LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HP39_LEIBR
TriTrypDb:
LbrM.35.1940 , LBRM2903_350025800 *
Length:
545

Annotations

LeishMANIAdb annotations

A membrane-associated WD40 domain protein. Might be a receptor for some unidentified partner molecule.. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 7, no: 4
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 11
GO:0110165 cellular anatomical entity 1 11

Expansion

Sequence features

A4HP39
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP39

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 217 221 PF00656 0.422
CLV_NRD_NRD_1 3 5 PF00675 0.350
CLV_NRD_NRD_1 408 410 PF00675 0.498
CLV_PCSK_KEX2_1 165 167 PF00082 0.540
CLV_PCSK_KEX2_1 3 5 PF00082 0.350
CLV_PCSK_KEX2_1 327 329 PF00082 0.432
CLV_PCSK_KEX2_1 408 410 PF00082 0.511
CLV_PCSK_PC1ET2_1 165 167 PF00082 0.484
CLV_PCSK_PC1ET2_1 327 329 PF00082 0.432
CLV_PCSK_SKI1_1 190 194 PF00082 0.591
CLV_PCSK_SKI1_1 216 220 PF00082 0.493
CLV_PCSK_SKI1_1 239 243 PF00082 0.485
CLV_PCSK_SKI1_1 397 401 PF00082 0.598
DEG_Kelch_Keap1_1 286 291 PF01344 0.344
DEG_SPOP_SBC_1 228 232 PF00917 0.240
DEG_SPOP_SBC_1 277 281 PF00917 0.219
DOC_ANK_TNKS_1 248 255 PF00023 0.397
DOC_ANK_TNKS_1 81 88 PF00023 0.312
DOC_CYCLIN_yCln2_LP_2 136 142 PF00134 0.296
DOC_MAPK_DCC_7 327 336 PF00069 0.379
DOC_MAPK_DCC_7 66 75 PF00069 0.388
DOC_MAPK_gen_1 3 12 PF00069 0.540
DOC_MAPK_gen_1 464 473 PF00069 0.416
DOC_MAPK_HePTP_8 324 336 PF00069 0.223
DOC_MAPK_HePTP_8 63 75 PF00069 0.380
DOC_MAPK_MEF2A_6 327 336 PF00069 0.379
DOC_MAPK_MEF2A_6 66 75 PF00069 0.388
DOC_PP2B_LxvP_1 296 299 PF13499 0.342
DOC_PP2B_PxIxI_1 331 337 PF00149 0.365
DOC_PP4_FxxP_1 225 228 PF00568 0.294
DOC_PP4_FxxP_1 329 332 PF00568 0.295
DOC_SPAK_OSR1_1 328 332 PF12202 0.391
DOC_USP7_MATH_1 198 202 PF00917 0.354
DOC_USP7_MATH_1 2 6 PF00917 0.713
DOC_USP7_MATH_1 228 232 PF00917 0.378
DOC_USP7_MATH_1 317 321 PF00917 0.337
DOC_USP7_MATH_1 94 98 PF00917 0.410
DOC_WW_Pin1_4 224 229 PF00397 0.296
DOC_WW_Pin1_4 241 246 PF00397 0.278
DOC_WW_Pin1_4 297 302 PF00397 0.269
DOC_WW_Pin1_4 313 318 PF00397 0.363
DOC_WW_Pin1_4 412 417 PF00397 0.295
DOC_WW_Pin1_4 528 533 PF00397 0.718
LIG_14-3-3_CanoR_1 3 10 PF00244 0.688
LIG_14-3-3_CanoR_1 381 386 PF00244 0.389
LIG_14-3-3_CanoR_1 408 414 PF00244 0.311
LIG_Actin_WH2_2 455 471 PF00022 0.362
LIG_Actin_WH2_2 49 67 PF00022 0.424
LIG_BRCT_BRCA1_1 221 225 PF00533 0.361
LIG_BRCT_BRCA1_1 257 261 PF00533 0.371
LIG_BRCT_BRCA1_1 79 83 PF00533 0.439
LIG_BRCT_BRCA1_1 98 102 PF00533 0.189
LIG_deltaCOP1_diTrp_1 48 53 PF00928 0.338
LIG_EH_1 132 136 PF12763 0.329
LIG_FHA_1 146 152 PF00498 0.329
LIG_FHA_1 209 215 PF00498 0.341
LIG_FHA_1 267 273 PF00498 0.361
LIG_FHA_1 279 285 PF00498 0.365
LIG_FHA_1 35 41 PF00498 0.350
LIG_FHA_2 111 117 PF00498 0.421
LIG_FHA_2 123 129 PF00498 0.323
LIG_FHA_2 205 211 PF00498 0.366
LIG_FHA_2 248 254 PF00498 0.378
LIG_FHA_2 335 341 PF00498 0.274
LIG_HCF-1_HBM_1 137 140 PF13415 0.292
LIG_Integrin_isoDGR_2 406 408 PF01839 0.547
LIG_IRF3_LxIS_1 238 244 PF10401 0.311
LIG_LIR_Apic_2 222 228 PF02991 0.213
LIG_LIR_Apic_2 412 416 PF02991 0.277
LIG_LIR_Gen_1 269 278 PF02991 0.356
LIG_LIR_Gen_1 330 340 PF02991 0.318
LIG_LIR_Gen_1 478 488 PF02991 0.276
LIG_LIR_Gen_1 52 60 PF02991 0.374
LIG_LIR_Gen_1 97 104 PF02991 0.349
LIG_LIR_Nem_3 267 273 PF02991 0.309
LIG_LIR_Nem_3 330 336 PF02991 0.289
LIG_LIR_Nem_3 428 433 PF02991 0.385
LIG_LIR_Nem_3 478 483 PF02991 0.319
LIG_LIR_Nem_3 492 497 PF02991 0.417
LIG_LIR_Nem_3 52 56 PF02991 0.393
LIG_LIR_Nem_3 97 101 PF02991 0.356
LIG_NRBOX 445 451 PF00104 0.324
LIG_Pex14_1 229 233 PF04695 0.307
LIG_Pex14_2 225 229 PF04695 0.288
LIG_Pex14_2 366 370 PF04695 0.436
LIG_Pex14_2 430 434 PF04695 0.310
LIG_REV1ctd_RIR_1 431 438 PF16727 0.387
LIG_SH2_CRK 413 417 PF00017 0.307
LIG_SH2_CRK 497 501 PF00017 0.629
LIG_SH2_CRK 98 102 PF00017 0.287
LIG_SH2_GRB2like 392 395 PF00017 0.305
LIG_SH2_GRB2like 421 424 PF00017 0.374
LIG_SH2_NCK_1 140 144 PF00017 0.241
LIG_SH2_NCK_1 392 396 PF00017 0.253
LIG_SH2_NCK_1 413 417 PF00017 0.325
LIG_SH2_NCK_1 98 102 PF00017 0.287
LIG_SH2_PTP2 333 336 PF00017 0.325
LIG_SH2_PTP2 470 473 PF00017 0.243
LIG_SH2_SRC 140 143 PF00017 0.254
LIG_SH2_SRC 333 336 PF00017 0.325
LIG_SH2_SRC 392 395 PF00017 0.305
LIG_SH2_STAP1 140 144 PF00017 0.297
LIG_SH2_STAP1 392 396 PF00017 0.405
LIG_SH2_STAP1 98 102 PF00017 0.287
LIG_SH2_STAT5 122 125 PF00017 0.324
LIG_SH2_STAT5 152 155 PF00017 0.328
LIG_SH2_STAT5 271 274 PF00017 0.247
LIG_SH2_STAT5 311 314 PF00017 0.532
LIG_SH2_STAT5 333 336 PF00017 0.270
LIG_SH2_STAT5 41 44 PF00017 0.309
LIG_SH2_STAT5 411 414 PF00017 0.306
LIG_SH2_STAT5 421 424 PF00017 0.421
LIG_SH2_STAT5 470 473 PF00017 0.232
LIG_SH2_STAT5 510 513 PF00017 0.683
LIG_SH2_STAT5 59 62 PF00017 0.255
LIG_SH2_STAT5 90 93 PF00017 0.268
LIG_SH3_1 436 442 PF00018 0.392
LIG_SH3_3 181 187 PF00018 0.292
LIG_SH3_3 242 248 PF00018 0.279
LIG_SH3_3 295 301 PF00018 0.233
LIG_SH3_3 436 442 PF00018 0.336
LIG_Sin3_3 15 22 PF02671 0.319
LIG_SUMO_SIM_par_1 171 178 PF11976 0.348
LIG_SUMO_SIM_par_1 398 404 PF11976 0.301
LIG_SUMO_SIM_par_1 487 493 PF11976 0.357
LIG_TRAF2_1 113 116 PF00917 0.421
LIG_TRAF2_1 201 204 PF00917 0.454
LIG_TRAF2_1 207 210 PF00917 0.399
LIG_TYR_ITIM 331 336 PF00017 0.332
LIG_TYR_ITIM 468 473 PF00017 0.440
LIG_TYR_ITIM 495 500 PF00017 0.545
LIG_TYR_ITSM 267 274 PF00017 0.197
LIG_WRC_WIRS_1 491 496 PF05994 0.438
LIG_WRC_WIRS_1 50 55 PF05994 0.363
MOD_CK1_1 227 233 PF00069 0.333
MOD_CK1_1 234 240 PF00069 0.293
MOD_CK1_1 315 321 PF00069 0.393
MOD_CK1_1 478 484 PF00069 0.412
MOD_CK1_1 5 11 PF00069 0.456
MOD_CK1_1 52 58 PF00069 0.395
MOD_CK1_1 527 533 PF00069 0.713
MOD_CK2_1 110 116 PF00069 0.407
MOD_CK2_1 122 128 PF00069 0.277
MOD_CK2_1 198 204 PF00069 0.394
MOD_CK2_1 247 253 PF00069 0.309
MOD_CK2_1 334 340 PF00069 0.294
MOD_Cter_Amidation 406 409 PF01082 0.527
MOD_GlcNHglycan 104 107 PF01048 0.499
MOD_GlcNHglycan 220 224 PF01048 0.460
MOD_GlcNHglycan 25 28 PF01048 0.696
MOD_GlcNHglycan 257 260 PF01048 0.598
MOD_GlcNHglycan 288 291 PF01048 0.629
MOD_GlcNHglycan 319 322 PF01048 0.639
MOD_GlcNHglycan 388 391 PF01048 0.480
MOD_GlcNHglycan 446 449 PF01048 0.568
MOD_GlcNHglycan 542 545 PF01048 0.464
MOD_GlcNHglycan 92 95 PF01048 0.476
MOD_GSK3_1 151 158 PF00069 0.314
MOD_GSK3_1 198 205 PF00069 0.432
MOD_GSK3_1 224 231 PF00069 0.336
MOD_GSK3_1 30 37 PF00069 0.396
MOD_GSK3_1 313 320 PF00069 0.408
MOD_GSK3_1 412 419 PF00069 0.322
MOD_GSK3_1 475 482 PF00069 0.272
MOD_GSK3_1 524 531 PF00069 0.700
MOD_GSK3_1 90 97 PF00069 0.353
MOD_N-GLC_1 110 115 PF02516 0.572
MOD_N-GLC_1 116 121 PF02516 0.539
MOD_N-GLC_1 264 269 PF02516 0.594
MOD_N-GLC_1 524 529 PF02516 0.460
MOD_NEK2_1 102 107 PF00069 0.262
MOD_NEK2_1 151 156 PF00069 0.335
MOD_NEK2_1 21 26 PF00069 0.641
MOD_NEK2_1 278 283 PF00069 0.307
MOD_NEK2_1 444 449 PF00069 0.339
MOD_NEK2_1 490 495 PF00069 0.301
MOD_NEK2_1 524 529 PF00069 0.738
MOD_NEK2_1 89 94 PF00069 0.285
MOD_PIKK_1 178 184 PF00454 0.475
MOD_PKA_1 3 9 PF00069 0.532
MOD_PKA_2 2 8 PF00069 0.683
MOD_PKA_2 347 353 PF00069 0.401
MOD_PKA_2 380 386 PF00069 0.359
MOD_PKA_2 94 100 PF00069 0.367
MOD_Plk_1 110 116 PF00069 0.335
MOD_Plk_1 202 208 PF00069 0.499
MOD_Plk_1 264 270 PF00069 0.391
MOD_Plk_1 518 524 PF00069 0.724
MOD_Plk_4 169 175 PF00069 0.289
MOD_Plk_4 208 214 PF00069 0.447
MOD_Plk_4 266 272 PF00069 0.336
MOD_Plk_4 426 432 PF00069 0.278
MOD_Plk_4 475 481 PF00069 0.339
MOD_Plk_4 490 496 PF00069 0.276
MOD_ProDKin_1 224 230 PF00069 0.297
MOD_ProDKin_1 241 247 PF00069 0.277
MOD_ProDKin_1 297 303 PF00069 0.268
MOD_ProDKin_1 313 319 PF00069 0.359
MOD_ProDKin_1 412 418 PF00069 0.303
MOD_ProDKin_1 528 534 PF00069 0.719
MOD_SUMO_rev_2 461 468 PF00179 0.479
TRG_DiLeu_BaLyEn_6 242 247 PF01217 0.323
TRG_DiLeu_BaLyEn_6 529 534 PF01217 0.719
TRG_ENDOCYTIC_2 270 273 PF00928 0.266
TRG_ENDOCYTIC_2 333 336 PF00928 0.279
TRG_ENDOCYTIC_2 470 473 PF00928 0.239
TRG_ENDOCYTIC_2 497 500 PF00928 0.632
TRG_ENDOCYTIC_2 98 101 PF00928 0.290
TRG_ER_diArg_1 2 4 PF00400 0.563
TRG_ER_diArg_1 408 410 PF00400 0.311
TRG_NES_CRM1_1 276 291 PF08389 0.214
TRG_Pf-PMV_PEXEL_1 249 253 PF00026 0.493
TRG_Pf-PMV_PEXEL_1 515 519 PF00026 0.496

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7G1 Leptomonas seymouri 65% 100%
A0A0S4ISR8 Bodo saltans 41% 100%
A0A1X0P7T5 Trypanosomatidae 51% 100%
A0A3Q8IKI2 Leishmania donovani 80% 100%
A0A3R7NQT8 Trypanosoma rangeli 46% 100%
A4IDE6 Leishmania infantum 79% 99%
D0A322 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 47% 100%
E9ASU7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 79% 100%
Q4Q1P9 Leishmania major 81% 100%
V5BJV5 Trypanosoma cruzi 48% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS