIG_LIR_Gen_1	288	297	PF02991	0.370
LIG_LIR_Gen_1	366	376	PF02991	0.245
LIG_LIR_Gen_1	82	91	PF02991	0.327
LIG_LIR_Nem_3	27	32	PF02991	0.385
LIG_LIR_Nem_3	288	293	PF02991	0.381
LIG_LIR_Nem_3	366	371	PF02991	0.245
LIG_LIR_Nem_3	82	87	PF02991	0.322
LIG_NRBOX	149	155	PF00104	0.307
LIG_NRBOX	184	190	PF00104	0.327
LIG_PCNA_PIPBox_1	12	21	PF02747	0.485
LIG_PCNA_yPIPBox_3	12	24	PF02747	0.511
LIG_PCNA_yPIPBox_3	141	154	PF02747	0.396
LIG_PCNA_yPIPBox_3	175	189	PF02747	0.384
LIG_Pex14_1	544	548	PF04695	0.168
LIG_PTB_Apo_2	4	11	PF02174	0.405
LIG_PTB_Phospho_1	4	10	PF10480	0.417
LIG_SH2_CRK	290	294	PF00017	0.370
LIG_SH2_CRK	568	572	PF00017	0.421
LIG_SH2_SRC	574	577	PF00017	0.340
LIG_SH2_SRC	598	601	PF00017	0.403
LIG_SH2_STAP1	123	127	PF00017	0.248
LIG_SH2_STAP1	84	88	PF00017	0.303
LIG_SH2_STAT3	71	74	PF00017	0.391
LIG_SH2_STAT5	10	13	PF00017	0.355
LIG_SH2_STAT5	252	255	PF00017	0.344
LIG_SH2_STAT5	367	370	PF00017	0.260
LIG_SH2_STAT5	4	7	PF00017	0.445
LIG_SH2_STAT5	84	87	PF00017	0.413
LIG_SH3_3	139	145	PF00018	0.339
LIG_SH3_3	481	487	PF00018	0.309
LIG_SH3_3	604	610	PF00018	0.428
LIG_SUMO_SIM_anti_2	458	463	PF11976	0.246
LIG_SUMO_SIM_par_1	342	348	PF11976	0.245
LIG_SUMO_SIM_par_1	458	463	PF11976	0.260
LIG_TRAF2_1	394	397	PF00917	0.267
LIG_TYR_ITIM	250	255	PF00017	0.296
LIG_UBA3_1	170	176	PF00899	0.365
LIG_UBA3_1	293	302	PF00899	0.345
LIG_UBA3_1	459	465	PF00899	0.245
LIG_UBA3_1	90	97	PF00899	0.354
MOD_CK1_1	160	166	PF00069	0.333
MOD_CK1_1	335	341	PF00069	0.352
MOD_CK1_1	384	390	PF00069	0.390
MOD_CK1_1	411	417	PF00069	0.245
MOD_CK1_1	420	426	PF00069	0.245
MOD_CK1_1	540	546	PF00069	0.279
MOD_CK1_1	547	553	PF00069	0.279
MOD_CK1_1	95	101	PF00069	0.526
MOD_CK2_1	114	120	PF00069	0.334
MOD_CK2_1	354	360	PF00069	0.304
MOD_CK2_1	391	397	PF00069	0.251
MOD_CK2_1	51	57	PF00069	0.473
MOD_CK2_1	95	101	PF00069	0.413
MOD_GlcNHglycan	116	119	PF01048	0.436
MOD_GlcNHglycan	314	317	PF01048	0.654
MOD_GlcNHglycan	383	386	PF01048	0.354
MOD_GlcNHglycan	389	392	PF01048	0.325
MOD_GlcNHglycan	416	419	PF01048	0.245
MOD_GlcNHglycan	534	537	PF01048	0.308
MOD_GSK3_1	352	359	PF00069	0.304
MOD_GSK3_1	381	388	PF00069	0.315
MOD_GSK3_1	408	415	PF00069	0.245
MOD_GSK3_1	420	427	PF00069	0.245
MOD_GSK3_1	440	447	PF00069	0.260
MOD_GSK3_1	46	53	PF00069	0.459
MOD_GSK3_1	540	547	PF00069	0.292
MOD_GSK3_1	549	556	PF00069	0.251
MOD_GSK3_1	606	613	PF00069	0.416
MOD_LATS_1	22	28	PF00433	0.352
MOD_N-GLC_1	22	27	PF02516	0.406
MOD_N-GLC_1	440	445	PF02516	0.260
MOD_N-GLC_1	6	11	PF02516	0.383
MOD_NEK2_1	113	118	PF00069	0.475
MOD_NEK2_1	225	230	PF00069	0.440
MOD_NEK2_1	460	465	PF00069	0.271
MOD_NEK2_1	5	10	PF00069	0.407
MOD_NEK2_1	549	554	PF00069	0.299
MOD_PIKK_1	408	414	PF00454	0.245
MOD_PIKK_1	420	426	PF00454	0.245
MOD_PIKK_1	460	466	PF00454	0.295
MOD_PIKK_1	79	85	PF00454	0.452
MOD_PKA_1	175	181	PF00069	0.421
MOD_PKA_1	92	98	PF00069	0.520
MOD_PKA_2	470	476	PF00069	0.260
MOD_PKA_2	50	56	PF00069	0.555
MOD_PKA_2	95	101	PF00069	0.413
MOD_PKB_1	310	318	PF00069	0.467
MOD_Plk_1	22	28	PF00069	0.403
MOD_Plk_1	329	335	PF00069	0.496
MOD_Plk_1	363	369	PF00069	0.250
MOD_Plk_1	444	450	PF00069	0.245
MOD_Plk_1	538	544	PF00069	0.245
MOD_Plk_1	6	12	PF00069	0.381
MOD_Plk_4	123	129	PF00069	0.345
MOD_Plk_4	14	20	PF00069	0.356
MOD_Plk_4	363	369	PF00069	0.307
MOD_Plk_4	433	439	PF00069	0.445
MOD_Plk_4	490	496	PF00069	0.279
MOD_Plk_4	544	550	PF00069	0.299
MOD_Plk_4	6	12	PF00069	0.381
MOD_ProDKin_1	606	612	PF00069	0.346
MOD_SUMO_for_1	214	217	PF00179	0.470
MOD_SUMO_for_1	615	618	PF00179	0.568
MOD_SUMO_rev_2	202	209	PF00179	0.542
MOD_SUMO_rev_2	315	325	PF00179	0.538
MOD_SUMO_rev_2	599	608	PF00179	0.517
TRG_ENDOCYTIC_2	252	255	PF00928	0.344
TRG_ENDOCYTIC_2	29	32	PF00928	0.372
TRG_ENDOCYTIC_2	290	293	PF00928	0.376
TRG_ENDOCYTIC_2	568	571	PF00928	0.417
TRG_ENDOCYTIC_2	592	595	PF00928	0.387
TRG_ENDOCYTIC_2	84	87	PF00928	0.310
TRG_ER_diArg_1	174	177	PF00400	0.470
TRG_ER_diArg_1	310	313	PF00400	0.687
TRG_ER_diArg_1	476	478	PF00400	0.245
TRG_ER_diArg_1	619	622	PF00400	0.517
TRG_NES_CRM1_1	370	386	PF08389	0.339
TRG_NLS_MonoExtC_3	211	216	PF00514	0.490
TRG_NLS_MonoExtC_3	619	625	PF00514	0.478
TRG_NLS_MonoExtN_4	172	179	PF00514	0.517
TRG_NLS_MonoExtN_4	210	216	PF00514	0.494
TRG_Pf-PMV_PEXEL_1	374	378	PF00026	0.245
TRG_Pf-PMV_PEXEL_1	477	481	PF00026	0.245
TRG_Pf-PMV_PEXEL_1	622	626	PF00026	0.331

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6K8	Leptomonas seymouri	87%	100%
A0A0S4J058	Bodo saltans	63%	100%
A0A1X0P7S6	Trypanosomatidae	72%	100%
A0A3R7JWC9	Trypanosoma rangeli	70%	100%
A0A3S7XAS0	Leishmania donovani	92%	100%
A4IDF9	Leishmania infantum	93%	100%
D0A338	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	100%
E9ASW0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
O94288	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	21%	85%
Q4Q1N6	Leishmania major	92%	100%
V5DKS9	Trypanosoma cruzi	71%	100%