Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HP44_LEIBR

TriTrypDb:

LbrM.35.1990 , LBRM2903_350026300

Length:

369

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005882	intermediate filament	6	1
GO:0099080	supramolecular complex	2	1
GO:0099081	supramolecular polymer	3	1
GO:0099512	supramolecular fiber	4	1
GO:0099513	polymeric cytoskeletal fiber	5	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HP44

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP44

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	334	338	PF00656	0.443
CLV_NRD_NRD_1	161	163	PF00675	0.519
CLV_NRD_NRD_1	318	320	PF00675	0.545
CLV_PCSK_KEX2_1	133	135	PF00082	0.597
CLV_PCSK_KEX2_1	163	165	PF00082	0.518
CLV_PCSK_KEX2_1	318	320	PF00082	0.519
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.477
CLV_PCSK_PC1ET2_1	163	165	PF00082	0.479
CLV_PCSK_PC7_1	129	135	PF00082	0.589
CLV_PCSK_SKI1_1	258	262	PF00082	0.568
CLV_PCSK_SKI1_1	318	322	PF00082	0.492
CLV_PCSK_SKI1_1	59	63	PF00082	0.469
DEG_APCC_DBOX_1	152	160	PF00400	0.321
DEG_APCC_DBOX_1	297	305	PF00400	0.509
DEG_SPOP_SBC_1	51	55	PF00917	0.405
DOC_MAPK_gen_1	153	161	PF00069	0.499
DOC_USP7_MATH_1	19	23	PF00917	0.468
DOC_USP7_MATH_1	207	211	PF00917	0.574
DOC_USP7_MATH_1	45	49	PF00917	0.674
DOC_USP7_MATH_1	51	55	PF00917	0.606
DOC_USP7_MATH_1	74	78	PF00917	0.650
DOC_USP7_UBL2_3	133	137	PF12436	0.319
DOC_WW_Pin1_4	43	48	PF00397	0.613
DOC_WW_Pin1_4	52	57	PF00397	0.421
DOC_WW_Pin1_4	8	13	PF00397	0.604
LIG_14-3-3_CanoR_1	203	211	PF00244	0.650
LIG_14-3-3_CanoR_1	29	38	PF00244	0.469
LIG_14-3-3_CanoR_1	350	358	PF00244	0.528
LIG_14-3-3_CanoR_1	6	12	PF00244	0.567
LIG_Actin_WH2_2	189	205	PF00022	0.370
LIG_BIR_II_1	1	5	PF00653	0.494
LIG_BRCT_BRCA1_1	10	14	PF00533	0.469
LIG_BRCT_BRCA1_1	209	213	PF00533	0.402
LIG_FHA_1	125	131	PF00498	0.459
LIG_FHA_1	65	71	PF00498	0.645
LIG_FHA_2	203	209	PF00498	0.389
LIG_LIR_Nem_3	357	361	PF02991	0.394
LIG_NRBOX	350	356	PF00104	0.396
LIG_PCNA_PIPBox_1	91	100	PF02747	0.404
LIG_SH2_GRB2like	333	336	PF00017	0.417
LIG_SH2_GRB2like	97	100	PF00017	0.394
LIG_SH2_NCK_1	333	337	PF00017	0.545
LIG_SH2_SRC	333	336	PF00017	0.395
LIG_SH2_SRC	97	100	PF00017	0.394
LIG_SH2_STAT3	229	232	PF00017	0.408
LIG_SH2_STAT5	229	232	PF00017	0.380
LIG_SH2_STAT5	97	100	PF00017	0.362
LIG_TRAF2_1	314	317	PF00917	0.497
MOD_CDK_SPxxK_3	52	59	PF00069	0.414
MOD_CK1_1	214	220	PF00069	0.542
MOD_CK1_1	4	10	PF00069	0.659
MOD_CK1_1	50	56	PF00069	0.593
MOD_CK2_1	243	249	PF00069	0.524
MOD_GlcNHglycan	1	4	PF01048	0.589
MOD_GlcNHglycan	15	18	PF01048	0.548
MOD_GlcNHglycan	205	208	PF01048	0.462
MOD_GlcNHglycan	21	24	PF01048	0.494
MOD_GlcNHglycan	324	327	PF01048	0.394
MOD_GlcNHglycan	49	52	PF01048	0.592
MOD_GlcNHglycan	70	73	PF01048	0.725
MOD_GSK3_1	203	210	PF00069	0.657
MOD_GSK3_1	4	11	PF00069	0.647
MOD_GSK3_1	43	50	PF00069	0.643
MOD_GSK3_1	60	67	PF00069	0.569
MOD_GSK3_1	70	77	PF00069	0.668
MOD_N-GLC_1	174	179	PF02516	0.463
MOD_N-GLC_1	258	263	PF02516	0.502
MOD_NEK2_1	1	6	PF00069	0.652
MOD_NEK2_1	124	129	PF00069	0.537
MOD_NEK2_1	202	207	PF00069	0.368
MOD_NEK2_1	322	327	PF00069	0.304
MOD_NEK2_1	354	359	PF00069	0.559
MOD_PIKK_1	258	264	PF00454	0.538
MOD_PIKK_1	349	355	PF00454	0.512
MOD_PIKK_1	80	86	PF00454	0.467
MOD_PKA_2	202	208	PF00069	0.411
MOD_PKA_2	341	347	PF00069	0.564
MOD_PKA_2	349	355	PF00069	0.459
MOD_Plk_1	124	130	PF00069	0.286
MOD_Plk_1	174	180	PF00069	0.460
MOD_Plk_1	207	213	PF00069	0.401
MOD_Plk_4	174	180	PF00069	0.318
MOD_Plk_4	300	306	PF00069	0.387
MOD_ProDKin_1	43	49	PF00069	0.609
MOD_ProDKin_1	52	58	PF00069	0.412
MOD_ProDKin_1	8	14	PF00069	0.607
MOD_SUMO_rev_2	88	96	PF00179	0.479
TRG_DiLeu_BaEn_3	316	322	PF01217	0.432
TRG_DiLeu_BaLyEn_6	126	131	PF01217	0.434
TRG_DiLeu_BaLyEn_6	32	37	PF01217	0.470
TRG_ER_diArg_1	153	156	PF00400	0.529
TRG_ER_diArg_1	161	164	PF00400	0.582
TRG_ER_diArg_1	318	320	PF00400	0.537
TRG_NLS_MonoExtC_3	161	166	PF00514	0.465
TRG_NLS_MonoExtN_4	162	167	PF00514	0.381

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEW3	Leptomonas seymouri	45%	91%
A0A0S4IWZ6	Bodo saltans	23%	100%
A0A1X0P838	Trypanosomatidae	25%	93%
A0A3S5H822	Leishmania donovani	67%	96%
A0A422NLC8	Trypanosoma rangeli	25%	100%
A4IDF1	Leishmania infantum	69%	100%
E9ASV2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	96%
Q4Q1P4	Leishmania major	67%	100%
V5B4D1	Trypanosoma cruzi	24%	100%