Major vault protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Major vault protein

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HP51_LEIBR

TriTrypDb:

LbrM.35.2060 , LBRM2903_350027000

Length:

876

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0005737	cytoplasm	2	11
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:1990904	ribonucleoprotein complex	2	11

Expansion

Sequence features

A4HP51

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP51

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	192	196	PF00656	0.483
CLV_NRD_NRD_1	260	262	PF00675	0.455
CLV_NRD_NRD_1	316	318	PF00675	0.406
CLV_NRD_NRD_1	402	404	PF00675	0.520
CLV_NRD_NRD_1	470	472	PF00675	0.684
CLV_NRD_NRD_1	633	635	PF00675	0.327
CLV_NRD_NRD_1	727	729	PF00675	0.459
CLV_PCSK_KEX2_1	290	292	PF00082	0.474
CLV_PCSK_KEX2_1	402	404	PF00082	0.520
CLV_PCSK_KEX2_1	633	635	PF00082	0.327
CLV_PCSK_KEX2_1	727	729	PF00082	0.526
CLV_PCSK_PC1ET2_1	290	292	PF00082	0.466
CLV_PCSK_SKI1_1	120	124	PF00082	0.317
CLV_PCSK_SKI1_1	153	157	PF00082	0.277
CLV_PCSK_SKI1_1	284	288	PF00082	0.437
CLV_PCSK_SKI1_1	318	322	PF00082	0.394
CLV_PCSK_SKI1_1	451	455	PF00082	0.170
CLV_PCSK_SKI1_1	471	475	PF00082	0.649
CLV_PCSK_SKI1_1	503	507	PF00082	0.250
CLV_PCSK_SKI1_1	510	514	PF00082	0.271
CLV_PCSK_SKI1_1	634	638	PF00082	0.327
CLV_PCSK_SKI1_1	680	684	PF00082	0.454
CLV_PCSK_SKI1_1	727	731	PF00082	0.459
CLV_PCSK_SKI1_1	771	775	PF00082	0.545
CLV_PCSK_SKI1_1	790	794	PF00082	0.347
DEG_SCF_FBW7_1	583	588	PF00400	0.550
DEG_SCF_FBW7_2	250	256	PF00400	0.566
DOC_CKS1_1	250	255	PF01111	0.557
DOC_CYCLIN_RxL_1	725	735	PF00134	0.468
DOC_CYCLIN_RxL_1	771	781	PF00134	0.596
DOC_CYCLIN_RxL_1	787	797	PF00134	0.468
DOC_CYCLIN_yCln2_LP_2	650	656	PF00134	0.550
DOC_MAPK_gen_1	680	688	PF00069	0.490
DOC_MAPK_gen_1	788	794	PF00069	0.532
DOC_MAPK_HePTP_8	563	575	PF00069	0.447
DOC_MAPK_MEF2A_6	120	127	PF00069	0.550
DOC_MAPK_MEF2A_6	566	575	PF00069	0.447
DOC_MAPK_MEF2A_6	680	688	PF00069	0.448
DOC_PP1_RVXF_1	501	507	PF00149	0.499
DOC_PP4_FxxP_1	156	159	PF00568	0.461
DOC_PP4_FxxP_1	326	329	PF00568	0.459
DOC_PP4_FxxP_1	551	554	PF00568	0.447
DOC_USP7_MATH_1	134	138	PF00917	0.538
DOC_USP7_MATH_1	34	38	PF00917	0.499
DOC_USP7_MATH_1	487	491	PF00917	0.447
DOC_USP7_MATH_1	615	619	PF00917	0.448
DOC_USP7_MATH_1	752	756	PF00917	0.496
DOC_USP7_UBL2_3	536	540	PF12436	0.464
DOC_WW_Pin1_4	139	144	PF00397	0.534
DOC_WW_Pin1_4	249	254	PF00397	0.514
DOC_WW_Pin1_4	361	366	PF00397	0.527
DOC_WW_Pin1_4	49	54	PF00397	0.384
DOC_WW_Pin1_4	524	529	PF00397	0.483
DOC_WW_Pin1_4	581	586	PF00397	0.527
DOC_WW_Pin1_4	858	863	PF00397	0.522
DOC_WW_Pin1_4	95	100	PF00397	0.370
LIG_14-3-3_CanoR_1	291	301	PF00244	0.451
LIG_14-3-3_CanoR_1	317	327	PF00244	0.432
LIG_14-3-3_CanoR_1	416	420	PF00244	0.468
LIG_14-3-3_CanoR_1	815	823	PF00244	0.635
LIG_APCC_ABBA_1	100	105	PF00400	0.461
LIG_BIR_II_1	1	5	PF00653	0.401
LIG_BIR_III_4	79	83	PF00653	0.527
LIG_BRCT_BRCA1_1	189	193	PF00533	0.507
LIG_BRCT_BRCA1_1	617	621	PF00533	0.447
LIG_CaM_IQ_9	782	798	PF13499	0.573
LIG_deltaCOP1_diTrp_1	578	581	PF00928	0.499
LIG_deltaCOP1_diTrp_1	90	100	PF00928	0.527
LIG_EVH1_2	44	48	PF00568	0.510
LIG_FHA_1	192	198	PF00498	0.527
LIG_FHA_1	21	27	PF00498	0.405
LIG_FHA_1	226	232	PF00498	0.341
LIG_FHA_1	322	328	PF00498	0.409
LIG_FHA_1	362	368	PF00498	0.527
LIG_FHA_1	418	424	PF00498	0.461
LIG_FHA_1	44	50	PF00498	0.505
LIG_FHA_1	452	458	PF00498	0.506
LIG_FHA_1	500	506	PF00498	0.461
LIG_FHA_1	556	562	PF00498	0.439
LIG_FHA_1	68	74	PF00498	0.522
LIG_FHA_2	186	192	PF00498	0.459
LIG_FHA_2	244	250	PF00498	0.559
LIG_FHA_2	433	439	PF00498	0.550
LIG_FHA_2	582	588	PF00498	0.527
LIG_FHA_2	658	664	PF00498	0.472
LIG_FHA_2	779	785	PF00498	0.538
LIG_FHA_2	828	834	PF00498	0.532
LIG_LIR_Apic_2	129	134	PF02991	0.481
LIG_LIR_Apic_2	246	250	PF02991	0.483
LIG_LIR_Apic_2	323	329	PF02991	0.430
LIG_LIR_Apic_2	438	444	PF02991	0.527
LIG_LIR_Gen_1	12	19	PF02991	0.433
LIG_LIR_Gen_1	206	215	PF02991	0.443
LIG_LIR_Gen_1	220	227	PF02991	0.457
LIG_LIR_Gen_1	46	56	PF02991	0.319
LIG_LIR_Gen_1	516	524	PF02991	0.447
LIG_LIR_Gen_1	618	629	PF02991	0.461
LIG_LIR_Nem_3	12	16	PF02991	0.422
LIG_LIR_Nem_3	152	157	PF02991	0.474
LIG_LIR_Nem_3	161	166	PF02991	0.480
LIG_LIR_Nem_3	206	211	PF02991	0.426
LIG_LIR_Nem_3	220	224	PF02991	0.448
LIG_LIR_Nem_3	373	378	PF02991	0.547
LIG_LIR_Nem_3	46	51	PF02991	0.398
LIG_LIR_Nem_3	516	522	PF02991	0.447
LIG_LIR_Nem_3	54	59	PF02991	0.461
LIG_LIR_Nem_3	578	583	PF02991	0.481
LIG_LIR_Nem_3	618	624	PF02991	0.447
LIG_LIR_Nem_3	79	84	PF02991	0.496
LIG_LIR_Nem_3	98	103	PF02991	0.367
LIG_LYPXL_L_2	102	111	PF13949	0.527
LIG_LYPXL_yS_3	163	166	PF13949	0.499
LIG_Pex14_2	217	221	PF04695	0.479
LIG_REV1ctd_RIR_1	323	328	PF16727	0.491
LIG_SH2_CRK	131	135	PF00017	0.527
LIG_SH2_CRK	208	212	PF00017	0.497
LIG_SH2_CRK	282	286	PF00017	0.470
LIG_SH2_CRK	299	303	PF00017	0.272
LIG_SH2_CRK	484	488	PF00017	0.450
LIG_SH2_CRK	56	60	PF00017	0.550
LIG_SH2_CRK	81	85	PF00017	0.517
LIG_SH2_NCK_1	131	135	PF00017	0.439
LIG_SH2_PTP2	462	465	PF00017	0.688
LIG_SH2_SRC	247	250	PF00017	0.541
LIG_SH2_STAP1	282	286	PF00017	0.438
LIG_SH2_STAP1	299	303	PF00017	0.311
LIG_SH2_STAP1	577	581	PF00017	0.447
LIG_SH2_STAP1	807	811	PF00017	0.577
LIG_SH2_STAT3	497	500	PF00017	0.527
LIG_SH2_STAT5	154	157	PF00017	0.474
LIG_SH2_STAT5	210	213	PF00017	0.386
LIG_SH2_STAT5	342	345	PF00017	0.447
LIG_SH2_STAT5	405	408	PF00017	0.450
LIG_SH2_STAT5	414	417	PF00017	0.416
LIG_SH2_STAT5	432	435	PF00017	0.447
LIG_SH2_STAT5	462	465	PF00017	0.638
LIG_SH2_STAT5	544	547	PF00017	0.512
LIG_SH2_STAT5	56	59	PF00017	0.477
LIG_SH2_STAT5	580	583	PF00017	0.461
LIG_SH2_STAT5	607	610	PF00017	0.520
LIG_SH2_STAT5	854	857	PF00017	0.519
LIG_SH3_1	247	253	PF00018	0.520
LIG_SH3_1	536	542	PF00018	0.457
LIG_SH3_2	250	255	PF14604	0.557
LIG_SH3_2	528	533	PF14604	0.502
LIG_SH3_3	247	253	PF00018	0.515
LIG_SH3_3	275	281	PF00018	0.392
LIG_SH3_3	374	380	PF00018	0.499
LIG_SH3_3	398	404	PF00018	0.555
LIG_SH3_3	47	53	PF00018	0.322
LIG_SH3_3	502	508	PF00018	0.527
LIG_SH3_3	525	531	PF00018	0.465
LIG_SH3_3	536	542	PF00018	0.439
LIG_SH3_3	56	62	PF00018	0.427
LIG_SH3_3	98	104	PF00018	0.441
LIG_SUMO_SIM_anti_2	23	29	PF11976	0.283
LIG_SUMO_SIM_par_1	520	525	PF11976	0.469
LIG_TRAF2_1	234	237	PF00917	0.523
LIG_TRAF2_1	435	438	PF00917	0.463
LIG_TRAF2_1	620	623	PF00917	0.527
LIG_TRAF2_1	722	725	PF00917	0.545
LIG_TRAF2_1	810	813	PF00917	0.594
LIG_TRAF2_1	88	91	PF00917	0.527
LIG_TRFH_1	100	104	PF08558	0.461
LIG_TRFH_1	277	281	PF08558	0.407
LIG_TRFH_1	325	329	PF08558	0.456
LIG_TYR_ITIM	486	491	PF00017	0.527
LIG_TYR_ITSM	159	166	PF00017	0.499
LIG_WRC_WIRS_1	218	223	PF05994	0.261
MOD_CDK_SPxK_1	249	255	PF00069	0.552
MOD_CDK_SPxxK_3	141	148	PF00069	0.550
MOD_CK1_1	141	147	PF00069	0.537
MOD_CK1_1	220	226	PF00069	0.422
MOD_CK1_1	361	367	PF00069	0.550
MOD_CK1_1	37	43	PF00069	0.493
MOD_CK1_1	555	561	PF00069	0.494
MOD_CK1_1	661	667	PF00069	0.461
MOD_CK1_1	739	745	PF00069	0.486
MOD_CK1_1	754	760	PF00069	0.550
MOD_CK1_1	761	767	PF00069	0.492
MOD_CK2_1	185	191	PF00069	0.490
MOD_CK2_1	231	237	PF00069	0.504
MOD_CK2_1	394	400	PF00069	0.534
MOD_CK2_1	405	411	PF00069	0.412
MOD_CK2_1	432	438	PF00069	0.550
MOD_CK2_1	754	760	PF00069	0.523
MOD_CK2_1	778	784	PF00069	0.522
MOD_CK2_1	827	833	PF00069	0.549
MOD_CK2_1	85	91	PF00069	0.527
MOD_GlcNHglycan	117	120	PF01048	0.302
MOD_GlcNHglycan	182	185	PF01048	0.503
MOD_GlcNHglycan	294	297	PF01048	0.497
MOD_GlcNHglycan	396	399	PF01048	0.342
MOD_GlcNHglycan	426	429	PF01048	0.283
MOD_GlcNHglycan	445	448	PF01048	0.290
MOD_GlcNHglycan	524	527	PF01048	0.261
MOD_GlcNHglycan	627	630	PF01048	0.277
MOD_GlcNHglycan	742	745	PF01048	0.470
MOD_GlcNHglycan	754	757	PF01048	0.437
MOD_GlcNHglycan	869	872	PF01048	0.652
MOD_GlcNHglycan	87	90	PF01048	0.309
MOD_GSK3_1	134	141	PF00069	0.535
MOD_GSK3_1	14	21	PF00069	0.462
MOD_GSK3_1	185	192	PF00069	0.500
MOD_GSK3_1	285	292	PF00069	0.543
MOD_GSK3_1	379	386	PF00069	0.550
MOD_GSK3_1	451	458	PF00069	0.539
MOD_GSK3_1	520	527	PF00069	0.450
MOD_GSK3_1	581	588	PF00069	0.548
MOD_GSK3_1	603	610	PF00069	0.499
MOD_GSK3_1	657	664	PF00069	0.477
MOD_GSK3_1	732	739	PF00069	0.425
MOD_GSK3_1	754	761	PF00069	0.548
MOD_GSK3_1	854	861	PF00069	0.571
MOD_N-GLC_1	21	26	PF02516	0.409
MOD_N-GLC_1	310	315	PF02516	0.527
MOD_N-GLC_1	356	361	PF02516	0.281
MOD_N-GLC_1	555	560	PF02516	0.277
MOD_NEK2_1	1	6	PF00069	0.576
MOD_NEK2_1	185	190	PF00069	0.468
MOD_NEK2_1	193	198	PF00069	0.516
MOD_NEK2_1	285	290	PF00069	0.471
MOD_NEK2_1	358	363	PF00069	0.544
MOD_NEK2_1	657	662	PF00069	0.461
MOD_NEK2_1	678	683	PF00069	0.447
MOD_NEK2_1	778	783	PF00069	0.508
MOD_NEK2_1	845	850	PF00069	0.539
MOD_OGLYCOS	425	430	PF02709	0.170
MOD_PIKK_1	451	457	PF00454	0.457
MOD_PIKK_1	489	495	PF00454	0.447
MOD_PIKK_1	496	502	PF00454	0.447
MOD_PIKK_1	51	57	PF00454	0.527
MOD_PIKK_1	661	667	PF00454	0.477
MOD_PIKK_1	814	820	PF00454	0.562
MOD_PKA_2	180	186	PF00069	0.510
MOD_PKA_2	415	421	PF00069	0.510
MOD_PKA_2	814	820	PF00069	0.628
MOD_Plk_1	21	27	PF00069	0.294
MOD_Plk_1	310	316	PF00069	0.474
MOD_Plk_1	321	327	PF00069	0.309
MOD_Plk_1	761	767	PF00069	0.556
MOD_Plk_2-3	593	599	PF00069	0.550
MOD_Plk_4	1	7	PF00069	0.580
MOD_Plk_4	134	140	PF00069	0.525
MOD_Plk_4	158	164	PF00069	0.461
MOD_Plk_4	21	27	PF00069	0.216
MOD_Plk_4	321	327	PF00069	0.356
MOD_Plk_4	379	385	PF00069	0.486
MOD_Plk_4	603	609	PF00069	0.461
MOD_Plk_4	736	742	PF00069	0.459
MOD_ProDKin_1	139	145	PF00069	0.534
MOD_ProDKin_1	249	255	PF00069	0.519
MOD_ProDKin_1	361	367	PF00069	0.527
MOD_ProDKin_1	49	55	PF00069	0.384
MOD_ProDKin_1	524	530	PF00069	0.483
MOD_ProDKin_1	581	587	PF00069	0.527
MOD_ProDKin_1	858	864	PF00069	0.523
MOD_ProDKin_1	95	101	PF00069	0.370
MOD_SUMO_for_1	109	112	PF00179	0.539
MOD_SUMO_rev_2	112	117	PF00179	0.506
MOD_SUMO_rev_2	464	474	PF00179	0.674
MOD_SUMO_rev_2	795	801	PF00179	0.570
TRG_DiLeu_BaEn_1	645	650	PF01217	0.370
TRG_DiLeu_BaEn_2	212	218	PF01217	0.490
TRG_ENDOCYTIC_2	13	16	PF00928	0.372
TRG_ENDOCYTIC_2	163	166	PF00928	0.499
TRG_ENDOCYTIC_2	208	211	PF00928	0.419
TRG_ENDOCYTIC_2	282	285	PF00928	0.403
TRG_ENDOCYTIC_2	299	302	PF00928	0.294
TRG_ENDOCYTIC_2	462	465	PF00928	0.655
TRG_ENDOCYTIC_2	488	491	PF00928	0.496
TRG_ENDOCYTIC_2	56	59	PF00928	0.461
TRG_ENDOCYTIC_2	580	583	PF00928	0.461
TRG_ENDOCYTIC_2	779	782	PF00928	0.538
TRG_ENDOCYTIC_2	81	84	PF00928	0.527
TRG_ER_diArg_1	401	403	PF00400	0.483
TRG_ER_diArg_1	632	634	PF00400	0.527
TRG_ER_diArg_1	709	712	PF00400	0.569
TRG_ER_diArg_1	714	717	PF00400	0.583
TRG_ER_diArg_1	727	729	PF00400	0.479
TRG_NES_CRM1_1	840	852	PF08389	0.523
TRG_Pf-PMV_PEXEL_1	451	455	PF00026	0.327
TRG_Pf-PMV_PEXEL_1	510	514	PF00026	0.277
TRG_Pf-PMV_PEXEL_1	728	732	PF00026	0.376
TRG_Pf-PMV_PEXEL_1	809	813	PF00026	0.612

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Z8	Leptomonas seymouri	71%	97%
A0A0N1I3S9	Leptomonas seymouri	35%	100%
A0A0S4ISQ0	Bodo saltans	45%	100%
A0A0S4JL46	Bodo saltans	36%	100%
A0A1X0NXD4	Trypanosomatidae	35%	100%
A0A1X0P2V2	Trypanosomatidae	36%	100%
A0A1X0P8P2	Trypanosomatidae	48%	100%
A0A3Q8IKW2	Leishmania donovani	32%	91%
A0A3S7WNY9	Leishmania donovani	35%	100%
A0A3S7XAQ4	Leishmania donovani	89%	100%
A0A422NIL8	Trypanosoma rangeli	36%	100%
A0A422NLE5	Trypanosoma rangeli	47%	100%
A0A422NYK3	Trypanosoma rangeli	35%	100%
A4H452	Leishmania braziliensis	35%	95%
A4HSC9	Leishmania infantum	35%	100%
A4HZA7	Leishmania infantum	32%	91%
A4IDF8	Leishmania infantum	90%	100%
C9ZPY2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
D0A1L3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
D0A336	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AIP9	Leishmania braziliensis	33%	100%
E9AKB0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9ASV9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
E9AUY7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	91%
P34118	Dictyostelium discoideum	36%	100%
P54659	Dictyostelium discoideum	35%	100%
Q14764	Homo sapiens	38%	98%
Q3SYU9	Bos taurus	37%	98%
Q4CUM2	Trypanosoma cruzi (strain CL Brener)	37%	100%
Q4Q1N7	Leishmania major	89%	100%
Q4QCJ5	Leishmania major	31%	99%
Q4QJJ7	Leishmania major	35%	95%
Q57Z03	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	36%	100%
Q5EAJ7	Strongylocentrotus purpuratus	37%	100%
Q5R9N2	Pongo abelii	38%	98%
Q5ZMI4	Gallus gallus	36%	100%
Q62667	Rattus norvegicus	38%	100%
Q6P3L0	Danio rerio	37%	100%
Q6PF69	Xenopus laevis	37%	100%
Q90405	Diplobatis ommata	37%	100%
Q9DGM7	Ictalurus punctatus	36%	100%
Q9EQK5	Mus musculus	38%	100%
V5AUX6	Trypanosoma cruzi	36%	100%
V5B0K2	Trypanosoma cruzi	36%	100%