Putative aldehyde dehydrogenase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

aldehyde dehydrogenase, putative

Species:

Leishmania braziliensis

UniProt:

A4HP40_LEIBR

TriTrypDb:

LbrM.35.1950 , LBRM2903_350025900

Length:

508

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HP40

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP40

Function

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Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006520	amino acid metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009063	amino acid catabolic process	4	1
GO:0009448	gamma-aminobutyric acid metabolic process	4	1
GO:0009450	gamma-aminobutyric acid catabolic process	5	1
GO:0009987	cellular process	1	1
GO:0016054	organic acid catabolic process	4	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004029	aldehyde dehydrogenase (NAD+) activity	6	5
GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity	5	5
GO:0004777	succinate-semialdehyde dehydrogenase (NAD+) activity	6	1
GO:0009013	succinate-semialdehyde dehydrogenase [NAD(P)+] activity	5	2
GO:0016491	oxidoreductase activity	2	12
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	4	12
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	3	12
GO:0043878	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity	5	5

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	101	103	PF00675	0.298
CLV_NRD_NRD_1	110	112	PF00675	0.276
CLV_NRD_NRD_1	250	252	PF00675	0.245
CLV_NRD_NRD_1	267	269	PF00675	0.209
CLV_NRD_NRD_1	449	451	PF00675	0.261
CLV_PCSK_KEX2_1	101	103	PF00082	0.309
CLV_PCSK_KEX2_1	110	112	PF00082	0.309
CLV_PCSK_KEX2_1	267	269	PF00082	0.279
CLV_PCSK_KEX2_1	274	276	PF00082	0.283
CLV_PCSK_KEX2_1	362	364	PF00082	0.269

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0E3T3B5	Malus domestica	33%	100%
A0A0E3T552	Malus domestica	33%	100%
A0A0N0P2K9	Leptomonas seymouri	36%	100%
A0A0N1HV25	Leptomonas seymouri	26%	91%
A0A0N1I2U5	Leptomonas seymouri	31%	95%
A0A0N1IL67	Leptomonas seymouri	72%	100%
A0A0N1PB61	Leptomonas seymouri	30%	87%
A0A0S4IS93	Bodo saltans	28%	100%
A0A0S4ITF6	Bodo saltans	32%	92%
A0A0S4IZS0	Bodo saltans	29%	98%

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