Tetratricopeptide repeat-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR repeat, putative

Species:

Leishmania braziliensis

UniProt:

A4HP42_LEIBR

TriTrypDb:

LbrM.35.1970 , LBRM2903_350026100

Length:

755

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HP42

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP42

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	115	119	PF00656	0.722
CLV_C14_Caspase3-7	356	360	PF00656	0.433
CLV_C14_Caspase3-7	496	500	PF00656	0.497
CLV_NRD_NRD_1	120	122	PF00675	0.686
CLV_NRD_NRD_1	200	202	PF00675	0.637
CLV_NRD_NRD_1	345	347	PF00675	0.529
CLV_NRD_NRD_1	444	446	PF00675	0.486
CLV_NRD_NRD_1	563	565	PF00675	0.412
CLV_PCSK_FUR_1	719	723	PF00082	0.542
CLV_PCSK_KEX2_1	120	122	PF00082	0.555
CLV_PCSK_KEX2_1	200	202	PF00082	0.637
CLV_PCSK_KEX2_1	444	446	PF00082	0.507
CLV_PCSK_KEX2_1	721	723	PF00082	0.787
CLV_PCSK_KEX2_1	728	730	PF00082	0.774
CLV_PCSK_PC1ET2_1	721	723	PF00082	0.711
CLV_PCSK_PC1ET2_1	728	730	PF00082	0.743
CLV_PCSK_SKI1_1	342	346	PF00082	0.433
CLV_PCSK_SKI1_1	349	353	PF00082	0.432
CLV_PCSK_SKI1_1	405	409	PF00082	0.518
CLV_PCSK_SKI1_1	460	464	PF00082	0.433
CLV_PCSK_SKI1_1	482	486	PF00082	0.459
CLV_PCSK_SKI1_1	564	568	PF00082	0.412
CLV_PCSK_SKI1_1	607	611	PF00082	0.349
CLV_PCSK_SKI1_1	662	666	PF00082	0.716
CLV_Separin_Metazoa	378	382	PF03568	0.545
DEG_APCC_DBOX_1	233	241	PF00400	0.476
DEG_APCC_DBOX_1	606	614	PF00400	0.456
DEG_ODPH_VHL_1	217	230	PF01847	0.488
DEG_SCF_TRCP1_1	359	365	PF00400	0.515
DOC_CKS1_1	178	183	PF01111	0.552
DOC_CYCLIN_RxL_1	346	356	PF00134	0.451
DOC_CYCLIN_RxL_1	402	410	PF00134	0.563
DOC_CYCLIN_RxL_1	479	486	PF00134	0.314
DOC_MAPK_gen_1	28	37	PF00069	0.525
DOC_MAPK_gen_1	346	354	PF00069	0.545
DOC_MAPK_gen_1	444	450	PF00069	0.513
DOC_MAPK_gen_1	509	518	PF00069	0.524
DOC_MAPK_MEF2A_6	15	22	PF00069	0.443
DOC_MAPK_MEF2A_6	346	354	PF00069	0.483
DOC_MAPK_MEF2A_6	482	491	PF00069	0.492
DOC_MAPK_MEF2A_6	511	519	PF00069	0.470
DOC_MAPK_NFAT4_5	347	355	PF00069	0.332
DOC_MAPK_RevD_3	432	445	PF00069	0.406
DOC_PP1_RVXF_1	480	486	PF00149	0.314
DOC_PP2B_LxvP_1	665	668	PF13499	0.692
DOC_PP4_FxxP_1	196	199	PF00568	0.510
DOC_PP4_FxxP_1	6	9	PF00568	0.475
DOC_USP7_MATH_1	145	149	PF00917	0.729
DOC_USP7_MATH_1	213	217	PF00917	0.721
DOC_USP7_MATH_1	363	367	PF00917	0.658
DOC_USP7_MATH_1	419	423	PF00917	0.499
DOC_USP7_MATH_1	640	644	PF00917	0.781
DOC_USP7_MATH_1	702	706	PF00917	0.777
DOC_USP7_UBL2_3	26	30	PF12436	0.525
DOC_USP7_UBL2_3	456	460	PF12436	0.474
DOC_WW_Pin1_4	124	129	PF00397	0.725
DOC_WW_Pin1_4	160	165	PF00397	0.670
DOC_WW_Pin1_4	171	176	PF00397	0.812
DOC_WW_Pin1_4	177	182	PF00397	0.707
DOC_WW_Pin1_4	218	223	PF00397	0.726
DOC_WW_Pin1_4	365	370	PF00397	0.714
DOC_WW_Pin1_4	386	391	PF00397	0.680
DOC_WW_Pin1_4	5	10	PF00397	0.577
DOC_WW_Pin1_4	674	679	PF00397	0.698
DOC_WW_Pin1_4	698	703	PF00397	0.570
LIG_14-3-3_CanoR_1	120	128	PF00244	0.689
LIG_14-3-3_CanoR_1	259	268	PF00244	0.460
LIG_14-3-3_CanoR_1	554	559	PF00244	0.551
LIG_14-3-3_CanoR_1	564	572	PF00244	0.484
LIG_14-3-3_CanoR_1	650	657	PF00244	0.551
LIG_14-3-3_CanoR_1	696	703	PF00244	0.777
LIG_14-3-3_CanoR_1	740	744	PF00244	0.555
LIG_14-3-3_CanoR_1	86	92	PF00244	0.451
LIG_Actin_WH2_2	244	261	PF00022	0.454
LIG_APCC_ABBA_1	47	52	PF00400	0.555
LIG_BIR_III_4	242	246	PF00653	0.552
LIG_BRCT_BRCA1_1	6	10	PF00533	0.474
LIG_CtBP_PxDLS_1	214	220	PF00389	0.540
LIG_CtBP_PxDLS_1	398	402	PF00389	0.478
LIG_deltaCOP1_diTrp_1	560	567	PF00928	0.348
LIG_DLG_GKlike_1	554	561	PF00625	0.551
LIG_eIF4E_1	44	50	PF01652	0.538
LIG_FHA_1	178	184	PF00498	0.551
LIG_FHA_1	260	266	PF00498	0.505
LIG_FHA_1	293	299	PF00498	0.525
LIG_FHA_1	427	433	PF00498	0.361
LIG_FHA_1	479	485	PF00498	0.422
LIG_FHA_1	578	584	PF00498	0.375
LIG_FHA_1	712	718	PF00498	0.766
LIG_FHA_2	106	112	PF00498	0.724
LIG_FHA_2	166	172	PF00498	0.683
LIG_FHA_2	227	233	PF00498	0.588
LIG_FHA_2	366	372	PF00498	0.760
LIG_FHA_2	467	473	PF00498	0.572
LIG_FHA_2	524	530	PF00498	0.511
LIG_GBD_Chelix_1	403	411	PF00786	0.513
LIG_HP1_1	63	67	PF01393	0.476
LIG_Integrin_RGD_1	384	386	PF01839	0.530
LIG_Integrin_RGD_1	521	523	PF01839	0.419
LIG_LIR_Gen_1	138	145	PF02991	0.647
LIG_LIR_Gen_1	166	175	PF02991	0.649
LIG_LIR_Gen_1	318	329	PF02991	0.528
LIG_LIR_Gen_1	523	531	PF02991	0.408
LIG_LIR_Gen_1	537	546	PF02991	0.422
LIG_LIR_Gen_1	69	77	PF02991	0.447
LIG_LIR_Nem_3	138	144	PF02991	0.649
LIG_LIR_Nem_3	166	170	PF02991	0.650
LIG_LIR_Nem_3	318	324	PF02991	0.494
LIG_LIR_Nem_3	409	415	PF02991	0.412
LIG_LIR_Nem_3	461	466	PF02991	0.426
LIG_LIR_Nem_3	52	58	PF02991	0.523
LIG_LIR_Nem_3	537	541	PF02991	0.389
LIG_LIR_Nem_3	69	74	PF02991	0.425
LIG_MYND_1	215	219	PF01753	0.540
LIG_Pex14_2	6	10	PF04695	0.474
LIG_PTB_Apo_2	586	593	PF02174	0.444
LIG_SH2_NCK_1	44	48	PF00017	0.561
LIG_SH2_PTP2	71	74	PF00017	0.483
LIG_SH2_STAP1	154	158	PF00017	0.541
LIG_SH2_STAP1	504	508	PF00017	0.416
LIG_SH2_STAP1	538	542	PF00017	0.545
LIG_SH2_STAT5	182	185	PF00017	0.539
LIG_SH2_STAT5	283	286	PF00017	0.621
LIG_SH2_STAT5	303	306	PF00017	0.412
LIG_SH2_STAT5	339	342	PF00017	0.408
LIG_SH2_STAT5	406	409	PF00017	0.514
LIG_SH2_STAT5	525	528	PF00017	0.401
LIG_SH2_STAT5	633	636	PF00017	0.621
LIG_SH2_STAT5	71	74	PF00017	0.483
LIG_SH2_STAT5	99	102	PF00017	0.711
LIG_SH3_3	172	178	PF00018	0.547
LIG_SH3_3	196	202	PF00018	0.515
LIG_SH3_3	216	222	PF00018	0.553
LIG_SH3_3	387	393	PF00018	0.762
LIG_SH3_3	618	624	PF00018	0.473
LIG_SH3_3	634	640	PF00018	0.572
LIG_SH3_3	654	660	PF00018	0.587
LIG_SUMO_SIM_anti_2	261	270	PF11976	0.595
LIG_SUMO_SIM_anti_2	438	443	PF11976	0.389
LIG_SUMO_SIM_anti_2	513	519	PF11976	0.507
LIG_SUMO_SIM_par_1	350	356	PF11976	0.606
LIG_SUMO_SIM_par_1	63	69	PF11976	0.483
LIG_TRAF2_1	135	138	PF00917	0.525
LIG_TRAF2_1	530	533	PF00917	0.309
LIG_TYR_ITIM	42	47	PF00017	0.553
LIG_WRC_WIRS_1	528	533	PF05994	0.313
MOD_CDK_SPxxK_3	218	225	PF00069	0.553
MOD_CK1_1	122	128	PF00069	0.619
MOD_CK1_1	148	154	PF00069	0.687
MOD_CK1_1	176	182	PF00069	0.685
MOD_CK1_1	285	291	PF00069	0.635
MOD_CK1_1	365	371	PF00069	0.599
MOD_CK1_1	391	397	PF00069	0.763
MOD_CK1_1	649	655	PF00069	0.667
MOD_CK1_1	711	717	PF00069	0.723
MOD_CK2_1	132	138	PF00069	0.731
MOD_CK2_1	165	171	PF00069	0.564
MOD_CK2_1	365	371	PF00069	0.779
MOD_CK2_1	419	425	PF00069	0.533
MOD_CK2_1	466	472	PF00069	0.528
MOD_CK2_1	523	529	PF00069	0.511
MOD_CK2_1	612	618	PF00069	0.481
MOD_Cter_Amidation	562	565	PF01082	0.412
MOD_GlcNHglycan	114	117	PF01048	0.746
MOD_GlcNHglycan	134	137	PF01048	0.581
MOD_GlcNHglycan	141	144	PF01048	0.596
MOD_GlcNHglycan	359	362	PF01048	0.630
MOD_GlcNHglycan	381	384	PF01048	0.803
MOD_GlcNHglycan	393	396	PF01048	0.537
MOD_GlcNHglycan	450	453	PF01048	0.567
MOD_GlcNHglycan	651	654	PF01048	0.590
MOD_GlcNHglycan	704	707	PF01048	0.719
MOD_GlcNHglycan	78	81	PF01048	0.492
MOD_GSK3_1	132	139	PF00069	0.692
MOD_GSK3_1	173	180	PF00069	0.805
MOD_GSK3_1	285	292	PF00069	0.540
MOD_GSK3_1	363	370	PF00069	0.653
MOD_GSK3_1	384	391	PF00069	0.777
MOD_GSK3_1	483	490	PF00069	0.474
MOD_GSK3_1	523	530	PF00069	0.299
MOD_GSK3_1	645	652	PF00069	0.655
MOD_GSK3_1	698	705	PF00069	0.838
MOD_GSK3_1	708	715	PF00069	0.620
MOD_N-GLC_1	448	453	PF02516	0.328
MOD_N-GLC_1	646	651	PF02516	0.748
MOD_NEK2_1	20	25	PF00069	0.460
MOD_NEK2_1	244	249	PF00069	0.554
MOD_NEK2_1	282	287	PF00069	0.588
MOD_NEK2_1	448	453	PF00069	0.471
MOD_NEK2_2	136	141	PF00069	0.530
MOD_NEK2_2	226	231	PF00069	0.408
MOD_NEK2_2	294	299	PF00069	0.309
MOD_NEK2_2	504	509	PF00069	0.502
MOD_NEK2_2	739	744	PF00069	0.718
MOD_PIKK_1	145	151	PF00454	0.781
MOD_PIKK_1	285	291	PF00454	0.421
MOD_PIKK_1	565	571	PF00454	0.382
MOD_PIKK_1	640	646	PF00454	0.758
MOD_PK_1	250	256	PF00069	0.340
MOD_PKA_2	112	118	PF00069	0.691
MOD_PKA_2	119	125	PF00069	0.710
MOD_PKA_2	258	264	PF00069	0.484
MOD_PKA_2	466	472	PF00069	0.609
MOD_PKA_2	649	655	PF00069	0.750
MOD_PKA_2	669	675	PF00069	0.827
MOD_PKA_2	695	701	PF00069	0.821
MOD_PKA_2	739	745	PF00069	0.567
MOD_PKB_1	552	560	PF00069	0.560
MOD_Plk_1	136	142	PF00069	0.658
MOD_Plk_1	226	232	PF00069	0.513
MOD_Plk_1	424	430	PF00069	0.486
MOD_Plk_1	51	57	PF00069	0.530
MOD_Plk_2-3	695	701	PF00069	0.664
MOD_Plk_4	136	142	PF00069	0.530
MOD_Plk_4	244	250	PF00069	0.455
MOD_Plk_4	499	505	PF00069	0.551
MOD_Plk_4	51	57	PF00069	0.431
MOD_Plk_4	537	543	PF00069	0.528
MOD_Plk_4	712	718	PF00069	0.545
MOD_ProDKin_1	124	130	PF00069	0.723
MOD_ProDKin_1	160	166	PF00069	0.671
MOD_ProDKin_1	171	177	PF00069	0.813
MOD_ProDKin_1	218	224	PF00069	0.726
MOD_ProDKin_1	365	371	PF00069	0.714
MOD_ProDKin_1	386	392	PF00069	0.677
MOD_ProDKin_1	5	11	PF00069	0.579
MOD_ProDKin_1	674	680	PF00069	0.698
MOD_ProDKin_1	698	704	PF00069	0.571
MOD_SUMO_rev_2	468	476	PF00179	0.561
MOD_SUMO_rev_2	90	96	PF00179	0.588
TRG_AP2beta_CARGO_1	318	328	PF09066	0.320
TRG_DiLeu_BaEn_1	263	268	PF01217	0.487
TRG_DiLeu_BaEn_1	312	317	PF01217	0.497
TRG_DiLeu_BaEn_2	68	74	PF01217	0.512
TRG_DiLeu_BaLyEn_6	33	38	PF01217	0.512
TRG_ENDOCYTIC_2	44	47	PF00928	0.554
TRG_ENDOCYTIC_2	525	528	PF00928	0.401
TRG_ENDOCYTIC_2	538	541	PF00928	0.359
TRG_ENDOCYTIC_2	633	636	PF00928	0.484
TRG_ENDOCYTIC_2	71	74	PF00928	0.483
TRG_ER_diArg_1	199	201	PF00400	0.595
TRG_ER_diArg_1	233	236	PF00400	0.496
TRG_ER_diArg_1	443	445	PF00400	0.508
TRG_ER_diArg_1	552	555	PF00400	0.576
TRG_Pf-PMV_PEXEL_1	349	353	PF00026	0.468
TRG_Pf-PMV_PEXEL_1	36	40	PF00026	0.445
TRG_Pf-PMV_PEXEL_1	564	569	PF00026	0.349

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6L1	Leptomonas seymouri	53%	90%
A0A1X0P7U7	Trypanosomatidae	34%	100%
A0A3S7XAR1	Leishmania donovani	71%	100%
A4IDE9	Leishmania infantum	70%	100%
D0A326	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9ASV0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
Q4Q1P6	Leishmania major	70%	99%
V5BPH3	Trypanosoma cruzi	34%	100%