S5 DRBM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ribosomal protein S5, C-terminal domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HP50_LEIBR

TriTrypDb:

LbrM.35.2050 , LBRM2903_350026900

Length:

431

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	12
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4HP50

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP50

PDB structure(s): 7ane_a

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	12
GO:0006518	peptide metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009059	macromolecule biosynthetic process	4	12
GO:0009987	cellular process	1	12
GO:0019538	protein metabolic process	3	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	12
GO:0043043	peptide biosynthetic process	5	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043603	amide metabolic process	3	12
GO:0043604	amide biosynthetic process	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0044271	cellular nitrogen compound biosynthetic process	4	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901566	organonitrogen compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0003735	structural constituent of ribosome	2	12
GO:0005198	structural molecule activity	1	12
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	63	67	PF00656	0.437
CLV_NRD_NRD_1	230	232	PF00675	0.413
CLV_NRD_NRD_1	309	311	PF00675	0.437
CLV_NRD_NRD_1	389	391	PF00675	0.522
CLV_NRD_NRD_1	41	43	PF00675	0.435
CLV_PCSK_FUR_1	386	390	PF00082	0.566
CLV_PCSK_KEX2_1	230	232	PF00082	0.328
CLV_PCSK_KEX2_1	308	310	PF00082	0.424
CLV_PCSK_KEX2_1	385	387	PF00082	0.585
CLV_PCSK_KEX2_1	388	390	PF00082	0.547
CLV_PCSK_KEX2_1	40	42	PF00082	0.410
CLV_PCSK_KEX2_1	425	427	PF00082	0.458
CLV_PCSK_PC1ET2_1	385	387	PF00082	0.636
CLV_PCSK_PC1ET2_1	388	390	PF00082	0.586
CLV_PCSK_PC1ET2_1	425	427	PF00082	0.458
CLV_PCSK_SKI1_1	10	14	PF00082	0.629
CLV_PCSK_SKI1_1	150	154	PF00082	0.328
CLV_PCSK_SKI1_1	195	199	PF00082	0.328
CLV_PCSK_SKI1_1	223	227	PF00082	0.316
CLV_PCSK_SKI1_1	350	354	PF00082	0.412
CLV_PCSK_SKI1_1	382	386	PF00082	0.679
CLV_PCSK_SKI1_1	78	82	PF00082	0.415
DEG_APCC_DBOX_1	388	396	PF00400	0.475
DEG_Nend_Nbox_1	1	3	PF02207	0.623
DOC_ANK_TNKS_1	215	222	PF00023	0.418
DOC_CDC14_PxL_1	93	101	PF14671	0.396
DOC_CKS1_1	122	127	PF01111	0.434
DOC_MAPK_gen_1	401	411	PF00069	0.469
DOC_MAPK_gen_1	45	53	PF00069	0.449
DOC_MAPK_MEF2A_6	45	53	PF00069	0.449
DOC_PP1_RVXF_1	148	155	PF00149	0.328
DOC_PP4_MxPP_1	316	319	PF00568	0.466
DOC_USP7_MATH_1	278	282	PF00917	0.328
DOC_USP7_MATH_1	384	388	PF00917	0.631
DOC_USP7_MATH_1	74	78	PF00917	0.501
DOC_USP7_UBL2_3	153	157	PF12436	0.344
DOC_USP7_UBL2_3	253	257	PF12436	0.449
DOC_WW_Pin1_4	121	126	PF00397	0.432
DOC_WW_Pin1_4	152	157	PF00397	0.328
DOC_WW_Pin1_4	399	404	PF00397	0.635
LIG_14-3-3_CanoR_1	118	123	PF00244	0.418
LIG_14-3-3_CanoR_1	27	33	PF00244	0.568
LIG_14-3-3_CanoR_1	389	393	PF00244	0.484
LIG_Actin_WH2_2	265	282	PF00022	0.344
LIG_APCC_ABBA_1	300	305	PF00400	0.409
LIG_APCC_ABBA_1	87	92	PF00400	0.400
LIG_BRCT_BRCA1_1	57	61	PF00533	0.437
LIG_deltaCOP1_diTrp_1	345	353	PF00928	0.420
LIG_EH_1	47	51	PF12763	0.443
LIG_EH1_1	235	243	PF00400	0.328
LIG_FHA_1	122	128	PF00498	0.425
LIG_FHA_1	264	270	PF00498	0.344
LIG_FHA_2	389	395	PF00498	0.477
LIG_FHA_2	400	406	PF00498	0.480
LIG_Integrin_RGD_1	368	370	PF01839	0.478
LIG_LIR_Apic_2	119	125	PF02991	0.419
LIG_LIR_Apic_2	31	35	PF02991	0.549
LIG_LIR_Gen_1	196	206	PF02991	0.363
LIG_LIR_Gen_1	270	279	PF02991	0.328
LIG_LIR_Nem_3	196	201	PF02991	0.363
LIG_LIR_Nem_3	270	276	PF02991	0.326
LIG_LIR_Nem_3	346	352	PF02991	0.421
LIG_LIR_Nem_3	88	93	PF02991	0.400
LIG_LYPXL_S_1	300	304	PF13949	0.428
LIG_LYPXL_yS_3	301	304	PF13949	0.433
LIG_MLH1_MIPbox_1	57	61	PF16413	0.437
LIG_MYND_1	125	129	PF01753	0.407
LIG_MYND_1	97	101	PF01753	0.397
LIG_Pex14_1	349	353	PF04695	0.416
LIG_Pex14_2	136	140	PF04695	0.374
LIG_SH2_CRK	164	168	PF00017	0.344
LIG_SH2_CRK	93	97	PF00017	0.388
LIG_SH2_NCK_1	344	348	PF00017	0.435
LIG_SH2_SRC	344	347	PF00017	0.432
LIG_SH2_STAP1	147	151	PF00017	0.328
LIG_SH2_STAP1	344	348	PF00017	0.420
LIG_SH2_STAT5	164	167	PF00017	0.331
LIG_SH2_STAT5	168	171	PF00017	0.325
LIG_SH2_STAT5	30	33	PF00017	0.581
LIG_SH2_STAT5	303	306	PF00017	0.412
LIG_SH2_STAT5	428	431	PF00017	0.508
LIG_SH2_STAT5	60	63	PF00017	0.428
LIG_SH3_2	211	216	PF14604	0.409
LIG_SH3_3	208	214	PF00018	0.399
LIG_SH3_3	259	265	PF00018	0.328
LIG_SH3_3	408	414	PF00018	0.500
LIG_SUMO_SIM_par_1	199	205	PF11976	0.337
LIG_TRAF2_1	185	188	PF00917	0.344
LIG_UBA3_1	313	321	PF00899	0.461
LIG_WRC_WIRS_1	12	17	PF05994	0.626
MOD_CDK_SPK_2	152	157	PF00069	0.344
MOD_CDK_SPK_2	399	404	PF00069	0.484
MOD_CK2_1	182	188	PF00069	0.328
MOD_CK2_1	278	284	PF00069	0.328
MOD_GlcNHglycan	170	173	PF01048	0.224
MOD_GlcNHglycan	36	39	PF01048	0.523
MOD_GlcNHglycan	66	69	PF01048	0.454
MOD_GSK3_1	1	8	PF00069	0.674
MOD_GSK3_1	384	391	PF00069	0.532
MOD_N-GLC_1	10	15	PF02516	0.603
MOD_NEK2_1	1	6	PF00069	0.493
MOD_NEK2_1	256	261	PF00069	0.328
MOD_NEK2_1	376	381	PF00069	0.635
MOD_NEK2_2	17	22	PF00069	0.367
MOD_PIKK_1	183	189	PF00454	0.344
MOD_PIKK_1	376	382	PF00454	0.679
MOD_PKA_1	388	394	PF00069	0.452
MOD_PKA_2	388	394	PF00069	0.482
MOD_PKA_2	61	67	PF00069	0.438
MOD_Plk_1	10	16	PF00069	0.605
MOD_Plk_4	118	124	PF00069	0.420
MOD_Plk_4	28	34	PF00069	0.522
MOD_Plk_4	292	298	PF00069	0.418
MOD_Plk_4	55	61	PF00069	0.437
MOD_ProDKin_1	121	127	PF00069	0.426
MOD_ProDKin_1	152	158	PF00069	0.328
MOD_ProDKin_1	399	405	PF00069	0.636
MOD_SUMO_rev_2	356	365	PF00179	0.484
MOD_SUMO_rev_2	88	96	PF00179	0.472
TRG_ENDOCYTIC_2	164	167	PF00928	0.344
TRG_ENDOCYTIC_2	30	33	PF00928	0.430
TRG_ENDOCYTIC_2	301	304	PF00928	0.418
TRG_ENDOCYTIC_2	344	347	PF00928	0.417
TRG_ENDOCYTIC_2	93	96	PF00928	0.393
TRG_ER_diArg_1	133	136	PF00400	0.395
TRG_ER_diArg_1	230	232	PF00400	0.413
TRG_ER_diArg_1	307	310	PF00400	0.435
TRG_ER_diArg_1	40	42	PF00400	0.416
TRG_NLS_MonoExtC_3	384	389	PF00514	0.583
TRG_NLS_MonoExtN_4	382	389	PF00514	0.593
TRG_Pf-PMV_PEXEL_1	390	394	PF00026	0.477

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I867	Leptomonas seymouri	92%	100%
A0A0S4IX34	Bodo saltans	80%	100%
A0A1X0P7T8	Trypanosomatidae	87%	99%
A0A3Q8INM9	Leishmania donovani	97%	100%
A0A422NLS3	Trypanosoma rangeli	87%	99%
A4IDF7	Leishmania infantum	97%	100%
D0A335	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	85%	99%
E9ASV8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4Q1N8	Leishmania major	97%	100%
V5BJT0	Trypanosoma cruzi	86%	99%