Putative ras-like small GTPases

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ras-like small GTPases, putative

Species:

Leishmania braziliensis

UniProt:

A4HP46_LEIBR

TriTrypDb:

LbrM.35.2010 , LBRM2903_350026500

Length:

894

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

A4HP46

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP46

Function

Biological processes
Term	Name	Level	Count
GO:0007165	signal transduction	2	6
GO:0009987	cellular process	1	6
GO:0050789	regulation of biological process	2	6
GO:0050794	regulation of cellular process	3	6
GO:0065007	biological regulation	1	6

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0003824	catalytic activity	1	6
GO:0003924	GTPase activity	7	6
GO:0005488	binding	1	6
GO:0005525	GTP binding	5	6
GO:0016462	pyrophosphatase activity	5	6
GO:0016787	hydrolase activity	2	6
GO:0016817	hydrolase activity, acting on acid anhydrides	3	6
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	6
GO:0017076	purine nucleotide binding	4	6
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	6
GO:0019001	guanyl nucleotide binding	5	6
GO:0032553	ribonucleotide binding	3	6
GO:0032555	purine ribonucleotide binding	4	6
GO:0032561	guanyl ribonucleotide binding	5	6
GO:0035639	purine ribonucleoside triphosphate binding	4	6
GO:0036094	small molecule binding	2	6
GO:0043167	ion binding	2	6
GO:0043168	anion binding	3	6
GO:0097159	organic cyclic compound binding	2	6
GO:0097367	carbohydrate derivative binding	2	6
GO:1901265	nucleoside phosphate binding	3	6
GO:1901363	heterocyclic compound binding	2	6
GO:0019003	GDP binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	314	318	PF00656	0.629
CLV_C14_Caspase3-7	528	532	PF00656	0.681
CLV_C14_Caspase3-7	54	58	PF00656	0.405
CLV_C14_Caspase3-7	637	641	PF00656	0.524
CLV_NRD_NRD_1	105	107	PF00675	0.405
CLV_NRD_NRD_1	209	211	PF00675	0.581
CLV_NRD_NRD_1	586	588	PF00675	0.537
CLV_NRD_NRD_1	833	835	PF00675	0.739
CLV_NRD_NRD_1	871	873	PF00675	0.599
CLV_PCSK_FUR_1	206	210	PF00082	0.516
CLV_PCSK_KEX2_1	104	106	PF00082	0.247
CLV_PCSK_KEX2_1	208	210	PF00082	0.632
CLV_PCSK_KEX2_1	833	835	PF00082	0.739
CLV_PCSK_KEX2_1	847	849	PF00082	0.699
CLV_PCSK_KEX2_1	870	872	PF00082	0.607
CLV_PCSK_PC1ET2_1	847	849	PF00082	0.633
CLV_PCSK_PC7_1	829	835	PF00082	0.582
CLV_PCSK_SKI1_1	107	111	PF00082	0.426
CLV_PCSK_SKI1_1	32	36	PF00082	0.332
CLV_PCSK_SKI1_1	443	447	PF00082	0.600
CLV_PCSK_SKI1_1	71	75	PF00082	0.405
CLV_PCSK_SKI1_1	715	719	PF00082	0.551
CLV_PCSK_SKI1_1	835	839	PF00082	0.598
CLV_PCSK_SKI1_1	858	862	PF00082	0.647
DEG_APCC_DBOX_1	105	113	PF00400	0.373
DEG_APCC_DBOX_1	306	314	PF00400	0.497
DEG_APCC_DBOX_1	92	100	PF00400	0.302
DEG_SCF_FBW7_1	347	354	PF00400	0.487
DEG_SCF_TRCP1_1	727	733	PF00400	0.560
DEG_SPOP_SBC_1	130	134	PF00917	0.247
DEG_SPOP_SBC_1	351	355	PF00917	0.590
DEG_SPOP_SBC_1	45	49	PF00917	0.247
DOC_CKS1_1	348	353	PF01111	0.490
DOC_CYCLIN_yClb1_LxF_4	69	74	PF00134	0.405
DOC_CYCLIN_yCln2_LP_2	422	425	PF00134	0.483
DOC_CYCLIN_yCln2_LP_2	758	764	PF00134	0.528
DOC_MAPK_DCC_7	337	347	PF00069	0.468
DOC_MAPK_DCC_7	392	400	PF00069	0.517
DOC_MAPK_DCC_7	752	760	PF00069	0.533
DOC_MAPK_gen_1	104	112	PF00069	0.426
DOC_MAPK_gen_1	212	220	PF00069	0.463
DOC_MAPK_gen_1	316	325	PF00069	0.336
DOC_MAPK_gen_1	816	825	PF00069	0.580
DOC_MAPK_MEF2A_6	326	335	PF00069	0.475
DOC_MAPK_MEF2A_6	392	400	PF00069	0.517
DOC_MAPK_MEF2A_6	93	100	PF00069	0.426
DOC_MAPK_NFAT4_5	326	334	PF00069	0.473
DOC_PP1_RVXF_1	69	75	PF00149	0.405
DOC_PP2B_LxvP_1	268	271	PF13499	0.555
DOC_PP2B_LxvP_1	275	278	PF13499	0.530
DOC_PP2B_LxvP_1	298	301	PF13499	0.582
DOC_PP2B_LxvP_1	393	396	PF13499	0.586
DOC_PP2B_LxvP_1	422	425	PF13499	0.483
DOC_PP2B_LxvP_1	823	826	PF13499	0.574
DOC_PP2B_PxIxI_1	17	23	PF00149	0.461
DOC_PP4_FxxP_1	598	601	PF00568	0.520
DOC_PP4_FxxP_1	760	763	PF00568	0.522
DOC_USP7_MATH_1	122	126	PF00917	0.247
DOC_USP7_MATH_1	261	265	PF00917	0.677
DOC_USP7_MATH_1	302	306	PF00917	0.592
DOC_USP7_MATH_1	351	355	PF00917	0.699
DOC_USP7_MATH_1	45	49	PF00917	0.405
DOC_USP7_MATH_1	454	458	PF00917	0.567
DOC_USP7_MATH_1	463	467	PF00917	0.549
DOC_USP7_MATH_1	534	538	PF00917	0.560
DOC_USP7_MATH_1	569	573	PF00917	0.627
DOC_USP7_MATH_1	679	683	PF00917	0.555
DOC_USP7_MATH_1	745	749	PF00917	0.688
DOC_USP7_MATH_1	763	767	PF00917	0.507
DOC_USP7_MATH_1	843	847	PF00917	0.653
DOC_USP7_UBL2_3	512	516	PF12436	0.574
DOC_USP7_UBL2_3	847	851	PF12436	0.635
DOC_WW_Pin1_4	213	218	PF00397	0.608
DOC_WW_Pin1_4	257	262	PF00397	0.764
DOC_WW_Pin1_4	347	352	PF00397	0.684
DOC_WW_Pin1_4	41	46	PF00397	0.247
DOC_WW_Pin1_4	450	455	PF00397	0.631
DOC_WW_Pin1_4	516	521	PF00397	0.577
DOC_WW_Pin1_4	539	544	PF00397	0.548
DOC_WW_Pin1_4	653	658	PF00397	0.573
DOC_WW_Pin1_4	728	733	PF00397	0.629
DOC_WW_Pin1_4	77	82	PF00397	0.332
DOC_WW_Pin1_4	792	797	PF00397	0.572
LIG_14-3-3_CanoR_1	104	110	PF00244	0.437
LIG_14-3-3_CanoR_1	123	128	PF00244	0.361
LIG_14-3-3_CanoR_1	326	332	PF00244	0.558
LIG_14-3-3_CanoR_1	677	685	PF00244	0.532
LIG_14-3-3_CanoR_1	71	81	PF00244	0.380
LIG_APCC_ABBAyCdc20_2	37	43	PF00400	0.405
LIG_BRCT_BRCA1_1	79	83	PF00533	0.247
LIG_EVH1_1	393	397	PF00568	0.505
LIG_FHA_1	270	276	PF00498	0.682
LIG_FHA_1	293	299	PF00498	0.676
LIG_FHA_1	31	37	PF00498	0.451
LIG_FHA_1	388	394	PF00498	0.631
LIG_FHA_1	417	423	PF00498	0.540
LIG_FHA_1	563	569	PF00498	0.631
LIG_FHA_1	626	632	PF00498	0.525
LIG_FHA_1	659	665	PF00498	0.577
LIG_FHA_1	679	685	PF00498	0.592
LIG_FHA_1	717	723	PF00498	0.555
LIG_FHA_1	757	763	PF00498	0.523
LIG_FHA_1	795	801	PF00498	0.589
LIG_FHA_1	806	812	PF00498	0.552
LIG_FHA_2	124	130	PF00498	0.385
LIG_FHA_2	131	137	PF00498	0.380
LIG_FHA_2	159	165	PF00498	0.556
LIG_FHA_2	52	58	PF00498	0.371
LIG_FHA_2	799	805	PF00498	0.572
LIG_FHA_2	9	15	PF00498	0.534
LIG_LIR_Apic_2	759	763	PF02991	0.524
LIG_LIR_Gen_1	134	145	PF02991	0.247
LIG_LIR_Gen_1	57	64	PF02991	0.405
LIG_LIR_Nem_3	13	19	PF02991	0.380
LIG_LIR_Nem_3	134	140	PF02991	0.380
LIG_LIR_Nem_3	57	62	PF02991	0.405
LIG_LIR_Nem_3	67	73	PF02991	0.302
LIG_LIR_Nem_3	887	893	PF02991	0.516
LIG_PCNA_PIPBox_1	423	432	PF02747	0.504
LIG_Pex14_2	220	224	PF04695	0.371
LIG_PTB_Apo_2	444	451	PF02174	0.557
LIG_REV1ctd_RIR_1	221	230	PF16727	0.375
LIG_SH2_CRK	70	74	PF00017	0.405
LIG_SH2_NCK_1	59	63	PF00017	0.405
LIG_SH2_SRC	39	42	PF00017	0.405
LIG_SH2_STAP1	430	434	PF00017	0.527
LIG_SH2_STAT3	149	152	PF00017	0.380
LIG_SH2_STAT5	179	182	PF00017	0.561
LIG_SH2_STAT5	39	42	PF00017	0.519
LIG_SH2_STAT5	59	62	PF00017	0.405
LIG_SH2_STAT5	64	67	PF00017	0.353
LIG_SH2_STAT5	90	93	PF00017	0.512
LIG_SH3_3	345	351	PF00018	0.461
LIG_SH3_3	391	397	PF00018	0.599
LIG_SH3_3	471	477	PF00018	0.551
LIG_SH3_3	514	520	PF00018	0.561
LIG_SH3_3	530	536	PF00018	0.566
LIG_SH3_3	751	757	PF00018	0.530
LIG_SUMO_SIM_par_1	21	27	PF11976	0.412
LIG_SUMO_SIM_par_1	775	783	PF11976	0.550
LIG_SUMO_SIM_par_1	96	102	PF11976	0.397
LIG_TRAF2_1	11	14	PF00917	0.441
LIG_TRAF2_1	525	528	PF00917	0.568
LIG_UBA3_1	227	235	PF00899	0.439
LIG_UBA3_1	589	593	PF00899	0.519
LIG_WW_3	532	536	PF00397	0.556
MOD_CAAXbox	891	894	PF01239	0.506
MOD_CDK_SPxxK_3	653	660	PF00069	0.566
MOD_CDK_SPxxK_3	730	737	PF00069	0.559
MOD_CDK_SPxxK_3	77	84	PF00069	0.247
MOD_CK1_1	292	298	PF00069	0.640
MOD_CK1_1	354	360	PF00069	0.653
MOD_CK1_1	406	412	PF00069	0.645
MOD_CK1_1	418	424	PF00069	0.576
MOD_CK1_1	44	50	PF00069	0.385
MOD_CK1_1	537	543	PF00069	0.673
MOD_CK1_1	613	619	PF00069	0.600
MOD_CK1_1	625	631	PF00069	0.512
MOD_CK1_1	656	662	PF00069	0.625
MOD_CK1_1	716	722	PF00069	0.566
MOD_CK1_1	728	734	PF00069	0.551
MOD_CK1_1	783	789	PF00069	0.637
MOD_CK1_1	79	85	PF00069	0.403
MOD_CK1_1	8	14	PF00069	0.627
MOD_CK1_1	828	834	PF00069	0.631
MOD_CK2_1	123	129	PF00069	0.306
MOD_CK2_1	159	165	PF00069	0.496
MOD_CK2_1	57	63	PF00069	0.307
MOD_CK2_1	684	690	PF00069	0.535
MOD_CK2_1	7	13	PF00069	0.616
MOD_CK2_1	79	85	PF00069	0.405
MOD_CK2_1	798	804	PF00069	0.601
MOD_GlcNHglycan	246	249	PF01048	0.610
MOD_GlcNHglycan	257	260	PF01048	0.706
MOD_GlcNHglycan	291	294	PF01048	0.653
MOD_GlcNHglycan	295	298	PF01048	0.602
MOD_GlcNHglycan	304	307	PF01048	0.361
MOD_GlcNHglycan	354	357	PF01048	0.611
MOD_GlcNHglycan	374	377	PF01048	0.658
MOD_GlcNHglycan	405	408	PF01048	0.650
MOD_GlcNHglycan	434	437	PF01048	0.725
MOD_GlcNHglycan	443	446	PF01048	0.665
MOD_GlcNHglycan	490	493	PF01048	0.590
MOD_GlcNHglycan	571	574	PF01048	0.603
MOD_GlcNHglycan	604	607	PF01048	0.667
MOD_GlcNHglycan	612	615	PF01048	0.658
MOD_GlcNHglycan	633	636	PF01048	0.560
MOD_GlcNHglycan	646	649	PF01048	0.672
MOD_GlcNHglycan	686	689	PF01048	0.599
MOD_GlcNHglycan	727	730	PF01048	0.602
MOD_GlcNHglycan	747	750	PF01048	0.706
MOD_GSK3_1	131	138	PF00069	0.258
MOD_GSK3_1	234	241	PF00069	0.671
MOD_GSK3_1	257	264	PF00069	0.670
MOD_GSK3_1	289	296	PF00069	0.698
MOD_GSK3_1	3	10	PF00069	0.688
MOD_GSK3_1	343	350	PF00069	0.604
MOD_GSK3_1	367	374	PF00069	0.556
MOD_GSK3_1	379	386	PF00069	0.587
MOD_GSK3_1	401	408	PF00069	0.545
MOD_GSK3_1	41	48	PF00069	0.377
MOD_GSK3_1	412	419	PF00069	0.520
MOD_GSK3_1	428	435	PF00069	0.519
MOD_GSK3_1	450	457	PF00069	0.642
MOD_GSK3_1	459	466	PF00069	0.584
MOD_GSK3_1	506	513	PF00069	0.600
MOD_GSK3_1	51	58	PF00069	0.323
MOD_GSK3_1	618	625	PF00069	0.547
MOD_GSK3_1	631	638	PF00069	0.482
MOD_GSK3_1	679	686	PF00069	0.678
MOD_GSK3_1	72	79	PF00069	0.405
MOD_GSK3_1	780	787	PF00069	0.708
MOD_GSK3_1	794	801	PF00069	0.645
MOD_GSK3_1	821	828	PF00069	0.574
MOD_GSK3_1	862	869	PF00069	0.659
MOD_LATS_1	484	490	PF00433	0.553
MOD_LATS_1	836	842	PF00433	0.583
MOD_N-GLC_1	477	482	PF02516	0.599
MOD_N-GLC_1	506	511	PF02516	0.602
MOD_N-GLC_1	792	797	PF02516	0.578
MOD_NEK2_1	311	316	PF00069	0.487
MOD_NEK2_1	352	357	PF00069	0.638
MOD_NEK2_1	5	10	PF00069	0.708
MOD_NEK2_1	55	60	PF00069	0.519
MOD_NEK2_1	568	573	PF00069	0.634
MOD_NEK2_1	580	585	PF00069	0.618
MOD_NEK2_1	643	648	PF00069	0.556
MOD_NEK2_1	669	674	PF00069	0.542
MOD_NEK2_1	866	871	PF00069	0.596
MOD_NEK2_1	99	104	PF00069	0.425
MOD_NEK2_2	327	332	PF00069	0.466
MOD_NEK2_2	713	718	PF00069	0.544
MOD_NEK2_2	775	780	PF00069	0.547
MOD_PIKK_1	196	202	PF00454	0.614
MOD_PIKK_1	64	70	PF00454	0.320
MOD_PIKK_1	786	792	PF00454	0.612
MOD_PIKK_1	851	857	PF00454	0.712
MOD_PK_1	780	786	PF00069	0.560
MOD_PKA_1	105	111	PF00069	0.247
MOD_PKA_2	105	111	PF00069	0.405
MOD_PKA_2	122	128	PF00069	0.247
MOD_PKA_2	325	331	PF00069	0.393
MOD_PKA_2	534	540	PF00069	0.559
MOD_PKA_2	708	714	PF00069	0.710
MOD_PKA_2	828	834	PF00069	0.731
MOD_PKA_2	862	868	PF00069	0.619
MOD_PKB_1	816	824	PF00069	0.579
MOD_Plk_1	12	18	PF00069	0.523
MOD_Plk_1	3	9	PF00069	0.583
MOD_Plk_1	463	469	PF00069	0.548
MOD_Plk_1	580	586	PF00069	0.537
MOD_Plk_1	780	786	PF00069	0.560
MOD_Plk_4	105	111	PF00069	0.405
MOD_Plk_4	12	18	PF00069	0.492
MOD_Plk_4	271	277	PF00069	0.568
MOD_Plk_4	343	349	PF00069	0.465
MOD_Plk_4	418	424	PF00069	0.623
MOD_Plk_4	463	469	PF00069	0.569
MOD_Plk_4	51	57	PF00069	0.405
MOD_Plk_4	679	685	PF00069	0.529
MOD_ProDKin_1	213	219	PF00069	0.603
MOD_ProDKin_1	257	263	PF00069	0.764
MOD_ProDKin_1	347	353	PF00069	0.688
MOD_ProDKin_1	41	47	PF00069	0.247
MOD_ProDKin_1	450	456	PF00069	0.631
MOD_ProDKin_1	516	522	PF00069	0.581
MOD_ProDKin_1	539	545	PF00069	0.545
MOD_ProDKin_1	653	659	PF00069	0.573
MOD_ProDKin_1	728	734	PF00069	0.625
MOD_ProDKin_1	77	83	PF00069	0.332
MOD_ProDKin_1	792	798	PF00069	0.574
MOD_SUMO_rev_2	314	321	PF00179	0.501
TRG_DiLeu_BaEn_1	548	553	PF01217	0.529
TRG_DiLeu_BaEn_2	138	144	PF01217	0.405
TRG_DiLeu_BaLyEn_6	68	73	PF01217	0.525
TRG_ENDOCYTIC_2	59	62	PF00928	0.405
TRG_ENDOCYTIC_2	70	73	PF00928	0.292
TRG_ER_diArg_1	103	106	PF00400	0.332
TRG_ER_diArg_1	206	209	PF00400	0.515
TRG_ER_diArg_1	870	872	PF00400	0.628
TRG_NES_CRM1_1	767	782	PF08389	0.537
TRG_Pf-PMV_PEXEL_1	667	671	PF00026	0.543

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IQV2	Leishmania donovani	51%	100%
A4IDF3	Leishmania infantum	51%	100%
E9ASV4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
Q4Q1P2	Leishmania major	47%	96%