MORN repeat family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MORN repeat, putative

Species:

Leishmania braziliensis

UniProt:

A4HP45_LEIBR

TriTrypDb:

LbrM.35.2000 , LBRM2903_350026400

Length:

941

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HP45

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP45

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	184	188	PF00656	0.516
CLV_C14_Caspase3-7	272	276	PF00656	0.563
CLV_C14_Caspase3-7	402	406	PF00656	0.469
CLV_C14_Caspase3-7	504	508	PF00656	0.335
CLV_C14_Caspase3-7	778	782	PF00656	0.453
CLV_C14_Caspase3-7	923	927	PF00656	0.335
CLV_NRD_NRD_1	439	441	PF00675	0.246
CLV_NRD_NRD_1	462	464	PF00675	0.335
CLV_NRD_NRD_1	470	472	PF00675	0.335
CLV_NRD_NRD_1	509	511	PF00675	0.335
CLV_NRD_NRD_1	735	737	PF00675	0.453
CLV_NRD_NRD_1	872	874	PF00675	0.236
CLV_PCSK_KEX2_1	462	464	PF00082	0.335
CLV_PCSK_KEX2_1	470	472	PF00082	0.335
CLV_PCSK_KEX2_1	509	511	PF00082	0.335
CLV_PCSK_KEX2_1	651	653	PF00082	0.335
CLV_PCSK_KEX2_1	735	737	PF00082	0.453
CLV_PCSK_KEX2_1	872	874	PF00082	0.236
CLV_PCSK_PC1ET2_1	651	653	PF00082	0.325
CLV_PCSK_SKI1_1	155	159	PF00082	0.664
CLV_PCSK_SKI1_1	198	202	PF00082	0.534
CLV_PCSK_SKI1_1	274	278	PF00082	0.563
CLV_PCSK_SKI1_1	74	78	PF00082	0.411
DEG_APCC_DBOX_1	509	517	PF00400	0.246
DEG_Nend_Nbox_1	1	3	PF02207	0.513
DEG_SPOP_SBC_1	17	21	PF00917	0.663
DOC_CYCLIN_yCln2_LP_2	56	62	PF00134	0.451
DOC_MAPK_FxFP_2	332	335	PF00069	0.523
DOC_MAPK_MEF2A_6	114	122	PF00069	0.361
DOC_MAPK_RevD_3	427	441	PF00069	0.342
DOC_PP2B_LxvP_1	192	195	PF13499	0.511
DOC_PP2B_LxvP_1	201	204	PF13499	0.493
DOC_PP4_FxxP_1	332	335	PF00568	0.523
DOC_USP7_MATH_1	109	113	PF00917	0.414
DOC_USP7_MATH_1	175	179	PF00917	0.674
DOC_USP7_MATH_1	206	210	PF00917	0.686
DOC_USP7_MATH_1	219	223	PF00917	0.598
DOC_USP7_MATH_1	23	27	PF00917	0.537
DOC_USP7_MATH_1	335	339	PF00917	0.600
DOC_USP7_MATH_1	355	359	PF00917	0.585
DOC_USP7_MATH_1	361	365	PF00917	0.593
DOC_USP7_MATH_1	366	370	PF00917	0.522
DOC_USP7_MATH_1	666	670	PF00917	0.682
DOC_USP7_MATH_1	8	12	PF00917	0.741
DOC_USP7_MATH_1	901	905	PF00917	0.551
DOC_WW_Pin1_4	318	323	PF00397	0.574
DOC_WW_Pin1_4	362	367	PF00397	0.763
DOC_WW_Pin1_4	379	384	PF00397	0.608
DOC_WW_Pin1_4	492	497	PF00397	0.547
DOC_WW_Pin1_4	672	677	PF00397	0.556
DOC_WW_Pin1_4	9	14	PF00397	0.542
DOC_WW_Pin1_4	94	99	PF00397	0.483
LIG_14-3-3_CanoR_1	301	310	PF00244	0.553
LIG_14-3-3_CanoR_1	695	703	PF00244	0.453
LIG_14-3-3_CanoR_1	872	881	PF00244	0.453
LIG_Actin_WH2_2	134	151	PF00022	0.400
LIG_Actin_WH2_2	776	793	PF00022	0.306
LIG_BRCT_BRCA1_1	33	37	PF00533	0.659
LIG_BRCT_BRCA1_1	926	930	PF00533	0.325
LIG_Clathr_ClatBox_2	309	314	PF01394	0.580
LIG_CtBP_PxDLS_1	322	326	PF00389	0.550
LIG_deltaCOP1_diTrp_1	473	481	PF00928	0.335
LIG_EH_1	34	38	PF12763	0.564
LIG_EH1_1	406	414	PF00400	0.536
LIG_eIF4E_1	589	595	PF01652	0.246
LIG_FHA_1	1	7	PF00498	0.541
LIG_FHA_1	382	388	PF00498	0.671
LIG_FHA_1	51	57	PF00498	0.460
LIG_FHA_1	808	814	PF00498	0.624
LIG_FHA_2	182	188	PF00498	0.518
LIG_FHA_2	27	33	PF00498	0.542
LIG_FHA_2	319	325	PF00498	0.556
LIG_FHA_2	390	396	PF00498	0.583
LIG_FHA_2	400	406	PF00498	0.529
LIG_FHA_2	561	567	PF00498	0.447
LIG_FHA_2	582	588	PF00498	0.246
LIG_FHA_2	695	701	PF00498	0.453
LIG_FHA_2	921	927	PF00498	0.335
LIG_Integrin_RGD_1	229	231	PF01839	0.453
LIG_LIR_Apic_2	312	317	PF02991	0.586
LIG_LIR_Apic_2	606	612	PF02991	0.555
LIG_LIR_Gen_1	418	427	PF02991	0.435
LIG_LIR_Nem_3	418	423	PF02991	0.633
LIG_LIR_Nem_3	464	469	PF02991	0.278
LIG_LIR_Nem_3	50	54	PF02991	0.399
LIG_LIR_Nem_3	546	550	PF02991	0.417
LIG_LIR_Nem_3	684	689	PF02991	0.262
LIG_LIR_Nem_3	750	754	PF02991	0.431
LIG_PDZ_Class_2	936	941	PF00595	0.457
LIG_Pex14_2	143	147	PF04695	0.528
LIG_Pex14_2	330	334	PF04695	0.599
LIG_Pex14_2	930	934	PF04695	0.418
LIG_SH2_CRK	466	470	PF00017	0.278
LIG_SH2_NCK_1	241	245	PF00017	0.537
LIG_SH2_NCK_1	390	394	PF00017	0.502
LIG_SH2_PTP2	609	612	PF00017	0.428
LIG_SH2_SRC	124	127	PF00017	0.546
LIG_SH2_SRC	815	818	PF00017	0.555
LIG_SH2_SRC	924	927	PF00017	0.246
LIG_SH2_STAP1	390	394	PF00017	0.502
LIG_SH2_STAT3	432	435	PF00017	0.246
LIG_SH2_STAT3	477	480	PF00017	0.335
LIG_SH2_STAT3	574	577	PF00017	0.246
LIG_SH2_STAT3	703	706	PF00017	0.246
LIG_SH2_STAT5	124	127	PF00017	0.424
LIG_SH2_STAT5	165	168	PF00017	0.517
LIG_SH2_STAT5	224	227	PF00017	0.349
LIG_SH2_STAT5	257	260	PF00017	0.531
LIG_SH2_STAT5	454	457	PF00017	0.335
LIG_SH2_STAT5	51	54	PF00017	0.405
LIG_SH2_STAT5	609	612	PF00017	0.428
LIG_SH2_STAT5	643	646	PF00017	0.335
LIG_SH2_STAT5	775	778	PF00017	0.453
LIG_SH2_STAT5	815	818	PF00017	0.555
LIG_SH2_STAT5	835	838	PF00017	0.183
LIG_SH3_1	30	36	PF00018	0.493
LIG_SH3_3	102	108	PF00018	0.463
LIG_SH3_3	290	296	PF00018	0.768
LIG_SH3_3	30	36	PF00018	0.668
LIG_SH3_3	380	386	PF00018	0.662
LIG_SH3_3	421	427	PF00018	0.526
LIG_SH3_3	657	663	PF00018	0.601
LIG_SUMO_SIM_par_1	52	57	PF11976	0.460
LIG_SxIP_EBH_1	14	28	PF03271	0.536
LIG_TRAF2_1	321	324	PF00917	0.544
LIG_TRAF2_1	584	587	PF00917	0.421
LIG_TYR_ITIM	49	54	PF00017	0.410
LIG_WW_3	662	666	PF00397	0.563
MOD_CDK_SPK_2	9	14	PF00069	0.538
MOD_CK1_1	12	18	PF00069	0.632
MOD_CK1_1	128	134	PF00069	0.567
MOD_CK1_1	249	255	PF00069	0.775
MOD_CK1_1	26	32	PF00069	0.643
MOD_CK1_1	264	270	PF00069	0.484
MOD_CK1_1	312	318	PF00069	0.595
MOD_CK1_1	364	370	PF00069	0.562
MOD_CK1_1	450	456	PF00069	0.246
MOD_CK1_1	50	56	PF00069	0.527
MOD_CK1_1	641	647	PF00069	0.335
MOD_CK1_1	670	676	PF00069	0.560
MOD_CK1_1	70	76	PF00069	0.296
MOD_CK1_1	877	883	PF00069	0.416
MOD_CK2_1	318	324	PF00069	0.558
MOD_CK2_1	389	395	PF00069	0.608
MOD_CK2_1	581	587	PF00069	0.457
MOD_CK2_1	853	859	PF00069	0.335
MOD_CMANNOS	311	314	PF00535	0.587
MOD_Cter_Amidation	460	463	PF01082	0.335
MOD_Cter_Amidation	507	510	PF01082	0.335
MOD_Cter_Amidation	870	873	PF01082	0.236
MOD_GlcNHglycan	126	130	PF01048	0.596
MOD_GlcNHglycan	173	176	PF01048	0.690
MOD_GlcNHglycan	177	180	PF01048	0.717
MOD_GlcNHglycan	208	211	PF01048	0.698
MOD_GlcNHglycan	214	217	PF01048	0.577
MOD_GlcNHglycan	233	236	PF01048	0.246
MOD_GlcNHglycan	264	267	PF01048	0.537
MOD_GlcNHglycan	311	314	PF01048	0.587
MOD_GlcNHglycan	335	338	PF01048	0.521
MOD_GlcNHglycan	370	373	PF01048	0.572
MOD_GlcNHglycan	413	416	PF01048	0.602
MOD_GlcNHglycan	635	638	PF01048	0.454
MOD_GlcNHglycan	640	643	PF01048	0.433
MOD_GlcNHglycan	652	655	PF01048	0.335
MOD_GlcNHglycan	690	693	PF01048	0.335
MOD_GlcNHglycan	743	746	PF01048	0.335
MOD_GlcNHglycan	876	879	PF01048	0.335
MOD_GSK3_1	147	154	PF00069	0.578
MOD_GSK3_1	171	178	PF00069	0.764
MOD_GSK3_1	208	215	PF00069	0.643
MOD_GSK3_1	264	271	PF00069	0.564
MOD_GSK3_1	274	281	PF00069	0.678
MOD_GSK3_1	312	319	PF00069	0.595
MOD_GSK3_1	344	351	PF00069	0.742
MOD_GSK3_1	355	362	PF00069	0.653
MOD_GSK3_1	364	371	PF00069	0.526
MOD_GSK3_1	377	384	PF00069	0.662
MOD_GSK3_1	50	57	PF00069	0.579
MOD_GSK3_1	560	567	PF00069	0.456
MOD_GSK3_1	64	71	PF00069	0.444
MOD_GSK3_1	666	673	PF00069	0.535
MOD_GSK3_1	718	725	PF00069	0.565
MOD_GSK3_1	743	750	PF00069	0.335
MOD_GSK3_1	758	765	PF00069	0.434
MOD_GSK3_1	8	15	PF00069	0.615
MOD_GSK3_1	920	927	PF00069	0.324
MOD_LATS_1	870	876	PF00433	0.246
MOD_N-GLC_1	268	273	PF02516	0.566
MOD_NEK2_1	1	6	PF00069	0.636
MOD_NEK2_1	18	23	PF00069	0.565
MOD_NEK2_1	196	201	PF00069	0.614
MOD_NEK2_1	251	256	PF00069	0.700
MOD_NEK2_1	261	266	PF00069	0.514
MOD_NEK2_1	604	609	PF00069	0.357
MOD_NEK2_1	66	71	PF00069	0.469
MOD_NEK2_1	77	82	PF00069	0.411
MOD_NEK2_2	165	170	PF00069	0.519
MOD_NEK2_2	219	224	PF00069	0.631
MOD_NEK2_2	786	791	PF00069	0.306
MOD_NEK2_2	901	906	PF00069	0.447
MOD_NEK2_2	925	930	PF00069	0.335
MOD_OFUCOSY	75	81	PF10250	0.406
MOD_PIKK_1	23	29	PF00454	0.620
MOD_PIKK_1	246	252	PF00454	0.648
MOD_PIKK_1	279	285	PF00454	0.722
MOD_PIKK_1	54	60	PF00454	0.565
MOD_PIKK_1	564	570	PF00454	0.566
MOD_PIKK_1	743	749	PF00454	0.421
MOD_PIKK_1	846	852	PF00454	0.335
MOD_PK_1	853	859	PF00069	0.335
MOD_PKA_1	872	878	PF00069	0.246
MOD_PKA_2	64	70	PF00069	0.343
MOD_PKA_2	694	700	PF00069	0.326
MOD_PKA_2	758	764	PF00069	0.552
MOD_PKA_2	871	877	PF00069	0.335
MOD_Plk_1	450	456	PF00069	0.335
MOD_Plk_1	605	611	PF00069	0.346
MOD_Plk_1	925	931	PF00069	0.325
MOD_Plk_2-3	543	549	PF00069	0.422
MOD_Plk_4	2	8	PF00069	0.519
MOD_Plk_4	219	225	PF00069	0.533
MOD_Plk_4	47	53	PF00069	0.551
MOD_Plk_4	605	611	PF00069	0.553
MOD_Plk_4	722	728	PF00069	0.448
MOD_Plk_4	738	744	PF00069	0.335
MOD_Plk_4	775	781	PF00069	0.453
MOD_Plk_4	853	859	PF00069	0.335
MOD_Plk_4	901	907	PF00069	0.519
MOD_Plk_4	925	931	PF00069	0.335
MOD_ProDKin_1	318	324	PF00069	0.569
MOD_ProDKin_1	362	368	PF00069	0.762
MOD_ProDKin_1	379	385	PF00069	0.606
MOD_ProDKin_1	492	498	PF00069	0.549
MOD_ProDKin_1	672	678	PF00069	0.543
MOD_ProDKin_1	9	15	PF00069	0.543
MOD_ProDKin_1	94	100	PF00069	0.480
MOD_SUMO_rev_2	34	43	PF00179	0.569
TRG_DiLeu_BaEn_1	464	469	PF01217	0.236
TRG_DiLeu_BaLyEn_6	91	96	PF01217	0.482
TRG_ENDOCYTIC_2	466	469	PF00928	0.466
TRG_ENDOCYTIC_2	51	54	PF00928	0.400
TRG_ENDOCYTIC_2	547	550	PF00928	0.418
TRG_ENDOCYTIC_2	751	754	PF00928	0.423
TRG_ENDOCYTIC_2	858	861	PF00928	0.246
TRG_ER_diArg_1	469	471	PF00400	0.335

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I572	Leptomonas seymouri	54%	99%
A0A3S7XAW7	Leishmania donovani	78%	100%
A4IDF2	Leishmania infantum	78%	100%
E9ASV3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q1P3	Leishmania major	79%	100%