Putative exoribonuclease 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

5'-3' exoribonuclease D, putative

Species:

Leishmania braziliensis

UniProt:

A4HP43_LEIBR

TriTrypDb:

LbrM.35.1980 , LBRM2903_350026200

Length:

899

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HP43

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP43

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0000956	nuclear-transcribed mRNA catabolic process	7	1
GO:0006401	RNA catabolic process	5	1
GO:0006402	mRNA catabolic process	6	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010629	negative regulation of gene expression	6	1
GO:0016071	mRNA metabolic process	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0046700	heterocycle catabolic process	4	1
GO:0048519	negative regulation of biological process	3	1
GO:0050789	regulation of biological process	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004518	nuclease activity	4	12
GO:0004527	exonuclease activity	5	12
GO:0005488	binding	1	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003723	RNA binding	4	1
GO:0004532	RNA exonuclease activity	5	1
GO:0004534	5'-3' RNA exonuclease activity	7	1
GO:0004540	RNA nuclease activity	4	1
GO:0008409	5'-3' exonuclease activity	6	1
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	1
GO:0016896	RNA exonuclease activity, producing 5'-phosphomonoesters	6	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	16	20	PF00656	0.514
CLV_C14_Caspase3-7	24	28	PF00656	0.481
CLV_MEL_PAP_1	654	660	PF00089	0.449
CLV_NRD_NRD_1	115	117	PF00675	0.244
CLV_NRD_NRD_1	419	421	PF00675	0.359
CLV_NRD_NRD_1	593	595	PF00675	0.169
CLV_NRD_NRD_1	740	742	PF00675	0.761
CLV_NRD_NRD_1	771	773	PF00675	0.666
CLV_NRD_NRD_1	789	791	PF00675	0.748
CLV_NRD_NRD_1	823	825	PF00675	0.676
CLV_NRD_NRD_1	886	888	PF00675	0.724
CLV_PCSK_FUR_1	113	117	PF00082	0.244
CLV_PCSK_FUR_1	727	731	PF00082	0.727
CLV_PCSK_FUR_1	769	773	PF00082	0.727
CLV_PCSK_KEX2_1	115	117	PF00082	0.244
CLV_PCSK_KEX2_1	686	688	PF00082	0.463
CLV_PCSK_KEX2_1	726	728	PF00082	0.680
CLV_PCSK_KEX2_1	729	731	PF00082	0.719
CLV_PCSK_KEX2_1	740	742	PF00082	0.461
CLV_PCSK_KEX2_1	759	761	PF00082	0.578
CLV_PCSK_KEX2_1	771	773	PF00082	0.568
CLV_PCSK_KEX2_1	788	790	PF00082	0.746
CLV_PCSK_KEX2_1	823	825	PF00082	0.670
CLV_PCSK_KEX2_1	886	888	PF00082	0.742
CLV_PCSK_PC1ET2_1	686	688	PF00082	0.463
CLV_PCSK_PC1ET2_1	726	728	PF00082	0.714
CLV_PCSK_PC1ET2_1	729	731	PF00082	0.747
CLV_PCSK_PC1ET2_1	759	761	PF00082	0.554
CLV_PCSK_PC1ET2_1	771	773	PF00082	0.538
CLV_PCSK_PC7_1	769	775	PF00082	0.575
CLV_PCSK_SKI1_1	166	170	PF00082	0.330
CLV_PCSK_SKI1_1	186	190	PF00082	0.113
CLV_PCSK_SKI1_1	274	278	PF00082	0.396
CLV_PCSK_SKI1_1	459	463	PF00082	0.290
CLV_PCSK_SKI1_1	553	557	PF00082	0.305
CLV_PCSK_SKI1_1	686	690	PF00082	0.445
CLV_PCSK_SKI1_1	707	711	PF00082	0.452
DEG_APCC_KENBOX_2	688	692	PF00400	0.291
DEG_SPOP_SBC_1	648	652	PF00917	0.303
DEG_SPOP_SBC_1	713	717	PF00917	0.601
DEG_SPOP_SBC_1	804	808	PF00917	0.653
DEG_SPOP_SBC_1	853	857	PF00917	0.755
DOC_CDC14_PxL_1	497	505	PF14671	0.455
DOC_CDC14_PxL_1	530	538	PF14671	0.469
DOC_CKS1_1	156	161	PF01111	0.444
DOC_CYCLIN_RxL_1	88	101	PF00134	0.444
DOC_CYCLIN_yCln2_LP_2	637	643	PF00134	0.590
DOC_MAPK_gen_1	315	323	PF00069	0.455
DOC_MAPK_gen_1	420	428	PF00069	0.467
DOC_MAPK_gen_1	591	599	PF00069	0.549
DOC_MAPK_gen_1	88	98	PF00069	0.444
DOC_MAPK_MEF2A_6	315	323	PF00069	0.365
DOC_MAPK_MEF2A_6	78	87	PF00069	0.468
DOC_MAPK_MEF2A_6	91	100	PF00069	0.404
DOC_MAPK_NFAT4_5	93	101	PF00069	0.444
DOC_PP2B_LxvP_1	579	582	PF13499	0.455
DOC_PP2B_LxvP_1	637	640	PF13499	0.630
DOC_USP7_MATH_1	310	314	PF00917	0.530
DOC_USP7_MATH_1	389	393	PF00917	0.547
DOC_USP7_MATH_1	400	404	PF00917	0.500
DOC_USP7_MATH_1	626	630	PF00917	0.632
DOC_USP7_MATH_1	722	726	PF00917	0.652
DOC_USP7_MATH_1	796	800	PF00917	0.739
DOC_USP7_MATH_1	804	808	PF00917	0.736
DOC_USP7_MATH_1	852	856	PF00917	0.683
DOC_USP7_UBL2_3	357	361	PF12436	0.502
DOC_USP7_UBL2_3	830	834	PF12436	0.746
DOC_WW_Pin1_4	155	160	PF00397	0.444
DOC_WW_Pin1_4	635	640	PF00397	0.632
DOC_WW_Pin1_4	649	654	PF00397	0.327
DOC_WW_Pin1_4	733	738	PF00397	0.741
DOC_WW_Pin1_4	800	805	PF00397	0.659
LIG_14-3-3_CanoR_1	136	144	PF00244	0.521
LIG_14-3-3_CanoR_1	186	191	PF00244	0.505
LIG_14-3-3_CanoR_1	210	216	PF00244	0.495
LIG_14-3-3_CanoR_1	249	258	PF00244	0.537
LIG_14-3-3_CanoR_1	37	45	PF00244	0.369
LIG_14-3-3_CanoR_1	383	391	PF00244	0.505
LIG_14-3-3_CanoR_1	518	522	PF00244	0.503
LIG_14-3-3_CanoR_1	535	539	PF00244	0.353
LIG_BRCT_BRCA1_1	113	117	PF00533	0.444
LIG_BRCT_BRCA1_1	159	163	PF00533	0.444
LIG_Clathr_ClatBox_1	596	600	PF01394	0.553
LIG_deltaCOP1_diTrp_1	181	192	PF00928	0.455
LIG_deltaCOP1_diTrp_1	492	495	PF00928	0.455
LIG_EH1_1	523	531	PF00400	0.444
LIG_eIF4E_1	497	503	PF01652	0.505
LIG_FHA_1	220	226	PF00498	0.455
LIG_FHA_1	314	320	PF00498	0.444
LIG_FHA_1	422	428	PF00498	0.494
LIG_FHA_1	508	514	PF00498	0.462
LIG_FHA_1	61	67	PF00498	0.444
LIG_FHA_1	636	642	PF00498	0.571
LIG_FHA_1	649	655	PF00498	0.509
LIG_FHA_1	880	886	PF00498	0.548
LIG_FHA_2	383	389	PF00498	0.561
LIG_FHA_2	700	706	PF00498	0.546
LIG_KLC1_Yacidic_2	46	51	PF13176	0.455
LIG_LIR_Apic_2	139	144	PF02991	0.532
LIG_LIR_Apic_2	490	496	PF02991	0.444
LIG_LIR_Gen_1	278	287	PF02991	0.401
LIG_LIR_Gen_1	292	301	PF02991	0.416
LIG_LIR_Gen_1	341	352	PF02991	0.469
LIG_LIR_Gen_1	44	52	PF02991	0.451
LIG_LIR_Gen_1	73	83	PF02991	0.455
LIG_LIR_LC3C_4	424	428	PF02991	0.480
LIG_LIR_Nem_3	182	188	PF02991	0.449
LIG_LIR_Nem_3	278	282	PF02991	0.391
LIG_LIR_Nem_3	292	297	PF02991	0.449
LIG_LIR_Nem_3	341	347	PF02991	0.441
LIG_LIR_Nem_3	363	369	PF02991	0.473
LIG_LIR_Nem_3	44	48	PF02991	0.462
LIG_LIR_Nem_3	490	494	PF02991	0.440
LIG_LIR_Nem_3	574	578	PF02991	0.458
LIG_LIR_Nem_3	705	709	PF02991	0.520
LIG_LIR_Nem_3	77	83	PF02991	0.457
LIG_LRP6_Inhibitor_1	461	467	PF00058	0.169
LIG_LYPXL_S_1	559	563	PF13949	0.330
LIG_LYPXL_yS_3	560	563	PF13949	0.530
LIG_MAD2	136	144	PF02301	0.519
LIG_Pex14_1	479	483	PF04695	0.444
LIG_Pex14_1	491	495	PF04695	0.444
LIG_Pex14_2	296	300	PF04695	0.444
LIG_Pex14_2	350	354	PF04695	0.444
LIG_Pex14_2	603	607	PF04695	0.498
LIG_Pex14_2	76	80	PF04695	0.455
LIG_Rb_LxCxE_1	463	485	PF01857	0.485
LIG_Rb_LxCxE_1	605	624	PF01857	0.422
LIG_SH2_CRK	141	145	PF00017	0.549
LIG_SH2_CRK	367	371	PF00017	0.463
LIG_SH2_CRK	499	503	PF00017	0.444
LIG_SH2_CRK	575	579	PF00017	0.444
LIG_SH2_CRK	706	710	PF00017	0.483
LIG_SH2_GRB2like	265	268	PF00017	0.403
LIG_SH2_GRB2like	45	48	PF00017	0.505
LIG_SH2_STAP1	45	49	PF00017	0.505
LIG_SH2_STAP1	661	665	PF00017	0.498
LIG_SH2_STAT3	446	449	PF00017	0.369
LIG_SH2_STAT5	174	177	PF00017	0.530
LIG_SH2_STAT5	208	211	PF00017	0.444
LIG_SH2_STAT5	265	268	PF00017	0.311
LIG_SH2_STAT5	326	329	PF00017	0.444
LIG_SH2_STAT5	335	338	PF00017	0.444
LIG_SH2_STAT5	437	440	PF00017	0.462
LIG_SH2_STAT5	473	476	PF00017	0.443
LIG_SH2_STAT5	484	487	PF00017	0.430
LIG_SH2_STAT5	49	52	PF00017	0.448
LIG_SH2_STAT5	494	497	PF00017	0.444
LIG_SH2_STAT5	609	612	PF00017	0.438
LIG_SH3_3	153	159	PF00018	0.444
LIG_SH3_3	304	310	PF00018	0.444
LIG_SH3_3	519	525	PF00018	0.444
LIG_SH3_3	546	552	PF00018	0.444
LIG_SH3_3	637	643	PF00018	0.568
LIG_SH3_3	86	92	PF00018	0.457
LIG_SH3_5	216	220	PF00018	0.549
LIG_SUMO_SIM_anti_2	81	87	PF11976	0.505
LIG_SUMO_SIM_par_1	310	316	PF11976	0.444
LIG_SUMO_SIM_par_1	562	567	PF11976	0.526
LIG_SUMO_SIM_par_1	595	602	PF11976	0.580
LIG_TYR_ITIM	342	347	PF00017	0.469
LIG_UBA3_1	349	357	PF00899	0.549
LIG_UBA3_1	359	364	PF00899	0.431
LIG_UBA3_1	412	421	PF00899	0.474
MOD_CDK_SPxxK_3	733	740	PF00069	0.523
MOD_CK1_1	139	145	PF00069	0.526
MOD_CK1_1	313	319	PF00069	0.442
MOD_CK1_1	38	44	PF00069	0.479
MOD_CK1_1	647	653	PF00069	0.544
MOD_CK1_1	725	731	PF00069	0.707
MOD_CK1_1	799	805	PF00069	0.705
MOD_CK1_1	843	849	PF00069	0.720
MOD_CK1_1	855	861	PF00069	0.698
MOD_CK1_1	873	879	PF00069	0.796
MOD_CK1_1	881	887	PF00069	0.713
MOD_CK2_1	236	242	PF00069	0.444
MOD_CK2_1	382	388	PF00069	0.529
MOD_CK2_1	750	756	PF00069	0.760
MOD_CK2_1	774	780	PF00069	0.742
MOD_CK2_1	834	840	PF00069	0.750
MOD_CK2_1	843	849	PF00069	0.729
MOD_Cter_Amidation	684	687	PF01082	0.474
MOD_Cter_Amidation	831	834	PF01082	0.767
MOD_Cter_Amidation	868	871	PF01082	0.722
MOD_GlcNHglycan	40	43	PF01048	0.297
MOD_GlcNHglycan	519	522	PF01048	0.329
MOD_GlcNHglycan	628	631	PF01048	0.634
MOD_GlcNHglycan	811	815	PF01048	0.634
MOD_GSK3_1	123	130	PF00069	0.458
MOD_GSK3_1	186	193	PF00069	0.505
MOD_GSK3_1	644	651	PF00069	0.559
MOD_GSK3_1	714	721	PF00069	0.562
MOD_GSK3_1	784	791	PF00069	0.766
MOD_GSK3_1	796	803	PF00069	0.638
MOD_GSK3_1	806	813	PF00069	0.653
MOD_GSK3_1	840	847	PF00069	0.703
MOD_GSK3_1	852	859	PF00069	0.648
MOD_GSK3_1	870	877	PF00069	0.764
MOD_GSK3_1	891	898	PF00069	0.710
MOD_LATS_1	758	764	PF00433	0.501
MOD_LATS_1	893	899	PF00433	0.514
MOD_N-GLC_1	220	225	PF02516	0.330
MOD_N-GLC_1	571	576	PF02516	0.297
MOD_N-GLC_1	718	723	PF02516	0.681
MOD_N-GLC_2	131	133	PF02516	0.305
MOD_NEK2_1	236	241	PF00069	0.453
MOD_NEK2_1	252	257	PF00069	0.418
MOD_NEK2_1	415	420	PF00069	0.446
MOD_NEK2_1	433	438	PF00069	0.379
MOD_NEK2_1	509	514	PF00069	0.542
MOD_NEK2_1	517	522	PF00069	0.513
MOD_NEK2_1	603	608	PF00069	0.425
MOD_NEK2_2	310	315	PF00069	0.444
MOD_NEK2_2	534	539	PF00069	0.530
MOD_PIKK_1	211	217	PF00454	0.505
MOD_PIKK_1	699	705	PF00454	0.525
MOD_PIKK_1	834	840	PF00454	0.752
MOD_PIKK_1	856	862	PF00454	0.659
MOD_PKA_1	788	794	PF00069	0.764
MOD_PKA_1	833	839	PF00069	0.691
MOD_PKA_1	863	869	PF00069	0.667
MOD_PKA_1	870	876	PF00069	0.588
MOD_PKA_2	382	388	PF00069	0.549
MOD_PKA_2	517	523	PF00069	0.503
MOD_PKA_2	534	540	PF00069	0.353
MOD_PKA_2	788	794	PF00069	0.719
MOD_PKA_2	796	802	PF00069	0.686
MOD_PKA_2	819	825	PF00069	0.704
MOD_PKA_2	843	849	PF00069	0.717
MOD_PKA_2	873	879	PF00069	0.759
MOD_PKA_2	891	897	PF00069	0.490
MOD_PKB_1	772	780	PF00069	0.499
MOD_PKB_1	842	850	PF00069	0.514
MOD_Plk_1	139	145	PF00069	0.523
MOD_Plk_1	220	226	PF00069	0.505
MOD_Plk_1	421	427	PF00069	0.526
MOD_Plk_1	453	459	PF00069	0.538
MOD_Plk_1	571	577	PF00069	0.497
MOD_Plk_1	611	617	PF00069	0.386
MOD_Plk_4	186	192	PF00069	0.552
MOD_Plk_4	394	400	PF00069	0.557
MOD_Plk_4	551	557	PF00069	0.444
MOD_Plk_4	603	609	PF00069	0.383
MOD_Plk_4	611	617	PF00069	0.366
MOD_ProDKin_1	155	161	PF00069	0.444
MOD_ProDKin_1	635	641	PF00069	0.614
MOD_ProDKin_1	649	655	PF00069	0.323
MOD_ProDKin_1	733	739	PF00069	0.743
MOD_ProDKin_1	800	806	PF00069	0.659
MOD_SUMO_rev_2	200	206	PF00179	0.444
MOD_SUMO_rev_2	547	555	PF00179	0.505
MOD_SUMO_rev_2	778	787	PF00179	0.655
TRG_DiLeu_BaEn_1	422	427	PF01217	0.448
TRG_DiLeu_BaLyEn_6	498	503	PF01217	0.444
TRG_ENDOCYTIC_2	265	268	PF00928	0.318
TRG_ENDOCYTIC_2	344	347	PF00928	0.460
TRG_ENDOCYTIC_2	366	369	PF00928	0.460
TRG_ENDOCYTIC_2	45	48	PF00928	0.453
TRG_ENDOCYTIC_2	49	52	PF00928	0.439
TRG_ENDOCYTIC_2	499	502	PF00928	0.452
TRG_ENDOCYTIC_2	560	563	PF00928	0.500
TRG_ENDOCYTIC_2	575	578	PF00928	0.373
TRG_ENDOCYTIC_2	706	709	PF00928	0.480
TRG_ER_diArg_1	113	116	PF00400	0.444
TRG_ER_diArg_1	144	147	PF00400	0.494
TRG_ER_diArg_1	370	373	PF00400	0.555
TRG_ER_diArg_1	423	426	PF00400	0.469
TRG_ER_diArg_1	740	743	PF00400	0.766
TRG_ER_diArg_1	788	790	PF00400	0.725
TRG_ER_diArg_1	823	826	PF00400	0.761
TRG_ER_diArg_1	841	844	PF00400	0.606
TRG_ER_diArg_1	885	887	PF00400	0.782
TRG_NES_CRM1_1	504	516	PF08389	0.502
TRG_NLS_Bipartite_1	759	777	PF00514	0.636
TRG_NLS_Bipartite_1	823	837	PF00514	0.713
TRG_NLS_MonoExtC_3	725	730	PF00514	0.474
TRG_NLS_MonoExtC_3	771	776	PF00514	0.591
TRG_NLS_MonoExtC_3	862	867	PF00514	0.583
TRG_NLS_MonoExtN_4	769	776	PF00514	0.672
TRG_NLS_MonoExtN_4	830	837	PF00514	0.701
TRG_NLS_MonoExtN_4	861	867	PF00514	0.582
TRG_Pf-PMV_PEXEL_1	177	181	PF00026	0.285
TRG_Pf-PMV_PEXEL_1	210	215	PF00026	0.244
TRG_Pf-PMV_PEXEL_1	594	598	PF00026	0.349
TRG_Pf-PMV_PEXEL_1	823	827	PF00026	0.503

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYA8	Leptomonas seymouri	86%	98%
A0A0S4IWC0	Bodo saltans	56%	100%
A0A0S4IZP1	Bodo saltans	31%	66%
A0A1X0P7T7	Trypanosomatidae	65%	100%
A0A3Q8IH53	Leishmania donovani	86%	100%
A0A3R7LZH3	Trypanosoma rangeli	62%	100%
A4IDF0	Leishmania infantum	86%	100%
D0A327	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9ASV1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q1P5	Leishmania major	88%	100%
Q5ZIP4	Gallus gallus	33%	95%
Q60SG7	Caenorhabditis briggsae	32%	92%
Q9FQ02	Arabidopsis thaliana	33%	89%
Q9FQ03	Arabidopsis thaliana	34%	88%
Q9FQ04	Arabidopsis thaliana	35%	95%
Q9VM71	Drosophila melanogaster	33%	99%
V5DKX1	Trypanosoma cruzi	60%	100%