Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HP41_LEIBR

TriTrypDb:

LbrM.35.1960 , LBRM2903_350026000

Length:

106

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4HP41

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP41

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.575
CLV_NRD_NRD_1	23	25	PF00675	0.616
CLV_NRD_NRD_1	3	5	PF00675	0.580
CLV_NRD_NRD_1	77	79	PF00675	0.359
CLV_PCSK_KEX2_1	11	13	PF00082	0.575
CLV_PCSK_KEX2_1	23	25	PF00082	0.616
CLV_PCSK_KEX2_1	3	5	PF00082	0.580
CLV_PCSK_KEX2_1	77	79	PF00082	0.394
CLV_PCSK_SKI1_1	3	7	PF00082	0.627
DEG_APCC_DBOX_1	10	18	PF00400	0.313
DEG_MDM2_SWIB_1	48	56	PF02201	0.404
DEG_Nend_Nbox_1	1	3	PF02207	0.393
DOC_USP7_MATH_1	10	14	PF00917	0.387
DOC_USP7_MATH_1	19	23	PF00917	0.364
LIG_14-3-3_CanoR_1	11	20	PF00244	0.412
LIG_14-3-3_CanoR_1	23	32	PF00244	0.460
LIG_Actin_WH2_2	42	59	PF00022	0.394
LIG_BIR_III_4	88	92	PF00653	0.559
LIG_deltaCOP1_diTrp_1	88	97	PF00928	0.611
LIG_FHA_1	68	74	PF00498	0.625
LIG_LIR_Gen_1	25	34	PF02991	0.382
LIG_LIR_Gen_1	70	80	PF02991	0.563
LIG_LIR_Nem_3	25	29	PF02991	0.418
LIG_LIR_Nem_3	70	75	PF02991	0.577
LIG_LIR_Nem_3	95	101	PF02991	0.571
LIG_Pex14_2	48	52	PF04695	0.289
LIG_REV1ctd_RIR_1	95	101	PF16727	0.666
LIG_SH2_CRK	38	42	PF00017	0.404
LIG_SH2_STAT5	26	29	PF00017	0.431
LIG_SH2_STAT5	47	50	PF00017	0.271
LIG_SH2_STAT5	72	75	PF00017	0.546
LIG_TYR_ITIM	36	41	PF00017	0.289
LIG_TYR_ITIM	45	50	PF00017	0.277
LIG_TYR_ITSM	68	75	PF00017	0.554
LIG_UBA3_1	53	61	PF00899	0.428
LIG_WRC_WIRS_1	94	99	PF05994	0.611
MOD_CK1_1	13	19	PF00069	0.463
MOD_CK1_1	22	28	PF00069	0.444
MOD_CK1_1	60	66	PF00069	0.546
MOD_CK2_1	22	28	PF00069	0.441
MOD_GlcNHglycan	17	20	PF01048	0.678
MOD_GlcNHglycan	8	11	PF01048	0.668
MOD_GSK3_1	15	22	PF00069	0.439
MOD_GSK3_1	6	13	PF00069	0.460
MOD_GSK3_1	63	70	PF00069	0.569
MOD_PKA_2	10	16	PF00069	0.355
MOD_PKA_2	22	28	PF00069	0.432
MOD_Plk_1	27	33	PF00069	0.486
MOD_Plk_4	93	99	PF00069	0.575
MOD_SUMO_rev_2	66	70	PF00179	0.495
TRG_ENDOCYTIC_2	26	29	PF00928	0.390
TRG_ENDOCYTIC_2	38	41	PF00928	0.197
TRG_ENDOCYTIC_2	47	50	PF00928	0.251
TRG_ENDOCYTIC_2	72	75	PF00928	0.546
TRG_ER_diArg_1	2	4	PF00400	0.386
TRG_ER_diArg_1	76	78	PF00400	0.604
TRG_Pf-PMV_PEXEL_1	99	103	PF00026	0.477

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P701	Leptomonas seymouri	74%	100%
A0A1X0P839	Trypanosomatidae	57%	100%
A0A3Q8IK31	Leishmania donovani	89%	100%
A0A422NLR1	Trypanosoma rangeli	57%	100%
A4IDE8	Leishmania infantum	89%	100%
D0A325	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9ASU9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q1P7	Leishmania major	89%	100%
V5B4H5	Trypanosoma cruzi	56%	100%